Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
CDK6	1777	COSM6965870,	prostate	carcinoma	p.A167V	Substitution - Missense	7:92725663-92725663,	PATHOGENIC	0.99242	28481359
CDK6	1777	COSM6981658,	large_intestine	carcinoma	p.S290C	Substitution - Missense	7:92615252-92615252,	PATHOGENIC	0.99089	28481359
CDK6	1777	COSM21143,	skin	malignant_melanoma	p.P199L	Substitution - Missense	7:92671477-92671477,	PATHOGENIC	0.99032	28481359
CDK6	1777	COSM6928584,	lung	carcinoma	p.G165V	Substitution - Missense	7:92725669-92725669,	PATHOGENIC	0.98881	28481359
CDK6	1777	COSM6913650,	central_nervous_system	glioma	p.S290F	Substitution - Missense	7:92615252-92615252,	PATHOGENIC	0.98859	28481359
CDK6	1777	COSM6984893,	large_intestine	carcinoma	p.E91*	Substitution - Nonsense	7:92774794-92774794,	PATHOGENIC	0.98651	28481359
CDK6	1777	COSM2864359,	endometrium	carcinoma	p.R168H	Substitution - Missense	7:92725660-92725660,	PATHOGENIC	0.98531	28481359
CDK6	1777	COSM6942634,	large_intestine	carcinoma	p.G165S	Substitution - Missense	7:92725670-92725670,	PATHOGENIC	0.98531	28481359
CDK6	1777	COSM6942634,	large_intestine	carcinoma	p.G165S	Substitution - Missense	7:92725670-92725670,	PATHOGENIC	0.98531	28481359
CDK6	1777	COSM6939117,	lung	carcinoma	p.Y170C	Substitution - Missense	7:92725654-92725654,	PATHOGENIC	0.98463	28481359
CDK6	1777	COSM198364,	prostate	carcinoma	p.R87Q	Substitution - Missense	7:92774805-92774805,	PATHOGENIC	0.9825	28481359
CDK6	1777	COSM6936662,	breast	carcinoma	p.D102N	Substitution - Missense	7:92774761-92774761,	PATHOGENIC	0.98202	28481359
CDK6	1777	COSM5608105,	skin	malignant_melanoma	p.L146L	Substitution - coding silent	7:92725727-92725727,	PATHOGENIC	0.97969	26343386
CDK6	1777	COSM6913117,	soft_tissue	malignant_fibrous_histiocytoma-pleomorphic_sarcoma	p.P199A	Substitution - Missense	7:92671478-92671478,	PATHOGENIC	0.97051	28481359
CDK6	1777	COSM1645402,	large_intestine	carcinoma	p.R220S	Substitution - Missense	7:92623076-92623076,	PATHOGENIC	0.97031	23700467
CDK6	1777	COSM1200577,	skin	malignant_melanoma	p.R220C	Substitution - Missense	7:92623076-92623076,	PATHOGENIC	0.96998	26343386
CDK6	1777	COSM1200577,	large_intestine	carcinoma	p.R220C	Substitution - Missense	7:92623076-92623076,	PATHOGENIC	0.96998	28481359
CDK6	1777	COSM1200577,	urinary_tract	carcinoma	p.R220C	Substitution - Missense	7:92623076-92623076,	PATHOGENIC	0.96998	28481359
CDK6	1777	COSM6952230,	large_intestine	carcinoma	p.K93T	Substitution - Missense	7:92774787-92774787,	PATHOGENIC	0.9607	28481359
CDK6	1777	COSM6960413,	lung	carcinoma	p.R288G	Substitution - Missense	7:92615259-92615259,	PATHOGENIC	0.95971	28481359
CDK6	1777	COSM6930755,	urinary_tract	carcinoma	p.E51K	Substitution - Missense	7:92833173-92833173,	PATHOGENIC	0.95714	28481359
CDK6	1777	COSM6983634,	prostate	carcinoma	p.R214C	Substitution - Missense	7:92671433-92671433,	PATHOGENIC	0.95634	28481359
CDK6	1777	COSM5608106,	skin	malignant_melanoma	p.K287R	Substitution - Missense	7:92615261-92615261,	PATHOGENIC	0.91864	26343386
CDK6	1777	COSM6956097,	lung	carcinoma	p.E99D	Substitution - Missense	7:92774768-92774768,	PATHOGENIC	0.89927	28481359
CDK6	1777	COSM3883377,	large_intestine	carcinoma	p.V234M	Substitution - Missense	7:92618206-92618206,	PATHOGENIC	0.89506	28481359
CDK6	1777	COSM6972701,	NS	malignant_melanoma	p.P74S	Substitution - Missense	7:92833104-92833104,	PATHOGENIC	0.86033	28481359
CDK6	1777	COSM6972701,	lung	carcinoma	p.P74S	Substitution - Missense	7:92833104-92833104,	PATHOGENIC	0.86033	28481359
CDK6	1777	COSM6913873,	skin	malignant_melanoma	p.D4N	Substitution - Missense	7:92833314-92833314,	PATHOGENIC	0.84599	28481359
CDK6	1777	COSM1579055,	central_nervous_system	glioma	p.P148P	Substitution - coding silent	7:92725719-92725719,	PATHOGENIC	0.82986	18186519
CDK6	1777	COSM1579055,	soft_tissue	haemangioblastoma	p.P148P	Substitution - coding silent	7:92725719-92725719,	PATHOGENIC	0.82986	25589003
CDK6	1777	COSM5608107,	skin	malignant_melanoma	p.F28F	Substitution - coding silent	7:92833240-92833240,	PATHOGENIC	0.82181	26343386
CDK6	1777	COSM6927619,	central_nervous_system	glioma	p.G50D	Substitution - Missense	7:92833175-92833175,	PATHOGENIC	0.76409	28481359
CDK6	1777	COSM6919267,	large_intestine	carcinoma	p.G5S	Substitution - Missense	7:92833311-92833311,	NEUTRAL	0.30126	28481359
CDK6	1777	COSM40926,	central_nervous_system	glioma	p.?	Unknown	7:92615137-92615137,	NEUTRAL	0.02338	18772396
CDK6	1777	COSM1330465,	large_intestine	carcinoma	p.Y196Y	Substitution - coding silent	7:92671485-92671485,	Info_not_available	0.68897	18186519