Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
JAK3	6193	COSM6979073,	NS	carcinoma	p.L389H	Substitution - Missense	19:17840318-17840318,	PATHOGENIC	0.99567	28481359
JAK3	6193	COSM327317,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.V674A	Substitution - Missense	19:17835109-17835109,	PATHOGENIC	0.99559	22675565
JAK3	6193	COSM327317,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.V674A	Substitution - Missense	19:17835109-17835109,	PATHOGENIC	0.99559	25430085
JAK3	6193	COSM327317,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.V674A	Substitution - Missense	19:17835109-17835109,	PATHOGENIC	0.99559	24048415
JAK3	6193	COSM327317,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.V674A	Substitution - Missense	19:17835109-17835109,	PATHOGENIC	0.99559	26917488
JAK3	6193	COSM327317,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.V674A	Substitution - Missense	19:17835109-17835109,	PATHOGENIC	0.99559	25430085
JAK3	6193	COSM327317,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.V674A	Substitution - Missense	19:17835109-17835109,	PATHOGENIC	0.99559	26917488
JAK3	6193	COSM327317,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.V674A	Substitution - Missense	19:17835109-17835109,	PATHOGENIC	0.99559	24446122
JAK3	6193	COSM6930990,	ovary	carcinoma	p.L910S	Substitution - Missense	19:17831750-17831750,	PATHOGENIC	0.99498	28481359
JAK3	6193	COSM6056890,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.L875H	Substitution - Missense	19:17832575-17832575,	PATHOGENIC	0.99422	27683039
JAK3	6193	COSM4606339,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.L875P	Substitution - Missense	19:17832575-17832575,	PATHOGENIC	0.99385	22237106
JAK3	6193	COSM6969172,	pancreas	carcinoma	p.G888D	Substitution - Missense	19:17832536-17832536,	PATHOGENIC	0.99358	28481359
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	25595890
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	25595890
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	22425895
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	23832011
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	24446122
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	23832011
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	25595890
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	26917488
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	22425895
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	23832011
JAK3	6193	COSM35864,	oesophagus	carcinoma	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	28481359
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	22425895
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	22425895
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	23832011
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	24446122
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	22425895
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	23832011
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	23832011
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	27997762
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	18397343
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	23832011
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	23832011
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	27997762
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	22425895
JAK3	6193	COSM35864,	urinary_tract	carcinoma	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	28481359
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	22425895
JAK3	6193	COSM35864,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R657Q	Substitution - Missense	19:17835160-17835160,	PATHOGENIC	0.9933	25595890
JAK3	6193	COSM20527,	stomach	carcinoma	p.L527P	Substitution - Missense	19:17838053-17838053,	PATHOGENIC	0.99329	Info_not_available
JAK3	6193	COSM20527,	stomach	carcinoma	p.L527P	Substitution - Missense	19:17838053-17838053,	PATHOGENIC	0.99329	Info_not_available
JAK3	6193	COSM6964519,	skin	malignant_melanoma	p.T533I	Substitution - Missense	19:17838035-17838035,	PATHOGENIC	0.99321	28481359
JAK3	6193	COSM6191556,	lung	carcinoma	p.W690*	Substitution - Nonsense	19:17834981-17834981,	PATHOGENIC	0.99308	26645239
JAK3	6193	COSM6920013,	breast	carcinoma	p.G908S	Substitution - Missense	19:17831757-17831757,	PATHOGENIC	0.99255	28481359
JAK3	6193	COSM6906601,	lung	carcinoma	p.I883T	Substitution - Missense	19:17832551-17832551,	PATHOGENIC	0.991	29420467
JAK3	6193	COSM6980850,	endometrium	carcinoma	p.T714M	Substitution - Missense	19:17834910-17834910,	PATHOGENIC	0.99008	28481359
JAK3	6193	COSM5702580,	autonomic_ganglia	neuroblastoma	p.P479H	Substitution - Missense	19:17839482-17839482,	PATHOGENIC	0.98991	26822237
JAK3	6193	COSM6976363,	NS	malignant_melanoma	p.E525K	Substitution - Missense	19:17838060-17838060,	PATHOGENIC	0.98983	28481359
JAK3	6193	COSM4169979,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.P477L	Substitution - Missense	19:17839488-17839488,	PATHOGENIC	0.98899	24345752
JAK3	6193	COSM6980121,	lung	carcinoma	p.E51*	Substitution - Nonsense	19:17844267-17844267,	PATHOGENIC	0.98863	28481359
JAK3	6193	COSM6970610,	skin	malignant_melanoma	p.P689S	Substitution - Missense	19:17834986-17834986,	PATHOGENIC	0.98831	28481359
JAK3	6193	COSM35858,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.M576K	Substitution - Missense	19:17837188-17837188,	PATHOGENIC	0.98776	17252020
JAK3	6193	COSM6926870,	skin	carcinoma	p.S483F	Substitution - Missense	19:17838384-17838384,	PATHOGENIC	0.98721	28481359
JAK3	6193	COSM6947235,	kidney	carcinoma	p.G712V	Substitution - Missense	19:17834916-17834916,	PATHOGENIC	0.98718	28481359
JAK3	6193	COSM34215,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.A573V	Substitution - Missense	19:17837197-17837197,	PATHOGENIC	0.98686	17456055
JAK3	6193	COSM34215,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.A573V	Substitution - Missense	19:17837197-17837197,	PATHOGENIC	0.98686	17252020
JAK3	6193	COSM34215,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A573V	Substitution - Missense	19:17837197-17837197,	PATHOGENIC	0.98686	22425895
JAK3	6193	COSM34215,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A573V	Substitution - Missense	19:17837197-17837197,	PATHOGENIC	0.98686	24837469
JAK3	6193	COSM34215,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A573V	Substitution - Missense	19:17837197-17837197,	PATHOGENIC	0.98686	24837469
JAK3	6193	COSM34215,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.A573V	Substitution - Missense	19:17837197-17837197,	PATHOGENIC	0.98686	18755984
JAK3	6193	COSM34215,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A573V	Substitution - Missense	19:17837197-17837197,	PATHOGENIC	0.98686	26773734
JAK3	6193	COSM34215,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A573V	Substitution - Missense	19:17837197-17837197,	PATHOGENIC	0.98686	24837469
JAK3	6193	COSM34215,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A573V	Substitution - Missense	19:17837197-17837197,	PATHOGENIC	0.98686	24048415
JAK3	6193	COSM34215,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A573V	Substitution - Missense	19:17837197-17837197,	PATHOGENIC	0.98686	24048415
JAK3	6193	COSM34215,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A573V	Substitution - Missense	19:17837197-17837197,	PATHOGENIC	0.98686	26917488
JAK3	6193	COSM34215,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A573V	Substitution - Missense	19:17837197-17837197,	PATHOGENIC	0.98686	24048415
JAK3	6193	COSM34215,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A573V	Substitution - Missense	19:17837197-17837197,	PATHOGENIC	0.98686	24837469
JAK3	6193	COSM34215,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A573V	Substitution - Missense	19:17837197-17837197,	PATHOGENIC	0.98686	24837469
JAK3	6193	COSM3099047,	skin	carcinoma	p.S20F	Substitution - Missense	19:17844359-17844359,	PATHOGENIC	0.98679	28481359
JAK3	6193	COSM4075502,	adrenal_gland	adrenal_cortical_carcinoma	p.R402H	Substitution - Missense	19:17840279-17840279,	PATHOGENIC	0.9863	28481359
JAK3	6193	COSM6920886,	breast	carcinoma	p.S15L	Substitution - Missense	19:17844374-17844374,	PATHOGENIC	0.98576	28481359
JAK3	6193	COSM6921394,	prostate	carcinoma	p.Q932H	Substitution - Missense	19:17831683-17831683,	PATHOGENIC	0.98302	28481359
JAK3	6193	COSM5731102,	breast	other	p.L635H	Substitution - Missense	19:17835934-17835934,	PATHOGENIC	0.98201	26832993
JAK3	6193	COSM6907430,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.H27N	Substitution - Missense	19:17844339-17844339,	PATHOGENIC	0.98189	24056718
JAK3	6193	COSM34214,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A572V	Substitution - Missense	19:17837200-17837200,	PATHOGENIC	0.98184	24048415
JAK3	6193	COSM34214,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A572V	Substitution - Missense	19:17837200-17837200,	PATHOGENIC	0.98184	19139084
JAK3	6193	COSM34214,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A572V	Substitution - Missense	19:17837200-17837200,	PATHOGENIC	0.98184	19139084
JAK3	6193	COSM34214,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.A572V	Substitution - Missense	19:17837200-17837200,	PATHOGENIC	0.98184	16843266
JAK3	6193	COSM34214,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.A572V	Substitution - Missense	19:17837200-17837200,	PATHOGENIC	0.98184	18755984
JAK3	6193	COSM34214,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A572V	Substitution - Missense	19:17837200-17837200,	PATHOGENIC	0.98184	19139084
JAK3	6193	COSM34214,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A572V	Substitution - Missense	19:17837200-17837200,	PATHOGENIC	0.98184	19139084
JAK3	6193	COSM6928325,	soft_tissue	other	p.W716R	Substitution - Missense	19:17834905-17834905,	PATHOGENIC	0.98121	28481359
JAK3	6193	COSM3098976,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.K885E	Substitution - Missense	19:17832546-17832546,	PATHOGENIC	0.98055	25595890
JAK3	6193	COSM6437951,	large_intestine	carcinoma	p.E571K	Substitution - Missense	19:17837204-17837204,	PATHOGENIC	0.98008	27756406
JAK3	6193	COSM6953909,	breast	carcinoma	p.F711S	Substitution - Missense	19:17834919-17834919,	PATHOGENIC	0.97992	28481359
JAK3	6193	COSM6437950,	large_intestine	carcinoma	p.R687K	Substitution - Missense	19:17834991-17834991,	PATHOGENIC	0.97967	27756406
JAK3	6193	COSM6941623,	skin	malignant_melanoma	p.Y980N	Substitution - Missense	19:17831268-17831268,	PATHOGENIC	0.97757	28481359
JAK3	6193	COSM6950974,	breast	carcinoma	p.W716*	Substitution - Nonsense	19:17834904-17834904,	PATHOGENIC	0.97721	28481359
JAK3	6193	COSM182104,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.S580L	Substitution - Missense	19:17837176-17837176,	PATHOGENIC	0.97714	27288520
JAK3	6193	COSM6494580,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.P477S	Substitution - Missense	19:17839489-17839489,	PATHOGENIC	0.97513	27534895
JAK3	6193	COSM6494580,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.P477S	Substitution - Missense	19:17839489-17839489,	PATHOGENIC	0.97513	27534895
JAK3	6193	COSM6970613,	skin	malignant_melanoma	p.W623*	Substitution - Nonsense	19:17835970-17835970,	PATHOGENIC	0.972	28481359
JAK3	6193	COSM1666992,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.L857P	Substitution - Missense	19:17832629-17832629,	PATHOGENIC	0.97132	24067491
JAK3	6193	COSM1666992,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.L857P	Substitution - Missense	19:17832629-17832629,	PATHOGENIC	0.97132	23832011
JAK3	6193	COSM1666992,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.L857P	Substitution - Missense	19:17832629-17832629,	PATHOGENIC	0.97132	26437031
JAK3	6193	COSM1666992,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.L857P	Substitution - Missense	19:17832629-17832629,	PATHOGENIC	0.97132	25595890
JAK3	6193	COSM6942702,	prostate	carcinoma	p.E601G	Substitution - Missense	19:17836036-17836036,	PATHOGENIC	0.9699	28481359
JAK3	6193	COSM1737948,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.V674F	Substitution - Missense	19:17835110-17835110,	PATHOGENIC	0.96885	24446122
JAK3	6193	COSM6926445,	lung	carcinoma	p.Q140R	Substitution - Missense	19:17843381-17843381,	PATHOGENIC	0.96825	28481359
JAK3	6193	COSM6933680,	breast	carcinoma	p.S1005F	Substitution - Missense	19:17830585-17830585,	PATHOGENIC	0.96748	28481359
JAK3	6193	COSM5731078,	NS	malignant_melanoma	p.G892D	Substitution - Missense	19:17832524-17832524,	PATHOGENIC	0.96723	25886620
JAK3	6193	COSM6953763,	large_intestine	carcinoma	p.?	Unknown	19:17832789-17832789,	PATHOGENIC	0.96629	28481359
JAK3	6193	COSM6904270,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.G642V	Substitution - Missense	19:17835205-17835205,	PATHOGENIC	0.96514	27248180
JAK3	6193	COSM6920216,	lung	carcinoma	p.S398C	Substitution - Missense	19:17840291-17840291,	PATHOGENIC	0.96486	28481359
JAK3	6193	COSM6689354,	lung	carcinoma	p.V836M	Substitution - Missense	19:17832693-17832693,	PATHOGENIC	0.96419	28481359
JAK3	6193	COSM6927715,	lung	carcinoma	p.A853S	Substitution - Missense	19:17832642-17832642,	PATHOGENIC	0.96402	28481359
JAK3	6193	COSM6938574,	prostate	carcinoma	p.L401V	Substitution - Missense	19:17840283-17840283,	PATHOGENIC	0.9639	28481359
JAK3	6193	COSM6975388,	ovary	carcinoma	p.R775H	Substitution - Missense	19:17834597-17834597,	PATHOGENIC	0.96008	28481359
JAK3	6193	COSM4385051,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.L70V	Substitution - Missense	19:17843877-17843877,	PATHOGENIC	0.95939	24030381
JAK3	6193	COSM6952869,	lung	carcinoma	p.D813Y	Substitution - Missense	19:17832843-17832843,	PATHOGENIC	0.95822	28481359
JAK3	6193	COSM6915399,	lung	carcinoma	p.S340W	Substitution - Missense	19:17841512-17841512,	PATHOGENIC	0.95631	28481359
JAK3	6193	COSM306058,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.95364	26917488
JAK3	6193	COSM306058,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.95364	24048415
JAK3	6193	COSM306058,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.95364	24446122
JAK3	6193	COSM306058,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.95364	26379152
JAK3	6193	COSM306058,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.95364	24446122
JAK3	6193	COSM306058,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.95364	24048415
JAK3	6193	COSM306058,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.95364	24048415
JAK3	6193	COSM6947049,	central_nervous_system	glioma	p.A57S	Substitution - Missense	19:17844249-17844249,	PATHOGENIC	0.95331	28481359
JAK3	6193	COSM6907212,	kidney	carcinoma	p.W81L	Substitution - Missense	19:17843843-17843843,	PATHOGENIC	0.95119	28481359
JAK3	6193	COSM6907212,	ovary	carcinoma	p.W81L	Substitution - Missense	19:17843843-17843843,	PATHOGENIC	0.95119	29420467
JAK3	6193	COSM6955280,	large_intestine	carcinoma	p.S340L	Substitution - Missense	19:17841512-17841512,	PATHOGENIC	0.95071	28481359
JAK3	6193	COSM1717474,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Y824D	Substitution - Missense	19:17832810-17832810,	PATHOGENIC	0.95067	24048415
JAK3	6193	COSM6962003,	pancreas	carcinoid-endocrine_tumour	p.G987D	Substitution - Missense	19:17831246-17831246,	PATHOGENIC	0.95012	28481359
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	27288520
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	24497536
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	26917488
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	24056718
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	24056718
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	26917488
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	24048415
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	26917488
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	24048415
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	25595890
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	24056718
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	22675565
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	24056718
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	24446122
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	24446122
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	26917488
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	22237106
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	24446122
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	26917488
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	24048415
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	26206799
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	24048415
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	24056718
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	20400977
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	24446122
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	24048415
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	26917488
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	25595890
JAK3	6193	COSM51374,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.9492	24056718
JAK3	6193	COSM5879618,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.G659E	Substitution - Missense	19:17835154-17835154,	PATHOGENIC	0.94822	27288520
JAK3	6193	COSM6940472,	urinary_tract	carcinoma	p.L412I	Substitution - Missense	19:17840250-17840250,	PATHOGENIC	0.94602	28481359
JAK3	6193	COSM48456,	lung	carcinoma	p.A127D	Substitution - Missense	19:17843420-17843420,	PATHOGENIC	0.94437	18948947
JAK3	6193	COSM6914784,	breast	carcinoma	p.P479T	Substitution - Missense	19:17839483-17839483,	PATHOGENIC	0.9393	28481359
JAK3	6193	COSM4606341,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.L10V	Substitution - Missense	19:17844390-17844390,	PATHOGENIC	0.93821	22237106
JAK3	6193	COSM6929250,	lung	carcinoma	p.Y536*	Substitution - Nonsense	19:17838025-17838025,	PATHOGENIC	0.93761	28481359
JAK3	6193	COSM6933386,	lung	carcinoma	p.L10M	Substitution - Missense	19:17844390-17844390,	PATHOGENIC	0.93603	28481359
JAK3	6193	COSM95620,	breast	carcinoma	p.S1008*	Substitution - Nonsense	19:17830576-17830576,	PATHOGENIC	0.93593	20668451
JAK3	6193	COSM327318,	skin	carcinoma	p.A572T	Substitution - Missense	19:17837201-17837201,	PATHOGENIC	0.93565	28984303
JAK3	6193	COSM327318,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A572T	Substitution - Missense	19:17837201-17837201,	PATHOGENIC	0.93565	22675565
JAK3	6193	COSM6191538,	large_intestine	carcinoma	p.L242P	Substitution - Missense	19:17842452-17842452,	PATHOGENIC	0.93536	25617745
JAK3	6193	COSM35860,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.I87T	Substitution - Missense	19:17843825-17843825,	PATHOGENIC	0.93263	17252020
JAK3	6193	COSM6986574,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.Q988P	Substitution - Missense	19:17831243-17831243,	PATHOGENIC	0.9309	28481359
JAK3	6193	COSM6437952,	large_intestine	carcinoma	p.V691M	Substitution - Missense	19:17834980-17834980,	PATHOGENIC	0.93016	27756406
JAK3	6193	COSM6927351,	large_intestine	carcinoma	p.P107T	Substitution - Missense	19:17843481-17843481,	PATHOGENIC	0.92991	28481359
JAK3	6193	COSM6978843,	pancreas	other	p.N778S	Substitution - Missense	19:17834588-17834588,	PATHOGENIC	0.92714	28481359
JAK3	6193	COSM1737949,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.V678L	Substitution - Missense	19:17835098-17835098,	PATHOGENIC	0.9267	26917488
JAK3	6193	COSM1737949,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.V678L	Substitution - Missense	19:17835098-17835098,	PATHOGENIC	0.9267	24446122
JAK3	6193	COSM5609211,	skin	malignant_melanoma	p.E751K	Substitution - Missense	19:17834670-17834670,	PATHOGENIC	0.92499	26343386
JAK3	6193	COSM5609195,	skin	carcinoma	p.S44F	Substitution - Missense	19:17844287-17844287,	PATHOGENIC	0.92296	28481359
JAK3	6193	COSM5609195,	skin	malignant_melanoma	p.S44F	Substitution - Missense	19:17844287-17844287,	PATHOGENIC	0.92296	26343386
JAK3	6193	COSM5609195,	skin	carcinoma	p.S44F	Substitution - Missense	19:17844287-17844287,	PATHOGENIC	0.92296	28481359
JAK3	6193	COSM5879620,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R657W	Substitution - Missense	19:17835161-17835161,	PATHOGENIC	0.92272	27288520
JAK3	6193	COSM5879620,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R657W	Substitution - Missense	19:17835161-17835161,	PATHOGENIC	0.92272	28481359
JAK3	6193	COSM6960081,	large_intestine	carcinoma	p.C227Y	Substitution - Missense	19:17842497-17842497,	PATHOGENIC	0.92171	28481359
JAK3	6193	COSM4978684,	pancreas	carcinoma	p.R870Q	Substitution - Missense	19:17832590-17832590,	PATHOGENIC	0.92162	28481359
JAK3	6193	COSM4075510,	endometrium	carcinoma	p.E7D	Substitution - Missense	19:17844397-17844397,	PATHOGENIC	0.91887	28481359
JAK3	6193	COSM6975849,	skin	carcinoma	p.S355C	Substitution - Missense	19:17841467-17841467,	PATHOGENIC	0.91851	28481359
JAK3	6193	COSM6983006,	salivary_gland	carcinoma	p.Q869*	Substitution - Nonsense	19:17832594-17832594,	PATHOGENIC	0.9159	28481359
JAK3	6193	COSM240272,	soft_tissue	angiosarcoma	p.G62S	Substitution - Missense	19:17844234-17844234,	PATHOGENIC	0.91393	28481359
JAK3	6193	COSM3098993,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.P725S	Substitution - Missense	19:17834878-17834878,	PATHOGENIC	0.90933	24030381
JAK3	6193	COSM6973294,	urinary_tract	carcinoma	p.G594*	Substitution - Nonsense	19:17837135-17837135,	PATHOGENIC	0.90808	28481359
JAK3	6193	COSM6984987,	large_intestine	carcinoma	p.F602S	Substitution - Missense	19:17836033-17836033,	PATHOGENIC	0.90797	28481359
JAK3	6193	COSM6914429,	skin	carcinoma	p.E51D	Substitution - Missense	19:17844265-17844265,	PATHOGENIC	0.90563	28481359
JAK3	6193	COSM110717,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.L156P	Substitution - Missense	19:17843126-17843126,	PATHOGENIC	0.90549	21821710
JAK3	6193	COSM6948305,	central_nervous_system	glioma	p.S355F	Substitution - Missense	19:17841467-17841467,	PATHOGENIC	0.905	28481359
JAK3	6193	COSM34216,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.P132T	Substitution - Missense	19:17843406-17843406,	PATHOGENIC	0.89559	16843266
JAK3	6193	COSM6910954,	skin	adnexal_tumour	p.E76K	Substitution - Missense	19:17843859-17843859,	PATHOGENIC	0.89311	28481359
JAK3	6193	COSM120496,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.P132A	Substitution - Missense	19:17843406-17843406,	PATHOGENIC	0.89263	21599579
JAK3	6193	COSM120496,	skin	adnexal_tumour	p.P132A	Substitution - Missense	19:17843406-17843406,	PATHOGENIC	0.89263	27311873
JAK3	6193	COSM6915860,	skin	carcinoma	p.E542K	Substitution - Missense	19:17838009-17838009,	PATHOGENIC	0.88991	28481359
JAK3	6193	COSM5574250,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Y1023H	Substitution - Missense	19:17830532-17830532,	PATHOGENIC	0.88889	26415585
JAK3	6193	COSM6928385,	urinary_tract	carcinoma	p.R918C	Substitution - Missense	19:17831727-17831727,	PATHOGENIC	0.88859	28481359
JAK3	6193	COSM6907376,	soft_tissue	leiomyoma	p.R537W	Substitution - Missense	19:17838024-17838024,	PATHOGENIC	0.88857	29484624
JAK3	6193	COSM6909595,	urinary_tract	carcinoma	p.I781M	Substitution - Missense	19:17834578-17834578,	PATHOGENIC	0.87504	28481359
JAK3	6193	COSM6191537,	large_intestine	carcinoma	p.S931L	Substitution - Missense	19:17831687-17831687,	PATHOGENIC	0.87426	25617745
JAK3	6193	COSM4775002,	central_nervous_system	glioma	p.P664L	Substitution - Missense	19:17835139-17835139,	PATHOGENIC	0.87129	28481359
JAK3	6193	COSM4775002,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.P664L	Substitution - Missense	19:17835139-17835139,	PATHOGENIC	0.87129	25595890
JAK3	6193	COSM4775002,	urinary_tract	carcinoma	p.P664L	Substitution - Missense	19:17835139-17835139,	PATHOGENIC	0.87129	28481359
JAK3	6193	COSM6977390,	large_intestine	carcinoma	p.L485M	Substitution - Missense	19:17838379-17838379,	PATHOGENIC	0.87053	28481359
JAK3	6193	COSM94559,	lung	carcinoma	p.D324V	Substitution - Missense	19:17841653-17841653,	PATHOGENIC	0.87005	20668451
JAK3	6193	COSM1717469,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.86744	24048415
JAK3	6193	COSM1717469,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.86744	24446122
JAK3	6193	COSM1717469,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.86744	24446122
JAK3	6193	COSM1717469,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.86744	26917488
JAK3	6193	COSM1717469,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.86744	24048415
JAK3	6193	COSM1717469,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.86744	26917488
JAK3	6193	COSM1717469,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.M511I	Substitution - Missense	19:17838299-17838299,	PATHOGENIC	0.86744	27288520
JAK3	6193	COSM120498,	kidney	carcinoma	p.Y238C	Substitution - Missense	19:17842464-17842464,	PATHOGENIC	0.86609	21868263
JAK3	6193	COSM1717475,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Y824H	Substitution - Missense	19:17832810-17832810,	PATHOGENIC	0.85723	24048415
JAK3	6193	COSM3098964,	large_intestine	carcinoma	p.V963I	Substitution - Missense	19:17831319-17831319,	PATHOGENIC	0.84941	28481359
JAK3	6193	COSM5706900,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R316S	Substitution - Missense	19:17841678-17841678,	PATHOGENIC	0.83984	26437031
JAK3	6193	COSM6938900,	eye	malignant_melanoma	p.F992S	Substitution - Missense	19:17831231-17831231,	PATHOGENIC	0.83888	28481359
JAK3	6193	COSM4991268,	skin	carcinoma	p.G46G	Substitution - coding silent	19:17844280-17844280,	PATHOGENIC	0.83381	25589618
JAK3	6193	COSM1666993,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.E958K	Substitution - Missense	19:17831334-17831334,	PATHOGENIC	0.83164	23832011
JAK3	6193	COSM1666993,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.E958K	Substitution - Missense	19:17831334-17831334,	PATHOGENIC	0.83164	24056718
JAK3	6193	COSM1666993,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E958K	Substitution - Missense	19:17831334-17831334,	PATHOGENIC	0.83164	26773734
JAK3	6193	COSM1666993,	skin	carcinoma	p.E958K	Substitution - Missense	19:17831334-17831334,	PATHOGENIC	0.83164	28481359
JAK3	6193	COSM6968705,	central_nervous_system	glioma	p.S880G	Substitution - Missense	19:17832561-17832561,	PATHOGENIC	0.82621	28481359
JAK3	6193	COSM6925724,	lung	carcinoma	p.F82L	Substitution - Missense	19:17843839-17843839,	PATHOGENIC	0.81109	28481359
JAK3	6193	COSM4991259,	skin	carcinoma	p.Q1094*	Substitution - Nonsense	19:17826838-17826838,	PATHOGENIC	0.80902	25589618
JAK3	6193	COSM4693750,	kidney	carcinoma	p.R916W	Substitution - Missense	19:17831733-17831733,	PATHOGENIC	0.8076	28481359
JAK3	6193	COSM4385047,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.A656T	Substitution - Missense	19:17835164-17835164,	PATHOGENIC	0.80273	24030381
JAK3	6193	COSM327294,	endometrium	carcinoma	p.R403H	Substitution - Missense	19:17840276-17840276,	PATHOGENIC	0.79957	28481359
JAK3	6193	COSM327294,	soft_tissue	perivascular_epithelioid_cell_tumour_(PEComa)	p.R403H	Substitution - Missense	19:17840276-17840276,	PATHOGENIC	0.79957	28481359
JAK3	6193	COSM327294,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R403H	Substitution - Missense	19:17840276-17840276,	PATHOGENIC	0.79957	22675565
JAK3	6193	COSM6936062,	lung	carcinoma	p.H463N	Substitution - Missense	19:17839531-17839531,	PATHOGENIC	0.79895	28481359
JAK3	6193	COSM6912143,	skin	malignant_melanoma	p.P1093S	Substitution - Missense	19:17826841-17826841,	PATHOGENIC	0.79817	28481359
JAK3	6193	COSM5946070,	NS	malignant_melanoma	p.V718L	Substitution - Missense	19:17834899-17834899,	PATHOGENIC	0.79598	25148578
JAK3	6193	COSM6962658,	pancreas	carcinoma	p.R1059S	Substitution - Missense	19:17830138-17830138,	PATHOGENIC	0.7949	28481359
JAK3	6193	COSM6970341,	large_intestine	carcinoma	p.S789A	Substitution - Missense	19:17832915-17832915,	PATHOGENIC	0.79023	28481359
JAK3	6193	COSM6908812,	lung	carcinoma	p.C193*	Substitution - Nonsense	19:17842598-17842598,	PATHOGENIC	0.78708	28481359
JAK3	6193	COSM110716,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E183G	Substitution - Missense	19:17843045-17843045,	PATHOGENIC	0.78455	21821710
JAK3	6193	COSM4943284,	breast	carcinoma	p.T381I	Substitution - Missense	19:17841389-17841389,	PATHOGENIC	0.78292	24185512
JAK3	6193	COSM94557,	breast	carcinoma	p.V1016I	Substitution - Missense	19:17830553-17830553,	PATHOGENIC	0.76636	20668451
JAK3	6193	COSM6969652,	NS	carcinoma	p.D863N	Substitution - Missense	19:17832612-17832612,	PATHOGENIC	0.7653	28481359
JAK3	6193	COSM5878675,	liver	carcinoma	p.E1069*	Substitution - Nonsense	19:17830110-17830110,	PATHOGENIC	0.76452	26096009
JAK3	6193	COSM6926078,	lung	carcinoma	p.S1000*	Substitution - Nonsense	19:17830600-17830600,	PATHOGENIC	0.76088	28481359
JAK3	6193	COSM6926078,	lung	carcinoma	p.S1000*	Substitution - Nonsense	19:17830600-17830600,	PATHOGENIC	0.76088	28481359
JAK3	6193	COSM4775027,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E960A	Substitution - Missense	19:17831327-17831327,	PATHOGENIC	0.7592	25595890
JAK3	6193	COSM6966468,	lung	carcinoma	p.C162*	Substitution - Nonsense	19:17843107-17843107,	PATHOGENIC	0.75582	28481359
JAK3	6193	COSM5735184,	soft_tissue	angiosarcoma	p.R103C	Substitution - Missense	19:17843778-17843778,	PATHOGENIC	0.75466	28481359
JAK3	6193	COSM6932559,	skin	malignant_melanoma	p.W803*	Substitution - Nonsense	19:17832871-17832871,	PATHOGENIC	0.74752	28481359
JAK3	6193	COSM6854643,	large_intestine	other	p.M592T	Substitution - Missense	19:17837140-17837140,	PATHOGENIC	0.74741	28524162
JAK3	6193	COSM6932428,	urinary_tract	carcinoma	p.E960K	Substitution - Missense	19:17831328-17831328,	PATHOGENIC	0.74319	28481359
JAK3	6193	COSM6932428,	urinary_tract	carcinoma	p.E960K	Substitution - Missense	19:17831328-17831328,	PATHOGENIC	0.74319	28481359
JAK3	6193	COSM4606340,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N108D	Substitution - Missense	19:17843478-17843478,	PATHOGENIC	0.73728	22237106
JAK3	6193	COSM4991261,	skin	carcinoma	p.P1093P	Substitution - coding silent	19:17826839-17826839,	PATHOGENIC	0.73103	25589618
JAK3	6193	COSM6923476,	lung	carcinoma	p.R984C	Substitution - Missense	19:17831256-17831256,	PATHOGENIC	0.71987	28481359
JAK3	6193	COSM4991263,	skin	carcinoma	p.F770F	Substitution - coding silent	19:17834611-17834611,	PATHOGENIC	0.71408	25589618
JAK3	6193	COSM6938032,	urinary_tract	carcinoma	p.P793H	Substitution - Missense	19:17832902-17832902,	PATHOGENIC	0.71301	28481359
JAK3	6193	COSM123817,	breast	carcinoma	p.R948C	Substitution - Missense	19:17831364-17831364,	PATHOGENIC	0.70906	27284958
JAK3	6193	COSM6956164,	breast	carcinoma	p.F358L	Substitution - Missense	19:17841457-17841457,	PATHOGENIC	0.70477	28481359
JAK3	6193	COSM5435956,	large_intestine	carcinoma	p.T21M	Substitution - Missense	19:17844356-17844356,	NEUTRAL	0.47232	28481359
JAK3	6193	COSM6972836,	adrenal_gland	adrenal_cortical_carcinoma	p.A171S	Substitution - Missense	19:17843082-17843082,	NEUTRAL	0.46889	28481359
JAK3	6193	COSM6927393,	pancreas	carcinoma	p.A660P	Substitution - Missense	19:17835152-17835152,	NEUTRAL	0.46256	28481359
JAK3	6193	COSM6913095,	central_nervous_system	glioma	p.R451Q	Substitution - Missense	19:17839566-17839566,	NEUTRAL	0.45923	28481359
JAK3	6193	COSM6976244,	lung	carcinoma	p.R33L	Substitution - Missense	19:17844320-17844320,	NEUTRAL	0.41719	28481359
JAK3	6193	COSM6963826,	lung	carcinoma	p.P791R	Substitution - Missense	19:17832908-17832908,	NEUTRAL	0.40798	28481359
JAK3	6193	COSM327290,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.L1035L	Substitution - coding silent	19:17830210-17830210,	NEUTRAL	0.39324	22675565
JAK3	6193	COSM5609205,	skin	malignant_melanoma	p.F1034F	Substitution - coding silent	19:17830213-17830213,	NEUTRAL	0.36805	26343386
JAK3	6193	COSM6910879,	central_nervous_system	glioma	p.P31L	Substitution - Missense	19:17844326-17844326,	NEUTRAL	0.36392	28481359
JAK3	6193	COSM6910393,	prostate	carcinoma	p.I430M	Substitution - Missense	19:17839628-17839628,	NEUTRAL	0.36042	28481359
JAK3	6193	COSM6910393,	prostate	carcinoma	p.I430M	Substitution - Missense	19:17839628-17839628,	NEUTRAL	0.36042	28481359
JAK3	6193	COSM5609193,	skin	malignant_melanoma	p.A312V	Substitution - Missense	19:17841689-17841689,	NEUTRAL	0.35149	26343386
JAK3	6193	COSM6978311,	endometrium	carcinoma	p.R478I	Substitution - Missense	19:17839485-17839485,	NEUTRAL	0.34545	28481359
JAK3	6193	COSM5991493,	skin	adnexal_tumour	p.M724I	Substitution - Missense	19:17834879-17834879,	NEUTRAL	0.33144	27311873
JAK3	6193	COSM5991494,	skin	adnexal_tumour	p.S727N	Substitution - Missense	19:17834871-17834871,	NEUTRAL	0.2906	27311873
JAK3	6193	COSM6978672,	breast	carcinoma	p.T496I	Substitution - Missense	19:17838345-17838345,	NEUTRAL	0.2891	28481359
JAK3	6193	COSM6948613,	large_intestine	carcinoma	p.Q807*	Substitution - Nonsense	19:17832861-17832861,	NEUTRAL	0.27876	28481359
JAK3	6193	COSM6940940,	lung	carcinoma	p.V773F	Substitution - Missense	19:17834604-17834604,	NEUTRAL	0.27805	28481359
JAK3	6193	COSM6962418,	breast	carcinoma	p.R222C	Substitution - Missense	19:17842513-17842513,	NEUTRAL	0.26019	28481359
JAK3	6193	COSM6909879,	urinary_tract	carcinoma	p.S959R	Substitution - Missense	19:17831329-17831329,	NEUTRAL	0.23886	28481359
JAK3	6193	COSM6920403,	oesophagus	carcinoma	p.V97L	Substitution - Missense	19:17843796-17843796,	NEUTRAL	0.23089	28481359
JAK3	6193	COSM34213,	thyroid	carcinoma	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	28351340
JAK3	6193	COSM34213,	central_nervous_system	glioma	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	24695838
JAK3	6193	COSM34213,	stomach	carcinoma	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	25656989
JAK3	6193	COSM34213,	skin	adnexal_tumour	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	27311873
JAK3	6193	COSM34213,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	27534895
JAK3	6193	COSM34213,	stomach	carcinoma	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	25656989
JAK3	6193	COSM34213,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	27534895
JAK3	6193	COSM34213,	central_nervous_system	glioma	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	24695838
JAK3	6193	COSM34213,	skin	adnexal_tumour	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	27311873
JAK3	6193	COSM34213,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	16843266
JAK3	6193	COSM34213,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	27534895
JAK3	6193	COSM34213,	large_intestine	carcinoma	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	28548125
JAK3	6193	COSM34213,	bone	calcifying_epithelial_odontogenic_tumour	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	29127140
JAK3	6193	COSM34213,	skin	adnexal_tumour	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	27311873
JAK3	6193	COSM34213,	skin	carcinoma	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	25589618
JAK3	6193	COSM34213,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	18755984
JAK3	6193	COSM34213,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	27534895
JAK3	6193	COSM34213,	thyroid	carcinoma	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	28351340
JAK3	6193	COSM34213,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	24048415
JAK3	6193	COSM34213,	stomach	carcinoma	p.V722I	Substitution - Missense	19:17834887-17834887,	NEUTRAL	0.23033	25656989
JAK3	6193	COSM6494576,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.L643L	Substitution - coding silent	19:17835201-17835201,	NEUTRAL	0.22889	27534895
JAK3	6193	COSM6494576,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.L643L	Substitution - coding silent	19:17835201-17835201,	NEUTRAL	0.22889	27534895
JAK3	6193	COSM6494576,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.L643L	Substitution - coding silent	19:17835201-17835201,	NEUTRAL	0.22889	27534895
JAK3	6193	COSM3724501,	ovary	carcinoma	p.S147N	Substitution - Missense	19:17843153-17843153,	NEUTRAL	0.22668	24658004
JAK3	6193	COSM6911147,	urinary_tract	carcinoma	p.R799C	Substitution - Missense	19:17832885-17832885,	NEUTRAL	0.20465	28481359
JAK3	6193	COSM6911147,	skin	malignant_melanoma	p.R799C	Substitution - Missense	19:17832885-17832885,	NEUTRAL	0.20465	28481359
JAK3	6193	COSM6956651,	large_intestine	carcinoma	p.R33W	Substitution - Missense	19:17844321-17844321,	NEUTRAL	0.20436	28481359
JAK3	6193	COSM6956651,	breast	carcinoma	p.R33W	Substitution - Missense	19:17844321-17844321,	NEUTRAL	0.20436	28481359
JAK3	6193	COSM7325490,	biliary_tract	carcinoma	p.A732S	Substitution - Missense	19:17834857-17834857,	NEUTRAL	0.1988	29360550
JAK3	6193	COSM1645481,	large_intestine	carcinoma	p.R540L	Substitution - Missense	19:17838014-17838014,	NEUTRAL	0.19326	23700467
JAK3	6193	COSM6931290,	lung	carcinoma	p.D922H	Substitution - Missense	19:17831715-17831715,	NEUTRAL	0.18403	28481359
JAK3	6193	COSM34172,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.Q501H	Substitution - Missense	19:17838329-17838329,	NEUTRAL	0.18159	18397343
JAK3	6193	COSM34172,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.Q501H	Substitution - Missense	19:17838329-17838329,	NEUTRAL	0.18159	Info_not_available
JAK3	6193	COSM6969440,	lung	carcinoma	p.R223C	Substitution - Missense	19:17842510-17842510,	NEUTRAL	0.17033	28481359
JAK3	6193	COSM35876,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.P434R	Substitution - Missense	19:17839617-17839617,	NEUTRAL	0.17004	17456055
JAK3	6193	COSM5878674,	liver	carcinoma	p.R1042W	Substitution - Missense	19:17830191-17830191,	NEUTRAL	0.16828	26096009
JAK3	6193	COSM95973,	breast	carcinoma	p.A772A	Substitution - coding silent	19:17834605-17834605,	NEUTRAL	0.16806	20668451
JAK3	6193	COSM5609197,	skin	malignant_melanoma	p.P420P	Substitution - coding silent	19:17839658-17839658,	NEUTRAL	0.16518	26343386
JAK3	6193	COSM5020932,	soft_tissue	haemangioblastoma	p.V544V	Substitution - coding silent	19:17838001-17838001,	NEUTRAL	0.15665	25589003
JAK3	6193	COSM6924010,	central_nervous_system	glioma	p.I386M	Substitution - Missense	19:17840326-17840326,	NEUTRAL	0.15508	28481359
JAK3	6193	COSM1717471,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q501H	Substitution - Missense	19:17838329-17838329,	NEUTRAL	0.14207	24048415
JAK3	6193	COSM34196,	breast	carcinoma	p.?	Unknown	19:17843352-17843352,	NEUTRAL	0.14108	18559588
JAK3	6193	COSM6925230,	lung	carcinoma	p.I87V	Substitution - Missense	19:17843826-17843826,	NEUTRAL	0.13171	28481359
JAK3	6193	COSM34195,	breast	carcinoma	p.V715I	Substitution - Missense	19:17834908-17834908,	NEUTRAL	0.13002	18559588
JAK3	6193	COSM4385053,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.A25V	Substitution - Missense	19:17844344-17844344,	NEUTRAL	0.1249	24030381
JAK3	6193	COSM6022928,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.G491S	Substitution - Missense	19:17838361-17838361,	NEUTRAL	0.122	26917488
JAK3	6193	COSM6922534,	large_intestine	carcinoma	p.V722A	Substitution - Missense	19:17834886-17834886,	NEUTRAL	0.12045	28481359
JAK3	6193	COSM327291,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.H562H	Substitution - coding silent	19:17837947-17837947,	NEUTRAL	0.11779	22675565
JAK3	6193	COSM6970843,	lung	carcinoma	p.V97A	Substitution - Missense	19:17843795-17843795,	NEUTRAL	0.11051	28481359
JAK3	6193	COSM5019096,	soft_tissue	haemangioblastoma	p.L875L	Substitution - coding silent	19:17832574-17832574,	NEUTRAL	0.10448	25589003
JAK3	6193	COSM5019096,	soft_tissue	haemangioblastoma	p.L875L	Substitution - coding silent	19:17832574-17832574,	NEUTRAL	0.10448	25589003
JAK3	6193	COSM5019096,	soft_tissue	haemangioblastoma	p.L875L	Substitution - coding silent	19:17832574-17832574,	NEUTRAL	0.10448	25589003
JAK3	6193	COSM5019096,	soft_tissue	haemangioblastoma	p.L875L	Substitution - coding silent	19:17832574-17832574,	NEUTRAL	0.10448	25589003
JAK3	6193	COSM6976360,	NS	malignant_melanoma	p.R613Q	Substitution - Missense	19:17836000-17836000,	NEUTRAL	0.10384	28481359
JAK3	6193	COSM6953068,	lung	carcinoma	p.V217M	Substitution - Missense	19:17842528-17842528,	NEUTRAL	0.10128	28481359
JAK3	6193	COSM5609203,	skin	malignant_melanoma	p.L344L	Substitution - coding silent	19:17841499-17841499,	NEUTRAL	0.09898	26343386
JAK3	6193	COSM6968124,	skin	malignant_melanoma	p.G182R	Substitution - Missense	19:17843049-17843049,	NEUTRAL	0.09476	28481359
JAK3	6193	COSM6975729,	pancreas	carcinoid-endocrine_tumour	p.E739K	Substitution - Missense	19:17834706-17834706,	NEUTRAL	0.09156	28481359
JAK3	6193	COSM6929937,	breast	carcinoma	p.G24A	Substitution - Missense	19:17844347-17844347,	NEUTRAL	0.08667	28481359
JAK3	6193	COSM6854646,	large_intestine	other	p.R215G	Substitution - Missense	19:17842534-17842534,	NEUTRAL	0.08661	28524162
JAK3	6193	COSM48455,	lung	carcinoma	p.S493C	Substitution - Missense	19:17838355-17838355,	NEUTRAL	0.08574	18948947
JAK3	6193	COSM6937404,	soft_tissue	liposarcoma	p.E371D	Substitution - Missense	19:17841418-17841418,	NEUTRAL	0.08361	28481359
JAK3	6193	COSM327292,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A853A	Substitution - coding silent	19:17832640-17832640,	NEUTRAL	0.08289	22675565
JAK3	6193	COSM34197,	stomach	carcinoma	p.?	Unknown	19:17843375-17843375,	NEUTRAL	0.08074	18559588
JAK3	6193	COSM6971748,	large_intestine	carcinoma	p.R741W	Substitution - Missense	19:17834700-17834700,	NEUTRAL	0.07919	28481359
JAK3	6193	COSM3773848,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.A753A	Substitution - coding silent	19:17834662-17834662,	NEUTRAL	0.07445	27534895
JAK3	6193	COSM3773848,	soft_tissue	haemangioblastoma	p.A753A	Substitution - coding silent	19:17834662-17834662,	NEUTRAL	0.07445	25589003
JAK3	6193	COSM6962006,	pancreas	carcinoid-endocrine_tumour	p.V372M	Substitution - Missense	19:17841417-17841417,	NEUTRAL	0.07358	28481359
JAK3	6193	COSM6494589,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R211R	Substitution - coding silent	19:17842546-17842546,	NEUTRAL	0.0735	27534895
JAK3	6193	COSM6494589,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R211R	Substitution - coding silent	19:17842546-17842546,	NEUTRAL	0.0735	27534895
JAK3	6193	COSM6929092,	central_nervous_system	glioma	p.A1068V	Substitution - Missense	19:17830112-17830112,	NEUTRAL	0.07236	28481359
JAK3	6193	COSM6962576,	lung	carcinoma	p.A178S	Substitution - Missense	19:17843061-17843061,	NEUTRAL	0.07124	28481359
JAK3	6193	COSM110718,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R172Q	Substitution - Missense	19:17843078-17843078,	NEUTRAL	0.06935	21821710
JAK3	6193	COSM110718,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R172Q	Substitution - Missense	19:17843078-17843078,	NEUTRAL	0.06935	21821710
JAK3	6193	COSM5609207,	skin	malignant_melanoma	p.G284E	Substitution - Missense	19:17842326-17842326,	NEUTRAL	0.06463	26343386
JAK3	6193	COSM6494586,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.H377H	Substitution - coding silent	19:17841400-17841400,	NEUTRAL	0.06268	27534895
JAK3	6193	COSM6934283,	breast	carcinoma	p.D661N	Substitution - Missense	19:17835149-17835149,	NEUTRAL	0.06267	28481359
JAK3	6193	COSM3099035,	large_intestine	carcinoma	p.R121H	Substitution - Missense	19:17843438-17843438,	NEUTRAL	0.06242	28481359
JAK3	6193	COSM3099035,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R121H	Substitution - Missense	19:17843438-17843438,	NEUTRAL	0.06242	27534895
JAK3	6193	COSM6940686,	kidney	carcinoma	p.H232N	Substitution - Missense	19:17842483-17842483,	NEUTRAL	0.06196	28481359
JAK3	6193	COSM48454,	lung	carcinoma	p.A1090S	Substitution - Missense	19:17826850-17826850,	NEUTRAL	0.05913	18948947
JAK3	6193	COSM6986011,	ovary	carcinoma	p.A1090D	Substitution - Missense	19:17826849-17826849,	NEUTRAL	0.05885	28481359
JAK3	6193	COSM6913731,	central_nervous_system	glioma	p.G491D	Substitution - Missense	19:17838360-17838360,	NEUTRAL	0.05384	28481359
JAK3	6193	COSM5389071,	skin	malignant_melanoma	p.I476I	Substitution - coding silent	19:17839490-17839490,	NEUTRAL	0.05319	26343386
JAK3	6193	COSM6965644,	central_nervous_system	glioma	p.R1103W	Substitution - Missense	19:17826811-17826811,	NEUTRAL	0.05257	28481359
JAK3	6193	COSM3822312,	large_intestine	carcinoma	p.R445Q	Substitution - Missense	19:17839584-17839584,	NEUTRAL	0.05077	28481359
JAK3	6193	COSM3822312,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R445Q	Substitution - Missense	19:17839584-17839584,	NEUTRAL	0.05077	26437031
JAK3	6193	COSM4774953,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S197N	Substitution - Missense	19:17842587-17842587,	NEUTRAL	0.04955	25595890
JAK3	6193	COSM4075508,	lung	carcinoma	p.R40C	Substitution - Missense	19:17844300-17844300,	NEUTRAL	0.04918	28481359
JAK3	6193	COSM4075508,	large_intestine	carcinoma	p.R40C	Substitution - Missense	19:17844300-17844300,	NEUTRAL	0.04918	28481359
JAK3	6193	COSM4075508,	endometrium	carcinoma	p.R40C	Substitution - Missense	19:17844300-17844300,	NEUTRAL	0.04918	27159395
JAK3	6193	COSM6972538,	urinary_tract	carcinoma	p.P151T	Substitution - Missense	19:17843142-17843142,	NEUTRAL	0.04846	28481359
JAK3	6193	COSM6995476,	ovary	germ_cell_tumour	p.T437N	Substitution - Missense	19:17839608-17839608,	NEUTRAL	0.04722	28954785
JAK3	6193	COSM1717472,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q503H	Substitution - Missense	19:17838323-17838323,	NEUTRAL	0.04691	24048415
JAK3	6193	COSM35867,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.P151R	Substitution - Missense	19:17843141-17843141,	NEUTRAL	0.04468	17456055
JAK3	6193	COSM35867,	soft_tissue	haemangioblastoma	p.P151R	Substitution - Missense	19:17843141-17843141,	NEUTRAL	0.04468	25589003
JAK3	6193	COSM6494583,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	19:17840351-17840351,	NEUTRAL	0.04355	27534895
JAK3	6193	COSM4991266,	skin	carcinoma	p.S504S	Substitution - coding silent	19:17838320-17838320,	NEUTRAL	0.03896	25589618
JAK3	6193	COSM327295,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R272H	Substitution - Missense	19:17842362-17842362,	NEUTRAL	0.03892	22675565
JAK3	6193	COSM6939414,	lung	carcinoma	p.I486M	Substitution - Missense	19:17838374-17838374,	NEUTRAL	0.03668	28481359
JAK3	6193	COSM6925262,	lung	carcinoma	p.Q1058R	Substitution - Missense	19:17830142-17830142,	NEUTRAL	0.03664	28481359
JAK3	6193	COSM6913118,	soft_tissue	malignant_fibrous_histiocytoma-pleomorphic_sarcoma	p.L262R	Substitution - Missense	19:17842392-17842392,	NEUTRAL	0.0345	28481359
JAK3	6193	COSM1641093,	breast	carcinoma	p.R40H	Substitution - Missense	19:17844299-17844299,	NEUTRAL	0.03336	28481359
JAK3	6193	COSM6937063,	autonomic_ganglia	neuroblastoma	p.Q56H	Substitution - Missense	19:17844250-17844250,	NEUTRAL	0.03258	28481359
JAK3	6193	COSM6915461,	breast	carcinoma	p.G460E	Substitution - Missense	19:17839539-17839539,	NEUTRAL	0.03226	28481359
JAK3	6193	COSM5609213,	skin	malignant_melanoma	p.N419N	Substitution - coding silent	19:17839661-17839661,	NEUTRAL	0.02896	26343386
JAK3	6193	COSM5609199,	skin	malignant_melanoma	p.P12S	Substitution - Missense	19:17844384-17844384,	NEUTRAL	0.02768	26343386
JAK3	6193	COSM5609199,	skin	malignant_melanoma	p.P12S	Substitution - Missense	19:17844384-17844384,	NEUTRAL	0.02768	28481359
JAK3	6193	COSM6944820,	urinary_tract	carcinoma	p.E1106K	Substitution - Missense	19:17826802-17826802,	NEUTRAL	0.02343	28481359
JAK3	6193	COSM75059,	biliary_tract	carcinoma	p.G1101R	Substitution - Missense	19:17826817-17826817,	NEUTRAL	0.02324	28481359
JAK3	6193	COSM1391559,	large_intestine	carcinoma	p.R697Q	Substitution - Missense	19:17834961-17834961,	NEUTRAL	0.01486	27756406
JAK3	6193	COSM6929534,	urinary_tract	carcinoma	p.R219K	Substitution - Missense	19:17842521-17842521,	NEUTRAL	0.0141	28481359
JAK3	6193	COSM6960495,	large_intestine	carcinoma	p.R432H	Substitution - Missense	19:17839623-17839623,	NEUTRAL	0.01309	28481359
JAK3	6193	COSM6494593,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.P84P	Substitution - coding silent	19:17843833-17843833,	NEUTRAL	0.01225	27534895
JAK3	6193	COSM992912,	urinary_tract	carcinoma	p.A1090T	Substitution - Missense	19:17826850-17826850,	NEUTRAL	0.01194	28481359
JAK3	6193	COSM6019336,	lung	carcinoma	p.?	Unknown	19:17831802-17831802,	NEUTRAL	0.01045	27694386
JAK3	6193	COSM6019336,	lung	carcinoma	p.?	Unknown	19:17831802-17831802,	NEUTRAL	0.01045	27694386
JAK3	6193	COSM327293,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A251T	Substitution - Missense	19:17842426-17842426,	NEUTRAL	0.00907	22675565
JAK3	6193	COSM711173,	lung	carcinoma	p.L499F	Substitution - Missense	19:17838335-17838335,	NEUTRAL	0.00901	28481359
JAK3	6193	COSM312104,	lung	carcinoma	p.T8T	Substitution - coding silent	19:17844394-17844394,	NEUTRAL	0.00426	22941188
JAK3	6193	COSM3822306,	lung	carcinoma	p.S1124L	Substitution - Missense	19:17826747-17826747,	NEUTRAL	0.00282	28481359
JAK3	6193	COSM5020530,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	19:17837923-17837923,	NEUTRAL	0.00111	27534895
JAK3	6193	COSM5020530,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	19:17837923-17837923,	NEUTRAL	0.00111	27534895
JAK3	6193	COSM5020530,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	19:17837923-17837923,	NEUTRAL	0.00111	27534895
JAK3	6193	COSM5020530,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	19:17837923-17837923,	NEUTRAL	0.00111	27534895
JAK3	6193	COSM5020530,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	19:17837923-17837923,	NEUTRAL	0.00111	27534895
JAK3	6193	COSM5020530,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	19:17837923-17837923,	NEUTRAL	0.00111	27534895
JAK3	6193	COSM5020530,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	19:17837923-17837923,	NEUTRAL	0.00111	27534895
JAK3	6193	COSM5020530,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	19:17837923-17837923,	NEUTRAL	0.00111	27534895
JAK3	6193	COSM5020530,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	19:17837923-17837923,	NEUTRAL	0.00111	27534895
JAK3	6193	COSM5020530,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	19:17837923-17837923,	NEUTRAL	0.00111	27534895
JAK3	6193	COSM5020530,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	19:17837923-17837923,	NEUTRAL	0.00111	27534895
JAK3	6193	COSM5020530,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	19:17837923-17837923,	NEUTRAL	0.00111	27534895
JAK3	6193	COSM5020530,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	19:17837923-17837923,	NEUTRAL	0.00111	27534895
JAK3	6193	COSM5020530,	soft_tissue	haemangioblastoma	p.?	Unknown	19:17837923-17837923,	NEUTRAL	0.00111	25589003
JAK3	6193	COSM5020530,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	19:17837923-17837923,	NEUTRAL	0.00111	27534895
JAK3	6193	COSM5020530,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	19:17837923-17837923,	NEUTRAL	0.00111	27534895
JAK3	6193	COSM5020530,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	19:17837923-17837923,	NEUTRAL	0.00111	27534895
JAK3	6193	COSM5020530,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	19:17837923-17837923,	NEUTRAL	0.00111	27534895
JAK3	6193	COSM35873,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.I933fs*8	Deletion - Frameshift	Info_not_available	Info_not_available	Info_not_available	17456055
JAK3	6193	COSM35878,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S789P	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	19470474
JAK3	6193	COSM51375, COSM51376, COSM51377, COSM51378, COSM51379,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm, lymphoid_neoplasm	p.G62S, p.L1017M, p.Q501H, p.R657Q, p.R918C	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	20400977
JAK3	6193	COSM120497,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.A572V	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	21599579
JAK3	6193	COSM1166627,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.A853fs*29	Insertion - Frameshift	19:17832643-17832644,	Info_not_available	Info_not_available	22976956
JAK3	6193	COSM5878458, COSM5945923,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.P151R, p.T8M	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	23153540
JAK3	6193	COSM4385049,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.T551fs*4	Deletion - Frameshift	19:17837978-17837981,	Info_not_available	Info_not_available	24030381
JAK3	6193	COSM1717470, COSM1717473,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.?, p.K563_C565del	Deletion - In frame, Unknown	19:17837938-17837946,	Info_not_available	Info_not_available	24048415
JAK3	6193	COSM5346896,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.V722I	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	24335104
JAK3	6193	COSM1737947,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q507P	Substitution - Missense	19:17838311-17838312,	Info_not_available	Info_not_available	24446122
JAK3	6193	COSM51378,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R657Q	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	24496301
JAK3	6193	COSM4381094,	breast	carcinoma	p.T21M	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	25009010
JAK3	6193	COSM253361, COSM4989845,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A573V, p.R445Q	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	25207766
JAK3	6193	COSM5346896,	pancreas	carcinoid-endocrine_tumour	p.V722I	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	25342539
JAK3	6193	COSM4767374,	peritoneum	mesothelioma	p.?	Unknown	Info_not_available	Info_not_available	Info_not_available	25588929
JAK3	6193	COSM6856668, COSM6856669, COSM6856681,	large_intestine	carcinoma	p.D519E, p.F359L, p.H514Q	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	25589621
JAK3	6193	COSM4775029,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E958_S959insW	Insertion - In frame	19:17831331-17831332,	Info_not_available	Info_not_available	25595890
JAK3	6193	COSM5346896,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.V722I	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	26110571
JAK3	6193	COSM5751284, COSM5751326, COSM5751328, COSM5751433, COSM5751473, COSM5751493, COSM5751671, COSM5751865, COSM5751976, COSM5752052, COSM5752062,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A572fs*90, p.E958fs*10, p.L612_R613insART, p.M511fs*9, p.Q283fs*20, p.Q865fs*17, p.R223fs*54, p.R657fs*5, p.S574fs*88, p.T512fs*8, p.V678fs*26	Complex - frameshift, Insertion - Frameshift, Insertion - In frame	19:17831334-17831335, 19:17832606-17832606, 19:17835098-17835099, 19:17835160-17835161, 19:17836002-17836003, 19:17837197-17837197, 19:17837201-17837202, 19:17838299-17838299, 19:17838299-17838300, 19:17842328-17842329, 19:17842509-17842510,	Info_not_available	Info_not_available	26206799
JAK3	6193	COSM5706898,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E985fs*53	Deletion - Frameshift	19:17831253-17831253,	Info_not_available	Info_not_available	26437031
JAK3	6193	COSM1737947,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q507P	Substitution - Missense	19:17838311-17838312,	Info_not_available	Info_not_available	26917488
JAK3	6193	COSM5885285,	thyroid	carcinoma	p.D863E	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	27245685
JAK3	6193	COSM5346896,	breast	carcinoma	p.V722I	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	27531819
JAK3	6193	COSM303863,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S789P	Substitution - Missense	19:17832915-17832915,	Info_not_available	0.68075	21680795
JAK3	6193	COSM35859,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.A593T	Substitution - Missense	19:17837138-17837138,	Info_not_available	0.67509	17252020
JAK3	6193	COSM6854649,	large_intestine	other	p.G313E	Substitution - Missense	19:17841686-17841686,	Info_not_available	0.60685	28524162
JAK3	6193	COSM94558,	lung	carcinoma	p.K748Q	Substitution - Missense	19:17834679-17834679,	Info_not_available	0.55667	20668451
JAK3	6193	COSM6995425,	ovary	germ_cell_tumour	p.L18L	Substitution - coding silent	19:17844364-17844364,	Info_not_available	0.55068	28954785
JAK3	6193	COSM3530604, COSM5609201, COSM5609209,	skin	malignant_melanoma	p.E639E, p.G436E, p.L735L	Substitution - Missense, Substitution - coding silent	19:17834716-17834716, 19:17835213-17835213, 19:17839611-17839611,	Info_not_available	0.5218, .60559, .69305	26343386
JAK3	6193	COSM6437949,	large_intestine	carcinoma	p.A706T	Substitution - Missense	19:17834935-17834935,	Info_not_available	0.51002	27756406
JAK3	6193	COSM1391581, COSM1391583, COSM3098958, COSM3099001, COSM5511053, COSM6909598, COSM6912427, COSM6913038, COSM6914015, COSM6915878, COSM6916017, COSM6916647, COSM6917560, COSM6921472, COSM6923075, COSM6925309, COSM6925951, COSM6926717, COSM6926883, COSM6927205, COSM6929531, COSM6929644, COSM6932181, COSM6932620, COSM6937542, COSM6941449, COSM6943579, COSM6947015, COSM6952389, COSM6954195, COSM6955283, COSM6957812, COSM6959683, COSM6965971, COSM6967863, COSM6970616, COSM6970753, COSM6982485, COSM6985236,	NS, breast, endometrium, large_intestine, lung, ovary, pancreas, prostate, skin, soft_tissue, urinary_tract, vulva	carcinoma, leiomyosarcoma, malignant_fibrous_histiocytoma-pleomorphic_sarcoma, malignant_melanoma	p.A178_P181delAQRP, p.A192V, p.A229_K237delADRHSLMAK, p.A607fs*2, p.A660fs*10, p.A746P, p.D519E, p.E1069K, p.E331K, p.E552*, p.E694fs*10, p.E997fs*45, p.G284K, p.G594E, p.G861R, p.I430_P434delIRRSP, p.L165fs*21, p.L205fs*2, p.L271V, p.L339M, p.L462fs*58, p.P291L, p.P311L, p.P84fs*63, p.Q305P, p.Q305V, p.Q375*, p.Q39fs*108, p.Q39fs*13, p.R14C, p.R920fs*47, p.T353K, p.T470_S473delTLTS, p.T551A, p.V217_R222>G, p.V28L, p.V342L, p.W690fs*66, p.Y1018H	Complex - deletion inframe, Deletion - Frameshift, Deletion - In frame, Insertion - Frameshift, Substitution - Missense, Substitution - Nonsense	19:17830110-17830110, 19:17830547-17830547, 19:17830610-17830611, 19:17831719-17831720, 19:17832618-17832618, 19:17834685-17834685, 19:17834971-17834972, 19:17834984-17834984, 19:17835152-17835152, 19:17836019-17836019, 19:17837134-17837134, 19:17837979-17837979, 19:17837982-17837982, 19:17838275-17838275, 19:17839499-17839510, 19:17839534-17839535, 19:17839615-17839629, 19:17841408-17841408, 19:17841473-17841473, 19:17841507-17841507, 19:17841516-17841516, 19:17841540-17841540, 19:17841692-17841693, 19:17841709-17841710, 19:17841710-17841711, 19:17841752-17841752, 19:17842326-17842327, 19:17842366-17842366, 19:17842466-17842492, 19:17842513-17842527, 19:17842565-17842566, 19:17842602-17842602, 19:17843049-17843060, 19:17843100-17843100, 19:17843834-17843834, 19:17844302-17844303, 19:17844303-17844303, 19:17844336-17844336, 19:17844378-17844378,	Info_not_available	0.5031, .51218, .51335, .5185, .55234, .57388, .57519, .60365, .61565, .62626, .63725, .63809, .64003, .64666, .66136, .68411, .69071, .69205, Info_not_available	28481359