1 => The disorder is placed on the map based on its association with a gene, but the underlying defect is not known
2 => The disorder has been placed on the map by linkage; no mutation has been found
3 => The molecular basis for the disorder is known; a mutation has been found in the gene
4 => A contiguous gene deletion or duplication syndrome, multiple genes are deleted or duplicated causing the phenotype
| Gene Symbol | Chromosomal Location | Gene MIM number | Mapping Method | Phenotype | Phenotype MIM number | Phenotype Mapping Key |
| CASP8 | 2q33.1 | 601763 | A | ?Autoimmune lymphoproliferative syndrome, type IIB, 607271 (3) | 607271 | 3 |
| CASP8 | 2q33.1 | 601763 | A | Hepatocellular carcinoma, somatic, 114550 (3) | 114550 | 3 |
| CASP8 | 2q33.1 | 601763 | A | {Breast cancer, protection against}, 114480 (3) | 114480 | 3 |
| CASP8 | 2q33.1 | 601763 | A | {Lung cancer, protection against}, 211980 (3) | 211980 | 3 |