Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
PAK1	8590	COSM6916671,	lung	carcinoma	p.F379C	Substitution - Missense	11:77337404-77337404,	PATHOGENIC	0.99503	28481359
PAK1	8590	COSM6943370,	NS	malignant_melanoma	p.P428L	Substitution - Missense	11:77336216-77336216,	PATHOGENIC	0.99449	28481359
PAK1	8590	COSM6939778,	urinary_tract	carcinoma	p.E166Q	Substitution - Missense	11:77358999-77358999,	PATHOGENIC	0.99441	28481359
PAK1	8590	COSM6930907,	breast	carcinoma	p.Q294E	Substitution - Missense	11:77349244-77349244,	PATHOGENIC	0.99435	28481359
PAK1	8590	COSM6972378,	small_intestine	carcinoma	p.T406I	Substitution - Missense	11:77336282-77336282,	PATHOGENIC	0.99319	28481359
PAK1	8590	COSM6938204,	breast	carcinoma	p.S38C	Substitution - Missense	11:77392408-77392408,	PATHOGENIC	0.99189	28481359
PAK1	8590	COSM6930389,	lung	carcinoma	p.Q485*	Substitution - Nonsense	11:77332828-77332828,	PATHOGENIC	0.99159	28481359
PAK1	8590	COSM6970525,	skin	malignant_melanoma	p.P487S	Substitution - Missense	11:77332822-77332822,	PATHOGENIC	0.99159	28481359
PAK1	8590	COSM5009193,	large_intestine	carcinoma	p.D389Y	Substitution - Missense	11:77337375-77337375,	PATHOGENIC	0.99134	24951259
PAK1	8590	COSM6909012,	endometrium	carcinoma	p.I85N	Substitution - Missense	11:77379931-77379931,	PATHOGENIC	0.99105	28481359
PAK1	8590	COSM326056,	large_intestine	carcinoma	p.E503K	Substitution - Missense	11:77332774-77332774,	PATHOGENIC	0.99074	28481359
PAK1	8590	COSM6954871,	lung	carcinoma	p.?	Unknown	11:77355843-77355843,	PATHOGENIC	0.99019	28481359
PAK1	8590	COSM6946263,	large_intestine	carcinoma	p.S155Y	Substitution - Missense	11:77374341-77374341,	PATHOGENIC	0.99019	28481359
PAK1	8590	COSM6961225,	kidney	carcinoma	p.C370F	Substitution - Missense	11:77340653-77340653,	PATHOGENIC	0.98992	28481359
PAK1	8590	COSM6910817,	central_nervous_system	glioma	p.?	Unknown	11:77349238-77349238,	PATHOGENIC	0.98964	28481359
PAK1	8590	COSM6935704,	lung	carcinoma	p.?	Unknown	11:77349289-77349289,	PATHOGENIC	0.98926	28481359
PAK1	8590	COSM6979508,	endometrium	carcinoma	p.?	Unknown	11:77353535-77353535,	PATHOGENIC	0.98913	28481359
PAK1	8590	COSM6932657,	lung	carcinoma	p.E417V	Substitution - Missense	11:77336249-77336249,	PATHOGENIC	0.98891	28481359
PAK1	8590	COSM6977033,	large_intestine	carcinoma	p.Y201C	Substitution - Missense	11:77355838-77355838,	PATHOGENIC	0.98891	28481359
PAK1	8590	COSM225317,	large_intestine	carcinoma	p.S133L	Substitution - Missense	11:77379282-77379282,	PATHOGENIC	0.98861	28481359
PAK1	8590	COSM225317,	large_intestine	carcinoma	p.S133L	Substitution - Missense	11:77379282-77379282,	PATHOGENIC	0.98861	28481359
PAK1	8590	COSM6907190,	large_intestine	carcinoma	p.L470Q	Substitution - Missense	11:77336090-77336090,	PATHOGENIC	0.98853	28481359
PAK1	8590	COSM6938163,	lung	carcinoma	p.I58T	Substitution - Missense	11:77392348-77392348,	PATHOGENIC	0.98763	28481359
PAK1	8590	COSM6929703,	skin	carcinoma	p.T219A	Substitution - Missense	11:77355785-77355785,	PATHOGENIC	0.9865	28481359
PAK1	8590	COSM6940721,	skin	malignant_melanoma	p.I312N	Substitution - Missense	11:77343882-77343882,	PATHOGENIC	0.98575	28481359
PAK1	8590	COSM6949241,	skin	carcinoma	p.I298N	Substitution - Missense	11:77343924-77343924,	PATHOGENIC	0.98575	28481359
PAK1	8590	COSM6966655,	lung	carcinoma	p.D180Y	Substitution - Missense	11:77358957-77358957,	PATHOGENIC	0.98559	28481359
PAK1	8590	COSM6939040,	breast	carcinoma	p.?	Unknown	11:77374366-77374366,	PATHOGENIC	0.98448	28481359
PAK1	8590	COSM6914338,	skin	carcinoma	p.R421W	Substitution - Missense	11:77336238-77336238,	PATHOGENIC	0.98434	28481359
PAK1	8590	COSM6949945,	penis	carcinoma	p.E339K	Substitution - Missense	11:77340747-77340747,	PATHOGENIC	0.98426	28481359
PAK1	8590	COSM6977165,	urinary_tract	carcinoma	p.R193C	Substitution - Missense	11:77358918-77358918,	PATHOGENIC	0.98329	28481359
PAK1	8590	COSM6927557,	breast	carcinoma	p.E456K	Substitution - Missense	11:77336133-77336133,	PATHOGENIC	0.98293	28481359
PAK1	8590	COSM6920874,	breast	carcinoma	p.E459K	Substitution - Missense	11:77336124-77336124,	PATHOGENIC	0.98293	28481359
PAK1	8590	COSM6892876,	large_intestine	carcinoma	p.R438Q	Substitution - Missense	11:77336186-77336186,	PATHOGENIC	0.98293	28481359
PAK1	8590	COSM6892876,	urinary_tract	carcinoma	p.R438Q	Substitution - Missense	11:77336186-77336186,	PATHOGENIC	0.98293	28481359
PAK1	8590	COSM6935889,	kidney	carcinoma	p.G451S	Substitution - Missense	11:77336148-77336148,	PATHOGENIC	0.98293	28481359
PAK1	8590	COSM6926166,	NS	carcinoma	p.R471K	Substitution - Missense	11:77336087-77336087,	PATHOGENIC	0.98293	28481359
PAK1	8590	COSM6982907,	lung	carcinoma	p.S333I	Substitution - Missense	11:77343819-77343819,	PATHOGENIC	0.98288	28481359
PAK1	8590	COSM6964054,	lung	carcinoma	p.D250H	Substitution - Missense	11:77355692-77355692,	PATHOGENIC	0.98283	28481359
PAK1	8590	COSM2018945,	large_intestine	carcinoma	p.R53Q	Substitution - Missense	11:77392363-77392363,	PATHOGENIC	0.98132	28481359
PAK1	8590	COSM6934526,	breast	carcinoma	p.M17I	Substitution - Missense	11:77392470-77392470,	PATHOGENIC	0.98132	28481359
PAK1	8590	COSM1357101,	large_intestine	carcinoma	p.F410L	Substitution - Missense	11:77336269-77336269,	PATHOGENIC	0.98108	28481359
PAK1	8590	COSM6921770,	lung	carcinoma	p.D52N	Substitution - Missense	11:77392367-77392367,	PATHOGENIC	0.98105	28481359
PAK1	8590	COSM6960610,	lung	carcinoma	p.E251K	Substitution - Missense	11:77355689-77355689,	PATHOGENIC	0.97821	28481359
PAK1	8590	COSM6915142,	lung	carcinoma	p.K308E	Substitution - Missense	11:77343895-77343895,	PATHOGENIC	0.97748	28481359
PAK1	8590	COSM6955129,	large_intestine	carcinoma	p.Y142C	Substitution - Missense	11:77379255-77379255,	PATHOGENIC	0.97735	28481359
PAK1	8590	COSM6952701,	lung	carcinoma	p.K141E	Substitution - Missense	11:77379259-77379259,	PATHOGENIC	0.97735	28481359
PAK1	8590	COSM6914766,	lung	carcinoma	p.V336M	Substitution - Missense	11:77340756-77340756,	PATHOGENIC	0.9769	28481359
PAK1	8590	COSM5009781,	large_intestine	carcinoma	p.L465F	Substitution - Missense	11:77336106-77336106,	PATHOGENIC	0.97286	28481359
PAK1	8590	COSM5009781,	large_intestine	carcinoma	p.L465F	Substitution - Missense	11:77336106-77336106,	PATHOGENIC	0.97286	24951259
PAK1	8590	COSM6966571,	lung	carcinoma	p.K245R	Substitution - Missense	11:77355706-77355706,	PATHOGENIC	0.97105	28481359
PAK1	8590	COSM6962129,	thyroid	carcinoma	p.P186L	Substitution - Missense	11:77358938-77358938,	PATHOGENIC	0.96265	28481359
PAK1	8590	COSM6938499,	large_intestine	carcinoma	p.A169V	Substitution - Missense	11:77358989-77358989,	PATHOGENIC	0.95817	28481359
PAK1	8590	COSM6933308,	urinary_tract	carcinoma	p.R56*	Substitution - Nonsense	11:77392355-77392355,	PATHOGENIC	0.94417	28481359
PAK1	8590	COSM6933308,	urinary_tract	carcinoma	p.R56*	Substitution - Nonsense	11:77392355-77392355,	PATHOGENIC	0.94417	28481359
PAK1	8590	COSM6927113,	lung	carcinoma	p.N486D	Substitution - Missense	11:77332825-77332825,	PATHOGENIC	0.94306	28481359
PAK1	8590	COSM6928009,	urinary_tract	carcinoma	p.K508N	Substitution - Missense	11:77332757-77332757,	PATHOGENIC	0.94164	28481359
PAK1	8590	COSM6928009,	urinary_tract	carcinoma	p.K508N	Substitution - Missense	11:77332757-77332757,	PATHOGENIC	0.94164	28481359
PAK1	8590	COSM6928009,	urinary_tract	carcinoma	p.K508N	Substitution - Missense	11:77332757-77332757,	PATHOGENIC	0.94164	28481359
PAK1	8590	COSM6914063,	biliary_tract	carcinoma	p.D52V	Substitution - Missense	11:77392366-77392366,	PATHOGENIC	0.93629	28481359
PAK1	8590	COSM6928032,	lung	carcinoma	p.I222V	Substitution - Missense	11:77355776-77355776,	PATHOGENIC	0.92742	28481359
PAK1	8590	COSM6952275,	large_intestine	carcinoma	p.F379L	Substitution - Missense	11:77337403-77337403,	PATHOGENIC	0.92637	28481359
PAK1	8590	COSM6986185,	urinary_tract	carcinoma	p.Y346*	Substitution - Nonsense	11:77340724-77340724,	PATHOGENIC	0.92521	28481359
PAK1	8590	COSM6955508,	breast	carcinoma	p.K243Q	Substitution - Missense	11:77355713-77355713,	PATHOGENIC	0.90143	28481359
PAK1	8590	COSM6952277,	large_intestine	carcinoma	p.E74D	Substitution - Missense	11:77379963-77379963,	PATHOGENIC	0.89289	28481359
PAK1	8590	COSM6930927,	ovary	carcinoma	p.G27S	Substitution - Missense	11:77392442-77392442,	PATHOGENIC	0.87362	28481359
PAK1	8590	COSM6954666,	ovary	carcinoma	p.K439N	Substitution - Missense	11:77336182-77336182,	PATHOGENIC	0.84535	28481359
PAK1	8590	COSM6938675,	large_intestine	carcinoma	p.R272W	Substitution - Missense	11:77353558-77353558,	PATHOGENIC	0.81068	28481359
PAK1	8590	COSM6918229,	large_intestine	carcinoma	p.D183A	Substitution - Missense	11:77358947-77358947,	PATHOGENIC	0.80683	28481359
PAK1	8590	COSM94907,	lung	carcinoma	p.Q519Q	Substitution - coding silent	11:77323355-77323355,	NEUTRAL	0.22928	20668451
PAK1	8590	COSM6911520,	lung	carcinoma	p.S115L	Substitution - Missense	11:77379336-77379336,	NEUTRAL	0.21228	28481359
PAK1	8590	COSM20520,	stomach	carcinoma	p.A26A	Substitution - coding silent	11:77392443-77392443,	NEUTRAL	0.09559	Info_not_available
PAK1	8590	COSM20520,	stomach	carcinoma	p.A26A	Substitution - coding silent	11:77392443-77392443,	NEUTRAL	0.09559	Info_not_available
PAK1	8590	COSM6930261, COSM6944103, COSM6963552,	lung, skin	carcinoma	p.M319delM, p.P463I, p.P463L	Deletion - In frame, Substitution - Missense	11:77336111-77336112, 11:77343859-77343861,	Info_not_available	Info_not_available	28481359