Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
SHC1	10840	COSM3771469,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.A460V	Substitution - Missense	1:154963849-154963849,	PATHOGENIC	0.9895	26648538
SHC1	10840	COSM48764,	lung	carcinoma	p.F202S	Substitution - Missense	1:154967719-154967719,	PATHOGENIC	0.97823	18948947
SHC1	10840	COSM5989915,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.I194T	Substitution - Missense	1:154967743-154967743,	PATHOGENIC	0.97823	26648538
SHC1	10840	COSM1600889,	liver	carcinoma	p.G431R	Substitution - Missense	1:154965548-154965548,	PATHOGENIC	0.96796	Info_not_available
SHC1	10840	COSM304474,	large_intestine	carcinoma	p.V213L	Substitution - Missense	1:154967687-154967687,	PATHOGENIC	0.92561	21892161
SHC1	10840	COSM2209518,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.A271V	Substitution - Missense	1:154966359-154966359,	NEUTRAL	0.13483	26648538
SHC1	10840	COSM315152,	lung	carcinoma	p.G333G	Substitution - coding silent	1:154966004-154966004,	NEUTRAL	0.07586	22941188
SHC1	10840	COSM2209531,	breast	carcinoma	p.V253fs*62	Insertion - Frameshift	1:154966421-154966422,	Info_not_available	Info_not_available	25850943
SHC1	10840	COSM6908392,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.P41P	Substitution - coding silent	1:154970074-154970074,	Info_not_available	0.52439	29386642