Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
STAT5A	11366	COSM6950266,	breast	carcinoma	p.R493T	Substitution - Missense	17:42306245-42306245,	PATHOGENIC	0.99551	28481359
STAT5A	11366	COSM6927365,	lung	carcinoma	p.E161K	Substitution - Missense	17:42295724-42295724,	PATHOGENIC	0.99459	28481359
STAT5A	11366	COSM6964441,	large_intestine	carcinoma	p.E404K	Substitution - Missense	17:42304382-42304382,	PATHOGENIC	0.99377	28481359
STAT5A	11366	COSM6975971,	salivary_gland	carcinoma	p.P495L	Substitution - Missense	17:42306251-42306251,	PATHOGENIC	0.9926	28481359
STAT5A	11366	COSM6971474,	stomach	carcinoma	p.M419I	Substitution - Missense	17:42304429-42304429,	PATHOGENIC	0.99249	28481359
STAT5A	11366	COSM6944704,	large_intestine	carcinoma	p.E509K	Substitution - Missense	17:42306292-42306292,	PATHOGENIC	0.98926	28481359
STAT5A	11366	COSM6959545,	central_nervous_system	glioma	p.G472D	Substitution - Missense	17:42305644-42305644,	PATHOGENIC	0.98712	28481359
STAT5A	11366	COSM6966674,	lung	carcinoma	p.?	Unknown	17:42299750-42299750,	PATHOGENIC	0.98698	28481359
STAT5A	11366	COSM6926617,	skin	carcinoma	p.Q8*	Substitution - Nonsense	17:42289433-42289433,	PATHOGENIC	0.9848	28481359
STAT5A	11366	COSM6936926,	skin	carcinoma	p.?	Unknown	17:42291971-42291971,	PATHOGENIC	0.98456	28481359
STAT5A	11366	COSM6972043,	ovary	carcinoma	p.S449T	Substitution - Missense	17:42304618-42304618,	PATHOGENIC	0.98309	28481359
STAT5A	11366	COSM6966514,	oesophagus	carcinoma	p.R659L	Substitution - Missense	17:42308247-42308247,	PATHOGENIC	0.98308	28481359
STAT5A	11366	COSM6934604,	stomach	carcinoma	p.R430Q	Substitution - Missense	17:42304561-42304561,	PATHOGENIC	0.98002	28481359
STAT5A	11366	COSM6951823,	central_nervous_system	glioma	p.A593D	Substitution - Missense	17:42307595-42307595,	PATHOGENIC	0.97993	28481359
STAT5A	11366	COSM6960532,	large_intestine	carcinoma	p.A478V	Substitution - Missense	17:42305662-42305662,	PATHOGENIC	0.97982	28481359
STAT5A	11366	COSM6936571,	ovary	carcinoma	p.Q143E	Substitution - Missense	17:42295670-42295670,	PATHOGENIC	0.97888	28481359
STAT5A	11366	COSM6936571,	ovary	carcinoma	p.Q143E	Substitution - Missense	17:42295670-42295670,	PATHOGENIC	0.97888	28481359
STAT5A	11366	COSM6950542,	cervix	carcinoma	p.A72V	Substitution - Missense	17:42289952-42289952,	PATHOGENIC	0.97875	28481359
STAT5A	11366	COSM6936949,	lung	carcinoma	p.D53N	Substitution - Missense	17:42289894-42289894,	PATHOGENIC	0.97874	28481359
STAT5A	11366	COSM6968709,	breast	carcinoma	p.E335Q	Substitution - Missense	17:42301288-42301288,	PATHOGENIC	0.97871	28481359
STAT5A	11366	COSM6983553,	liver	carcinoma	p.G576R	Substitution - Missense	17:42307447-42307447,	PATHOGENIC	0.97801	28481359
STAT5A	11366	COSM6957752,	soft_tissue	sarcoma	p.S138F	Substitution - Missense	17:42295656-42295656,	PATHOGENIC	0.97515	28481359
STAT5A	11366	COSM6984044,	NS	malignant_melanoma	p.S128F	Substitution - Missense	17:42295626-42295626,	PATHOGENIC	0.9741	28481359
STAT5A	11366	COSM6331298,	endometrium	carcinoma	p.G625R	Substitution - Missense	17:42307690-42307690,	PATHOGENIC	0.97055	28481359
STAT5A	11366	COSM4066538,	large_intestine	carcinoma	p.G358R	Substitution - Missense	17:42301357-42301357,	PATHOGENIC	0.96782	28481359
STAT5A	11366	COSM6978394,	lung	carcinoma	p.S542G	Substitution - Missense	17:42306391-42306391,	PATHOGENIC	0.96706	28481359
STAT5A	11366	COSM4730444,	large_intestine	carcinoma	p.Q340R	Substitution - Missense	17:42301304-42301304,	PATHOGENIC	0.96327	28481359
STAT5A	11366	COSM6986707,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E445Q	Substitution - Missense	17:42304605-42304605,	PATHOGENIC	0.95491	28481359
STAT5A	11366	COSM6961747,	stomach	carcinoma	p.R638H	Substitution - Missense	17:42308184-42308184,	PATHOGENIC	0.95438	28481359
STAT5A	11366	COSM6953196,	urinary_tract	carcinoma	p.E445K	Substitution - Missense	17:42304605-42304605,	PATHOGENIC	0.95321	28481359
STAT5A	11366	COSM6934241,	skin	carcinoma	p.P367L	Substitution - Missense	17:42301385-42301385,	PATHOGENIC	0.94815	28481359
STAT5A	11366	COSM6953064,	lung	carcinoma	p.L355M	Substitution - Missense	17:42301348-42301348,	PATHOGENIC	0.94384	28481359
STAT5A	11366	COSM6962459,	breast	carcinoma	p.K359N	Substitution - Missense	17:42301362-42301362,	PATHOGENIC	0.93878	28481359
STAT5A	11366	COSM6960530,	large_intestine	carcinoma	p.R430W	Substitution - Missense	17:42304560-42304560,	PATHOGENIC	0.92092	28481359
STAT5A	11366	COSM6959547,	central_nervous_system	glioma	p.P725L	Substitution - Missense	17:42309436-42309436,	PATHOGENIC	0.91719	28481359
STAT5A	11366	COSM6928109,	urinary_tract	carcinoma	p.R769H	Substitution - Missense	17:42310590-42310590,	PATHOGENIC	0.91157	28481359
STAT5A	11366	COSM4730454,	endometrium	carcinoma	p.P636L	Substitution - Missense	17:42308178-42308178,	PATHOGENIC	0.91011	28481359
STAT5A	11366	COSM48778,	lung	carcinoma	p.I28V	Substitution - Missense	17:42289493-42289493,	PATHOGENIC	0.9061	18948947
STAT5A	11366	COSM6938624,	urinary_tract	carcinoma	p.G750E	Substitution - Missense	17:42310533-42310533,	PATHOGENIC	0.89447	28481359
STAT5A	11366	COSM6970375,	large_intestine	carcinoma	p.R618C	Substitution - Missense	17:42307669-42307669,	PATHOGENIC	0.86587	28481359
STAT5A	11366	COSM6791697,	lung	carcinoma	p.R110Q	Substitution - Missense	17:42292015-42292015,	PATHOGENIC	0.83951	28481359
STAT5A	11366	COSM6970116,	lung	carcinoma	p.I374M	Substitution - Missense	17:42301407-42301407,	PATHOGENIC	0.81725	28481359
STAT5A	11366	COSM6977270,	prostate	carcinoma	p.R649W	Substitution - Missense	17:42308216-42308216,	NEUTRAL	0.25418	28481359
STAT5A	11366	COSM6967064,	prostate	carcinoma	p.R778C	Substitution - Missense	17:42310616-42310616,	NEUTRAL	0.16056	28481359
STAT5A	11366	COSM6967064,	lung	carcinoma	p.R778C	Substitution - Missense	17:42310616-42310616,	NEUTRAL	0.16056	28481359
STAT5A	11366	COSM5751213, COSM5751609,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.L533fs*45, p.N642fs*17	Deletion - Frameshift, Insertion - Frameshift	17:42306364-42306364, 17:42308195-42308196,	Info_not_available	Info_not_available	26206799
STAT5A	11366	COSM5106430, COSM6937979, COSM6973730, COSM6977055, COSM6979364,	large_intestine, lung, stomach, urinary_tract	carcinoma	p.C730*, p.G77fs*23, p.K439delK, p.Q17fs*69, p.Q368fs*9	Deletion - In frame, Insertion - Frameshift, Substitution - Nonsense	17:42289450-42289451, 17:42289965-42289966, 17:42301380-42301381, 17:42304585-42304587, 17:42309452-42309452,	Info_not_available	0.63616, Info_not_available	28481359