Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
CDKN1B	1785	COSM936862,	breast	carcinoma	p.E22*	Substitution - Nonsense	12:12717903-12717903,	PATHOGENIC	0.98829	28481359
CDKN1B	1785	COSM5945857,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.W76*	Substitution - Nonsense	12:12718067-12718067,	PATHOGENIC	0.98199	28481359
CDKN1B	1785	COSM5945857,	small_intestine	carcinoid-endocrine_tumour	p.W76*	Substitution - Nonsense	12:12718067-12718067,	PATHOGENIC	0.98199	28481359
CDKN1B	1785	COSM6946658,	large_intestine	carcinoma	p.P11S	Substitution - Missense	12:12717870-12717870,	PATHOGENIC	0.97883	28481359
CDKN1B	1785	COSM6955498,	prostate	carcinoma	p.E39*	Substitution - Nonsense	12:12717954-12717954,	PATHOGENIC	0.97618	28481359
CDKN1B	1785	COSM6908901,	stomach	carcinoma	p.W60C	Substitution - Missense	12:12718019-12718019,	PATHOGENIC	0.97524	28481359
CDKN1B	1785	COSM6936681,	small_intestine	carcinoid-endocrine_tumour	p.W60C	Substitution - Missense	12:12718019-12718019,	PATHOGENIC	0.97455	28481359
CDKN1B	1785	COSM6962439,	lung	carcinoma	p.A21V	Substitution - Missense	12:12717901-12717901,	PATHOGENIC	0.97426	28481359
CDKN1B	1785	COSM6938753,	biliary_tract	carcinoma	p.R5L	Substitution - Missense	12:12717853-12717853,	PATHOGENIC	0.97285	28481359
CDKN1B	1785	COSM1247956,	lung	carcinoma	p.W60*	Substitution - Nonsense	12:12718018-12718018,	PATHOGENIC	0.97267	28481359
CDKN1B	1785	COSM1247956,	breast	carcinoma	p.W60*	Substitution - Nonsense	12:12718018-12718018,	PATHOGENIC	0.97267	28481359
CDKN1B	1785	COSM6935007,	small_intestine	carcinoid-endocrine_tumour	p.W76G	Substitution - Missense	12:12718065-12718065,	PATHOGENIC	0.9725	28481359
CDKN1B	1785	COSM6927678,	large_intestine	carcinoma	p.Y88C	Substitution - Missense	12:12718102-12718102,	PATHOGENIC	0.97247	28481359
CDKN1B	1785	COSM4513762,	skin	malignant_melanoma	p.L32F	Substitution - Missense	12:12717933-12717933,	PATHOGENIC	0.97168	28481359
CDKN1B	1785	COSM4384675,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.P69L	Substitution - Missense	12:12718045-12718045,	PATHOGENIC	0.9709	24030381
CDKN1B	1785	COSM6986194,	testis	germ_cell_tumour	p.E54Q	Substitution - Missense	12:12717999-12717999,	PATHOGENIC	0.96878	28481359
CDKN1B	1785	COSM5029099,	breast	carcinoma	p.?	Unknown	12:12718824-12718824,	PATHOGENIC	0.96016	22722193
CDKN1B	1785	COSM5029099,	breast	carcinoma	p.?	Unknown	12:12718824-12718824,	PATHOGENIC	0.96016	28481359
CDKN1B	1785	COSM5029099,	urinary_tract	carcinoma	p.?	Unknown	12:12718824-12718824,	PATHOGENIC	0.96016	28481359
CDKN1B	1785	COSM1727744,	central_nervous_system	glioma	p.?	Unknown	12:12718315-12718315,	PATHOGENIC	0.9595	28481359
CDKN1B	1785	COSM1727744,	central_nervous_system	glioma	p.?	Unknown	12:12718315-12718315,	PATHOGENIC	0.9595	28481359
CDKN1B	1785	COSM6980164,	breast	carcinoma	p.?	Unknown	12:12718824-12718824,	PATHOGENIC	0.95903	28481359
CDKN1B	1785	COSM6929581,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D108N	Substitution - Missense	12:12718161-12718161,	PATHOGENIC	0.95748	28481359
CDKN1B	1785	COSM1360001,	urinary_tract	carcinoma	p.G72D	Substitution - Missense	12:12718054-12718054,	PATHOGENIC	0.95079	28481359
CDKN1B	1785	COSM1360001,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.G72D	Substitution - Missense	12:12718054-12718054,	PATHOGENIC	0.95079	28481359
CDKN1B	1785	COSM1360001,	urinary_tract	carcinoma	p.G72D	Substitution - Missense	12:12718054-12718054,	PATHOGENIC	0.95079	28481359
CDKN1B	1785	COSM5029208,	breast	carcinoma	p.T198A	Substitution - Missense	12:12718941-12718941,	PATHOGENIC	0.94373	22722193
CDKN1B	1785	COSM6983838,	salivary_gland	carcinoma	p.A18V	Substitution - Missense	12:12717892-12717892,	PATHOGENIC	0.93849	28481359
CDKN1B	1785	COSM256597,	endometrium	carcinoma	p.E172*	Substitution - Nonsense	12:12718863-12718863,	PATHOGENIC	0.93589	28481359
CDKN1B	1785	COSM4969597,	urinary_tract	carcinoma	p.*199S	Nonstop extension	12:12718945-12718945,	PATHOGENIC	0.93554	28481359
CDKN1B	1785	COSM4969597,	urinary_tract	carcinoma	p.*199S	Nonstop extension	12:12718945-12718945,	PATHOGENIC	0.93554	28481359
CDKN1B	1785	COSM4384673,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.E40K	Substitution - Missense	12:12717957-12717957,	PATHOGENIC	0.93448	24030381
CDKN1B	1785	COSM6969805,	breast	carcinoma	p.K165*	Substitution - Nonsense	12:12718842-12718842,	PATHOGENIC	0.93371	28481359
CDKN1B	1785	COSM6969157,	thyroid	carcinoma	p.E86*	Substitution - Nonsense	12:12718095-12718095,	PATHOGENIC	0.93282	28481359
CDKN1B	1785	COSM6979920,	thyroid	carcinoma	p.G72A	Substitution - Missense	12:12718054-12718054,	PATHOGENIC	0.92808	28481359
CDKN1B	1785	COSM6918057,	large_intestine	carcinoma	p.N168K	Substitution - Missense	12:12718853-12718853,	PATHOGENIC	0.92625	28481359
CDKN1B	1785	COSM3688044,	breast	carcinoma	p.E171*	Substitution - Nonsense	12:12718860-12718860,	PATHOGENIC	0.92043	22722193
CDKN1B	1785	COSM94063,	lung	carcinoma	p.M52I	Substitution - Missense	12:12717995-12717995,	PATHOGENIC	0.9198	20668451
CDKN1B	1785	COSM6931015,	urinary_tract	carcinoma	p.R50T	Substitution - Missense	12:12717988-12717988,	PATHOGENIC	0.91551	28481359
CDKN1B	1785	COSM5029207,	breast	carcinoma	p.E71*	Substitution - Nonsense	12:12718050-12718050,	PATHOGENIC	0.89703	22722193
CDKN1B	1785	COSM6933671,	breast	carcinoma	p.D158Y	Substitution - Missense	12:12718311-12718311,	PATHOGENIC	0.86971	28481359
CDKN1B	1785	COSM4384674,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.T42A	Substitution - Missense	12:12717963-12717963,	PATHOGENIC	0.85832	24030381
CDKN1B	1785	COSM6960611,	lung	carcinoma	p.S140R	Substitution - Missense	12:12718257-12718257,	PATHOGENIC	0.8486	28481359
CDKN1B	1785	COSM6909392,	lung	carcinoma	p.R194K	Substitution - Missense	12:12718930-12718930,	PATHOGENIC	0.84474	28481359
CDKN1B	1785	COSM4146812,	soft_tissue	haemangioblastoma	p.V109G	Substitution - Missense	12:12718165-12718165,	PATHOGENIC	0.82271	25589003
CDKN1B	1785	COSM4146812,	soft_tissue	haemangioblastoma	p.V109G	Substitution - Missense	12:12718165-12718165,	PATHOGENIC	0.82271	25589003
CDKN1B	1785	COSM4146812,	soft_tissue	haemangioblastoma	p.V109G	Substitution - Missense	12:12718165-12718165,	PATHOGENIC	0.82271	25589003
CDKN1B	1785	COSM4146812,	soft_tissue	haemangioblastoma	p.V109G	Substitution - Missense	12:12718165-12718165,	PATHOGENIC	0.82271	25589003
CDKN1B	1785	COSM4146812,	soft_tissue	haemangioblastoma	p.V109G	Substitution - Missense	12:12718165-12718165,	PATHOGENIC	0.82271	25589003
CDKN1B	1785	COSM4146812,	soft_tissue	haemangioblastoma	p.V109G	Substitution - Missense	12:12718165-12718165,	PATHOGENIC	0.82271	25589003
CDKN1B	1785	COSM4146812,	soft_tissue	haemangioblastoma	p.V109G	Substitution - Missense	12:12718165-12718165,	PATHOGENIC	0.82271	25589003
CDKN1B	1785	COSM4146812,	soft_tissue	haemangioblastoma	p.V109G	Substitution - Missense	12:12718165-12718165,	PATHOGENIC	0.82271	25589003
CDKN1B	1785	COSM4146812,	soft_tissue	haemangioblastoma	p.V109G	Substitution - Missense	12:12718165-12718165,	PATHOGENIC	0.82271	25589003
CDKN1B	1785	COSM4146812,	soft_tissue	haemangioblastoma	p.V109G	Substitution - Missense	12:12718165-12718165,	PATHOGENIC	0.82271	25589003
CDKN1B	1785	COSM4146812,	soft_tissue	haemangioblastoma	p.V109G	Substitution - Missense	12:12718165-12718165,	PATHOGENIC	0.82271	25589003
CDKN1B	1785	COSM4146812,	soft_tissue	haemangioblastoma	p.V109G	Substitution - Missense	12:12718165-12718165,	PATHOGENIC	0.82271	25589003
CDKN1B	1785	COSM4146812,	soft_tissue	haemangioblastoma	p.V109G	Substitution - Missense	12:12718165-12718165,	PATHOGENIC	0.82271	25589003
CDKN1B	1785	COSM6916333,	liver	carcinoma	p.Y89*	Substitution - Nonsense	12:12718106-12718106,	PATHOGENIC	0.80798	28481359
CDKN1B	1785	COSM1247955,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R169K	Substitution - Missense	12:12718855-12718855,	PATHOGENIC	0.806	24030381
CDKN1B	1785	COSM4384676,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R90K	Substitution - Missense	12:12718108-12718108,	PATHOGENIC	0.79274	24030381
CDKN1B	1785	COSM6966740,	NS	carcinoid-endocrine_tumour	p.M16T	Substitution - Missense	12:12717886-12717886,	PATHOGENIC	0.78168	28481359
CDKN1B	1785	COSM5029096,	lung	carcinoma	p.T42I	Substitution - Missense	12:12717964-12717964,	PATHOGENIC	0.76979	28481359
CDKN1B	1785	COSM5029096,	breast	carcinoma	p.T42I	Substitution - Missense	12:12717964-12717964,	PATHOGENIC	0.76979	22722193
CDKN1B	1785	COSM5421248,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q57*	Substitution - Nonsense	12:12718008-12718008,	PATHOGENIC	0.75431	28481359
CDKN1B	1785	COSM6921905,	lung	carcinoma	p.S138*	Substitution - Nonsense	12:12718252-12718252,	NEUTRAL	0.4887	28481359
CDKN1B	1785	COSM6924536,	biliary_tract	carcinoma	p.A116T	Substitution - Missense	12:12718185-12718185,	NEUTRAL	0.48311	28481359
CDKN1B	1785	COSM6924229,	stomach	carcinoid-endocrine_tumour	p.L118*	Substitution - Nonsense	12:12718192-12718192,	NEUTRAL	0.30105	28481359
CDKN1B	1785	COSM6921904,	lung	carcinoma	p.P122Q	Substitution - Missense	12:12718204-12718204,	NEUTRAL	0.23353	28481359
CDKN1B	1785	COSM4767739,	biliary_tract	carcinoma	p.?	Unknown	12:12718818-12718818,	NEUTRAL	0.15424	24997986
CDKN1B	1785	COSM5751571, COSM5751738,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q104fs*21, p.W60fs*65	Complex - frameshift, Insertion - Frameshift	12:12718019-12718019, 12:12718149-12718150,	Info_not_available	Info_not_available	26206799
CDKN1B	1785	COSM5967270,	salivary_gland	carcinoma	p.P26fs*99	Insertion - Frameshift	12:12717913-12717914,	Info_not_available	Info_not_available	27334835
CDKN1B	1785	COSM6498638,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.0	Whole gene deletion	Info_not_available	Info_not_available	Info_not_available	27369867
CDKN1B	1785	COSM5029097, COSM5029098,	breast	carcinoma	p.K134fs*11, p.P137fs*8	Deletion - Frameshift	12:12718240-12718240, 12:12718249-12718249,	Info_not_available	Info_not_available	22722193
CDKN1B	1785	COSM4990214,	skin	carcinoma	p.L130L	Substitution - coding silent	12:12718229-12718229,	Info_not_available	0.6027	25589618
CDKN1B	1785	COSM1161891, COSM1247954, COSM1360002, COSM1605759, COSM1628450, COSM268297, COSM4671225, COSM6910615, COSM6916855, COSM6918079, COSM6927047, COSM6927135, COSM6933562, COSM6933801, COSM6939443, COSM6940600, COSM6944288, COSM6945512, COSM6945523, COSM6950010, COSM6950213, COSM6950858, COSM6951667, COSM6952049, COSM6952885, COSM6960783, COSM6962024, COSM6964281, COSM6969460, COSM6975278, COSM6977194, COSM6983541, COSM6986487,	NS, breast, central_nervous_system, endometrium, haematopoietic_and_lymphoid_tissue, large_intestine, lung, pancreas, prostate, skin, small_intestine, thyroid, urinary_tract	carcinoid-endocrine_tumour, carcinoma, glioma, lymphoid_neoplasm, malignant_melanoma	p.?, p.A121fs*24, p.A98V, p.A98fs*27, p.D17fs*108, p.D51fs*73, p.E53fs*18, p.E80_K81>VR, p.E86fs*33, p.G97D, p.G97fs*22, p.G97fs*28, p.H129fs*8, p.H23fs*102, p.K59fs*12, p.K73fs*52, p.K96fs*29, p.N31fs*11, p.N8fs*1, p.P137fs*8, p.Q104fs*19, p.Q65fs*60, p.R15fs*27, p.R43W, p.R43fs*28, p.R93fs*32, p.S10fs*32, p.S125fs*1, p.S83fs*37, p.T170fs*>26, p.T42fs*30, p.W60_K68>*	Complex - compound substitution, Complex - deletion inframe, Complex - frameshift, Deletion - Frameshift, Insertion - Frameshift, Substitution - Missense, Unknown	12:12717859-12717860, 12:12717864-12717864, 12:12717882-12717882, 12:12717886-12717887, 12:12717905-12717906, 12:12717930-12717930, 12:12717962-12717963, 12:12717964-12717964, 12:12717965-12717966, 12:12717987-12717988, 12:12717995-12717995, 12:12718014-12718014, 12:12718018-12718041, 12:12718027-12718028, 12:12718051-12718052, 12:12718078-12718081, 12:12718086-12718099, 12:12718087-12718102, 12:12718095-12718100, 12:12718109-12718110, 12:12718118-12718119, 12:12718119-12718119, 12:12718124-12718125, 12:12718125-12718126, 12:12718129-12718129, 12:12718129-12718130, 12:12718132-12718132, 12:12718197-12718197, 12:12718211-12718212, 12:12718223-12718224, 12:12718248-12718248, 12:12718822-12718831, 12:12718856-12718865,	Info_not_available	0.52259, .68422, Info_not_available	28481359
CDKN1B	1785	COSM4384672, COSM4384677, COSM4385664,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.D17E, p.G182D, p.K96fs*29	Insertion - Frameshift, Substitution - Missense	12:12717890-12717890, 12:12718124-12718125, 12:12718894-12718894,	Info_not_available	0.51221, .69486, Info_not_available	24030381