Interacting Partner	Detection_method	PPI_type	Lit_support	PPI_score	Source_databases
AKT1	Affinity Capture-Western, Biochemical Activity, Co-localization, coimmunoprecipitation, experimental interaction detection, proximity ligation assay	phosphorylation reaction, physical, physical association	12042314, 16780593, 25241761, 28919423	0.65	BioGRID, IntAct, MINT
ARHGDIA	Two-hybrid, two hybrid pooling approach	physical, physical association	16169070	0.37	BioGRID, IntAct
CAMK1	Affinity Capture-Western, Biochemical Activity	physical	23707388	NA	BioGRID
CASP8	Negative Genetic	genetic	28319113	NA	BioGRID
CCNA1	Affinity Capture-Western, Reconstituted Complex, two hybrid pooling approach	physical, physical association	15583032, 16774918, 18692475	0.37	BioGRID, IntAct, MINT
CCNA2	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex	physical	12947099, 17254966, 26186194, 26496610, 28514442, 9311993, 9660939, 9716181, 9724724	NA	BioGRID
CCNB1	Affinity Capture-MS, anti tag coimmunoprecipitation, pull down	association, physical, physical association	26496610, 8756624	0.56	BioGRID, IntAct
CCND1	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	association, physical, physical association	11360184, 11940657, 12036906, 15695403, 17053782, 17254966, 19556892, 19767775, 25416956, 26496610, 28514442, 8978686, 9106657, 9311993	0.69	BioGRID, IntAct
CCND2	Affinity Capture-MS, Two-hybrid, split luciferase complementation, two hybrid array, two hybrid bait and prey pooling approach, two hybrid pooling approach, validated two hybrid	physical, physical association	16189514, 25910212, 26186194, 28514442	0.70	BioGRID, IntAct
CCND3	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid pooling approach	physical, physical association	10342870, 10597239, 11360184, 16189514, 16782892, 23718855, 26186194, 28514442, 8978686, 9716181	0.37	BioGRID, IntAct
CCNE1	Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, proximity ligation assay, pull down	association, physical, physical association	10393546, 11940657, 12529437, 17254966, 17254967, 17293600, 19470470, 20837141, 25241761, 27175940, 8756624, 8891332, 8978686, 9192873, 9218599, 9311993, 9632134, 9660939, 9716181, 9891079	0.82	BioGRID, IntAct
CCNE2	Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, molecular sieving, two hybrid	physical, physical association	24358021, 9840927, 9840943	0.65	BioGRID, IntAct
CDC34	Biochemical Activity, Protein-peptide	physical	19123975, 22748924	NA	BioGRID
CDK1	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	18615582, 23602568, 24358021, 26186194, 28514442	0.53	BioGRID, IntAct
CDK2	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-localization, Protein-peptide, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, footprinting, molecular sieving, proximity ligation assay, surface plasmon resonance, tandem affinity purification	association, direct interaction, physical, physical association	10198259, 10323868, 10393546, 10585280, 11940657, 12417722, 12529437, 12800980, 12972555, 15355997, 15557281, 15619620, 15647383, 15890360, 16326706, 16782892, 17053782, 17254966, 17254967, 17418410, 17671428, 18285702, 18615582, 18850315, 19631451, 21423803, 21439954, 23455922, 23602568, 24358021, 25241761, 25852190, 26186194, 26450989, 26496610, 27175940, 27998760, 28514442, 8978686, 9192873, 9218599, 9311993, 9380407, 9472014, 9632134, 9658399, 9660939, 9724724	0.97	BioGRID, IntAct, MINT
CDK3	Affinity Capture-MS, tandem affinity purification	association, physical	23602568, 26186194, 28514442	0.35	BioGRID, IntAct
CDK4	Affinity Capture-MS, Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, proximity ligation assay, tandem affinity purification	association, physical, physical association	10198259, 10908655, 11360184, 11940657, 15695403, 16326706, 16782892, 17053782, 18285702, 18615582, 18850315, 19470470, 20837141, 21439954, 23602568, 23707388, 25241761, 26186194, 28514442, 8978686, 9106657, 9311993, 9464540, 9632134, 9658399	0.87	BioGRID, IntAct, MINT
CDK5	Affinity Capture-MS, Biochemical Activity, Reconstituted Complex, anti tag coimmunoprecipitation, footprinting, surface plasmon resonance, tandem affinity purification	association, direct interaction, physical, physical association	15890360, 23455922, 23543736, 23602568, 25852190, 26186194, 28514442	0.84	BioGRID, IntAct
CDK6	Affinity Capture-MS, Affinity Capture-Western, Co-localization, proximity ligation assay	physical, physical association	11360184, 16782892, 18615582, 21439954, 25241761, 28514442	0.40	BioGRID, IntAct
CDK7	Affinity Capture-MS	physical	28514442	NA	BioGRID
CDKN1A	Co-localization, Phenotypic Enhancement, proximity ligation assay	genetic, physical, physical association	18850315, 25241761	0.40	BioGRID, IntAct
CKS1B	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Protein-peptide, Reconstituted Complex, enzymatic study, isothermal titration calorimetry, x-ray crystallography	physical, physical association, ubiquitination reaction	12140288, 12813041, 16209941, 18805092, 19584057, 23910095, 28514442	0.67	BioGRID, IntAct
CKS2	Affinity Capture-MS	physical	28514442	NA	BioGRID
COP1	Affinity Capture-Western, Biochemical Activity, Co-fractionation, Reconstituted Complex	physical	26254224	NA	BioGRID
COPS5	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, fluorescence microscopy, pull down	association, colocalization, physical, physical association	12082530, 15480426, 16951171, 17951406, 18202760, 18285702, 22350412, 24671224, 28919423	0.60	BioGRID, IntAct
COPS6	Affinity Capture-Western	physical	25945542	NA	BioGRID
CUL1	Protein-peptide, Reconstituted Complex, enzymatic study, pull down	physical, physical association, ubiquitination reaction	10559916, 11961546, 18805092, 22959436	0.61	BioGRID, IntAct
CUL4A	Affinity Capture-Western	physical	16467204, 16537899, 19056892, 26613412	NA	BioGRID
DCLRE1C	Reconstituted Complex	physical	22134138	NA	BioGRID
DDB1	Affinity Capture-Western	physical	21237244	NA	BioGRID
ELAVL1	Affinity Capture-RNA	physical	19322201	NA	BioGRID
GNL3	Affinity Capture-Western, Reconstituted Complex	physical	27998760	NA	BioGRID
GRB2	Co-fractionation, Reconstituted Complex, isothermal titration calorimetry	direct interaction, physical	11278754, 19523899	0.44	BioGRID, IntAct
HIST1H1A	Biochemical Activity	physical	11940657	NA	BioGRID
HIST1H1B	Biochemical Activity	physical	17671428	NA	BioGRID
HSP90AA1	Synthetic Lethality	genetic	27453043	NA	BioGRID
HSPA8	Affinity Capture-Western	physical	26775844	NA	BioGRID
IGF1R	Negative Genetic	genetic	28319113	NA	BioGRID
IRF1	Two-hybrid, two hybrid array	physical, physical association	21988832	0.37	BioGRID, IntAct
JAK2	Affinity Capture-Western, Biochemical Activity, anti bait coimmunoprecipitation	physical, physical association	21423214	0.40	BioGRID, IntAct
KAT2B	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	22547391	NA	BioGRID
KPNA1	Affinity Capture-Western, Protein-peptide, Reconstituted Complex	physical	15057270	NA	BioGRID
KPNA4	Reconstituted Complex	physical	15057270	NA	BioGRID
KPNA6	Reconstituted Complex, anti tag coimmunoprecipitation	physical, physical association	22770219	0.40	BioGRID, IntAct
LYN	Affinity Capture-Western, Biochemical Activity, anti bait coimmunoprecipitation, protein kinase assay	phosphorylation reaction, physical, physical association	17254966	0.54	BioGRID, IntAct
MAPK10	Reconstituted Complex	physical	12963725	NA	BioGRID
MAPK8	Affinity Capture-Western, Reconstituted Complex	physical	12963725	NA	BioGRID
MYC	Affinity Capture-Western, PCA	physical	26701207	NA	BioGRID
NUP50	Reconstituted Complex, Two-hybrid	physical	10891500	NA	BioGRID
PIN1	Affinity Capture-Western, Protein-peptide, Reconstituted Complex	physical	19584057	NA	BioGRID
PRB2	Affinity Capture-Western	physical	10825149	NA	BioGRID
PSMB1	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	23725357	NA	BioGRID
RBX1	Biochemical Activity, enzymatic study	physical, ubiquitination reaction	18805092	0.44	BioGRID, IntAct
RCHY1	Affinity Capture-Western, Biochemical Activity	physical	18006823, 21236467	NA	BioGRID
RHOA	Affinity Capture-Western, anti bait coimmunoprecipitation, pull down	direct interaction, physical, physical association	19470470, 23333463	0.54	BioGRID, IntAct
RNF123	Affinity Capture-Western, Reconstituted Complex	physical	15531880, 15746103	NA	BioGRID
RPS6KA1	Affinity Capture-Western, Biochemical Activity, anti bait coimmunoprecipitation, protein kinase assay	phosphorylation reaction, physical, physical association	19470470	0.54	BioGRID, IntAct
SGK1	Biochemical Activity	physical	18570873	NA	BioGRID
SIRT6	Affinity Capture-Western, Reconstituted Complex	physical	27794562	NA	BioGRID
SKP1	Protein-peptide, isothermal titration calorimetry, x-ray crystallography	physical, physical association	10559916, 16209941, 23910095	0.52	BioGRID, IntAct
SKP2	Affinity Capture-Western, Biochemical Activity, Protein-peptide, Reconstituted Complex, enzymatic study, isothermal titration calorimetry, pull down, x-ray crystallography	physical, physical association, ubiquitination reaction	10559916, 11463388, 11565034, 12042314, 12140288, 12813041, 15075339, 15355997, 15469821, 15735731, 16209941, 16774918, 18239684, 18805092, 19112177, 19686743, 20160477, 20160482, 20663873, 21237244, 21503567, 22310285, 22524983, 22632967, 22959436, 23910095, 23911321, 24085301, 26450989	0.75	BioGRID, IntAct
SPDYA	Affinity Capture-Western, Reconstituted Complex	physical	12972555, 17671428	NA	BioGRID
SRC	Affinity Capture-Western, Biochemical Activity, protein kinase assay	phosphorylation reaction, physical	17254967	0.44	BioGRID, IntAct
STMN1	Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	physical, physical association	15652749, 21423803	0.59	BioGRID, IntAct
TRAF2	Co-localization, Two-hybrid, proximity ligation assay, two hybrid array, two hybrid bait and prey pooling approach, two hybrid pooling approach, validated two hybrid	physical, physical association	16189514, 25241761, 25910212	0.75	BioGRID, IntAct
TRIM21	Affinity Capture-Western	physical	16880511	NA	BioGRID
TSC1	Affinity Capture-Western	physical	15355997	NA	BioGRID
TSC2	Affinity Capture-Western	physical	15355997, 17470459	NA	BioGRID
TXNIP	Affinity Capture-Western	physical	18202760	NA	BioGRID
UBAC1	Reconstituted Complex	physical	15531880	NA	BioGRID
UBC	Affinity Capture-Western	physical	25411243	NA	BioGRID
UBE2B	Biochemical Activity	physical	19123975	NA	BioGRID
UBE2D2	Biochemical Activity, enzymatic study	physical, ubiquitination reaction	18805092, 19123975	0.44	BioGRID, IntAct
UBE2I	Biochemical Activity	physical	26450989	NA	BioGRID
UBE3A	Affinity Capture-Western, Biochemical Activity	physical	19591933	NA	BioGRID
UCHL1	Affinity Capture-Western, anti bait coimmunoprecipitation, fluorescence microscopy	colocalization, physical, physical association	12082530	0.46	BioGRID, IntAct
VCP	Affinity Capture-Western	physical	23383273	NA	BioGRID
VHL	Negative Genetic	genetic	28319113	NA	BioGRID
WEE1	Synthetic Lethality	genetic	27453043	NA	BioGRID
XPO1	Affinity Capture-Western, Reconstituted Complex	physical	11889117, 12529437, 27175940	NA	BioGRID
YWHAB	Reconstituted Complex, pull down	physical, physical association	15057270	0.40	BioGRID, IntAct
YWHAE	Affinity Capture-Western, Reconstituted Complex, pull down	physical, physical association	15057270	0.40	BioGRID, IntAct
YWHAQ	Affinity Capture-Western, coimmunoprecipitation, experimental interaction detection	association, physical, physical association	12042314, 17470459, 18281517	0.72	BioGRID, IntAct, MINT
YWHAZ	Reconstituted Complex	physical	15057270	NA	BioGRID