Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
IL6ST	6021	COSM1728377,	liver	other	p.P216H	Substitution - Missense	5:55964157-55964157,	PATHOGENIC	0.99334	24501689
IL6ST	6021	COSM1728377,	liver	other	p.P216H	Substitution - Missense	5:55964157-55964157,	PATHOGENIC	0.99334	24501689
IL6ST	6021	COSM1728377,	liver	other	p.P216H	Substitution - Missense	5:55964157-55964157,	PATHOGENIC	0.99334	24501689
IL6ST	6021	COSM1728377,	liver	other	p.P216H	Substitution - Missense	5:55964157-55964157,	PATHOGENIC	0.99334	24501689
IL6ST	6021	COSM249426,	kidney	carcinoma	p.K709*	Substitution - Nonsense	5:55941714-55941714,	PATHOGENIC	0.98886	22138691
IL6ST	6021	COSM6005789,	skin	adnexal_tumour	p.V762M	Substitution - Missense	5:55941555-55941555,	PATHOGENIC	0.97631	27287813
IL6ST	6021	COSM6005789,	skin	adnexal_tumour	p.V762M	Substitution - Missense	5:55941555-55941555,	PATHOGENIC	0.97631	27287813
IL6ST	6021	COSM5025131,	breast	carcinoma	p.V623L	Substitution - Missense	5:55947563-55947563,	PATHOGENIC	0.95132	25850943
IL6ST	6021	COSM5990703,	liver	carcinoma	p.A200V	Substitution - Missense	5:55964205-55964205,	PATHOGENIC	0.94832	26850916
IL6ST	6021	COSM6005549,	prostate	carcinoma	p.P434R	Substitution - Missense	5:55954959-55954959,	PATHOGENIC	0.9326	20579941
IL6ST	6021	COSM4992356,	skin	carcinoma	p.G600E	Substitution - Missense	5:55951505-55951505,	PATHOGENIC	0.8544	25589618
IL6ST	6021	COSM5967545,	skin	adnexal_tumour	p.D844E	Substitution - Missense	5:55941307-55941307,	PATHOGENIC	0.80318	25918615
IL6ST	6021	COSM5024891,	breast	carcinoma	p.N43T	Substitution - Missense	5:55969792-55969792,	PATHOGENIC	0.76749	25850943
IL6ST	6021	COSM4992358,	skin	carcinoma	p.L124W	Substitution - Missense	5:55968396-55968396,	PATHOGENIC	0.72552	25589618
IL6ST	6021	COSM4992357,	skin	carcinoma	p.F557F	Substitution - coding silent	5:55951957-55951957,	PATHOGENIC	0.70695	25589618
IL6ST	6021	COSM5020367,	soft_tissue	haemangioblastoma	p.E151E	Substitution - coding silent	5:55968314-55968314,	NEUTRAL	0.4017	25589003
IL6ST	6021	COSM4605993,	upper_aerodigestive_tract	carcinoma	p.T280A	Substitution - Missense	5:55960537-55960537,	NEUTRAL	0.23248	25056374
IL6ST	6021	COSM5025102,	breast	carcinoma	p.Y57*	Substitution - Nonsense	5:55969749-55969749,	NEUTRAL	0.10357	25850943
IL6ST	6021	COSM6005662,	prostate	carcinoma	p.V252I	Substitution - Missense	5:55963411-55963411,	NEUTRAL	0.09551	20579941
IL6ST	6021	COSM6904263,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.P338S	Substitution - Missense	5:55957253-55957253,	NEUTRAL	0.09019	27248180
IL6ST	6021	COSM5019669,	soft_tissue	haemangioblastoma	p.G148R	Substitution - Missense	5:55968325-55968325,	NEUTRAL	0.08693	25589003
IL6ST	6021	COSM5019669,	soft_tissue	haemangioblastoma	p.G148R	Substitution - Missense	5:55968325-55968325,	NEUTRAL	0.08693	25589003
IL6ST	6021	COSM5019669,	soft_tissue	haemangioblastoma	p.G148R	Substitution - Missense	5:55968325-55968325,	NEUTRAL	0.08693	25589003
IL6ST	6021	COSM6005663,	prostate	carcinoma	p.V885I	Substitution - Missense	5:55941186-55941186,	NEUTRAL	0.0411	20579941
IL6ST	6021	COSM6005663,	large_intestine	other	p.V885I	Substitution - Missense	5:55941186-55941186,	NEUTRAL	0.0411	28524162
IL6ST	6021	COSM5019621,	soft_tissue	haemangioblastoma	p.L397V	Substitution - Missense	5:55956103-55956103,	NEUTRAL	0.02446	25589003
IL6ST	6021	COSM5019621,	soft_tissue	haemangioblastoma	p.L397V	Substitution - Missense	5:55956103-55956103,	NEUTRAL	0.02446	25589003
IL6ST	6021	COSM5019621,	soft_tissue	haemangioblastoma	p.L397V	Substitution - Missense	5:55956103-55956103,	NEUTRAL	0.02446	25589003
IL6ST	6021	COSM6005664,	prostate	carcinoma	p.G805S	Substitution - Missense	5:55941426-55941426,	NEUTRAL	0.01117	20579941
IL6ST	6021	COSM4606209,	upper_aerodigestive_tract	carcinoma	p.T3T	Substitution - coding silent	5:55976270-55976270,	NEUTRAL	0.00661	25056374
IL6ST	6021	COSM251361, COSM3666639, COSM3666640, COSM3736991, COSM3736995, COSM3736996, COSM3736997, COSM3736998, COSM3736999, COSM3737000, COSM3737001, COSM3737002, COSM3737003, COSM3737004, COSM3737007,	liver	other	p.D215_P216ins12, p.D215del, p.E195_V196del, p.F191_I194>L, p.K168_N193del, p.K173_D177del, p.S187_F191del, p.S187_Y190delSTVY, p.T188_V192>I, p.V184_S187>A, p.V189_V192del, p.V189_V192delVYFV, p.V192_I194del, p.Y186_V192>F, p.Y186_Y190delYSTVY	Complex - deletion inframe, Deletion - In frame, Insertion - In frame	5:55964157-55964158, 5:55964159-55964161, 5:55964216-55964221, 5:55964221-55964229, 5:55964222-55964231, 5:55964224-55964301, 5:55964228-55964239, 5:55964229-55964240, 5:55964230-55964241, 5:55964230-55964247, 5:55964231-55964245, 5:55964233-55964244, 5:55964233-55964247, 5:55964245-55964253, 5:55964272-55964286,	Info_not_available	Info_not_available	19020503
IL6ST	6021	COSM251361, COSM3666639, COSM3736988, COSM3736989, COSM3736990, COSM3736991,	liver	other	p.K173_D177del, p.T188fs*3, p.V189_V192delVYFV, p.Y186_F191>I, p.Y186_Y190delYSTVY, p.Y190_N193del	Complex - deletion inframe, Deletion - Frameshift, Deletion - In frame	5:55964225-55964236, 5:55964228-55964239, 5:55964229-55964242, 5:55964233-55964247, 5:55964233-55964248, 5:55964272-55964286,	Info_not_available	Info_not_available	23046672
IL6ST	6021	COSM251361, COSM3666635, COSM3666637, COSM3666638, COSM3666639, COSM3666640, COSM3736988, COSM3736990, COSM3736991, COSM3736996, COSM3736997, COSM3737004, COSM3737009, COSM4610810, COSM4610811, COSM4610812, COSM4610813, COSM4610814, COSM4610815, COSM4657322, COSM4657323, COSM4657324, COSM4657325,	liver	other	p.A418_F421delACDF, p.D185_V189del, p.D215_P216insKVTSDHINFD, p.D215del, p.F191_N193delFVN, p.K173_D177del, p.N213_F214insLVTSDHIN, p.P216del, p.S187_Y190delSTVY, p.T188_F191del, p.T188_V192>I, p.T188_V192del, p.V189_I194>DV, p.V189_N193>D, p.V189_V192>F, p.V189_V192del, p.V189_V192delVYFV, p.Y186_F191>I, p.Y186_Y190delYSTVY, p.Y190_N193>S, p.Y190_N193del, p.Y190_N193delYFVN	Complex - deletion inframe, Deletion - In frame, Insertion - In frame	5:55956029-55956040, 5:55964156-55964158, 5:55964158-55964159, 5:55964159-55964161, 5:55964162-55964163, 5:55964224-55964238, 5:55964225-55964236, 5:55964226-55964234, 5:55964226-55964235, 5:55964226-55964237, 5:55964227-55964238, 5:55964227-55964241, 5:55964228-55964239, 5:55964228-55964240, 5:55964229-55964240, 5:55964230-55964239, 5:55964230-55964241, 5:55964231-55964242, 5:55964233-55964244, 5:55964233-55964247, 5:55964233-55964248, 5:55964238-55964252, 5:55964272-55964286,	Info_not_available	Info_not_available	24501689
IL6ST	6021	COSM4603955,	upper_aerodigestive_tract	carcinoma	p.I31fs*4	Insertion - Frameshift	5:55969829-55969830,	Info_not_available	Info_not_available	25056374
IL6ST	6021	COSM251361, COSM7002224, COSM7002225, COSM7002226, COSM7002227,	liver	other	p.F191_N193del, p.V189_N193del, p.V192_I194del, p.Y186_F191del, p.Y186_Y190delYSTVY	Deletion - In frame	5:55964222-55964230, 5:55964225-55964239, 5:55964227-55964235, 5:55964231-55964248, 5:55964233-55964247,	Info_not_available	Info_not_available	26516697
IL6ST	6021	COSM4610815, COSM5990165,	liver	other	p.V189_N193>D, p.Y186_Y190del	Complex - deletion inframe, Deletion - In frame	5:55964227-55964238, 5:55964236-55964250,	Info_not_available	Info_not_available	26961851
IL6ST	6021	COSM3666638,	liver	carcinoma, other	p.Y190_N193delYFVN	Deletion - In frame	5:55964226-55964237,	Info_not_available	Info_not_available	28323122
IL6ST	6021	COSM6506520,	lung	carcinoma	p.A896V	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	28721068
IL6ST	6021	COSM32818,	large_intestine	carcinoma	p.T415I	Substitution - Missense	5:55956048-55956048,	Info_not_available	0.6751	16959974
IL6ST	6021	COSM5020232, COSM5020697,	soft_tissue	haemangioblastoma	p.?, p.I454T	Substitution - Missense, Unknown	5:55954899-55954899, 5:55963512-55963515,	Info_not_available	0.62238, Info_not_available	25589003
IL6ST	6021	COSM1645242,	large_intestine	carcinoma	p.T17A	Substitution - Missense	5:55976230-55976230,	Info_not_available	0.57635	23700467