| Gene Name | HGNC ID | COSMIC_MutID | Primary site | Primary histology | AA-Mutation | Mutation Type | Genomic Position | FATHMM prediction | FATHMM score | Literature evidence |
| MAP3K5 | 6857 | COSM5609313, | skin | malignant_melanoma | p.S866F | Substitution - Missense | 6:136605291-136605291, | PATHOGENIC | 0.99577 | 26343386 |
| MAP3K5 | 6857 | COSM5609314, | skin | malignant_melanoma | p.P879S | Substitution - Missense | 6:136605253-136605253, | PATHOGENIC | 0.98921 | 26343386 |
| MAP3K5 | 6857 | COSM108960, | skin | malignant_melanoma | p.R256C | Substitution - Missense | 6:136698529-136698529, | PATHOGENIC | 0.98191 | 26343386 |
| MAP3K5 | 6857 | COSM5025013, | breast | carcinoma | p.Y224C | Substitution - Missense | 6:136698624-136698624, | PATHOGENIC | 0.96114 | 25850943 |
| MAP3K5 | 6857 | COSM5609305, | skin | malignant_melanoma | p.G790* | Substitution - Nonsense | 6:136613167-136613167, | PATHOGENIC | 0.94952 | 26343386 |
| MAP3K5 | 6857 | COSM5609310, | skin | malignant_melanoma | p.G1012R | Substitution - Missense | 6:136592459-136592459, | PATHOGENIC | 0.94536 | 26343386 |
| MAP3K5 | 6857 | COSM4399377, | skin | malignant_melanoma | p.E710K | Substitution - Missense | 6:136622870-136622870, | PATHOGENIC | 0.93741 | 25515853 |
| MAP3K5 | 6857 | COSM4399377, | skin | malignant_melanoma | p.E710K | Substitution - Missense | 6:136622870-136622870, | PATHOGENIC | 0.93741 | 25515853 |
| MAP3K5 | 6857 | COSM4992434, | skin | carcinoma | p.A264S | Substitution - Missense | 6:136698505-136698505, | PATHOGENIC | 0.92393 | 25589618 |
| MAP3K5 | 6857 | COSM3015424, | skin | malignant_melanoma | p.E1200K | Substitution - Missense | 6:136567794-136567794, | PATHOGENIC | 0.90351 | 26343386 |
| MAP3K5 | 6857 | COSM5609315, | skin | malignant_melanoma | p.F406F | Substitution - coding silent | 6:136694175-136694175, | PATHOGENIC | 0.87888 | 26343386 |
| MAP3K5 | 6857 | COSM94666, | lung | carcinoma | p.E109K | Substitution - Missense | 6:136791833-136791833, | PATHOGENIC | 0.86073 | 20668451 |
| MAP3K5 | 6857 | COSM5609308, | skin | malignant_melanoma | p.T342T | Substitution - coding silent | 6:136696007-136696007, | PATHOGENIC | 0.8495 | 26343386 |
| MAP3K5 | 6857 | COSM5609311, | skin | malignant_melanoma | p.? | Unknown | 6:136642570-136642570, | PATHOGENIC | 0.79455 | 26343386 |
| MAP3K5 | 6857 | COSM5609303, | skin | malignant_melanoma | p.N702N | Substitution - coding silent | 6:136622892-136622892, | PATHOGENIC | 0.7881 | 26343386 |
| MAP3K5 | 6857 | COSM5609306, | skin | malignant_melanoma | p.R1329Q | Substitution - Missense | 6:136561534-136561534, | PATHOGENIC | 0.76261 | 26343386 |
| MAP3K5 | 6857 | COSM4992433, | skin | carcinoma | p.F633F | Substitution - coding silent | 6:136639578-136639578, | PATHOGENIC | 0.74338 | 25589618 |
| MAP3K5 | 6857 | COSM5609302, | skin | malignant_melanoma | p.L1016L | Substitution - coding silent | 6:136592445-136592445, | PATHOGENIC | 0.74113 | 26343386 |
| MAP3K5 | 6857 | COSM3620993, | skin | carcinoma | p.L794L | Substitution - coding silent | 6:136613153-136613153, | PATHOGENIC | 0.70832 | 25589618 |
| MAP3K5 | 6857 | COSM5609304, | skin | malignant_melanoma | p.Q1289Q | Substitution - coding silent | 6:136562510-136562510, | NEUTRAL | 0.42725 | 26343386 |
| MAP3K5 | 6857 | COSM5609312, | skin | malignant_melanoma | p.V1319V | Substitution - coding silent | 6:136561563-136561563, | NEUTRAL | 0.33659 | 26343386 |
| MAP3K5 | 6857 | COSM450573, | soft_tissue | haemangioblastoma | p.L519L | Substitution - coding silent | 6:136656430-136656430, | NEUTRAL | 0.30576 | 25589003 |
| MAP3K5 | 6857 | COSM450573, | soft_tissue | haemangioblastoma | p.L519L | Substitution - coding silent | 6:136656430-136656430, | NEUTRAL | 0.30576 | 25589003 |
| MAP3K5 | 6857 | COSM450573, | soft_tissue | haemangioblastoma | p.L519L | Substitution - coding silent | 6:136656430-136656430, | NEUTRAL | 0.30576 | 25589003 |
| MAP3K5 | 6857 | COSM450573, | soft_tissue | haemangioblastoma | p.L519L | Substitution - coding silent | 6:136656430-136656430, | NEUTRAL | 0.30576 | 25589003 |
| MAP3K5 | 6857 | COSM450573, | soft_tissue | haemangioblastoma | p.L519L | Substitution - coding silent | 6:136656430-136656430, | NEUTRAL | 0.30576 | 25589003 |
| MAP3K5 | 6857 | COSM5609309, | skin | malignant_melanoma | p.A727A | Substitution - coding silent | 6:136614256-136614256, | NEUTRAL | 0.20505 | 26343386 |
| MAP3K5 | 6857 | COSM5020783, | soft_tissue | haemangioblastoma | p.I1214T | Substitution - Missense | 6:136567751-136567751, | NEUTRAL | 0.17953 | 25589003 |
| MAP3K5 | 6857 | COSM5024883, | breast | carcinoma | p.G20D | Substitution - Missense | 6:136792099-136792099, | NEUTRAL | 0.10823 | 25850943 |
| MAP3K5 | 6857 | COSM5020779, | soft_tissue | haemangioblastoma | p.T989T | Substitution - coding silent | 6:136592526-136592526, | NEUTRAL | 0.08738 | 25589003 |
| MAP3K5 | 6857 | COSM5609307, | skin | malignant_melanoma | p.P240P | Substitution - coding silent | 6:136698575-136698575, | NEUTRAL | 0.07723 | 26343386 |
| MAP3K5 | 6857 | COSM1073737, | skin | malignant_melanoma | p.H590H | Substitution - coding silent | 6:136651002-136651002, | NEUTRAL | 0.05406 | 26343386 |
| MAP3K5 | 6857 | COSM5019555, COSM5019665, COSM5019777, | soft_tissue | haemangioblastoma | p.D988_T989insD, p.N1024fs*21, p.T1314I | Deletion - Frameshift, Insertion - In frame, Substitution - Missense | 6:136561579-136561579, 6:136592327-136592327, 6:136592528-136592529, | Info_not_available | 0.59595, Info_not_available | 25589003 |
| MAP3K5 | 6857 | COSM4992432, | skin | carcinoma | p.K657K | Substitution - coding silent | 6:136637370-136637370, | Info_not_available | 0.57874 | 25589618 |