Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
RPS6KA3	10432	COSM250741,	liver	carcinoma	p.L590*	Substitution - Nonsense	23:20163036-20163036,	PATHOGENIC	0.99754	25021421
RPS6KA3	10432	COSM251406,	liver	carcinoma	p.?	Unknown	23:20167588-20167588,	PATHOGENIC	0.99663	25021421
RPS6KA3	10432	COSM5990622,	liver	carcinoma	p.P542S	Substitution - Missense	23:20165039-20165039,	PATHOGENIC	0.9947	26850916
RPS6KA3	10432	COSM13358,	central_nervous_system	glioma	p.L608F	Substitution - Missense	23:20162983-20162983,	PATHOGENIC	0.99452	16618716
RPS6KA3	10432	COSM13358,	central_nervous_system	glioma	p.L608F	Substitution - Missense	23:20162983-20162983,	PATHOGENIC	0.99452	16618716
RPS6KA3	10432	COSM95217,	lung	carcinoma	p.R110Q	Substitution - Missense	23:20195142-20195142,	PATHOGENIC	0.9918	20668451
RPS6KA3	10432	COSM250742,	liver	carcinoma	p.G314*	Substitution - Nonsense	23:20176493-20176493,	PATHOGENIC	0.9916	25021421
RPS6KA3	10432	COSM5990619,	liver	carcinoma	p.A565V	Substitution - Missense	23:20164969-20164969,	PATHOGENIC	0.99141	26850916
RPS6KA3	10432	COSM182647,	liver	carcinoma	p.G614S	Substitution - Missense	23:20162965-20162965,	PATHOGENIC	0.99129	26850916
RPS6KA3	10432	COSM251393,	liver	carcinoma	p.L568Q	Substitution - Missense	23:20164960-20164960,	PATHOGENIC	0.98957	25021421
RPS6KA3	10432	COSM1557314,	liver	carcinoma	p.V606I	Substitution - Missense	23:20162989-20162989,	PATHOGENIC	0.98488	26850916
RPS6KA3	10432	COSM5990620,	liver	carcinoma	p.G563S	Substitution - Missense	23:20164976-20164976,	PATHOGENIC	0.98418	26850916
RPS6KA3	10432	COSM251394,	liver	carcinoma	p.L201P	Substitution - Missense	23:20188526-20188526,	PATHOGENIC	0.97983	25021421
RPS6KA3	10432	COSM251409,	liver	carcinoma	p.E528*	Substitution - Nonsense	23:20167609-20167609,	PATHOGENIC	0.97926	25021421
RPS6KA3	10432	COSM250745,	liver	carcinoma	p.Y97C	Substitution - Missense	23:20204057-20204057,	PATHOGENIC	0.97639	25021421
RPS6KA3	10432	COSM251407,	liver	carcinoma	p.?	Unknown	23:20188535-20188535,	PATHOGENIC	0.97546	25021421
RPS6KA3	10432	COSM20565,	stomach	carcinoma	p.Y483C	Substitution - Missense	23:20167743-20167743,	PATHOGENIC	0.97112	Info_not_available
RPS6KA3	10432	COSM20565,	stomach	carcinoma	p.Y483C	Substitution - Missense	23:20167743-20167743,	PATHOGENIC	0.97112	Info_not_available
RPS6KA3	10432	COSM5990623,	liver	carcinoma	p.S253F	Substitution - Missense	23:20187844-20187844,	PATHOGENIC	0.96306	26850916
RPS6KA3	10432	COSM250744,	liver	carcinoma	p.Y226N	Substitution - Missense	23:20187926-20187926,	PATHOGENIC	0.95525	25021421
RPS6KA3	10432	COSM5990621,	liver	carcinoma	p.P554S	Substitution - Missense	23:20165003-20165003,	PATHOGENIC	0.95045	26850916
RPS6KA3	10432	COSM251410,	liver	carcinoma	p.V256M	Substitution - Missense	23:20187836-20187836,	PATHOGENIC	0.94314	25021421
RPS6KA3	10432	COSM250743,	liver	carcinoma	p.D250N	Substitution - Missense	23:20187854-20187854,	PATHOGENIC	0.94314	25021421
RPS6KA3	10432	COSM32547,	breast	carcinoma	p.I416V	Substitution - Missense	23:20172853-20172853,	PATHOGENIC	0.85647	16959974
RPS6KA3	10432	COSM4722733,	liver	carcinoma	p.R242C	Substitution - Missense	23:20187878-20187878,	PATHOGENIC	0.83166	26850916
RPS6KA3	10432	COSM251408,	liver	carcinoma	p.S21I	Substitution - Missense	23:20266571-20266571,	NEUTRAL	0.41988	25021421
RPS6KA3	10432	COSM251385, COSM5878505,	liver	carcinoma	p.L546fs*4, p.M611V	Complex - frameshift, Substitution - Missense	23:20162974-20162974, 23:20165025-20165027,	Info_not_available	Info_not_available	25021421