* We recommend a score >= 0.08 for meaningful Gene-Disease associations

GeneID	Gene_Symbol	DisGeNet_diseaseID	Disease_name	DisGeNet score	DisGeNet_sourceDB
6197	RPS6KA3	C0265252	Coffin-Lowry syndrome	0.712526487145508	BEFREE;CTD_human;GAD;LHGDN;MGD;ORPHANET;UNIPROT
6197	RPS6KA3	C3714756	Intellectual Disability	0.203831819601666	BEFREE;HPO;LHGDN
6197	RPS6KA3	C0027627	Neoplasm Metastasis	0.201098907136852	BEFREE;CTD_human
6197	RPS6KA3	C0025362	Mental Retardation	0.200549453568426	BEFREE;HPO
6197	RPS6KA3	C0036572	Seizures	0.200274726784213	BEFREE;HPO
6197	RPS6KA3	C0796225	Mental Retardation, X-Linked 19	0.200274726784213	BEFREE;UNIPROT
6197	RPS6KA3	C2239176	Liver carcinoma	0.200274726784213	BEFREE;CTD_human
6197	RPS6KA3	C4021787	Abnormal diaphysis morphology	0.2	HPO
6197	RPS6KA3	C4072825	Thickened facial skin with coarse facial features	0.2	HPO
6197	RPS6KA3	C4072831	Delayed closure of the soft spot on the skull	0.2	HPO
6197	RPS6KA3	C4072834	Rough hair texture	0.2	HPO
6197	RPS6KA3	C4082243	Maxillary retrognathia	0.2	HPO
6197	RPS6KA3	C4280495	Concave bridge of nose	0.2	HPO
6197	RPS6KA3	C4280516	Thick craniofacial bones	0.2	HPO
6197	RPS6KA3	C4280517	Enlargement of craniofacial bones	0.2	HPO
6197	RPS6KA3	C4280518	Hypertrophy of craniofacial bones	0.2	HPO
6197	RPS6KA3	C4280560	Increased thickness of cranium	0.2	HPO
6197	RPS6KA3	C4280606	Hanging skin	0.2	HPO
6197	RPS6KA3	C4280613	Angle class 3 malocclusion	0.2	HPO
6197	RPS6KA3	C4280614	Angle class 2 malocclusion	0.2	HPO
6197	RPS6KA3	C4280617	Tooth mass arch size discrepancy	0.2	HPO
6197	RPS6KA3	C4280618	Inadequate arch length for tooth size	0.2	HPO
6197	RPS6KA3	C4280636	Hypertrophy of supraorbital ridge	0.2	HPO
6197	RPS6KA3	C4280637	Hypertrophy of supraorbital margins	0.2	HPO
6197	RPS6KA3	C4280638	Hyperplasia of supraorbital ridge	0.2	HPO
6197	RPS6KA3	C4280639	Hyperplasia of supraorbital margins	0.2	HPO
6197	RPS6KA3	C4280640	Retrusion of upper jaw bones	0.2	HPO
6197	RPS6KA3	C4280641	Hypotrophic maxilla	0.2	HPO
6197	RPS6KA3	C4280642	Deficiency of upper jaw bones	0.2	HPO
6197	RPS6KA3	C4280643	Decreased projection of maxilla	0.2	HPO
6197	RPS6KA3	C4280644	Increased size of mandible	0.2	HPO
6197	RPS6KA3	C4280645	Hypertrophy of lower jaw	0.2	HPO
6197	RPS6KA3	C0005941	Bone Diseases, Developmental	0.2	CTD_human
6197	RPS6KA3	C0010495	Cutis Laxa	0.2	HPO
6197	RPS6KA3	C0014544	Epilepsy	0.2	HPO
6197	RPS6KA3	C0016202	Flatfoot	0.2	HPO
6197	RPS6KA3	C0018784	Sensorineural Hearing Loss (disorder)	0.2	HPO
6197	RPS6KA3	C0019294	Hernia, Inguinal	0.2	HPO
6197	RPS6KA3	C0020534	Orbital separation excessive	0.2	HPO
6197	RPS6KA3	C0020608	Hypodontia	0.2	HPO
6197	RPS6KA3	C0022821	Kyphosis deformity of spine	0.2	HPO
6197	RPS6KA3	C0023012	Language Delay	0.2	HPO
6197	RPS6KA3	C0024433	Macrostomia	0.2	HPO
6197	RPS6KA3	C0024636	Malocclusion	0.2	HPO
6197	RPS6KA3	C0026266	Mitral Valve Insufficiency	0.2	HPO
6197	RPS6KA3	C0026827	Muscle hypotonia	0.2	HPO
6197	RPS6KA3	C0027626	Neoplasm Invasiveness	0.2	CTD_human
6197	RPS6KA3	C0033922	Psychomotor Disorders	0.2	CTD_human
6197	RPS6KA3	C0034888	Rectal Prolapse	0.2	HPO
6197	RPS6KA3	C0037822	Speech Disorders	0.2	HPO
6197	RPS6KA3	C0037932	Curvature of spine	0.2	HPO
6197	RPS6KA3	C0040427	Tooth Abnormalities	0.2	HPO
6197	RPS6KA3	C0040433	Tooth Crowding	0.2	HPO
6197	RPS6KA3	C0041667	Underweight	0.2	HPO
6197	RPS6KA3	C0042140	Uterine Prolapse	0.2	HPO
6197	RPS6KA3	C0158731	Congenital pectus carinatum	0.2	HPO
6197	RPS6KA3	C0221354	Frontal bossing	0.2	HPO
6197	RPS6KA3	C0221357	Brachydactyly	0.2	HPO
6197	RPS6KA3	C0233715	Speech impairment	0.2	HPO
6197	RPS6KA3	C0239137	Coxa valga	0.2	HPO
6197	RPS6KA3	C0240310	Hypoplasia of the maxilla	0.2	HPO
6197	RPS6KA3	C0240379	Open mouth	0.2	HPO
6197	RPS6KA3	C0240635	Byzanthine arch palate	0.2	HPO
6197	RPS6KA3	C0241210	Speech Delay	0.2	HPO
6197	RPS6KA3	C0262444	Dental abnormalities	0.2	HPO
6197	RPS6KA3	C0263401	Cutis marmorata	0.2	HPO
6197	RPS6KA3	C0264133	Acquired flat foot	0.2	HPO
6197	RPS6KA3	C0264142	Spade-like hand	0.2	HPO
6197	RPS6KA3	C0265696	Sternum bifidum	0.2	HPO
6197	RPS6KA3	C0277959	Coarse hair	0.2	HPO
6197	RPS6KA3	C0302501	Mandibular hyperplasia	0.2	HPO
6197	RPS6KA3	C0349588	Short stature	0.2	HPO
6197	RPS6KA3	C0399526	Class III malocclusion	0.2	HPO
6197	RPS6KA3	C0423110	Downward slant of palpebral fissure	0.2	HPO
6197	RPS6KA3	C0423113	Telecanthus	0.2	HPO
6197	RPS6KA3	C0423903	Low intelligence	0.2	HPO
6197	RPS6KA3	C0424688	Small head	0.2	HPO
6197	RPS6KA3	C0424731	Single transverse palmar crease	0.2	HPO
6197	RPS6KA3	C0426421	Wide nose	0.2	HPO
6197	RPS6KA3	C0426429	Broad nasal tip	0.2	HPO
6197	RPS6KA3	C0426870	Large hand	0.2	HPO
6197	RPS6KA3	C0426886	Tapering fingers (finding)	0.2	HPO
6197	RPS6KA3	C0454644	Delayed speech and language development	0.2	HPO
6197	RPS6KA3	C0541764	Delayed bone age	0.2	HPO
6197	RPS6KA3	C0575081	Gait abnormality	0.2	HPO
6197	RPS6KA3	C0575158	Kyphoscoliosis deformity of spine	0.2	HPO
6197	RPS6KA3	C0576225	Long foot	0.2	HPO
6197	RPS6KA3	C0581342	Redundant skin	0.2	HPO
6197	RPS6KA3	C0678230	Congenital Epicanthus	0.2	HPO
6197	RPS6KA3	C0700208	Acquired scoliosis	0.2	HPO
6197	RPS6KA3	C0917816	Mental deficiency	0.2	HPO
6197	RPS6KA3	C1262477	Weight decreased	0.2	HPO
6197	RPS6KA3	C1305420	Prominent ear	0.2	HPO
6197	RPS6KA3	C1317785	Tooth size discrepancy	0.2	HPO
6197	RPS6KA3	C1398312	Narrow palate	0.2	HPO
6197	RPS6KA3	C1836542	Depressed nasal bridge	0.2	HPO
6197	RPS6KA3	C1836688	Narrow iliac wings	0.2	HPO
6197	RPS6KA3	C1837084	Short metacarpal	0.2	HPO
6197	RPS6KA3	C1837260	Prominent forehead	0.2	HPO
6197	RPS6KA3	C1837397	Global developmental delay, severe	0.2	HPO
6197	RPS6KA3	C1839326	Abnormally-shaped vertebrae	0.2	HPO
6197	RPS6KA3	C1839739	Prominent lower lip	0.2	HPO
6197	RPS6KA3	C1839829	Short distal phalanges	0.2	HPO
6197	RPS6KA3	C1840077	Anteverted nostril	0.2	HPO
6197	RPS6KA3	C1842060	Prominent supraorbital ridges	0.2	HPO
6197	RPS6KA3	C1843367	Poor school performance	0.2	HPO
6197	RPS6KA3	C1844577	Hyperextensible digits	0.2	HPO
6197	RPS6KA3	C1844806	Weight less than 3rd percentile	0.2	HPO
6197	RPS6KA3	C1844809	Thick nasal alae	0.2	HPO
6197	RPS6KA3	C1844810	Thick nasal septum	0.2	HPO
6197	RPS6KA3	C1844813	Widely spaced teeth	0.2	HPO
6197	RPS6KA3	C1844818	Lumbar gibbus deformity	0.2	HPO
6197	RPS6KA3	C1844822	'Drumstick' terminal phalanges	0.2	HPO
6197	RPS6KA3	C1844825	Hyperconvex fingernails	0.2	HPO
6197	RPS6KA3	C1844906	Broad fingers	0.2	HPO
6197	RPS6KA3	C1845112	Hyperkyphosis	0.2	HPO
6197	RPS6KA3	C1845847	Coarse facial features	0.2	HPO
6197	RPS6KA3	C1847879	X-linked dominant	0.2	HPO
6197	RPS6KA3	C1853237	Isolated cases	0.2	HPO
6197	RPS6KA3	C1853246	Everted lower lip vermilion	0.2	HPO
6197	RPS6KA3	C1853487	Bushy eyebrows	0.2	HPO
6197	RPS6KA3	C1854301	Motor delay	0.2	HPO
6197	RPS6KA3	C1854919	Severe psychomotor retardation	0.2	HPO
6197	RPS6KA3	C1855285	Protruding ears	0.2	HPO
6197	RPS6KA3	C1856786	Hypoplastic fingernails	0.2	HPO
6197	RPS6KA3	C1858452	Thickened calvaria	0.2	HPO
6197	RPS6KA3	C1859520	Progressive spasticity	0.2	HPO
6197	RPS6KA3	C1860253	Accessory proximal metacarpal ossification centers	0.2	HPO
6197	RPS6KA3	C1866234	Protruding lower lip	0.2	HPO
6197	RPS6KA3	C1867446	Bulging forehead	0.2	HPO
6197	RPS6KA3	C1868085	Craniofacial hyperostosis	0.2	HPO
6197	RPS6KA3	C1868571	Thick, flared eyebrows	0.2	HPO
6197	RPS6KA3	C2051831	Pectus excavatum	0.2	HPO
6197	RPS6KA3	C2053437	Full lower lip	0.2	HPO
6197	RPS6KA3	C2227134	mandibular excess (physical finding)	0.2	HPO
6197	RPS6KA3	C2674608	Feeding difficulties in infancy	0.2	HPO
6197	RPS6KA3	C2930812	Generalized elastolysis	0.2	HPO
6197	RPS6KA3	C3278923	Dilated ventricles (finding)	0.2	HPO
6197	RPS6KA3	C3549698	Coxa valga deformity	0.2	HPO
6197	RPS6KA3	C3550546	Depressed nasal root/bridge	0.2	HPO
6197	RPS6KA3	C3551535	Mitral regurgitation, mild	0.2	HPO
6197	RPS6KA3	C3553764	Joint hyperflexibility	0.2	HPO
6197	RPS6KA3	C3840083	Late closure of anterior fontanel	0.2	HPO
6197	RPS6KA3	C4020849	Bowed and upward slanting eyebrows	0.2	HPO
6197	RPS6KA3	C4020874	No development of motor milestones	0.2	HPO
6197	RPS6KA3	C4020876	Dull intelligence	0.2	HPO
6197	RPS6KA3	C1136249	Mental Retardation, X-Linked	0.00328236603323995	BEFREE;LHGDN
6197	RPS6KA3	C0004135	Ataxia Telangiectasia	0.00273291246481375	LHGDN
6197	RPS6KA3	C0033578	Prostatic Neoplasms	0.00273291246481375	LHGDN
6197	RPS6KA3	C0018671	Head and Neck Neoplasms	0.002407028523288	GAD
6197	RPS6KA3	C0027643	Neoplasm Recurrence, Local	0.002407028523288	GAD
6197	RPS6KA3	C0085183	Neoplasms, Second Primary	0.002407028523288	GAD
6197	RPS6KA3	C0006142	Malignant neoplasm of breast	0.0010989071368524	BEFREE
6197	RPS6KA3	C0678222	Breast Carcinoma	0.0010989071368524	BEFREE
6197	RPS6KA3	C3539878	Triple Negative Breast Neoplasms	0.0008241803526393	BEFREE
6197	RPS6KA3	C0026764	Multiple Myeloma	0.0005494535684262	BEFREE
6197	RPS6KA3	C0027819	Neuroblastoma	0.0005494535684262	BEFREE
6197	RPS6KA3	C0028754	Obesity	0.0005494535684262	BEFREE
6197	RPS6KA3	C0029925	Ovarian Carcinoma	0.0005494535684262	BEFREE
6197	RPS6KA3	C0178874	Tumor Progression	0.0005494535684262	BEFREE
6197	RPS6KA3	C0343084	Capillary Leak Syndrome	0.0005494535684262	BEFREE
6197	RPS6KA3	C0376358	Malignant neoplasm of prostate	0.0005494535684262	BEFREE
6197	RPS6KA3	C0596263	Carcinogenesis	0.0005494535684262	BEFREE
6197	RPS6KA3	C0600139	Prostate carcinoma	0.0005494535684262	BEFREE
6197	RPS6KA3	C0700095	Central neuroblastoma	0.0005494535684262	BEFREE
6197	RPS6KA3	C1140680	Malignant neoplasm of ovary	0.0005494535684262	BEFREE
6197	RPS6KA3	C4021790	Abnormality of the skeletal system	0.0002747267842131	BEFREE
6197	RPS6KA3	C0000768	Congenital Abnormality	0.0002747267842131	BEFREE
6197	RPS6KA3	C0001125	Acidosis, Lactic	0.0002747267842131	BEFREE
6197	RPS6KA3	C0003873	Rheumatoid Arthritis	0.0002747267842131	BEFREE
6197	RPS6KA3	C0007102	Malignant tumor of colon	0.0002747267842131	BEFREE
6197	RPS6KA3	C0007137	Squamous cell carcinoma	0.0002747267842131	BEFREE
6197	RPS6KA3	C0008497	Choriocarcinoma	0.0002747267842131	BEFREE
6197	RPS6KA3	C0008626	Congenital chromosomal disease	0.0002747267842131	BEFREE
6197	RPS6KA3	C0009402	Colorectal Carcinoma	0.0002747267842131	BEFREE
6197	RPS6KA3	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	0.0002747267842131	BEFREE
6197	RPS6KA3	C0023418	leukemia	0.0002747267842131	BEFREE
6197	RPS6KA3	C0023470	Myeloid Leukemia	0.0002747267842131	BEFREE
6197	RPS6KA3	C0023492	Leukemia, T-Cell	0.0002747267842131	BEFREE
6197	RPS6KA3	C0024790	Paroxysmal nocturnal hemoglobinuria	0.0002747267842131	BEFREE
6197	RPS6KA3	C0024894	Mastitis	0.0002747267842131	BEFREE
6197	RPS6KA3	C0026106	Mild Mental Retardation	0.0002747267842131	BEFREE
6197	RPS6KA3	C0027022	Myeloproliferative disease	0.0002747267842131	BEFREE
6197	RPS6KA3	C0028326	Noonan Syndrome	0.0002747267842131	BEFREE
6197	RPS6KA3	C0029453	Osteopenia	0.0002747267842131	BEFREE
6197	RPS6KA3	C0029463	Osteosarcoma	0.0002747267842131	BEFREE
6197	RPS6KA3	C0033975	Psychotic Disorders	0.0002747267842131	BEFREE
6197	RPS6KA3	C0036220	Kaposi Sarcoma	0.0002747267842131	BEFREE
6197	RPS6KA3	C0041409	Turner Syndrome, Male	0.0002747267842131	BEFREE
6197	RPS6KA3	C0042769	Virus Diseases	0.0002747267842131	BEFREE
6197	RPS6KA3	C0043119	Werner Syndrome	0.0002747267842131	BEFREE
6197	RPS6KA3	C0086025	Codependency	0.0002747267842131	BEFREE
6197	RPS6KA3	C0233794	Memory impairment	0.0002747267842131	BEFREE
6197	RPS6KA3	C0242379	Malignant neoplasm of lung	0.0002747267842131	BEFREE
6197	RPS6KA3	C0242596	Neoplasm, Residual	0.0002747267842131	BEFREE
6197	RPS6KA3	C0265253	Stickler syndrome (disorder)	0.0002747267842131	BEFREE
6197	RPS6KA3	C0278488	Carcinoma breast stage IV	0.0002747267842131	BEFREE
6197	RPS6KA3	C0281267	bilateral breast cancer	0.0002747267842131	BEFREE
6197	RPS6KA3	C0332996	Persistent embryonic structure	0.0002747267842131	BEFREE
6197	RPS6KA3	C0338656	Impaired cognition	0.0002747267842131	BEFREE
6197	RPS6KA3	C0349204	Nonorganic psychosis	0.0002747267842131	BEFREE
6197	RPS6KA3	C0424295	Hyperactive behavior	0.0002747267842131	BEFREE
6197	RPS6KA3	C0497406	Overweight	0.0002747267842131	BEFREE
6197	RPS6KA3	C0585442	Osteosarcoma of bone	0.0002747267842131	BEFREE
6197	RPS6KA3	C0598935	Tumor Initiation	0.0002747267842131	BEFREE
6197	RPS6KA3	C0677898	invasive cancer	0.0002747267842131	BEFREE
6197	RPS6KA3	C0684249	Carcinoma of lung	0.0002747267842131	BEFREE
6197	RPS6KA3	C0699790	Colon Carcinoma	0.0002747267842131	BEFREE
6197	RPS6KA3	C0854917	Rhabdoid Tumor of the Kidney	0.0002747267842131	BEFREE
6197	RPS6KA3	C1168401	Squamous cell carcinoma of the head and neck	0.0002747267842131	BEFREE
6197	RPS6KA3	C1176475	Ductal Carcinoma	0.0002747267842131	BEFREE
6197	RPS6KA3	C1292778	Chronic myeloproliferative disorder	0.0002747267842131	BEFREE
6197	RPS6KA3	C1306460	Primary malignant neoplasm of lung	0.0002747267842131	BEFREE
6197	RPS6KA3	C1458155	Mammary Neoplasms	0.0002747267842131	BEFREE
6197	RPS6KA3	C1512409	Hepatocarcinogenesis	0.0002747267842131	BEFREE
6197	RPS6KA3	C1527249	Colorectal Cancer	0.0002747267842131	BEFREE
6197	RPS6KA3	C1527349	Ductal Breast Carcinoma	0.0002747267842131	BEFREE
6197	RPS6KA3	C1961099	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	0.0002747267842131	BEFREE
6197	RPS6KA3	C2020284	Stickler syndrome, type 1	0.0002747267842131	BEFREE
6197	RPS6KA3	C3495439	Inflammatory disorder of breast	0.0002747267842131	BEFREE
6197	RPS6KA3	C3887505	DYSFUNCTION - SKIN DISORDERS	0.0002747267842131	BEFREE