1 => The disorder is placed on the map based on its association with a gene, but the underlying defect is not known
2 => The disorder has been placed on the map by linkage; no mutation has been found
3 => The molecular basis for the disorder is known; a mutation has been found in the gene
4 => A contiguous gene deletion or duplication syndrome, multiple genes are deleted or duplicated causing the phenotype
| Gene Symbol | Chromosomal Location | Gene MIM number | Mapping Method | Phenotype | Phenotype MIM number | Phenotype Mapping Key |
| RPS6KA3 | Xp22.12 | 300075 | Fd, RE | Coffin-Lowry syndrome, 303600 (3) | 303600 | 3 |
| RPS6KA3 | Xp22.12 | 300075 | Fd, RE | Mental retardation, X-linked 19, 300844 (3) | 300844 | 3 |