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PTPRN
Gene Name PTPRN (QuickGO )Interactive visualization of PTPRN structures tutorial to explore the interactive visualization)
Synonyms PTPRN, ICA3, ICA512
Protein Name PTPRN
Alternative Name(s)
Receptor-type tyrosine-protein phosphatase-like N;R-PTP-N;Islet cell antigen 512;ICA 512;Islet cell autoantigen 3;PTP IA-2;ICA512-N-terminal fragment;ICA512-NTF;ICA512-transmembrane fragment;ICA512-TMF;ICA512-cleaved cytosolic fragment;ICA512-CCF;
EntrezGene ID 5798 (Comparative Toxicogenomics)
UniProt AC (Human)
Q16849
(protein sequence )
Enzyme Class N/A Molecular Weight 105848 Dalton Protein Length 979 amino acids (AA) Genome Browsers NCBI | ENSG00000054356 (Ensembl) | UCSC Crosslinking annotations Query our ID-mapping tableOrthologues Quest For Orthologues (QFO) | GeneTree Classification Superfamily: Class I Cys-based PTPs --> Family: R-PTP | Historic class: Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CATH ID: 3.90.190.10 | SCOP Fold: CC1 Phosphatase activity inactive | Catalytic signature motif: HCSDGAGR
Localization (UniProt annotation) Membrane Cytoplasmic vesicle, secretoryvesicle membrane Perikaryon Cell projection, axon Cell junction, synapse Cell membrane Endosome Note=Detected on neuronalsecretory vesicles, but not on synaptic vesicles Colocalizes withinsulin-containing secretory granules (PubMed:25561468) Primarilydetected on secretory vesicle membranes Transiently found at thecell membrane, when secretory vesicles fuse with the cell membraneto release their cargo Is then endocytosed and recycled tosecretory vesicles via the Golgi apparatus membranes ICA512-transmembrane fragment: Cytoplasmicvesicle, secretory vesicle membrane ICA512-cleaved cytosolic fragment: Nucleus Function (UniProt annotation) Plays a role in vesicle-mediated secretory processes(PubMed:24843546) Required for normal accumulation of secretoryvesicles in hippocampus, pituitary and pancreatic islets (Bysimilarity) Required for the accumulation of normal levels ofinsulin-containing vesicles and preventing their degradation(PubMed:24843546) Plays a role in insulin secretion in responseto glucose stimuli (PubMed:24843546) Required for normalaccumulation of the neurotransmitters norepinephrine, dopamine andserotonin in the brain (By similarity) In females, but not inmales, required for normal accumulation and secretion of pituitaryhormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity) Required to maintainnormal levels of renin expression and renin release (Bysimilarity) Seems to lack intrinsic enzyme activity (Bysimilarity) May regulate catalytic active protein-tyrosinephosphatases such as PTPRA through dimerization (By similarity) ICA512-transmembrane fragment: ICA512-TMF regulatesdynamics and exocytosis of insulin secretory granules (SGs);binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed torestrain SGs mobility and exocytosis by tethering them to theactin cytoskeleton depending on UTRN; the function is inhibited bycytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacingSNTB2 ICA512-cleaved cytosolic fragment: ICA512-CCFtranslocated to the nucleus promotes expression of insulin andother granule-related genes; the function implicates binding toand regulating activity of STAT5B probably by preventing itsdephosphorylation and potentially by inducing its sumoylation byrecruiting PIAS4 (PubMed:15596545, PubMed:16622421,PubMed:18178618) Enhances pancreatic beta-cell proliferation byconverging with signaling by STAT5B and STAT3 (PubMed:15596545,PubMed:16622421, PubMed:18178618) ICA512-CCF located in thecytoplasm regulates dynamics and exocytosis of insulin secretorygranules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2thus enhancing SGs mobility and exocytosis (PubMed:18824546,PubMed:20886068) Catalytic Activity (UniProt annotation) NA Protein Sequence MRRPRRPGGLGGSGGLRLLLCLLLLSSRPGGCSAVSAHGCLFDRRLCSHLEVCIQDGLFGQCQVGVGQARPLLQVTSPVL
QRLQGVLRQLMSQGLSWHDDLTQYVISQEMERIPRLRPPEPRPRDRSGLAPKRPGPAGELLLQDIPTGSAPAAQHRLPQP
PVGKGGAGASSSLSPLQAELLPPLLEHLLLPPQPPHPSLSYEPALLQPYLFHQFGSRDGSRVSEGSPGMVSVGPLPKAEA
PALFSRTASKGIFGDHPGHSYGDLPGPSPAQLFQDSGLLYLAQELPAPSRARVPRLPEQGSSSRAEDSPEGYEKEGLGDR
GEKPASPAVQPDAALQRLAAVLAGYGVELRQLTPEQLSTLLTLLQLLPKGAGRNPGGVVNVGADIKKTMEGPVEGRDTAE
LPARTSPMPGHPTASPTSSEVQQVPSPVSSEPPKAARPPVTPVLLEKKSPLGQSQPTVAGQPSARPAAEEYGYIVTDQKP
LSLAAGVKLLEILAEHVHMSSGSFINISVVGPALTFRIRHNEQNLSLADVTQQAGLVKSELEAQTGLQILQTGVGQREEA
AAVLPQTAHSTSPMRSVLLTLVALAGVAGLLVALAVALCVRQHARQQDKERLAALGPEGAHGDTTFEYQDLCRQHMATKS
LFNRAEGPPEPSRVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQ
AEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWE
SGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGT
PASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFE
FALTAVAEEVNAILKALPQ
ELM Motif Motif Instance Description Motif Regex NA NA NA NA
Pathway ID Pathway Name Pathway Description (KEGG) hsa04940 Type I diabetes mellitus Type I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-presenting cell (APC), such as macrophages and dendritic cells, and presented in a complex with MHC-II molecules on the surface of the APC. Then immunogenic signals from APC activate CD4+ T cells, predominantly of the Th1 subset. Antigen-activated Th1 cells produce IL-2 and IFNgamma. They activate macrophages and cytotoxic CD8+ T cells, and these effector cells may kill islet beta-cells by one or both of two types of mechanisms: (1) direct interactions of antigen-specific cytotoxic T cells with a beta-cell autoantigen-MHC-I complex on the beta-cell, and (2) non-specific inflammatory mediators, such as free radicals/oxidants and cytokines (IL-1, TNFalpha, TNFbeta, IFNgamma).Type I diabetes is a polygenic disease. One of the principle determining genetic factors in diabetes incidence is the inheritance of mutant MHC-II alleles. Another plausible candidate gene is the insulin gene.
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ATXN10 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID BZW2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID C19orf25 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CALR Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID CALU Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID CAND2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CANX Affinity Capture-MS, Proximity Label-MS physical 27432908 , 27880917 , (Europe PMC )NA BioGRID CAPN2 Biochemical Activity physical 11483505 , (Europe PMC )NA BioGRID CCDC51 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CIP2A Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CLN6 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CLN8 Two-hybrid physical 23142642 , (Europe PMC )NA BioGRID CMTM6 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CNIH4 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID COLGALT1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID COX2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CSE1L Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CYB5D2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID DDOST Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID DNAAF5 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DNAJB11 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID DYM Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID EIF3K Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID ERP44 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID GANAB Affinity Capture-MS, Proximity Label-MS physical 27432908 , 27880917 , (Europe PMC )NA BioGRID GRAMD1A Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID HEATR3 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID HLA-F Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID HSP90B1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID HSPA5 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID HYOU1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID IPO5 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID KIF14 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID LMBR1L Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID LTN1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MAL Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct MFSD8 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID MIA3 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID MICAL2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID MON2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID NCDN Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID NUP210 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID OS9 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID P4HB Affinity Capture-MS, Proximity Label-MS physical 27432908 , 27880917 , (Europe PMC )NA BioGRID PDIA3 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PDIA4 Affinity Capture-MS, Proximity Label-MS physical 27432908 , 27880917 , (Europe PMC )NA BioGRID PDIA6 Affinity Capture-MS, Proximity Label-MS physical 27432908 , 27880917 , (Europe PMC )NA BioGRID PEX19 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID PLA2G7 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID PLOD1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PLOD3 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PLP1 Two-hybrid, two hybrid, two hybrid array, two hybrid bait and prey pooling approach, two hybrid prey pooling approach, validated two hybrid physical, physical association 21516116 , 25416956 , 25910212 , 26871637 , Europe PMC )0.37, 0.56, 0.79 BioGRID, IntAct, MINT PPIB Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PRKCSH Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PTPRN Affinity Capture-MS, tox-r dimerization assay association, physical 15978577 , 27432908 , (Europe PMC )0.31 BioGRID, IntAct, MINT PTPRN2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID RANBP6 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID RINT1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID RPN2 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID SAAL1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SCO2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SEC61A1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SEC61A2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SGSM2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID SLC39A7 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SNTB2 Reconstituted Complex, pull down, two hybrid direct interaction, physical, physical association 11043403 , 11483505 , (Europe PMC )0.37, 0.44 BioGRID, IntAct SNX19 Proximity Label-MS, anti tag coimmunoprecipitation, two hybrid physical, physical association 16273344 , 27880917 , (Europe PMC )0.51 BioGRID, IntAct SPTBN4 Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, two hybrid physical, physical association 11086001 , (Europe PMC )0.51 BioGRID, IntAct SPTLC2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TBC1D15 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TMEM214 Affinity Capture-MS physical 27432908 , 28514442 , (Europe PMC )NA BioGRID TMEM43 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TNPO1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TNPO3 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TRIM13 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TTYH3 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TXNDC5 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID UBQLN4 Two-hybrid, two hybrid physical, physical association 16713569 , (Europe PMC )0.37 BioGRID, IntAct UGGT1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID XPO4 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID XPO5 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID XPO6 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID XPOT Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID ZW10 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source MAL Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct NOS1AP pull down direct interaction 11043403 , (Europe PMC )0.44 IntAct PLP1 Two-hybrid, two hybrid, two hybrid array, two hybrid bait and prey pooling approach, two hybrid prey pooling approach, validated two hybrid physical, physical association 21516116 , 25416956 , 25910212 , 26871637 , Europe PMC )0.37, 0.56, 0.79 BioGRID, IntAct, MINT PPIA anti tag coimmunoprecipitation, two hybrid physical association 16273344 , (Europe PMC )0.51 IntAct PTPRN Affinity Capture-MS, tox-r dimerization assay association, physical 15978577 , 27432908 , (Europe PMC )0.31 BioGRID, IntAct, MINT PTPRS anti tag coimmunoprecipitation, two hybrid physical association 16273344 , (Europe PMC )0.51 IntAct PTPRT anti tag coimmunoprecipitation, two hybrid physical association 16273344 , (Europe PMC )0.51 IntAct SNTB2 Reconstituted Complex, pull down, two hybrid direct interaction, physical, physical association 11043403 , 11483505 , (Europe PMC )0.37, 0.44 BioGRID, IntAct SNX19 Proximity Label-MS, anti tag coimmunoprecipitation, two hybrid physical, physical association 16273344 , 27880917 , (Europe PMC )0.51 BioGRID, IntAct SPTBN4 Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, two hybrid physical, physical association 11086001 , (Europe PMC )0.51 BioGRID, IntAct UBQLN4 Two-hybrid, two hybrid physical, physical association 16713569 , (Europe PMC )0.37 BioGRID, IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ATXN10 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID BZW2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID C19orf25 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CALR Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID CALU Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID CAND2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CANX Affinity Capture-MS, Proximity Label-MS physical 27432908 , 27880917 , (Europe PMC )NA BioGRID CAPN2 Biochemical Activity physical 11483505 , (Europe PMC )NA BioGRID CCDC51 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CIP2A Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CLN6 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CLN8 Two-hybrid physical 23142642 , (Europe PMC )NA BioGRID CMTM6 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CNIH4 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID COLGALT1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID COX2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CSE1L Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CYB5D2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID DDOST Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID DNAAF5 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DNAJB11 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID DYM Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID EIF3K Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID ERP44 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID GANAB Affinity Capture-MS, Proximity Label-MS physical 27432908 , 27880917 , (Europe PMC )NA BioGRID GRAMD1A Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID HEATR3 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID HLA-F Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID HSP90B1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID HSPA5 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID HYOU1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID IPO5 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID KIF14 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID LMBR1L Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID LTN1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MADD anti tag coimmunoprecipitation, two hybrid physical association 16273344 , (Europe PMC )0.51 IntAct MAL Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct MFSD8 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID MIA3 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID MICAL2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID MON2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID NCDN Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID NOS1AP pull down direct interaction 11043403 , (Europe PMC )0.44 IntAct NUP210 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID OS9 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID P4HB Affinity Capture-MS, Proximity Label-MS physical 27432908 , 27880917 , (Europe PMC )NA BioGRID PDIA3 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PDIA4 Affinity Capture-MS, Proximity Label-MS physical 27432908 , 27880917 , (Europe PMC )NA BioGRID PDIA6 Affinity Capture-MS, Proximity Label-MS physical 27432908 , 27880917 , (Europe PMC )NA BioGRID PEX19 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID PLA2G7 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID PLOD1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PLOD3 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PLP1 Two-hybrid, two hybrid, two hybrid array, two hybrid bait and prey pooling approach, two hybrid prey pooling approach, validated two hybrid physical, physical association 21516116 , 25416956 , 25910212 , 26871637 , Europe PMC )0.37, 0.56, 0.79 BioGRID, IntAct, MINT PPIA anti tag coimmunoprecipitation, two hybrid physical association 16273344 , (Europe PMC )0.51 IntAct PPIB Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PRKCSH Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PTPRN Affinity Capture-MS, tox-r dimerization assay association, physical 15978577 , 27432908 , (Europe PMC )0.31 BioGRID, IntAct, MINT PTPRN2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PTPRS anti tag coimmunoprecipitation, two hybrid physical association 16273344 , (Europe PMC )0.51 IntAct PTPRT anti tag coimmunoprecipitation, two hybrid physical association 16273344 , (Europe PMC )0.51 IntAct RANBP6 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID RINT1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID RPN2 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID SAAL1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SCO2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SEC61A1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SEC61A2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SGSM2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID SLC39A7 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SNTB2 Reconstituted Complex, pull down, two hybrid direct interaction, physical, physical association 11043403 , 11483505 , (Europe PMC )0.37, 0.44 BioGRID, IntAct SNX19 Proximity Label-MS, anti tag coimmunoprecipitation, two hybrid physical, physical association 16273344 , 27880917 , (Europe PMC )0.51 BioGRID, IntAct SPTBN4 Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, two hybrid physical, physical association 11086001 , (Europe PMC )0.51 BioGRID, IntAct SPTLC2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TBC1D15 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TMEM214 Affinity Capture-MS physical 27432908 , 28514442 , (Europe PMC )NA BioGRID TMEM43 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TNPO1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TNPO3 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TRIM13 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TTYH3 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TXNDC5 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID UBQLN4 Two-hybrid, two hybrid physical, physical association 16713569 , (Europe PMC )0.37 BioGRID, IntAct UGGT1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID XPO4 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID XPO5 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID XPO6 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID XPOT Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID ZW10 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID
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