Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
CASP8	1509	COSM6917794,	skin	carcinoma	p.?	Unknown	2:201286458-201286458,	PATHOGENIC	0.99858	28481359
CASP8	1509	COSM5049779,	upper_aerodigestive_tract	carcinoma	p.C443F	Substitution - Missense	2:201285290-201285290,	PATHOGENIC	0.99733	26107208
CASP8	1509	COSM6958731,	upper_aerodigestive_tract	carcinoma	p.K370R	Substitution - Missense	2:201285071-201285071,	PATHOGENIC	0.99659	28481359
CASP8	1509	COSM6937071,	cervix	carcinoma	p.D415Y	Substitution - Missense	2:201285205-201285205,	PATHOGENIC	0.9963	28481359
CASP8	1509	COSM4521752,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.G335R	Substitution - Missense	2:201284965-201284965,	PATHOGENIC	0.99618	28481359
CASP8	1509	COSM3713592,	urinary_tract	carcinoma	p.Q375E	Substitution - Missense	2:201285085-201285085,	PATHOGENIC	0.99586	28481359
CASP8	1509	COSM3355737,	large_intestine	carcinoma	p.R430Q	Substitution - Missense	2:201285251-201285251,	PATHOGENIC	0.99563	12949717
CASP8	1509	COSM6948372,	lung	carcinoma	p.D415N	Substitution - Missense	2:201285205-201285205,	PATHOGENIC	0.99563	28481359
CASP8	1509	COSM3355737,	urinary_tract	carcinoma	p.R430Q	Substitution - Missense	2:201285251-201285251,	PATHOGENIC	0.99563	28481359
CASP8	1509	COSM6971449,	stomach	carcinoma	p.L460P	Substitution - Missense	2:201286482-201286482,	PATHOGENIC	0.99513	28481359
CASP8	1509	COSM6940294,	urinary_tract	carcinoma	p.F373C	Substitution - Missense	2:201285080-201285080,	PATHOGENIC	0.99507	28481359
CASP8	1509	COSM6943645,	large_intestine	carcinoma	p.L446P	Substitution - Missense	2:201285299-201285299,	PATHOGENIC	0.99471	28481359
CASP8	1509	COSM4884872,	lung	carcinoma	p.Q375*	Substitution - Nonsense	2:201285085-201285085,	PATHOGENIC	0.99466	28481359
CASP8	1509	COSM6906475,	urinary_tract	carcinoma	p.K23E	Substitution - Missense	2:201266553-201266553,	PATHOGENIC	0.99461	29420467
CASP8	1509	COSM6916664,	vulva	carcinoma	p.?	Unknown	2:201272637-201272637,	PATHOGENIC	0.99403	28481359
CASP8	1509	COSM209552,	central_nervous_system	glioma	p.G342D	Substitution - Missense	2:201284987-201284987,	PATHOGENIC	0.99383	28481359
CASP8	1509	COSM3724393,	upper_aerodigestive_tract	carcinoma	p.?	Unknown	2:201272636-201272636,	PATHOGENIC	0.99347	23619168
CASP8	1509	COSM3724393,	upper_aerodigestive_tract	carcinoma	p.?	Unknown	2:201272636-201272636,	PATHOGENIC	0.99347	23619168
CASP8	1509	COSM1014869,	upper_aerodigestive_tract	carcinoma	p.N258S	Substitution - Missense	2:201276888-201276888,	PATHOGENIC	0.99285	23619168
CASP8	1509	COSM5025010,	breast	carcinoma	p.F416S	Substitution - Missense	2:201285209-201285209,	PATHOGENIC	0.99217	25850943
CASP8	1509	COSM6975302,	large_intestine	carcinoma	p.L418P	Substitution - Missense	2:201285215-201285215,	PATHOGENIC	0.99217	28481359
CASP8	1509	COSM3713595,	skin	adnexal_tumour	p.P411L	Substitution - Missense	2:201285194-201285194,	PATHOGENIC	0.99203	28481359
CASP8	1509	COSM3713595,	upper_aerodigestive_tract	carcinoma	p.P411L	Substitution - Missense	2:201285194-201285194,	PATHOGENIC	0.99203	28481359
CASP8	1509	COSM3713595,	large_intestine	carcinoma	p.P411L	Substitution - Missense	2:201285194-201285194,	PATHOGENIC	0.99203	28481359
CASP8	1509	COSM4462723,	upper_aerodigestive_tract	carcinoma	p.Q378*	Substitution - Nonsense	2:201285094-201285094,	PATHOGENIC	0.99195	28481359
CASP8	1509	COSM6978915,	large_intestine	carcinoma	p.P249R	Substitution - Missense	2:201276861-201276861,	PATHOGENIC	0.99102	28481359
CASP8	1509	COSM6943744,	urinary_tract	carcinoma	p.F372L	Substitution - Missense	2:201285076-201285076,	PATHOGENIC	0.99019	28481359
CASP8	1509	COSM3355728,	stomach	carcinoma	p.F493S	Substitution - Missense	2:201286581-201286581,	PATHOGENIC	0.98954	15705878
CASP8	1509	COSM6985080,	endometrium	carcinoma	p.D325Y	Substitution - Missense	2:201284935-201284935,	PATHOGENIC	0.98935	28481359
CASP8	1509	COSM1014867,	large_intestine	carcinoma	p.C253Y	Substitution - Missense	2:201276873-201276873,	PATHOGENIC	0.987	28481359
CASP8	1509	COSM6909649,	NS	carcinoma	p.R102K	Substitution - Missense	2:201266791-201266791,	PATHOGENIC	0.98599	28481359
CASP8	1509	COSM6909649,	upper_aerodigestive_tract	carcinoma	p.R102K	Substitution - Missense	2:201266791-201266791,	PATHOGENIC	0.98599	28481359
CASP8	1509	COSM1014879,	large_intestine	carcinoma	p.E399*	Substitution - Nonsense	2:201285157-201285157,	PATHOGENIC	0.98256	28978093
CASP8	1509	COSM6910436,	endometrium	carcinoma	p.D173Y	Substitution - Missense	2:201272647-201272647,	PATHOGENIC	0.98242	28481359
CASP8	1509	COSM2907147,	central_nervous_system	glioma	p.A421T	Substitution - Missense	2:201285223-201285223,	PATHOGENIC	0.9813	28481359
CASP8	1509	COSM6954938,	large_intestine	carcinoma	p.?	Unknown	2:201271515-201271515,	PATHOGENIC	0.98005	28481359
CASP8	1509	COSM6948832,	urinary_tract	carcinoma	p.L7V	Substitution - Missense	2:201266505-201266505,	PATHOGENIC	0.97804	28481359
CASP8	1509	COSM5983782,	lung	carcinoma	p.H295Y	Substitution - Missense	2:201284845-201284845,	PATHOGENIC	0.97699	28481359
CASP8	1509	COSM1199652,	endometrium	carcinoma	p.M136I	Substitution - Missense	2:201271522-201271522,	PATHOGENIC	0.97658	28481359
CASP8	1509	COSM6854215,	large_intestine	carcinoma	p.Q479Q	Substitution - coding silent	2:201286540-201286540,	PATHOGENIC	0.97578	28978093
CASP8	1509	COSM6915908,	large_intestine	carcinoma	p.L65R	Substitution - Missense	2:201266680-201266680,	PATHOGENIC	0.97221	28481359
CASP8	1509	COSM6941956,	large_intestine	carcinoma	p.F493V	Substitution - Missense	2:201286580-201286580,	PATHOGENIC	0.97162	28481359
CASP8	1509	COSM6962956,	skin	carcinoma	p.T461I	Substitution - Missense	2:201286485-201286485,	PATHOGENIC	0.97135	28481359
CASP8	1509	COSM6981278,	skin	malignant_melanoma	p.I140T	Substitution - Missense	2:201271533-201271533,	PATHOGENIC	0.96824	28481359
CASP8	1509	COSM6906478,	urinary_tract	carcinoma	p.D28Y	Substitution - Missense	2:201266568-201266568,	PATHOGENIC	0.96627	29420467
CASP8	1509	COSM6938563,	lung	carcinoma	p.E85V	Substitution - Missense	2:201266740-201266740,	PATHOGENIC	0.96584	28481359
CASP8	1509	COSM2907041,	skin	carcinoma	p.S99F	Substitution - Missense	2:201266782-201266782,	PATHOGENIC	0.96568	28481359
CASP8	1509	COSM2907041,	lung	carcinoma	p.S99F	Substitution - Missense	2:201266782-201266782,	PATHOGENIC	0.96568	28481359
CASP8	1509	COSM2907041,	skin	carcinoma	p.S99F	Substitution - Missense	2:201266782-201266782,	PATHOGENIC	0.96568	28481359
CASP8	1509	COSM2907041,	upper_aerodigestive_tract	carcinoma	p.S99F	Substitution - Missense	2:201266782-201266782,	PATHOGENIC	0.96568	25056374
CASP8	1509	COSM6970927,	pancreas	carcinoma	p.W437*	Substitution - Nonsense	2:201285272-201285272,	PATHOGENIC	0.96482	28481359
CASP8	1509	COSM442109,	ovary	carcinoma	p.S333F	Substitution - Missense	2:201284960-201284960,	PATHOGENIC	0.95849	28481359
CASP8	1509	COSM6933373,	lung	carcinoma	p.R265L	Substitution - Missense	2:201276909-201276909,	PATHOGENIC	0.94879	28481359
CASP8	1509	COSM6936181,	breast	carcinoma	p.E297Q	Substitution - Missense	2:201284851-201284851,	PATHOGENIC	0.94858	28481359
CASP8	1509	COSM6090081,	urinary_tract	carcinoma	p.E56*	Substitution - Nonsense	2:201266652-201266652,	PATHOGENIC	0.94349	28481359
CASP8	1509	COSM6995707,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.Q482H	Substitution - Missense	2:201286549-201286549,	PATHOGENIC	0.94196	29191655
CASP8	1509	COSM6995707,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.Q482H	Substitution - Missense	2:201286549-201286549,	PATHOGENIC	0.94196	29191655
CASP8	1509	COSM6995707,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.Q482H	Substitution - Missense	2:201286549-201286549,	PATHOGENIC	0.94196	29191655
CASP8	1509	COSM6995707,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.Q482H	Substitution - Missense	2:201286549-201286549,	PATHOGENIC	0.94196	29191655
CASP8	1509	COSM6995707,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.Q482H	Substitution - Missense	2:201286549-201286549,	PATHOGENIC	0.94196	29191655
CASP8	1509	COSM6995707,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.Q482H	Substitution - Missense	2:201286549-201286549,	PATHOGENIC	0.94196	29191655
CASP8	1509	COSM6995707,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.Q482H	Substitution - Missense	2:201286549-201286549,	PATHOGENIC	0.94196	29191655
CASP8	1509	COSM6995707,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.Q482H	Substitution - Missense	2:201286549-201286549,	PATHOGENIC	0.94196	29191655
CASP8	1509	COSM6995707,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.Q482H	Substitution - Missense	2:201286549-201286549,	PATHOGENIC	0.94196	29191655
CASP8	1509	COSM6995707,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.Q482H	Substitution - Missense	2:201286549-201286549,	PATHOGENIC	0.94196	29191655
CASP8	1509	COSM6995707,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.Q482H	Substitution - Missense	2:201286549-201286549,	PATHOGENIC	0.94196	29191655
CASP8	1509	COSM6920726,	lung	carcinoma	p.Q97E	Substitution - Missense	2:201266775-201266775,	PATHOGENIC	0.94181	28481359
CASP8	1509	COSM6920726,	lung	carcinoma	p.Q97E	Substitution - Missense	2:201266775-201266775,	PATHOGENIC	0.94181	28481359
CASP8	1509	COSM2907153,	large_intestine	carcinoma	p.R430*	Substitution - Nonsense	2:201285250-201285250,	PATHOGENIC	0.94146	28481359
CASP8	1509	COSM2907153,	large_intestine	carcinoma	p.R430*	Substitution - Nonsense	2:201285250-201285250,	PATHOGENIC	0.94146	12949717
CASP8	1509	COSM159759,	lung	carcinoma	p.Q482*	Substitution - Nonsense	2:201286547-201286547,	PATHOGENIC	0.93988	28481359
CASP8	1509	COSM159759,	upper_aerodigestive_tract	carcinoma	p.Q482*	Substitution - Nonsense	2:201286547-201286547,	PATHOGENIC	0.93988	28581676
CASP8	1509	COSM159759,	urinary_tract	carcinoma	p.Q482*	Substitution - Nonsense	2:201286547-201286547,	PATHOGENIC	0.93988	28481359
CASP8	1509	COSM159759,	upper_aerodigestive_tract	carcinoma	p.Q482*	Substitution - Nonsense	2:201286547-201286547,	PATHOGENIC	0.93988	28481359
CASP8	1509	COSM2907183,	upper_aerodigestive_tract	carcinoma	p.*497S	Nonstop extension	2:201286593-201286593,	PATHOGENIC	0.93787	9271594
CASP8	1509	COSM2907183,	upper_aerodigestive_tract	carcinoma	p.*497S	Nonstop extension	2:201286593-201286593,	PATHOGENIC	0.93787	9271594
CASP8	1509	COSM3718306,	autonomic_ganglia	neuroblastoma	p.A96V	Substitution - Missense	2:201266773-201266773,	PATHOGENIC	0.93776	11466626
CASP8	1509	COSM3355724,	stomach	carcinoma	p.C196Y	Substitution - Missense	2:201272717-201272717,	PATHOGENIC	0.93394	15705878
CASP8	1509	COSM6909467,	urinary_tract	carcinoma	p.D18H	Substitution - Missense	2:201266538-201266538,	PATHOGENIC	0.93008	28481359
CASP8	1509	COSM418911,	NS	carcinoma	p.R250Q	Substitution - Missense	2:201276864-201276864,	PATHOGENIC	0.92267	28481359
CASP8	1509	COSM126597,	lung	carcinoma	p.S392*	Substitution - Nonsense	2:201285137-201285137,	PATHOGENIC	0.91952	28481359
CASP8	1509	COSM6959783,	lung	carcinoma	p.H295N	Substitution - Missense	2:201284845-201284845,	PATHOGENIC	0.9189	28481359
CASP8	1509	COSM6943417,	breast	carcinoma	p.D472N	Substitution - Missense	2:201286517-201286517,	PATHOGENIC	0.91885	28481359
CASP8	1509	COSM6920420,	large_intestine	carcinoma	p.K370N	Substitution - Missense	2:201285072-201285072,	PATHOGENIC	0.91798	28481359
CASP8	1509	COSM6984342,	endometrium	carcinoma	p.R488I	Substitution - Missense	2:201286566-201286566,	PATHOGENIC	0.91136	28481359
CASP8	1509	COSM1482637,	endometrium	carcinoma	p.R250W	Substitution - Missense	2:201276863-201276863,	PATHOGENIC	0.90609	28481359
CASP8	1509	COSM1482637,	breast	carcinoma	p.R250W	Substitution - Missense	2:201276863-201276863,	PATHOGENIC	0.90609	28481359
CASP8	1509	COSM1482637,	skin	carcinoma	p.R250W	Substitution - Missense	2:201276863-201276863,	PATHOGENIC	0.90609	28481359
CASP8	1509	COSM1482637,	upper_aerodigestive_tract	carcinoma	p.R250W	Substitution - Missense	2:201276863-201276863,	PATHOGENIC	0.90609	28481359
CASP8	1509	COSM1482637,	skin	carcinoma	p.R250W	Substitution - Missense	2:201276863-201276863,	PATHOGENIC	0.90609	28481359
CASP8	1509	COSM6979928,	endometrium	carcinoma	p.A41D	Substitution - Missense	2:201266608-201266608,	PATHOGENIC	0.90188	28481359
CASP8	1509	COSM6972734,	small_intestine	carcinoma	p.L192M	Substitution - Missense	2:201272704-201272704,	PATHOGENIC	0.90035	28481359
CASP8	1509	COSM6620635,	large_intestine	carcinoma	p.L184P	Substitution - Missense	2:201272681-201272681,	PATHOGENIC	0.88675	28481359
CASP8	1509	COSM3713589,	skin	carcinoma	p.L365F	Substitution - Missense	2:201285055-201285055,	PATHOGENIC	0.87385	28481359
CASP8	1509	COSM3713589,	skin	carcinoma	p.L365F	Substitution - Missense	2:201285055-201285055,	PATHOGENIC	0.87385	28481359
CASP8	1509	COSM6938460,	large_intestine	carcinoma	p.R265Q	Substitution - Missense	2:201276909-201276909,	PATHOGENIC	0.8661	28481359
CASP8	1509	COSM6363342,	cervix	carcinoma	p.R449Q	Substitution - Missense	2:201285308-201285308,	PATHOGENIC	0.85571	28481359
CASP8	1509	COSM6363342,	cervix	carcinoma	p.R449Q	Substitution - Missense	2:201285308-201285308,	PATHOGENIC	0.85571	28481359
CASP8	1509	COSM3724390,	upper_aerodigestive_tract	carcinoma	p.E148K	Substitution - Missense	2:201271556-201271556,	PATHOGENIC	0.85208	23619168
CASP8	1509	COSM6834769,	skin	carcinoma	p.Q244*	Substitution - Nonsense	2:201276845-201276845,	PATHOGENIC	0.84887	28481359
CASP8	1509	COSM6918351,	lung	carcinoma	p.S141P	Substitution - Missense	2:201271535-201271535,	PATHOGENIC	0.83561	28481359
CASP8	1509	COSM6918351,	lung	carcinoma	p.S141P	Substitution - Missense	2:201271535-201271535,	PATHOGENIC	0.83561	28481359
CASP8	1509	COSM6854404,	large_intestine	carcinoma	p.K368K	Substitution - coding silent	2:201285066-201285066,	PATHOGENIC	0.8186	28978093
CASP8	1509	COSM4605741,	upper_aerodigestive_tract	carcinoma	p.?	Unknown	2:201276826-201276826,	PATHOGENIC	0.81679	25056374
CASP8	1509	COSM5125331,	urinary_tract	carcinoma	p.D454N	Substitution - Missense	2:201286463-201286463,	PATHOGENIC	0.81266	28481359
CASP8	1509	COSM4891116,	urinary_tract	carcinoma	p.T458I	Substitution - Missense	2:201286476-201286476,	PATHOGENIC	0.78526	28481359
CASP8	1509	COSM4891116,	urinary_tract	carcinoma	p.T458I	Substitution - Missense	2:201286476-201286476,	PATHOGENIC	0.78526	28481359
CASP8	1509	COSM6983800,	salivary_gland	carcinoma	p.K201N	Substitution - Missense	2:201272733-201272733,	PATHOGENIC	0.73703	28481359
CASP8	1509	COSM3724387,	breast	carcinoma	p.Q139*	Substitution - Nonsense	2:201271529-201271529,	PATHOGENIC	0.71513	25850943
CASP8	1509	COSM3724387,	upper_aerodigestive_tract	carcinoma	p.Q139*	Substitution - Nonsense	2:201271529-201271529,	PATHOGENIC	0.71513	23619168
CASP8	1509	COSM3355738,	large_intestine	carcinoma	p.Q383H	Substitution - Missense	2:201285111-201285111,	PATHOGENIC	0.71474	12949717
CASP8	1509	COSM6974846,	large_intestine	carcinoma	p.D454G	Substitution - Missense	2:201286464-201286464,	PATHOGENIC	0.70977	28481359
CASP8	1509	COSM6977148,	urinary_tract	carcinoma	p.Q356R	Substitution - Missense	2:201285029-201285029,	NEUTRAL	0.47991	28481359
CASP8	1509	COSM6912654,	lung	carcinoma	p.E393V	Substitution - Missense	2:201285140-201285140,	NEUTRAL	0.42471	28481359
CASP8	1509	COSM6946104,	large_intestine	carcinoma	p.D320N	Substitution - Missense	2:201284920-201284920,	NEUTRAL	0.36832	28481359
CASP8	1509	COSM6974433,	upper_aerodigestive_tract	carcinoma	p.E311Q	Substitution - Missense	2:201284893-201284893,	NEUTRAL	0.31184	28481359
CASP8	1509	COSM6971017,	pancreas	carcinoma	p.C426Y	Substitution - Missense	2:201285239-201285239,	NEUTRAL	0.30445	28481359
CASP8	1509	COSM6926989,	large_intestine	carcinoma	p.R265W	Substitution - Missense	2:201276908-201276908,	NEUTRAL	0.3025	28481359
CASP8	1509	COSM6926989,	urinary_tract	carcinoma	p.R265W	Substitution - Missense	2:201276908-201276908,	NEUTRAL	0.3025	28481359
CASP8	1509	COSM3355722,	stomach	carcinoma	p.M169L	Substitution - Missense	2:201271619-201271619,	NEUTRAL	0.29654	15705878
CASP8	1509	COSM6985077,	endometrium	carcinoma	p.D190G	Substitution - Missense	2:201272699-201272699,	NEUTRAL	0.26027	28481359
CASP8	1509	COSM6958671,	upper_aerodigestive_tract	carcinoma	p.E307Q	Substitution - Missense	2:201284881-201284881,	NEUTRAL	0.26011	28481359
CASP8	1509	COSM121069,	lung	carcinoma	p.S403*	Substitution - Nonsense	2:201285170-201285170,	NEUTRAL	0.26003	28481359
CASP8	1509	COSM6967614,	breast	carcinoma	p.D73E	Substitution - Missense	2:201266705-201266705,	NEUTRAL	0.23702	28481359
CASP8	1509	COSM4568785,	pancreas	carcinoma	p.Y397*	Substitution - Nonsense	2:201285153-201285153,	NEUTRAL	0.20461	28481359
CASP8	1509	COSM6955580,	urinary_tract	carcinoma	p.E311K	Substitution - Missense	2:201284893-201284893,	NEUTRAL	0.19518	28481359
CASP8	1509	COSM6906755,	oesophagus	carcinoma	p.L271R	Substitution - Missense	2:201276927-201276927,	NEUTRAL	0.1872	29420467
CASP8	1509	COSM6913133,	large_intestine	carcinoma	p.T289M	Substitution - Missense	2:201284828-201284828,	NEUTRAL	0.17687	28481359
CASP8	1509	COSM6982639,	endometrium	carcinoma	p.R408G	Substitution - Missense	2:201285184-201285184,	NEUTRAL	0.1554	28481359
CASP8	1509	COSM6984815,	large_intestine	carcinoma	p.E212*	Substitution - Nonsense	2:201272764-201272764,	NEUTRAL	0.14826	28481359
CASP8	1509	COSM6926219,	skin	carcinoma	p.E293K	Substitution - Missense	2:201284839-201284839,	NEUTRAL	0.13492	28481359
CASP8	1509	COSM6926219,	breast	carcinoma	p.E293K	Substitution - Missense	2:201284839-201284839,	NEUTRAL	0.13492	28481359
CASP8	1509	COSM6923322,	lung	carcinoma	p.Q49*	Substitution - Nonsense	2:201266631-201266631,	NEUTRAL	0.13021	28481359
CASP8	1509	COSM6923322,	lung	carcinoma	p.Q49*	Substitution - Nonsense	2:201266631-201266631,	NEUTRAL	0.13021	28481359
CASP8	1509	COSM6944887,	skin	carcinoma	p.P432S	Substitution - Missense	2:201285256-201285256,	NEUTRAL	0.11916	28481359
CASP8	1509	COSM6959138,	large_intestine	carcinoma	p.I312F	Substitution - Missense	2:201284896-201284896,	NEUTRAL	0.10785	28481359
CASP8	1509	COSM6962175,	lung	carcinoma	p.M476I	Substitution - Missense	2:201286531-201286531,	NEUTRAL	0.10539	28481359
CASP8	1509	COSM6927904,	upper_aerodigestive_tract	carcinoma	p.G187*	Substitution - Nonsense	2:201272689-201272689,	NEUTRAL	0.10247	28481359
CASP8	1509	COSM6937068,	cervix	carcinoma	p.C304Y	Substitution - Missense	2:201284873-201284873,	NEUTRAL	0.10108	28481359
CASP8	1509	COSM6978716,	large_intestine	carcinoma	p.D496E	Substitution - Missense	2:201286591-201286591,	NEUTRAL	0.09568	28481359
CASP8	1509	COSM6957279,	penis	carcinoma	p.T92P	Substitution - Missense	2:201266760-201266760,	NEUTRAL	0.09107	28481359
CASP8	1509	COSM6926966,	upper_aerodigestive_tract	carcinoma	p.E217*	Substitution - Nonsense	2:201274891-201274891,	NEUTRAL	0.08516	28481359
CASP8	1509	COSM6926966,	lung	carcinoma	p.E217*	Substitution - Nonsense	2:201274891-201274891,	NEUTRAL	0.08516	28481359
CASP8	1509	COSM6979269,	lung	carcinoma	p.P229A	Substitution - Missense	2:201274927-201274927,	NEUTRAL	0.08041	28481359
CASP8	1509	COSM6979657,	lung	carcinoma	p.E434D	Substitution - Missense	2:201285264-201285264,	NEUTRAL	0.07943	28481359
CASP8	1509	COSM6908541,	upper_aerodigestive_tract	carcinoma	p.E231*	Substitution - Nonsense	2:201274933-201274933,	NEUTRAL	0.05855	28581676
CASP8	1509	COSM1014847,	endometrium	carcinoma	p.R68Q	Substitution - Missense	2:201266689-201266689,	NEUTRAL	0.058	28481359
CASP8	1509	COSM1014847,	large_intestine	carcinoma	p.R68Q	Substitution - Missense	2:201266689-201266689,	NEUTRAL	0.058	28481359
CASP8	1509	COSM1014847,	endometrium	carcinoma	p.R68Q	Substitution - Missense	2:201266689-201266689,	NEUTRAL	0.058	28481359
CASP8	1509	COSM1014847,	large_intestine	carcinoma	p.R68Q	Substitution - Missense	2:201266689-201266689,	NEUTRAL	0.058	28481359
CASP8	1509	COSM6946101,	large_intestine	carcinoma	p.N80H	Substitution - Missense	2:201266724-201266724,	NEUTRAL	0.05326	28481359
CASP8	1509	COSM6972393,	biliary_tract	carcinoma	p.H281N	Substitution - Missense	2:201276956-201276956,	NEUTRAL	0.04822	28481359
CASP8	1509	COSM6942994,	urinary_tract	carcinoma	p.Q32*	Substitution - Nonsense	2:201266580-201266580,	NEUTRAL	0.04741	28481359
CASP8	1509	COSM5967298,	salivary_gland	carcinoma	p.E235*	Substitution - Nonsense	2:201274945-201274945,	NEUTRAL	0.04657	27334835
CASP8	1509	COSM94008,	breast	carcinoma	p.L360F	Substitution - Missense	2:201285042-201285042,	NEUTRAL	0.04634	20668451
CASP8	1509	COSM1494792,	adrenal_gland	adrenal_cortical_carcinoma	p.Y310C	Substitution - Missense	2:201284891-201284891,	NEUTRAL	0.045	28481359
CASP8	1509	COSM3355739,	large_intestine	carcinoma	p.R194I	Substitution - Missense	2:201272711-201272711,	NEUTRAL	0.04387	12949717
CASP8	1509	COSM1014856,	large_intestine	carcinoma	p.I160I	Substitution - coding silent	2:201271594-201271594,	NEUTRAL	0.04256	24951259
CASP8	1509	COSM6970932,	endometrium	carcinoma	p.S161A	Substitution - Missense	2:201271595-201271595,	NEUTRAL	0.0414	28481359
CASP8	1509	COSM6973767,	breast	carcinoma	p.R47G	Substitution - Missense	2:201266625-201266625,	NEUTRAL	0.03024	28481359
CASP8	1509	COSM6907264,	kidney	carcinoma	p.T407M	Substitution - Missense	2:201285182-201285182,	NEUTRAL	0.02546	29420467
CASP8	1509	COSM6932195,	skin	carcinoma	p.E158*	Substitution - Nonsense	2:201271586-201271586,	NEUTRAL	0.02448	28481359
CASP8	1509	COSM5009943,	large_intestine	carcinoma	p.A433T	Substitution - Missense	2:201285259-201285259,	NEUTRAL	0.01947	24951259
CASP8	1509	COSM3355740,	stomach	carcinoma	p.?	Unknown	2:201269606-201269606,	NEUTRAL	0.01457	15705878
CASP8	1509	COSM6966854,	urinary_tract	carcinoma	p.D302N	Substitution - Missense	2:201284866-201284866,	NEUTRAL	0.00981	28481359
CASP8	1509	COSM6941091,	skin	malignant_melanoma	p.P405L	Substitution - Missense	2:201285176-201285176,	NEUTRAL	0.00964	28481359
CASP8	1509	COSM5008250,	large_intestine	carcinoma	p.N208N	Substitution - coding silent	2:201272754-201272754,	NEUTRAL	0.00572	24951259
CASP8	1509	COSM2907035,	vulva	carcinoma	p.L62delL	Deletion - In frame	2:201266670-201266672,	Info_not_available	Info_not_available	12055196
CASP8	1509	COSM3355736,	large_intestine	carcinoma	p.K478fs*19	Insertion - Frameshift	2:201286534-201286535,	Info_not_available	Info_not_available	12949717
CASP8	1509	COSM3355742,	liver	carcinoma	p.V427fs*28	Deletion - Frameshift	2:201285238-201285239,	Info_not_available	Info_not_available	15531912
CASP8	1509	COSM3355718, COSM3355719, COSM3355720, COSM3355723, COSM3355725, COSM3355726, COSM3355727, COSM3355729, COSM3355741,	stomach	carcinoma	p.?, p.A197fs*14, p.C426fs*30, p.E84del, p.G251fs*4, p.I340fs*13	Deletion - Frameshift, Deletion - In frame, Insertion - Frameshift, Unknown	2:201266487-201266487, 2:201266487-201266488, 2:201266735-201266737, 2:201272718-201272719, 2:201276864-201276864, 2:201277023-201277024, 2:201284982-201284985, 2:201285236-201285237, 2:201286637-201286638,	Info_not_available	Info_not_available	15705878
CASP8	1509	COSM2907089, COSM3724364,	upper_aerodigestive_tract	carcinoma	p.I207fs*15, p.P363delP	Deletion - Frameshift, Deletion - In frame	2:201272748-201272751, 2:201285049-201285051,	Info_not_available	Info_not_available	23619168
CASP8	1509	COSM252967,	upper_aerodigestive_tract	carcinoma	p.F373fs*26	Deletion - Frameshift	2:201285076-201285076,	Info_not_available	Info_not_available	25056374
CASP8	1509	COSM3355742,	upper_aerodigestive_tract	carcinoma	p.V427fs*28	Deletion - Frameshift	2:201285238-201285239,	Info_not_available	Info_not_available	26107208
CASP8	1509	COSM6024556,	NS	carcinoma	p.R194fs*17	Frameshift	Info_not_available	Info_not_available	Info_not_available	26182302
CASP8	1509	COSM6495704,	large_intestine	carcinoma	p.K478fs*11	Frameshift	Info_not_available	Info_not_available	Info_not_available	26650777
CASP8	1509	COSM6856780,	breast	carcinoma	p.E89fs*20	Deletion - Frameshift	2:201266751-201266751,	Info_not_available	Info_not_available	27284958
CASP8	1509	COSM293522,	upper_aerodigestive_tract	carcinoma	p.K490fs*>7	Deletion - Frameshift	2:201286567-201286567,	Info_not_available	Info_not_available	28581676
CASP8	1509	COSM6995706,	soft_tissue	malignant_fibrous_histiocytoma-pleomorphic_sarcoma	p.D190E	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	28932590
CASP8	1509	COSM6906384,	breast	carcinoma	p.E89fs*20	Deletion - Frameshift	2:201266749-201266749,	Info_not_available	Info_not_available	29420467
CASP8	1509	COSM293522, COSM5010184, COSM5010325,	large_intestine	carcinoma	p.K337K, p.K490fs*>7, p.L491fs*6	Deletion - Frameshift, Insertion - Frameshift, Substitution - coding silent	2:201284973-201284973, 2:201286566-201286567, 2:201286567-201286567,	Info_not_available	0.68052, Info_not_available	24951259
CASP8	1509	COSM95793,	ovary	other	p.F67F	Substitution - coding silent	2:201266687-201266687,	Info_not_available	0.5957	20668451
CASP8	1509	COSM6854083, COSM6854086,	large_intestine	carcinoma	p.D40fs*31, p.E293V	Insertion - Frameshift, Substitution - Missense	2:201266604-201266605, 2:201284840-201284840,	Info_not_available	0.52458, Info_not_available	28978093
CASP8	1509	COSM1014887, COSM1404464, COSM1565158, COSM209554, COSM252967, COSM293522, COSM3355742, COSM3731389, COSM5010325, COSM6913177, COSM6918089, COSM6932766, COSM6934452, COSM6936473, COSM6940633, COSM6945504, COSM6946509, COSM6948942, COSM6949027, COSM6949517, COSM6951312, COSM6956638, COSM6958741, COSM6959119, COSM6962675, COSM6970994, COSM6981071, COSM6984818,	NS, biliary_tract, breast, cervix, endometrium, large_intestine, lung, ovary, skin, small_intestine, upper_aerodigestive_tract, urinary_tract	carcinoma, malignant_melanoma	p.D380fs*2, p.E217fs*18, p.E434_S441delEGTWYIQS, p.E85delE, p.F152L, p.F373fs*26, p.I199M, p.I225fs*21, p.I350fs*4, p.I374fs*24, p.I374fs*8, p.K370fs*11, p.K478fs*10, p.K490fs*>7, p.L155fs*6, p.L184fs*24, p.L318fs*6, p.L446M, p.L491fs*6, p.N475fs*13, p.P31L, p.Q375_A376>*, p.Q479fs*8, p.R449*, p.R452*, p.V222fs*13, p.V306I, p.V427fs*28	Complex - deletion inframe, Deletion - Frameshift, Deletion - In frame, Insertion - Frameshift, Substitution - Missense, Substitution - Nonsense	2:201266578-201266578, 2:201266734-201266736, 2:201271570-201271570, 2:201271577-201271596, 2:201272680-201272690, 2:201272727-201272727, 2:201274890-201274891, 2:201274902-201274903, 2:201274914-201274914, 2:201284878-201284878, 2:201284911-201284912, 2:201285005-201285005, 2:201285070-201285071, 2:201285075-201285076, 2:201285076-201285076, 2:201285079-201285082, 2:201285085-201285089, 2:201285095-201285096, 2:201285238-201285239, 2:201285260-201285283, 2:201285298-201285298, 2:201285307-201285307, 2:201285316-201285316, 2:201286523-201286523, 2:201286531-201286531, 2:201286539-201286542, 2:201286566-201286567, 2:201286567-201286567,	Info_not_available	0.50497, .51979, .55837, .59988, .63892, .66938, .69638, Info_not_available	28481359
CASP8	1509	COSM252413, COSM5967301,	salivary_gland	carcinoma	p.N323fs*31, p.R68*	Deletion - Frameshift, Substitution - Nonsense	2:201266688-201266688, 2:201284930-201284930,	Info_not_available	0.50444, Info_not_available	27334835