Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
SMAD3	6769	COSM6957554,	penis	carcinoma	p.S391R	Substitution - Missense	15:67190429-67190429,	PATHOGENIC	0.99466	28481359
SMAD3	6769	COSM6023586,	large_intestine	carcinoma	p.D408Y	Substitution - Missense	15:67190480-67190480,	PATHOGENIC	0.99314	23139211
SMAD3	6769	COSM6023574,	large_intestine	carcinoma	p.H399R	Substitution - Missense	15:67190454-67190454,	PATHOGENIC	0.99308	23139211
SMAD3	6769	COSM33157,	large_intestine	carcinoma	p.P393L	Substitution - Missense	15:67190436-67190436,	PATHOGENIC	0.98956	16959974
SMAD3	6769	COSM2257399,	large_intestine	carcinoma	p.?	Unknown	15:67165385-67165385,	PATHOGENIC	0.9868	23139211
SMAD3	6769	COSM6971032,	large_intestine	carcinoma	p.L407P	Substitution - Missense	15:67190478-67190478,	PATHOGENIC	0.98592	28481359
SMAD3	6769	COSM6023906,	upper_aerodigestive_tract	carcinoma	p.L296H	Substitution - Missense	15:67184742-67184742,	PATHOGENIC	0.98454	23913824
SMAD3	6769	COSM6023609,	large_intestine	carcinoma	p.R90L	Substitution - Missense	15:67164957-67164957,	PATHOGENIC	0.98371	23139211
SMAD3	6769	COSM6023609,	large_intestine	carcinoma	p.R90L	Substitution - Missense	15:67164957-67164957,	PATHOGENIC	0.98371	28481359
SMAD3	6769	COSM6955196,	large_intestine	carcinoma	p.G73D	Substitution - Missense	15:67164906-67164906,	PATHOGENIC	0.97892	28481359
SMAD3	6769	COSM6936776,	prostate	carcinoma	p.?	Unknown	15:67166854-67166854,	PATHOGENIC	0.97835	28481359
SMAD3	6769	COSM6941056,	soft_tissue	haemangioendothelioma	p.G337R	Substitution - Missense	15:67184864-67184864,	PATHOGENIC	0.97803	28481359
SMAD3	6769	COSM6947226,	ovary	carcinoma	p.G379V	Substitution - Missense	15:67187491-67187491,	PATHOGENIC	0.97756	28481359
SMAD3	6769	COSM6023596,	large_intestine	carcinoma	p.E187*	Substitution - Nonsense	15:67166805-67166805,	PATHOGENIC	0.97704	23139211
SMAD3	6769	COSM1226715,	endometrium	carcinoma	p.R373H	Substitution - Missense	15:67187473-67187473,	PATHOGENIC	0.97574	28481359
SMAD3	6769	COSM6929036,	central_nervous_system	glioma	p.V363I	Substitution - Missense	15:67187442-67187442,	PATHOGENIC	0.97574	28481359
SMAD3	6769	COSM1226715,	large_intestine	carcinoma	p.R373H	Substitution - Missense	15:67187473-67187473,	PATHOGENIC	0.97574	16828225
SMAD3	6769	COSM1226723,	large_intestine	carcinoma	p.R368Q	Substitution - Missense	15:67187458-67187458,	PATHOGENIC	0.97564	23139211
SMAD3	6769	COSM6941307,	central_nervous_system	glioma	p.G379D	Substitution - Missense	15:67187491-67187491,	PATHOGENIC	0.97517	28481359
SMAD3	6769	COSM6941307,	large_intestine	carcinoma	p.G379D	Substitution - Missense	15:67187491-67187491,	PATHOGENIC	0.97517	28481359
SMAD3	6769	COSM6918871,	large_intestine	carcinoma	p.W326*	Substitution - Nonsense	15:67184833-67184833,	PATHOGENIC	0.97437	28481359
SMAD3	6769	COSM32690,	large_intestine	carcinoma	p.?	Unknown	15:67184865-67184865,	PATHOGENIC	0.97437	16959974
SMAD3	6769	COSM194272,	large_intestine	carcinoma	p.G325D	Substitution - Missense	15:67184829-67184829,	PATHOGENIC	0.97437	23139211
SMAD3	6769	COSM303245,	large_intestine	carcinoma	p.V331I	Substitution - Missense	15:67184846-67184846,	PATHOGENIC	0.97437	28481359
SMAD3	6769	COSM6945118,	pancreas	carcinoma	p.Y364S	Substitution - Missense	15:67187446-67187446,	PATHOGENIC	0.97404	28481359
SMAD3	6769	COSM6943483,	pancreas	carcinoma	p.S423I	Substitution - Missense	15:67190526-67190526,	PATHOGENIC	0.97403	28481359
SMAD3	6769	COSM6972746,	small_intestine	carcinoma	p.F343V	Substitution - Missense	15:67187382-67187382,	PATHOGENIC	0.97351	28481359
SMAD3	6769	COSM6906712,	large_intestine	carcinoma	p.?	Unknown	15:67187510-67187510,	PATHOGENIC	0.97334	29420467
SMAD3	6769	COSM6981596,	urinary_tract	carcinoma	p.E306Q	Substitution - Missense	15:67184771-67184771,	PATHOGENIC	0.97295	28481359
SMAD3	6769	COSM6023584,	large_intestine	carcinoma	p.E383*	Substitution - Nonsense	15:67187502-67187502,	PATHOGENIC	0.97159	28481359
SMAD3	6769	COSM6023584,	large_intestine	carcinoma	p.E383*	Substitution - Nonsense	15:67187502-67187502,	PATHOGENIC	0.97159	23139211
SMAD3	6769	COSM6962704,	pancreas	carcinoma	p.C421Y	Substitution - Missense	15:67190520-67190520,	PATHOGENIC	0.97146	28481359
SMAD3	6769	COSM6981419,	urinary_tract	carcinoma	p.V315F	Substitution - Missense	15:67184798-67184798,	PATHOGENIC	0.9709	28481359
SMAD3	6769	COSM6023613,	large_intestine	carcinoma	p.G381E	Substitution - Missense	15:67187497-67187497,	PATHOGENIC	0.96977	23139211
SMAD3	6769	COSM6023599,	large_intestine	carcinoma	p.?	Unknown	15:67187510-67187510,	PATHOGENIC	0.96977	23139211
SMAD3	6769	COSM4728215,	endometrium	carcinoma	p.A305T	Substitution - Missense	15:67184768-67184768,	PATHOGENIC	0.96821	28481359
SMAD3	6769	COSM4990764,	skin	carcinoma	p.P211S	Substitution - Missense	15:67170577-67170577,	PATHOGENIC	0.96766	25589618
SMAD3	6769	COSM6945985,	pancreas	carcinoma	p.G82E	Substitution - Missense	15:67164933-67164933,	PATHOGENIC	0.9657	28481359
SMAD3	6769	COSM6983347,	large_intestine	carcinoma	p.C270F	Substitution - Missense	15:67181391-67181391,	PATHOGENIC	0.96305	28481359
SMAD3	6769	COSM6958203,	lung	carcinoma	p.S422Y	Substitution - Missense	15:67190523-67190523,	PATHOGENIC	0.96291	28481359
SMAD3	6769	COSM6958203,	pancreas	carcinoma	p.S422Y	Substitution - Missense	15:67190523-67190523,	PATHOGENIC	0.96291	28481359
SMAD3	6769	COSM6952342,	large_intestine	carcinoma	p.E171K	Substitution - Missense	15:67165363-67165363,	PATHOGENIC	0.96269	28481359
SMAD3	6769	COSM5342615,	skin	malignant_melanoma	p.Q358*	Substitution - Nonsense	15:67187427-67187427,	PATHOGENIC	0.96238	28481359
SMAD3	6769	COSM6941651,	stomach	carcinoma	p.N319S	Substitution - Missense	15:67184811-67184811,	PATHOGENIC	0.96215	28481359
SMAD3	6769	COSM434194,	urinary_tract	carcinoma	p.A382V	Substitution - Missense	15:67187500-67187500,	PATHOGENIC	0.96158	28481359
SMAD3	6769	COSM6023580,	large_intestine	carcinoma	p.E246*	Substitution - Nonsense	15:67181318-67181318,	PATHOGENIC	0.96138	23139211
SMAD3	6769	COSM6023608,	large_intestine	carcinoma	p.P336S	Substitution - Missense	15:67184861-67184861,	PATHOGENIC	0.96123	23139211
SMAD3	6769	COSM295046,	large_intestine	carcinoma	p.R268H	Substitution - Missense	15:67181385-67181385,	PATHOGENIC	0.95974	28481359
SMAD3	6769	COSM295046,	large_intestine	carcinoma	p.R268H	Substitution - Missense	15:67181385-67181385,	PATHOGENIC	0.95974	28481359
SMAD3	6769	COSM6023570,	large_intestine	carcinoma	p.D258N	Substitution - Missense	15:67181354-67181354,	PATHOGENIC	0.95945	23139211
SMAD3	6769	COSM4728213,	urinary_tract	carcinoma	p.D262N	Substitution - Missense	15:67181366-67181366,	PATHOGENIC	0.95945	28481359
SMAD3	6769	COSM6023570,	small_intestine	carcinoma	p.D258N	Substitution - Missense	15:67181354-67181354,	PATHOGENIC	0.95945	28481359
SMAD3	6769	COSM6963796,	large_intestine	carcinoma	p.N175D	Substitution - Missense	15:67165375-67165375,	PATHOGENIC	0.95818	28481359
SMAD3	6769	COSM4168906,	testis	germ_cell_tumour	p.G245R	Substitution - Missense	15:67181315-67181315,	PATHOGENIC	0.95792	28481359
SMAD3	6769	COSM4056421,	large_intestine	carcinoma	p.A250T	Substitution - Missense	15:67181330-67181330,	PATHOGENIC	0.95792	23139211
SMAD3	6769	COSM2257401,	large_intestine	carcinoma	p.E239K	Substitution - Missense	15:67181297-67181297,	PATHOGENIC	0.95792	28481359
SMAD3	6769	COSM6023610,	large_intestine	carcinoma	p.E228K	Substitution - Missense	15:67181264-67181264,	PATHOGENIC	0.95792	23139211
SMAD3	6769	COSM4168906,	large_intestine	carcinoma	p.G245R	Substitution - Missense	15:67181315-67181315,	PATHOGENIC	0.95792	28481359
SMAD3	6769	COSM4728211,	large_intestine	carcinoma	p.R243H	Substitution - Missense	15:67181310-67181310,	PATHOGENIC	0.95792	28481359
SMAD3	6769	COSM6930210,	large_intestine	carcinoma	p.W232*	Substitution - Nonsense	15:67181277-67181277,	PATHOGENIC	0.95792	28481359
SMAD3	6769	COSM6941325,	breast	carcinoma	p.S416F	Substitution - Missense	15:67190505-67190505,	PATHOGENIC	0.95544	28481359
SMAD3	6769	COSM84294,	skin	carcinoma	p.S422F	Substitution - Missense	15:67190523-67190523,	PATHOGENIC	0.95544	25589618
SMAD3	6769	COSM6960627,	endometrium	carcinoma	p.R420C	Substitution - Missense	15:67190516-67190516,	PATHOGENIC	0.95544	28481359
SMAD3	6769	COSM6941325,	large_intestine	carcinoma	p.S416F	Substitution - Missense	15:67190505-67190505,	PATHOGENIC	0.95544	28481359
SMAD3	6769	COSM5008241,	large_intestine	carcinoma	p.R287P	Substitution - Missense	15:67181442-67181442,	PATHOGENIC	0.95453	24951259
SMAD3	6769	COSM6930646,	large_intestine	carcinoma	p.V315G	Substitution - Missense	15:67184799-67184799,	PATHOGENIC	0.95385	28481359
SMAD3	6769	COSM6956046,	urinary_tract	carcinoma	p.Y237S	Substitution - Missense	15:67181292-67181292,	PATHOGENIC	0.95358	28481359
SMAD3	6769	COSM6976001,	endometrium	carcinoma	p.P172H	Substitution - Missense	15:67165367-67165367,	PATHOGENIC	0.95244	28481359
SMAD3	6769	COSM5610585,	skin	malignant_melanoma	p.P161H	Substitution - Missense	15:67165334-67165334,	PATHOGENIC	0.95242	26343386
SMAD3	6769	COSM6973570,	ovary	sex_cord-stromal_tumour	p.P136R	Substitution - Missense	15:67165259-67165259,	PATHOGENIC	0.95222	28481359
SMAD3	6769	COSM6975984,	large_intestine	carcinoma	p.?	Unknown	15:67181454-67181454,	PATHOGENIC	0.95115	28481359
SMAD3	6769	COSM6941031,	large_intestine	carcinoma	p.R93L	Substitution - Missense	15:67164966-67164966,	PATHOGENIC	0.95056	28481359
SMAD3	6769	COSM6960403,	large_intestine	carcinoma	p.Q322*	Substitution - Nonsense	15:67184819-67184819,	PATHOGENIC	0.94947	28481359
SMAD3	6769	COSM6915694,	large_intestine	carcinoma	p.K63T	Substitution - Missense	15:67066342-67066342,	PATHOGENIC	0.94895	28481359
SMAD3	6769	COSM6983560,	liver	carcinoma	p.N276S	Substitution - Missense	15:67181409-67181409,	PATHOGENIC	0.94894	28481359
SMAD3	6769	COSM98061,	large_intestine	carcinoma	p.S425C	Substitution - Missense	15:67190532-67190532,	PATHOGENIC	0.94884	23139211
SMAD3	6769	COSM98061,	breast	carcinoma	p.S425C	Substitution - Missense	15:67190532-67190532,	PATHOGENIC	0.94884	27284958
SMAD3	6769	COSM6910091,	prostate	carcinoma	p.V122M	Substitution - Missense	15:67165052-67165052,	PATHOGENIC	0.94824	28481359
SMAD3	6769	COSM6910091,	prostate	carcinoma	p.V122M	Substitution - Missense	15:67165052-67165052,	PATHOGENIC	0.94824	28481359
SMAD3	6769	COSM6974397,	skin	carcinoma	p.E102K	Substitution - Missense	15:67164992-67164992,	PATHOGENIC	0.9479	28481359
SMAD3	6769	COSM5610583,	skin	malignant_melanoma	p.F166C	Substitution - Missense	15:67165349-67165349,	PATHOGENIC	0.94761	26343386
SMAD3	6769	COSM6784638,	urinary_tract	carcinoma	p.R287Q	Substitution - Missense	15:67181442-67181442,	PATHOGENIC	0.94678	28481359
SMAD3	6769	COSM6937522,	lung	carcinoma	p.R288K	Substitution - Missense	15:67181445-67181445,	PATHOGENIC	0.94678	28481359
SMAD3	6769	COSM6784638,	breast	carcinoma	p.R287Q	Substitution - Missense	15:67181442-67181442,	PATHOGENIC	0.94678	28481359
SMAD3	6769	COSM434193,	large_intestine	carcinoma	p.R93Q	Substitution - Missense	15:67164966-67164966,	PATHOGENIC	0.94627	28481359
SMAD3	6769	COSM434193,	large_intestine	carcinoma	p.R93Q	Substitution - Missense	15:67164966-67164966,	PATHOGENIC	0.94627	23139211
SMAD3	6769	COSM434193,	endometrium	carcinoma	p.R93Q	Substitution - Missense	15:67164966-67164966,	PATHOGENIC	0.94627	28481359
SMAD3	6769	COSM4995594,	lung	carcinoma	p.P151L	Substitution - Missense	15:67165304-67165304,	PATHOGENIC	0.94358	28481359
SMAD3	6769	COSM6973576,	ovary	sex_cord-stromal_tumour	p.V138L	Substitution - Missense	15:67165264-67165264,	PATHOGENIC	0.94156	28481359
SMAD3	6769	COSM6923052,	stomach	carcinoma	p.F260V	Substitution - Missense	15:67181360-67181360,	PATHOGENIC	0.94135	28481359
SMAD3	6769	COSM6923052,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.F260V	Substitution - Missense	15:67181360-67181360,	PATHOGENIC	0.94135	28481359
SMAD3	6769	COSM6956567,	lung	carcinoma	p.P137L	Substitution - Missense	15:67165262-67165262,	PATHOGENIC	0.94052	28481359
SMAD3	6769	COSM1708328,	large_intestine	carcinoma	p.R373C	Substitution - Missense	15:67187472-67187472,	PATHOGENIC	0.94039	28481359
SMAD3	6769	COSM1708328,	large_intestine	carcinoma	p.R373C	Substitution - Missense	15:67187472-67187472,	PATHOGENIC	0.94039	28481359
SMAD3	6769	COSM1708328,	large_intestine	carcinoma	p.R373C	Substitution - Missense	15:67187472-67187472,	PATHOGENIC	0.94039	23139211
SMAD3	6769	COSM1708328,	large_intestine	carcinoma	p.R373C	Substitution - Missense	15:67187472-67187472,	PATHOGENIC	0.94039	23139211
SMAD3	6769	COSM6945888,	large_intestine	carcinoma	p.Y298*	Substitution - Nonsense	15:67184749-67184749,	PATHOGENIC	0.93904	28481359
SMAD3	6769	COSM6023595,	large_intestine	carcinoma	p.H126R	Substitution - Missense	15:67165065-67165065,	PATHOGENIC	0.93837	23139211
SMAD3	6769	COSM6964839,	large_intestine	carcinoma	p.Y384*	Substitution - Nonsense	15:67187507-67187507,	PATHOGENIC	0.93752	28481359
SMAD3	6769	COSM6023905,	upper_aerodigestive_tract	carcinoma	p.V277G	Substitution - Missense	15:67181412-67181412,	PATHOGENIC	0.93571	23913824
SMAD3	6769	COSM2257413,	large_intestine	carcinoma	p.S266L	Substitution - Missense	15:67181379-67181379,	PATHOGENIC	0.93564	23139211
SMAD3	6769	COSM6191621,	large_intestine	carcinoma	p.T261I	Substitution - Missense	15:67181364-67181364,	PATHOGENIC	0.93529	25617745
SMAD3	6769	COSM6918562,	central_nervous_system	glioma	p.A168P	Substitution - Missense	15:67165354-67165354,	PATHOGENIC	0.9347	28481359
SMAD3	6769	COSM6918562,	central_nervous_system	glioma	p.A168P	Substitution - Missense	15:67165354-67165354,	PATHOGENIC	0.9347	28481359
SMAD3	6769	COSM6023587,	large_intestine	carcinoma	p.Y384*	Substitution - Nonsense	15:67187507-67187507,	PATHOGENIC	0.93425	23139211
SMAD3	6769	COSM6023591,	large_intestine	carcinoma	p.F269L	Substitution - Missense	15:67181387-67181387,	PATHOGENIC	0.93364	23139211
SMAD3	6769	COSM6979515,	endometrium	carcinoma	p.L271P	Substitution - Missense	15:67181394-67181394,	PATHOGENIC	0.93364	28481359
SMAD3	6769	COSM4807723,	large_intestine	carcinoma	p.S425F	Substitution - Missense	15:67190532-67190532,	PATHOGENIC	0.93098	28481359
SMAD3	6769	COSM4944531,	pancreas	carcinoma	p.R279K	Substitution - Missense	15:67181418-67181418,	PATHOGENIC	0.93067	28481359
SMAD3	6769	COSM6914502,	central_nervous_system	glioma	p.P229L	Substitution - Missense	15:67181268-67181268,	PATHOGENIC	0.91876	28481359
SMAD3	6769	COSM6930497,	NS	malignant_melanoma	p.P124S	Substitution - Missense	15:67165058-67165058,	PATHOGENIC	0.91848	28481359
SMAD3	6769	COSM6023594,	large_intestine	carcinoma	p.A105V	Substitution - Missense	15:67165002-67165002,	PATHOGENIC	0.91793	23139211
SMAD3	6769	COSM6971820,	large_intestine	carcinoma	p.P95L	Substitution - Missense	15:67164972-67164972,	PATHOGENIC	0.91793	28481359
SMAD3	6769	COSM6941910,	urinary_tract	carcinoma	p.*426Y	Nonstop extension	15:67190536-67190536,	PATHOGENIC	0.91387	28481359
SMAD3	6769	COSM6943549,	cervix	carcinoma	p.R323C	Substitution - Missense	15:67184822-67184822,	PATHOGENIC	0.91087	28481359
SMAD3	6769	COSM6949368,	stomach	carcinoma	p.E50K	Substitution - Missense	15:67066302-67066302,	PATHOGENIC	0.90895	28481359
SMAD3	6769	COSM6191622,	large_intestine	carcinoma	p.R69S	Substitution - Missense	15:67164895-67164895,	PATHOGENIC	0.90837	25617745
SMAD3	6769	COSM964264,	large_intestine	carcinoma	p.R268C	Substitution - Missense	15:67181384-67181384,	PATHOGENIC	0.90624	24951259
SMAD3	6769	COSM964264,	large_intestine	carcinoma	p.R268C	Substitution - Missense	15:67181384-67181384,	PATHOGENIC	0.90624	24951259
SMAD3	6769	COSM964264,	large_intestine	carcinoma	p.R268C	Substitution - Missense	15:67181384-67181384,	PATHOGENIC	0.90624	28481359
SMAD3	6769	COSM964264,	large_intestine	carcinoma	p.R268C	Substitution - Missense	15:67181384-67181384,	PATHOGENIC	0.90624	23139211
SMAD3	6769	COSM964264,	large_intestine	carcinoma	p.R268C	Substitution - Missense	15:67181384-67181384,	PATHOGENIC	0.90624	28481359
SMAD3	6769	COSM964264,	endometrium	carcinoma	p.R268C	Substitution - Missense	15:67181384-67181384,	PATHOGENIC	0.90624	29420467
SMAD3	6769	COSM964264,	large_intestine	carcinoma	p.R268C	Substitution - Missense	15:67181384-67181384,	PATHOGENIC	0.90624	28481359
SMAD3	6769	COSM6923880,	lung	carcinoma	p.A281E	Substitution - Missense	15:67181424-67181424,	PATHOGENIC	0.8882	28481359
SMAD3	6769	COSM6925258,	large_intestine	carcinoma	p.R80W	Substitution - Missense	15:67164926-67164926,	PATHOGENIC	0.88586	28481359
SMAD3	6769	COSM6925258,	lung	carcinoma	p.R80W	Substitution - Missense	15:67164926-67164926,	PATHOGENIC	0.88586	28481359
SMAD3	6769	COSM6931985,	central_nervous_system	glioma	p.P9L	Substitution - Missense	15:67066180-67066180,	PATHOGENIC	0.88559	28481359
SMAD3	6769	COSM6023605,	large_intestine	carcinoma	p.L97M	Substitution - Missense	15:67164977-67164977,	PATHOGENIC	0.88495	23139211
SMAD3	6769	COSM5008629,	large_intestine	carcinoma	p.K81N	Substitution - Missense	15:67164931-67164931,	PATHOGENIC	0.87974	24951259
SMAD3	6769	COSM6023566,	large_intestine	carcinoma	p.Q47*	Substitution - Nonsense	15:67066293-67066293,	PATHOGENIC	0.87724	23139211
SMAD3	6769	COSM6922660,	large_intestine	carcinoma	p.S99N	Substitution - Missense	15:67164984-67164984,	PATHOGENIC	0.87618	28481359
SMAD3	6769	COSM4643916,	large_intestine	carcinoma	p.A202T	Substitution - Missense	15:67166850-67166850,	PATHOGENIC	0.86892	23139211
SMAD3	6769	COSM4643916,	large_intestine	carcinoma	p.A202T	Substitution - Missense	15:67166850-67166850,	PATHOGENIC	0.86892	23139211
SMAD3	6769	COSM6023907,	upper_aerodigestive_tract	carcinoma	p.P211P	Substitution - coding silent	15:67170579-67170579,	PATHOGENIC	0.86487	23913824
SMAD3	6769	COSM5002397,	large_intestine	carcinoma	p.R368*	Substitution - Nonsense	15:67187457-67187457,	PATHOGENIC	0.85733	28481359
SMAD3	6769	COSM1374204,	urinary_tract	carcinoma	p.P9S	Substitution - Missense	15:67066179-67066179,	PATHOGENIC	0.85448	28481359
SMAD3	6769	COSM6974496,	NS	carcinoma	p.S317F	Substitution - Missense	15:67184805-67184805,	PATHOGENIC	0.85365	28481359
SMAD3	6769	COSM6913274,	large_intestine	carcinoma	p.C270W	Substitution - Missense	15:67181392-67181392,	PATHOGENIC	0.85025	28481359
SMAD3	6769	COSM6959520,	central_nervous_system	glioma	p.T66I	Substitution - Missense	15:67066351-67066351,	PATHOGENIC	0.84255	28481359
SMAD3	6769	COSM6961967,	pancreas	carcinoid-endocrine_tumour	p.G17D	Substitution - Missense	15:67066204-67066204,	PATHOGENIC	0.83932	28481359
SMAD3	6769	COSM5020381,	soft_tissue	haemangioblastoma	p.I170V	Substitution - Missense	15:67165360-67165360,	PATHOGENIC	0.83214	25589003
SMAD3	6769	COSM5020381,	ovary	carcinoma	p.I170V	Substitution - Missense	15:67165360-67165360,	PATHOGENIC	0.83214	28481359
SMAD3	6769	COSM5020381,	soft_tissue	haemangioblastoma	p.I170V	Substitution - Missense	15:67165360-67165360,	PATHOGENIC	0.83214	25589003
SMAD3	6769	COSM6023612,	large_intestine	carcinoma	p.K43R	Substitution - Missense	15:67066282-67066282,	PATHOGENIC	0.82883	23139211
SMAD3	6769	COSM6910837,	central_nervous_system	glioma	p.P229S	Substitution - Missense	15:67181267-67181267,	PATHOGENIC	0.82839	28481359
SMAD3	6769	COSM6784661,	large_intestine	carcinoma	p.R243C	Substitution - Missense	15:67181309-67181309,	PATHOGENIC	0.81897	28481359
SMAD3	6769	COSM6947098,	large_intestine	carcinoma	p.I235M	Substitution - Missense	15:67181287-67181287,	PATHOGENIC	0.81642	28481359
SMAD3	6769	COSM6949979,	large_intestine	carcinoma	p.C64*	Substitution - Nonsense	15:67066346-67066346,	PATHOGENIC	0.80788	28481359
SMAD3	6769	COSM6949979,	large_intestine	carcinoma	p.C64*	Substitution - Nonsense	15:67066346-67066346,	PATHOGENIC	0.80788	28481359
SMAD3	6769	COSM6972593,	NS	carcinoma	p.E284D	Substitution - Missense	15:67181434-67181434,	PATHOGENIC	0.79966	28481359
SMAD3	6769	COSM3981624,	endometrium	carcinoma	p.R93*	Substitution - Nonsense	15:67164965-67164965,	PATHOGENIC	0.79847	28481359
SMAD3	6769	COSM3981624,	large_intestine	carcinoma	p.R93*	Substitution - Nonsense	15:67164965-67164965,	PATHOGENIC	0.79847	28481359
SMAD3	6769	COSM3981624,	large_intestine	carcinoma	p.R93*	Substitution - Nonsense	15:67164965-67164965,	PATHOGENIC	0.79847	28481359
SMAD3	6769	COSM3981624,	large_intestine	carcinoma	p.R93*	Substitution - Nonsense	15:67164965-67164965,	PATHOGENIC	0.79847	28481359
SMAD3	6769	COSM6970111,	lung	carcinoma	p.R69W	Substitution - Missense	15:67066359-67066359,	PATHOGENIC	0.79292	28481359
SMAD3	6769	COSM6023593,	large_intestine	carcinoma	p.I67I	Substitution - coding silent	15:67066355-67066355,	PATHOGENIC	0.75623	23139211
SMAD3	6769	COSM6920550,	large_intestine	carcinoma	p.M106V	Substitution - Missense	15:67165004-67165004,	PATHOGENIC	0.73718	28481359
SMAD3	6769	COSM5009852,	large_intestine	carcinoma	p.P124P	Substitution - coding silent	15:67165060-67165060,	PATHOGENIC	0.73203	24951259
SMAD3	6769	COSM6949673,	endometrium	carcinoma	p.V60I	Substitution - Missense	15:67066332-67066332,	NEUTRAL	0.49216	28481359
SMAD3	6769	COSM6023588,	large_intestine	carcinoma	p.F111F	Substitution - coding silent	15:67165021-67165021,	NEUTRAL	0.39722	23139211
SMAD3	6769	COSM5610589,	skin	malignant_melanoma	p.F376F	Substitution - coding silent	15:67187483-67187483,	NEUTRAL	0.22637	26343386
SMAD3	6769	COSM1226719,	skin	malignant_melanoma	p.R287W	Substitution - Missense	15:67181441-67181441,	NEUTRAL	0.20962	28481359
SMAD3	6769	COSM1226719,	large_intestine	carcinoma	p.R287W	Substitution - Missense	15:67181441-67181441,	NEUTRAL	0.20962	28481359
SMAD3	6769	COSM1226719,	large_intestine	carcinoma	p.R287W	Substitution - Missense	15:67181441-67181441,	NEUTRAL	0.20962	28481359
SMAD3	6769	COSM6023597,	large_intestine	carcinoma	p.T261T	Substitution - coding silent	15:67181365-67181365,	NEUTRAL	0.14426	23139211
SMAD3	6769	COSM4414061,	large_intestine	carcinoma	p.V244V	Substitution - coding silent	15:67181314-67181314,	NEUTRAL	0.14404	23139211
SMAD3	6769	COSM6023614,	large_intestine	carcinoma	p.?	Unknown	15:67190406-67190406,	NEUTRAL	0.11409	23139211
SMAD3	6769	COSM5610587, COSM5611387,	skin	malignant_melanoma	p.P182S, p.S275S	Substitution - Missense, Substitution - coding silent	15:67166789-67166790, 15:67181407-67181407,	Info_not_available	0.6756, Info_not_available	26343386
SMAD3	6769	COSM5021105,	soft_tissue	haemangioblastoma	p.E22E	Substitution - coding silent	15:67066220-67066220,	Info_not_available	0.6702	25589003
SMAD3	6769	COSM6444833,	endometrium	carcinoma	p.K36N	Substitution - Missense	15:67066262-67066262,	Info_not_available	0.64408	27159395
SMAD3	6769	COSM6023564, COSM6023598, COSM6023604, COSM6023606, COSM6023611, COSM6023615, COSM964263,	large_intestine	carcinoma	p.?, p.P209P, p.R287fs*24, p.S422_S423insRN, p.S423fs*4, p.T56T, p.V389_T390del	Deletion - Frameshift, Deletion - In frame, Insertion - Frameshift, Insertion - In frame, Substitution - coding silent, Unknown	15:67066322-67066322, 15:67164892-67164892, 15:67170573-67170573, 15:67181440-67181441, 15:67190423-67190428, 15:67190522-67190523, 15:67190524-67190524,	Info_not_available	0.64148, .68288, Info_not_available	23139211
SMAD3	6769	COSM6908878, COSM6909558, COSM6922269, COSM6922698, COSM6927549, COSM6929611, COSM6929991, COSM6933653, COSM6934068, COSM6936456, COSM6946744, COSM6959759, COSM6959815, COSM6971021, COSM6978350,	biliary_tract, breast, large_intestine, ovary, pancreas, small_intestine, stomach, testis, urinary_tract	carcinoma, germ_cell_tumour, sex_cord-stromal_tumour	p.C227*, p.C89fs*22, p.E28delE, p.E32R, p.F348fs*18, p.G82fs*36, p.L15fs*79, p.L16V, p.N165fs*1, p.P182fs*4, p.R69fs*47, p.S418fs*>8, p.T390fs*1, p.V389fs*8, p.Y226delY	Complex - frameshift, Deletion - Frameshift, Deletion - In frame, Insertion - Frameshift, Substitution - Missense, Substitution - Nonsense	15:67066195-67066261, 15:67066200-67066200, 15:67066231-67066233, 15:67066248-67066249, 15:67066355-67066355, 15:67164932-67164932, 15:67164953-67164954, 15:67165343-67165344, 15:67166787-67166787, 15:67181257-67181259, 15:67181263-67181263, 15:67187398-67187401, 15:67190421-67190422, 15:67190422-67190423, 15:67190509-67190509,	Info_not_available	0.5437, .64227, Info_not_available	28481359