Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
SYK	11491	COSM6932530,	breast	carcinoma	p.?	Unknown	9:90878763-90878763,	PATHOGENIC	0.99757	28481359
SYK	11491	COSM6943651,	large_intestine	carcinoma	p.H62R	Substitution - Missense	9:90844083-90844083,	PATHOGENIC	0.99387	28481359
SYK	11491	COSM6943653,	large_intestine	carcinoma	p.V410M	Substitution - Missense	9:90877686-90877686,	PATHOGENIC	0.99256	28481359
SYK	11491	COSM6937805,	urinary_tract	carcinoma	p.R411Q	Substitution - Missense	9:90877690-90877690,	PATHOGENIC	0.99256	28481359
SYK	11491	COSM6917614,	skin	malignant_melanoma	p.M412I	Substitution - Missense	9:90877694-90877694,	PATHOGENIC	0.99256	28481359
SYK	11491	COSM3731052,	large_intestine	carcinoma	p.E419K	Substitution - Missense	9:90877713-90877713,	PATHOGENIC	0.99224	28481359
SYK	11491	COSM3731052,	skin	carcinoma	p.E419K	Substitution - Missense	9:90877713-90877713,	PATHOGENIC	0.99224	28481359
SYK	11491	COSM6956969,	skin	carcinoma	p.F120S	Substitution - Missense	9:90844257-90844257,	PATHOGENIC	0.99151	28481359
SYK	11491	COSM1701313,	skin	malignant_melanoma	p.G555E	Substitution - Missense	9:90888525-90888525,	PATHOGENIC	0.98851	28481359
SYK	11491	COSM6918512,	urinary_tract	carcinoma	p.E353*	Substitution - Nonsense	9:90874794-90874794,	PATHOGENIC	0.9884	28481359
SYK	11491	COSM6978502,	endometrium	carcinoma	p.G18D	Substitution - Missense	9:90843951-90843951,	PATHOGENIC	0.98834	28481359
SYK	11491	COSM6970319,	skin	malignant_melanoma	p.G37R	Substitution - Missense	9:90844007-90844007,	PATHOGENIC	0.98834	28481359
SYK	11491	COSM6959677,	thyroid	carcinoma	p.R22Q	Substitution - Missense	9:90843963-90843963,	PATHOGENIC	0.98834	28481359
SYK	11491	COSM6946989,	soft_tissue	malignant_fibrous_histiocytoma-pleomorphic_sarcoma	p.G491R	Substitution - Missense	9:90878912-90878912,	PATHOGENIC	0.98794	28481359
SYK	11491	COSM6977607,	breast	carcinoma	p.M457I	Substitution - Missense	9:90878812-90878812,	PATHOGENIC	0.98777	28481359
SYK	11491	COSM6987620,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Y436D	Substitution - Missense	9:90877764-90877764,	PATHOGENIC	0.98696	28481359
SYK	11491	COSM6911366,	skin	carcinoma	p.G360E	Substitution - Missense	9:90874816-90874816,	PATHOGENIC	0.98659	28481359
SYK	11491	COSM6956702,	pancreas	carcinoma	p.D351N	Substitution - Missense	9:90874788-90874788,	PATHOGENIC	0.98659	28481359
SYK	11491	COSM6980393,	lung	carcinoma	p.M539I	Substitution - Missense	9:90887853-90887853,	PATHOGENIC	0.98624	28481359
SYK	11491	COSM6980393,	lung	carcinoma	p.M539I	Substitution - Missense	9:90887853-90887853,	PATHOGENIC	0.98624	28481359
SYK	11491	COSM6945828,	NS	carcinoma	p.D531Y	Substitution - Missense	9:90887827-90887827,	PATHOGENIC	0.98624	28481359
SYK	11491	COSM1625224,	liver	carcinoma	p.E26K	Substitution - Missense	9:90843974-90843974,	PATHOGENIC	0.9848	Info_not_available
SYK	11491	COSM6925540,	skin	carcinoma	p.A75V	Substitution - Missense	9:90844122-90844122,	PATHOGENIC	0.98469	28481359
SYK	11491	COSM6909006,	endometrium	carcinoma	p.D531N	Substitution - Missense	9:90887827-90887827,	PATHOGENIC	0.98439	28481359
SYK	11491	COSM6909006,	urinary_tract	carcinoma	p.D531N	Substitution - Missense	9:90887827-90887827,	PATHOGENIC	0.98439	28481359
SYK	11491	COSM6909006,	prostate	carcinoma	p.D531N	Substitution - Missense	9:90887827-90887827,	PATHOGENIC	0.98439	28481359
SYK	11491	COSM4993463,	skin	carcinoma	p.S93F	Substitution - Missense	9:90844176-90844176,	PATHOGENIC	0.98318	25589618
SYK	11491	COSM4993463,	skin	carcinoma	p.S93F	Substitution - Missense	9:90844176-90844176,	PATHOGENIC	0.98318	25589618
SYK	11491	COSM6975327,	large_intestine	carcinoma	p.E144G	Substitution - Missense	9:90845447-90845447,	PATHOGENIC	0.98257	28481359
SYK	11491	COSM6954274,	prostate	carcinoma	p.Y246S	Substitution - Missense	9:90864608-90864608,	PATHOGENIC	0.9823	28481359
SYK	11491	COSM98962,	stomach	carcinoma	p.Y246C	Substitution - Missense	9:90864608-90864608,	PATHOGENIC	0.98108	21097718
SYK	11491	COSM6966972,	NS	malignant_melanoma	p.F16I	Substitution - Missense	9:90843944-90843944,	PATHOGENIC	0.98076	28481359
SYK	11491	COSM95297,	ovary	other	p.D405N	Substitution - Missense	9:90877671-90877671,	PATHOGENIC	0.98018	20668451
SYK	11491	COSM6981223,	skin	malignant_melanoma	p.Q31*	Substitution - Nonsense	9:90843989-90843989,	PATHOGENIC	0.9798	28481359
SYK	11491	COSM6958020,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Y325D	Substitution - Missense	9:90874710-90874710,	PATHOGENIC	0.97906	28481359
SYK	11491	COSM6925935,	breast	carcinoma	p.G509E	Substitution - Missense	9:90887762-90887762,	PATHOGENIC	0.97692	28481359
SYK	11491	COSM6952485,	skin	malignant_melanoma	p.P319S	Substitution - Missense	9:90874692-90874692,	PATHOGENIC	0.97671	28481359
SYK	11491	COSM6944467,	endometrium	carcinoma	p.A204T	Substitution - Missense	9:90862237-90862237,	PATHOGENIC	0.97411	28481359
SYK	11491	COSM6905949,	NS	malignant_melanoma	p.G231E	Substitution - Missense	9:90862319-90862319,	PATHOGENIC	0.97397	28481359
SYK	11491	COSM6934803,	urinary_tract	carcinoma	p.R593M	Substitution - Missense	9:90895539-90895539,	PATHOGENIC	0.97396	28481359
SYK	11491	COSM6961907,	pancreas	carcinoid-endocrine_tumour	p.Q145*	Substitution - Nonsense	9:90845449-90845449,	PATHOGENIC	0.9738	28481359
SYK	11491	COSM6929701,	skin	carcinoma	p.E230*	Substitution - Nonsense	9:90862315-90862315,	PATHOGENIC	0.97306	28481359
SYK	11491	COSM1110998,	urinary_tract	carcinoma	p.R604H	Substitution - Missense	9:90895572-90895572,	PATHOGENIC	0.97048	28481359
SYK	11491	COSM6955103,	large_intestine	carcinoma	p.V537A	Substitution - Missense	9:90887846-90887846,	PATHOGENIC	0.96964	28481359
SYK	11491	COSM6986548,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.?	Unknown	9:90895527-90895527,	PATHOGENIC	0.96947	28481359
SYK	11491	COSM6984687,	central_nervous_system	glioma	p.A418D	Substitution - Missense	9:90877711-90877711,	PATHOGENIC	0.96923	28481359
SYK	11491	COSM6909516,	urinary_tract	carcinoma	p.G112R	Substitution - Missense	9:90844232-90844232,	PATHOGENIC	0.96775	28481359
SYK	11491	COSM6945605,	kidney	carcinoma	p.Q439H	Substitution - Missense	9:90877775-90877775,	PATHOGENIC	0.96702	28481359
SYK	11491	COSM6944061,	skin	carcinoma	p.D27N	Substitution - Missense	9:90843977-90843977,	PATHOGENIC	0.96649	28481359
SYK	11491	COSM6923617,	large_intestine	carcinoma	p.G185*	Substitution - Nonsense	9:90845569-90845569,	PATHOGENIC	0.9611	28481359
SYK	11491	COSM6928030,	lung	carcinoma	p.G201C	Substitution - Missense	9:90862228-90862228,	PATHOGENIC	0.95438	28481359
SYK	11491	COSM6932404,	central_nervous_system	glioma	p.T236M	Substitution - Missense	9:90862334-90862334,	PATHOGENIC	0.95411	28481359
SYK	11491	COSM5575992,	stomach	carcinoma	p.G569W	Substitution - Missense	9:90888566-90888566,	PATHOGENIC	0.95323	26489445
SYK	11491	COSM48799,	lung	carcinoma	p.D580H	Substitution - Missense	9:90888599-90888599,	PATHOGENIC	0.9511	18948947
SYK	11491	COSM6841498,	urinary_tract	carcinoma	p.P518L	Substitution - Missense	9:90887789-90887789,	PATHOGENIC	0.95083	28481359
SYK	11491	COSM6936741,	large_intestine	carcinoma	p.R42C	Substitution - Missense	9:90844022-90844022,	PATHOGENIC	0.94276	28481359
SYK	11491	COSM6936741,	large_intestine	carcinoma	p.R42C	Substitution - Missense	9:90844022-90844022,	PATHOGENIC	0.94276	28481359
SYK	11491	COSM6926739,	breast	carcinoma	p.W421*	Substitution - Nonsense	9:90877721-90877721,	PATHOGENIC	0.94253	28481359
SYK	11491	COSM6926739,	breast	carcinoma	p.W421*	Substitution - Nonsense	9:90877721-90877721,	PATHOGENIC	0.94253	28481359
SYK	11491	COSM6978618,	skin	malignant_melanoma	p.G224E	Substitution - Missense	9:90862298-90862298,	PATHOGENIC	0.93532	28481359
SYK	11491	COSM3908791,	lung	carcinoma	p.D219N	Substitution - Missense	9:90862282-90862282,	PATHOGENIC	0.93466	28481359
SYK	11491	COSM6950872,	lung	carcinoma	p.K338*	Substitution - Nonsense	9:90874749-90874749,	PATHOGENIC	0.93125	28481359
SYK	11491	COSM6967724,	skin	malignant_melanoma	p.E210K	Substitution - Missense	9:90862255-90862255,	PATHOGENIC	0.92924	28481359
SYK	11491	COSM6928080,	urinary_tract	carcinoma	p.Q94R	Substitution - Missense	9:90844179-90844179,	PATHOGENIC	0.91597	28481359
SYK	11491	COSM6969509,	breast	carcinoma	p.D8N	Substitution - Missense	9:90843920-90843920,	PATHOGENIC	0.91573	28481359
SYK	11491	COSM3659460,	NS	malignant_melanoma	p.D580N	Substitution - Missense	9:90888599-90888599,	PATHOGENIC	0.90684	28481359
SYK	11491	COSM3659460,	skin	malignant_melanoma	p.D580N	Substitution - Missense	9:90888599-90888599,	PATHOGENIC	0.90684	28481359
SYK	11491	COSM3659460,	skin	malignant_melanoma	p.D580N	Substitution - Missense	9:90888599-90888599,	PATHOGENIC	0.90684	28481359
SYK	11491	COSM6978895,	thyroid	carcinoma	p.Q141R	Substitution - Missense	9:90845438-90845438,	PATHOGENIC	0.90548	28481359
SYK	11491	COSM6946464,	large_intestine	carcinoma	p.S84T	Substitution - Missense	9:90844149-90844149,	PATHOGENIC	0.90426	28481359
SYK	11491	COSM6912683,	large_intestine	carcinoma	p.Y47N	Substitution - Missense	9:90844037-90844037,	PATHOGENIC	0.89368	28481359
SYK	11491	COSM6974161,	breast	carcinoma	p.I448M	Substitution - Missense	9:90878785-90878785,	PATHOGENIC	0.89002	28481359
SYK	11491	COSM6984483,	endometrium	carcinoma	p.F526L	Substitution - Missense	9:90887814-90887814,	PATHOGENIC	0.87049	28481359
SYK	11491	COSM6955101,	large_intestine	carcinoma	p.R344*	Substitution - Nonsense	9:90874767-90874767,	PATHOGENIC	0.86527	28481359
SYK	11491	COSM3764053,	soft_tissue	haemangioblastoma	p.L423L	Substitution - coding silent	9:90877727-90877727,	PATHOGENIC	0.84529	25589003
SYK	11491	COSM3764053,	soft_tissue	haemangioblastoma	p.L423L	Substitution - coding silent	9:90877727-90877727,	PATHOGENIC	0.84529	25589003
SYK	11491	COSM3764053,	soft_tissue	haemangioblastoma	p.L423L	Substitution - coding silent	9:90877727-90877727,	PATHOGENIC	0.84529	25589003
SYK	11491	COSM3764053,	soft_tissue	haemangioblastoma	p.L423L	Substitution - coding silent	9:90877727-90877727,	PATHOGENIC	0.84529	25589003
SYK	11491	COSM3764053,	soft_tissue	haemangioblastoma	p.L423L	Substitution - coding silent	9:90877727-90877727,	PATHOGENIC	0.84529	25589003
SYK	11491	COSM3764053,	soft_tissue	haemangioblastoma	p.L423L	Substitution - coding silent	9:90877727-90877727,	PATHOGENIC	0.84529	25589003
SYK	11491	COSM3764053,	soft_tissue	haemangioblastoma	p.L423L	Substitution - coding silent	9:90877727-90877727,	PATHOGENIC	0.84529	25589003
SYK	11491	COSM6449039,	lung	carcinoma	p.A389T	Substitution - Missense	9:90877623-90877623,	PATHOGENIC	0.81105	28481359
SYK	11491	COSM6946991,	soft_tissue	malignant_fibrous_histiocytoma-pleomorphic_sarcoma	p.D589N	Substitution - Missense	9:90888626-90888626,	PATHOGENIC	0.76889	28481359
SYK	11491	COSM4419828,	soft_tissue	haemangioblastoma	p.L492L	Substitution - coding silent	9:90878917-90878917,	PATHOGENIC	0.75958	25589003
SYK	11491	COSM4419828,	soft_tissue	haemangioblastoma	p.L492L	Substitution - coding silent	9:90878917-90878917,	PATHOGENIC	0.75958	25589003
SYK	11491	COSM4419828,	soft_tissue	haemangioblastoma	p.L492L	Substitution - coding silent	9:90878917-90878917,	PATHOGENIC	0.75958	25589003
SYK	11491	COSM4419828,	soft_tissue	haemangioblastoma	p.L492L	Substitution - coding silent	9:90878917-90878917,	PATHOGENIC	0.75958	25589003
SYK	11491	COSM5897726,	central_nervous_system	glioma	p.P299S	Substitution - Missense	9:90874252-90874252,	NEUTRAL	0.48464	28481359
SYK	11491	COSM6973191,	upper_aerodigestive_tract	carcinoma	p.Y516*	Substitution - Nonsense	9:90887784-90887784,	NEUTRAL	0.37275	28481359
SYK	11491	COSM6910453,	testis	germ_cell_tumour	p.R273C	Substitution - Missense	9:90865068-90865068,	NEUTRAL	0.3405	28481359
SYK	11491	COSM6910453,	endometrium	carcinoma	p.R273C	Substitution - Missense	9:90865068-90865068,	NEUTRAL	0.3405	28481359
SYK	11491	COSM6965102,	urinary_tract	carcinoma	p.V373L	Substitution - Missense	9:90877575-90877575,	NEUTRAL	0.24632	28481359
SYK	11491	COSM3764055,	soft_tissue	haemangioblastoma	p.Y484Y	Substitution - coding silent	9:90878893-90878893,	NEUTRAL	0.16886	25589003
SYK	11491	COSM3764055,	soft_tissue	haemangioblastoma	p.Y484Y	Substitution - coding silent	9:90878893-90878893,	NEUTRAL	0.16886	25589003
SYK	11491	COSM3764055,	soft_tissue	haemangioblastoma	p.Y484Y	Substitution - coding silent	9:90878893-90878893,	NEUTRAL	0.16886	25589003
SYK	11491	COSM3764055,	soft_tissue	haemangioblastoma	p.Y484Y	Substitution - coding silent	9:90878893-90878893,	NEUTRAL	0.16886	25589003
SYK	11491	COSM3764055,	soft_tissue	haemangioblastoma	p.Y484Y	Substitution - coding silent	9:90878893-90878893,	NEUTRAL	0.16886	25589003
SYK	11491	COSM3764055,	soft_tissue	haemangioblastoma	p.Y484Y	Substitution - coding silent	9:90878893-90878893,	NEUTRAL	0.16886	25589003
SYK	11491	COSM3764055,	soft_tissue	haemangioblastoma	p.Y484Y	Substitution - coding silent	9:90878893-90878893,	NEUTRAL	0.16886	25589003
SYK	11491	COSM6956805,	lung	carcinoma	p.P274L	Substitution - Missense	9:90865072-90865072,	NEUTRAL	0.15603	28481359
SYK	11491	COSM4993465,	skin	carcinoma	p.S93S	Substitution - coding silent	9:90844177-90844177,	NEUTRAL	0.14073	25589618
SYK	11491	COSM4993465,	skin	carcinoma	p.S93S	Substitution - coding silent	9:90844177-90844177,	NEUTRAL	0.14073	25589618
SYK	11491	COSM95296,	lung	carcinoma	p.S293C	Substitution - Missense	9:90874234-90874234,	NEUTRAL	0.13849	20668451
SYK	11491	COSM5977732,	central_nervous_system	glioma	p.S293N	Substitution - Missense	9:90874235-90874235,	NEUTRAL	0.12902	26487540
SYK	11491	COSM6937803,	urinary_tract	carcinoma	p.A77T	Substitution - Missense	9:90844127-90844127,	NEUTRAL	0.12297	28481359
SYK	11491	COSM3221664,	lung	carcinoma	p.S3N	Substitution - Missense	9:90843906-90843906,	NEUTRAL	0.12274	28481359
SYK	11491	COSM6932178,	breast	carcinoma	p.R497C	Substitution - Missense	9:90878930-90878930,	NEUTRAL	0.07122	28481359
SYK	11491	COSM6932178,	breast	carcinoma	p.R497C	Substitution - Missense	9:90878930-90878930,	NEUTRAL	0.07122	28481359
SYK	11491	COSM4993467,	skin	carcinoma	p.T375T	Substitution - coding silent	9:90877583-90877583,	NEUTRAL	0.05161	25589618
SYK	11491	COSM6926555,	urinary_tract	carcinoma	p.S283F	Substitution - Missense	9:90874205-90874205,	NEUTRAL	0.03786	28481359
SYK	11491	COSM3764057,	soft_tissue	haemangioblastoma	p.F490F	Substitution - coding silent	9:90878911-90878911,	NEUTRAL	0.03757	25589003
SYK	11491	COSM3764057,	soft_tissue	haemangioblastoma	p.F490F	Substitution - coding silent	9:90878911-90878911,	NEUTRAL	0.03757	25589003
SYK	11491	COSM3764057,	soft_tissue	haemangioblastoma	p.F490F	Substitution - coding silent	9:90878911-90878911,	NEUTRAL	0.03757	25589003
SYK	11491	COSM6933982,	skin	malignant_melanoma	p.G272S	Substitution - Missense	9:90865065-90865065,	NEUTRAL	0.03123	28481359
SYK	11491	COSM5019826,	soft_tissue	haemangioblastoma	p.?	Unknown	9:90877567-90877567,	NEUTRAL	0.02796	25589003
SYK	11491	COSM6920316,	lung	carcinoma	p.A309S	Substitution - Missense	9:90874282-90874282,	NEUTRAL	0.02507	28481359
SYK	11491	COSM3764051,	soft_tissue	haemangioblastoma	p.R411R	Substitution - coding silent	9:90877691-90877691,	NEUTRAL	0.02381	25589003
SYK	11491	COSM3764051,	soft_tissue	haemangioblastoma	p.R411R	Substitution - coding silent	9:90877691-90877691,	NEUTRAL	0.02381	25589003
SYK	11491	COSM3764051,	soft_tissue	haemangioblastoma	p.R411R	Substitution - coding silent	9:90877691-90877691,	NEUTRAL	0.02381	25589003
SYK	11491	COSM3764051,	soft_tissue	haemangioblastoma	p.R411R	Substitution - coding silent	9:90877691-90877691,	NEUTRAL	0.02381	25589003
SYK	11491	COSM3764051,	soft_tissue	haemangioblastoma	p.R411R	Substitution - coding silent	9:90877691-90877691,	NEUTRAL	0.02381	25589003
SYK	11491	COSM3764051,	soft_tissue	haemangioblastoma	p.R411R	Substitution - coding silent	9:90877691-90877691,	NEUTRAL	0.02381	25589003
SYK	11491	COSM3764051,	soft_tissue	haemangioblastoma	p.R411R	Substitution - coding silent	9:90877691-90877691,	NEUTRAL	0.02381	25589003
SYK	11491	COSM6964316,	lung	carcinoma	p.Q287L	Substitution - Missense	9:90874217-90874217,	NEUTRAL	0.01968	28481359
SYK	11491	COSM6943712,	large_intestine	carcinoma	p.A282V	Substitution - Missense	9:90865096-90865096,	NEUTRAL	0.01891	28481359
SYK	11491	COSM4419975,	soft_tissue	haemangioblastoma	p.P332P	Substitution - coding silent	9:90874733-90874733,	NEUTRAL	0.01274	25589003
SYK	11491	COSM4419975,	soft_tissue	haemangioblastoma	p.P332P	Substitution - coding silent	9:90874733-90874733,	NEUTRAL	0.01274	25589003
SYK	11491	COSM4419975,	soft_tissue	haemangioblastoma	p.P332P	Substitution - coding silent	9:90874733-90874733,	NEUTRAL	0.01274	25589003
SYK	11491	COSM4419975,	soft_tissue	haemangioblastoma	p.P332P	Substitution - coding silent	9:90874733-90874733,	NEUTRAL	0.01274	25589003
SYK	11491	COSM4419975,	soft_tissue	haemangioblastoma	p.P332P	Substitution - coding silent	9:90874733-90874733,	NEUTRAL	0.01274	25589003
SYK	11491	COSM4419975,	soft_tissue	haemangioblastoma	p.P332P	Substitution - coding silent	9:90874733-90874733,	NEUTRAL	0.01274	25589003
SYK	11491	COSM4419975,	soft_tissue	haemangioblastoma	p.P332P	Substitution - coding silent	9:90874733-90874733,	NEUTRAL	0.01274	25589003
SYK	11491	COSM265425, COSM4747627, COSM6910810, COSM6923655, COSM6942175, COSM6960039, COSM6963257, COSM6976388,	NS, biliary_tract, central_nervous_system, large_intestine, pancreas, skin	carcinoma, glioma, malignant_melanoma	p.G33fs*2, p.K261R, p.M166fs*14, p.P388L, p.P85_Y91delPADLCHY, p.R175fs*4, p.T81N	Deletion - Frameshift, Deletion - In frame, Insertion - Frameshift, Substitution - Missense	9:90843991-90843991, 9:90844140-90844141, 9:90844150-90844170, 9:90845506-90845507, 9:90845534-90845535, 9:90864653-90864653, 9:90877621-90877621, 9:90877621-90877622,	Info_not_available	0.64303, .66689, Info_not_available	28481359