Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
SMAD2	6768	COSM268520,	large_intestine	carcinoma	p.S464*	Substitution - Nonsense	18:47841840-47841840,	PATHOGENIC	0.99915	23139211
SMAD2	6768	COSM268520,	large_intestine	carcinoma	p.S464*	Substitution - Nonsense	18:47841840-47841840,	PATHOGENIC	0.99915	23139211
SMAD2	6768	COSM268520,	skin	carcinoma	p.S464*	Substitution - Nonsense	18:47841840-47841840,	PATHOGENIC	0.99915	25589618
SMAD2	6768	COSM268520,	large_intestine	carcinoma	p.S464*	Substitution - Nonsense	18:47841840-47841840,	PATHOGENIC	0.99915	28481359
SMAD2	6768	COSM268520,	prostate	carcinoma	p.S464*	Substitution - Nonsense	18:47841840-47841840,	PATHOGENIC	0.99915	28481359
SMAD2	6768	COSM268520,	prostate	carcinoma	p.S464*	Substitution - Nonsense	18:47841840-47841840,	PATHOGENIC	0.99915	28481359
SMAD2	6768	COSM268520,	large_intestine	carcinoma	p.S464*	Substitution - Nonsense	18:47841840-47841840,	PATHOGENIC	0.99915	28481359
SMAD2	6768	COSM268520,	breast	carcinoma	p.S464*	Substitution - Nonsense	18:47841840-47841840,	PATHOGENIC	0.99915	28481359
SMAD2	6768	COSM268520,	lung	carcinoma	p.S464*	Substitution - Nonsense	18:47841840-47841840,	PATHOGENIC	0.99915	28481359
SMAD2	6768	COSM268520,	large_intestine	carcinoma	p.S464*	Substitution - Nonsense	18:47841840-47841840,	PATHOGENIC	0.99915	23700467
SMAD2	6768	COSM268520,	breast	carcinoma	p.S464*	Substitution - Nonsense	18:47841840-47841840,	PATHOGENIC	0.99915	28481359
SMAD2	6768	COSM268154,	large_intestine	carcinoma	p.S464*	Substitution - Nonsense	18:47841840-47841840,	PATHOGENIC	0.99912	28481359
SMAD2	6768	COSM268154,	large_intestine	carcinoma	p.S464*	Substitution - Nonsense	18:47841840-47841840,	PATHOGENIC	0.99912	28481359
SMAD2	6768	COSM6920614,	large_intestine	carcinoma	p.P459H	Substitution - Missense	18:47841855-47841855,	PATHOGENIC	0.99912	28481359
SMAD2	6768	COSM4169157,	large_intestine	carcinoma	p.S464L	Substitution - Missense	18:47841840-47841840,	PATHOGENIC	0.99901	23139211
SMAD2	6768	COSM4169157,	peritoneum	other	p.S464L	Substitution - Missense	18:47841840-47841840,	PATHOGENIC	0.99901	24944587
SMAD2	6768	COSM2878623,	endometrium	carcinoma	p.R462C	Substitution - Missense	18:47841847-47841847,	PATHOGENIC	0.99901	28481359
SMAD2	6768	COSM4169134,	peritoneum	other	p.S467L	Substitution - Missense	18:47841831-47841831,	PATHOGENIC	0.99892	24944587
SMAD2	6768	COSM4169134,	breast	carcinoma	p.S467L	Substitution - Missense	18:47841831-47841831,	PATHOGENIC	0.99892	28481359
SMAD2	6768	COSM6191619,	large_intestine	carcinoma	p.S467T	Substitution - Missense	18:47841832-47841832,	PATHOGENIC	0.99888	25617745
SMAD2	6768	COSM5118504,	large_intestine	carcinoma	p.S467P	Substitution - Missense	18:47841832-47841832,	PATHOGENIC	0.99876	28481359
SMAD2	6768	COSM5118504,	large_intestine	carcinoma	p.S467P	Substitution - Missense	18:47841832-47841832,	PATHOGENIC	0.99876	23139211
SMAD2	6768	COSM6949681,	endometrium	carcinoma	p.G457R	Substitution - Missense	18:47841862-47841862,	PATHOGENIC	0.99853	28481359
SMAD2	6768	COSM6941033,	large_intestine	carcinoma	p.C463F	Substitution - Missense	18:47841843-47841843,	PATHOGENIC	0.99853	28481359
SMAD2	6768	COSM2878622,	large_intestine	carcinoma	p.S465N	Substitution - Missense	18:47841837-47841837,	PATHOGENIC	0.99843	28481359
SMAD2	6768	COSM4169135,	peritoneum	other	p.C463Y	Substitution - Missense	18:47841843-47841843,	PATHOGENIC	0.99843	24944587
SMAD2	6768	COSM2878622,	large_intestine	carcinoma	p.S465N	Substitution - Missense	18:47841837-47841837,	PATHOGENIC	0.99843	28481359
SMAD2	6768	COSM6940101,	NS	carcinoma	p.S2*	Substitution - Nonsense	18:47896752-47896752,	PATHOGENIC	0.99838	28481359
SMAD2	6768	COSM48768,	lung	carcinoma	p.S245C	Substitution - Missense	18:47851324-47851324,	PATHOGENIC	0.99837	18948947
SMAD2	6768	COSM6023520,	large_intestine	carcinoma	p.*468YSFTNQVQ*	Nonstop extension	18:47841827-47841827,	PATHOGENIC	0.99827	23139211
SMAD2	6768	COSM6937376,	skin	malignant_melanoma	p.P218L	Substitution - Missense	18:47868325-47868325,	PATHOGENIC	0.99809	28481359
SMAD2	6768	COSM5902037,	large_intestine	carcinoma	p.P218S	Substitution - Missense	18:47868326-47868326,	PATHOGENIC	0.99809	23139211
SMAD2	6768	COSM6912936,	skin	carcinoma	p.P246L	Substitution - Missense	18:47851321-47851321,	PATHOGENIC	0.99808	28481359
SMAD2	6768	COSM6986620,	skin	carcinoma	p.E248Q	Substitution - Missense	18:47851316-47851316,	PATHOGENIC	0.99699	28481359
SMAD2	6768	COSM6944849,	bone	chondrosarcoma	p.M1I	Substitution - Missense	18:47896754-47896754,	PATHOGENIC	0.99698	28481359
SMAD2	6768	COSM6923997,	central_nervous_system	glioma	p.E219K	Substitution - Missense	18:47868323-47868323,	PATHOGENIC	0.99672	28481359
SMAD2	6768	COSM6784621,	lung	carcinoma	p.Q455*	Substitution - Nonsense	18:47841868-47841868,	PATHOGENIC	0.99655	28481359
SMAD2	6768	COSM6854776,	large_intestine	other	p.S255F	Substitution - Missense	18:47851294-47851294,	PATHOGENIC	0.99623	28524162
SMAD2	6768	COSM6932806,	lung	carcinoma	p.P377S	Substitution - Missense	18:47845669-47845669,	PATHOGENIC	0.99588	28481359
SMAD2	6768	COSM6053940,	large_intestine	carcinoma	p.P445H	Substitution - Missense	18:47841897-47841897,	PATHOGENIC	0.99559	8752209
SMAD2	6768	COSM6023910,	lung	carcinoma	p.D450H	Substitution - Missense	18:47841883-47841883,	PATHOGENIC	0.99533	8971158
SMAD2	6768	COSM6920169,	bone	osteosarcoma	p.Q429*	Substitution - Nonsense	18:47841946-47841946,	PATHOGENIC	0.99488	28481359
SMAD2	6768	COSM6964511,	large_intestine	carcinoma	p.C463*	Substitution - Nonsense	18:47841842-47841842,	PATHOGENIC	0.99488	28481359
SMAD2	6768	COSM6964511,	large_intestine	carcinoma	p.C463*	Substitution - Nonsense	18:47841842-47841842,	PATHOGENIC	0.99488	28481359
SMAD2	6768	COSM6023531,	large_intestine	carcinoma	p.T413N	Substitution - Missense	18:47845382-47845382,	PATHOGENIC	0.99474	23139211
SMAD2	6768	COSM988682,	stomach	carcinoma	p.S276L	Substitution - Missense	18:47848645-47848645,	PATHOGENIC	0.99471	28481359
SMAD2	6768	COSM988682,	large_intestine	carcinoma	p.S276L	Substitution - Missense	18:47848645-47848645,	PATHOGENIC	0.99471	23139211
SMAD2	6768	COSM6959283,	biliary_tract	carcinoma	p.P271S	Substitution - Missense	18:47848661-47848661,	PATHOGENIC	0.99471	28481359
SMAD2	6768	COSM988682,	large_intestine	carcinoma	p.S276L	Substitution - Missense	18:47848645-47848645,	PATHOGENIC	0.99471	23139211
SMAD2	6768	COSM988682,	large_intestine	carcinoma	p.S276L	Substitution - Missense	18:47848645-47848645,	PATHOGENIC	0.99471	28481359
SMAD2	6768	COSM988682,	urinary_tract	carcinoma	p.S276L	Substitution - Missense	18:47848645-47848645,	PATHOGENIC	0.99471	28481359
SMAD2	6768	COSM988682,	large_intestine	carcinoma	p.S276L	Substitution - Missense	18:47848645-47848645,	PATHOGENIC	0.99471	23139211
SMAD2	6768	COSM988682,	upper_aerodigestive_tract	carcinoma	p.S276L	Substitution - Missense	18:47848645-47848645,	PATHOGENIC	0.99471	16478646
SMAD2	6768	COSM6982359,	NS	carcinoma	p.T409S	Substitution - Missense	18:47845394-47845394,	PATHOGENIC	0.99465	28481359
SMAD2	6768	COSM6053941,	stomach	carcinoma	p.L440R	Substitution - Missense	18:47841912-47841912,	PATHOGENIC	0.99462	28481359
SMAD2	6768	COSM6053941,	large_intestine	carcinoma	p.L440R	Substitution - Missense	18:47841912-47841912,	PATHOGENIC	0.99462	8752209
SMAD2	6768	COSM6023528,	large_intestine	carcinoma	p.A22V	Substitution - Missense	18:47896692-47896692,	PATHOGENIC	0.99453	23139211
SMAD2	6768	COSM4728202,	large_intestine	carcinoma	p.T303R	Substitution - Missense	18:47848564-47848564,	PATHOGENIC	0.99434	28481359
SMAD2	6768	COSM4728202,	large_intestine	carcinoma	p.T303R	Substitution - Missense	18:47848564-47848564,	PATHOGENIC	0.99434	23139211
SMAD2	6768	COSM4728202,	large_intestine	carcinoma	p.T303R	Substitution - Missense	18:47848564-47848564,	PATHOGENIC	0.99434	28481359
SMAD2	6768	COSM4991167,	skin	carcinoma	p.S21L	Substitution - Missense	18:47896695-47896695,	PATHOGENIC	0.99422	25589618
SMAD2	6768	COSM6191618,	large_intestine	carcinoma	p.L446Q	Substitution - Missense	18:47841894-47841894,	PATHOGENIC	0.9942	25617745
SMAD2	6768	COSM6970794,	breast	carcinoma	p.A391D	Substitution - Missense	18:47845448-47845448,	PATHOGENIC	0.99407	28481359
SMAD2	6768	COSM6023533,	large_intestine	carcinoma	p.R130*	Substitution - Nonsense	18:47869375-47869375,	PATHOGENIC	0.99375	23139211
SMAD2	6768	COSM6965238,	prostate	carcinoma	p.P305T	Substitution - Missense	18:47848559-47848559,	PATHOGENIC	0.99374	28481359
SMAD2	6768	COSM6913074,	large_intestine	carcinoma	p.S296*	Substitution - Nonsense	18:47848585-47848585,	PATHOGENIC	0.99374	28481359
SMAD2	6768	COSM6931525,	breast	carcinoma	p.Q168*	Substitution - Nonsense	18:47869261-47869261,	PATHOGENIC	0.99371	28481359
SMAD2	6768	COSM6927872,	skin	carcinoma	p.M416R	Substitution - Missense	18:47845373-47845373,	PATHOGENIC	0.99336	28481359
SMAD2	6768	COSM6983093,	breast	carcinoma	p.P360L	Substitution - Missense	18:47845719-47845719,	PATHOGENIC	0.99333	28481359
SMAD2	6768	COSM6904335,	ovary	carcinoma	p.?	Unknown	18:47848688-47848688,	PATHOGENIC	0.99298	28984674
SMAD2	6768	COSM256209,	large_intestine	carcinoma	p.P305L	Substitution - Missense	18:47848558-47848558,	PATHOGENIC	0.99294	28481359
SMAD2	6768	COSM256209,	large_intestine	carcinoma	p.P305L	Substitution - Missense	18:47848558-47848558,	PATHOGENIC	0.99294	23139211
SMAD2	6768	COSM256209,	large_intestine	carcinoma	p.P305L	Substitution - Missense	18:47848558-47848558,	PATHOGENIC	0.99294	23139211
SMAD2	6768	COSM2878633,	large_intestine	carcinoma	p.A292V	Substitution - Missense	18:47848597-47848597,	PATHOGENIC	0.99294	23139211
SMAD2	6768	COSM5593210,	skin	malignant_melanoma	p.S308L	Substitution - Missense	18:47848549-47848549,	PATHOGENIC	0.99294	26343386
SMAD2	6768	COSM6023539,	large_intestine	carcinoma	p.E270*	Substitution - Nonsense	18:47848664-47848664,	PATHOGENIC	0.99257	23139211
SMAD2	6768	COSM6953740,	large_intestine	carcinoma	p.S433R	Substitution - Missense	18:47841934-47841934,	PATHOGENIC	0.99178	28481359
SMAD2	6768	COSM6853929,	large_intestine	carcinoma	p.V431A	Substitution - Missense	18:47841939-47841939,	PATHOGENIC	0.99175	28978093
SMAD2	6768	COSM6854015,	large_intestine	carcinoma	p.F402I	Substitution - Missense	18:47845416-47845416,	PATHOGENIC	0.9915	28978093
SMAD2	6768	COSM6973963,	large_intestine	carcinoma	p.I384N	Substitution - Missense	18:47845469-47845469,	PATHOGENIC	0.9915	28481359
SMAD2	6768	COSM6053934,	large_intestine	carcinoma	p.I384T	Substitution - Missense	18:47845469-47845469,	PATHOGENIC	0.99145	11172591
SMAD2	6768	COSM6854295,	large_intestine	carcinoma	p.F402L	Substitution - Missense	18:47845416-47845416,	PATHOGENIC	0.99145	28978093
SMAD2	6768	COSM6936234,	NS	malignant_melanoma	p.S118F	Substitution - Missense	18:47869410-47869410,	PATHOGENIC	0.99145	28481359
SMAD2	6768	COSM6928624,	large_intestine	carcinoma	p.?	Unknown	18:47845339-47845339,	PATHOGENIC	0.9913	28481359
SMAD2	6768	COSM1388905,	large_intestine	carcinoma	p.R428K	Substitution - Missense	18:47841948-47841948,	PATHOGENIC	0.99099	28481359
SMAD2	6768	COSM6956597,	large_intestine	carcinoma	p.E42Q	Substitution - Missense	18:47896633-47896633,	PATHOGENIC	0.99095	28481359
SMAD2	6768	COSM6968957,	small_intestine	carcinoma	p.L313S	Substitution - Missense	18:47848534-47848534,	PATHOGENIC	0.99087	28481359
SMAD2	6768	COSM6023532,	large_intestine	carcinoma	p.V319A	Substitution - Missense	18:47848516-47848516,	PATHOGENIC	0.99087	23139211
SMAD2	6768	COSM6023524,	large_intestine	carcinoma	p.F302L	Substitution - Missense	18:47848568-47848568,	PATHOGENIC	0.99087	23139211
SMAD2	6768	COSM255912,	endometrium	carcinoma	p.T220M	Substitution - Missense	18:47865130-47865130,	PATHOGENIC	0.99086	28481359
SMAD2	6768	COSM255912,	large_intestine	carcinoma	p.T220M	Substitution - Missense	18:47865130-47865130,	PATHOGENIC	0.99086	28481359
SMAD2	6768	COSM6053932,	large_intestine	carcinoma	p.F7S	Substitution - Missense	18:47896737-47896737,	PATHOGENIC	0.99082	11172591
SMAD2	6768	COSM241692,	large_intestine	carcinoma	p.E439*	Substitution - Nonsense	18:47841916-47841916,	PATHOGENIC	0.99081	28481359
SMAD2	6768	COSM6959364,	small_intestine	carcinoma	p.S433N	Substitution - Missense	18:47841933-47841933,	PATHOGENIC	0.9908	28481359
SMAD2	6768	COSM6936514,	lung	carcinoma	p.A354P	Substitution - Missense	18:47845738-47845738,	PATHOGENIC	0.99076	28481359
SMAD2	6768	COSM6913540,	skin	malignant_melanoma	p.S3F	Substitution - Missense	18:47896749-47896749,	PATHOGENIC	0.99061	28481359
SMAD2	6768	COSM6913278,	large_intestine	carcinoma	p.C275Y	Substitution - Missense	18:47848648-47848648,	PATHOGENIC	0.99053	28481359
SMAD2	6768	COSM6959818,	endometrium	carcinoma	p.R310T	Substitution - Missense	18:47848543-47848543,	PATHOGENIC	0.99025	28481359
SMAD2	6768	COSM6959818,	large_intestine	carcinoma	p.R310T	Substitution - Missense	18:47848543-47848543,	PATHOGENIC	0.99025	28481359
SMAD2	6768	COSM6906579,	large_intestine	carcinoma	p.L61R	Substitution - Missense	18:47896575-47896575,	PATHOGENIC	0.99019	29420467
SMAD2	6768	COSM6973762,	bone	osteosarcoma	p.V336L	Substitution - Missense	18:47845792-47845792,	PATHOGENIC	0.99014	28481359
SMAD2	6768	COSM6978523,	lung	carcinoma	p.G342V	Substitution - Missense	18:47845773-47845773,	PATHOGENIC	0.99014	28481359
SMAD2	6768	COSM6854451,	large_intestine	carcinoma	p.G335V	Substitution - Missense	18:47845794-47845794,	PATHOGENIC	0.99014	28978093
SMAD2	6768	COSM32692,	large_intestine	carcinoma	p.?	Unknown	18:47841951-47841951,	PATHOGENIC	0.99013	16959974
SMAD2	6768	COSM6023535,	large_intestine	carcinoma	p.R285M	Substitution - Missense	18:47848618-47848618,	PATHOGENIC	0.9896	23139211
SMAD2	6768	COSM6784620,	breast	carcinoma	p.T92M	Substitution - Missense	18:47870526-47870526,	PATHOGENIC	0.98958	28481359
SMAD2	6768	COSM4991163,	skin	carcinoma	p.Y165D	Substitution - Missense	18:47869270-47869270,	PATHOGENIC	0.98939	25589618
SMAD2	6768	COSM2878644,	large_intestine	carcinoma	p.V75A	Substitution - Missense	18:47896533-47896533,	PATHOGENIC	0.98912	23139211
SMAD2	6768	COSM6970263,	lung	carcinoma	p.V12L	Substitution - Missense	18:47896723-47896723,	PATHOGENIC	0.98908	28481359
SMAD2	6768	COSM1226711,	skin	carcinoma	p.W422*	Substitution - Nonsense	18:47845354-47845354,	PATHOGENIC	0.98901	28481359
SMAD2	6768	COSM6191617,	large_intestine	carcinoma	p.S417N	Substitution - Missense	18:47845370-47845370,	PATHOGENIC	0.98901	25617745
SMAD2	6768	COSM6053942,	small_intestine	carcinoma	p.D450E	Substitution - Missense	18:47841881-47841881,	PATHOGENIC	0.98881	28481359
SMAD2	6768	COSM6053942,	large_intestine	carcinoma	p.D450E	Substitution - Missense	18:47841881-47841881,	PATHOGENIC	0.98881	8752209
SMAD2	6768	COSM6945049,	bone	osteosarcoma	p.W134*	Substitution - Nonsense	18:47869361-47869361,	PATHOGENIC	0.98871	28481359
SMAD2	6768	COSM6910391,	prostate	carcinoma	p.W132*	Substitution - Nonsense	18:47869367-47869367,	PATHOGENIC	0.98871	28481359
SMAD2	6768	COSM4991165,	soft_tissue	leiomyoma	p.R130Q	Substitution - Missense	18:47869374-47869374,	PATHOGENIC	0.98871	29484624
SMAD2	6768	COSM4991165,	skin	carcinoma	p.R130Q	Substitution - Missense	18:47869374-47869374,	PATHOGENIC	0.98871	25589618
SMAD2	6768	COSM4991165,	soft_tissue	leiomyoma	p.R130Q	Substitution - Missense	18:47869374-47869374,	PATHOGENIC	0.98871	29484624
SMAD2	6768	COSM6918305,	large_intestine	carcinoma	p.R133H	Substitution - Missense	18:47869365-47869365,	PATHOGENIC	0.98871	28481359
SMAD2	6768	COSM6910391,	prostate	carcinoma	p.W132*	Substitution - Nonsense	18:47869367-47869367,	PATHOGENIC	0.98871	28481359
SMAD2	6768	COSM6023526,	large_intestine	carcinoma	p.Y167C	Substitution - Missense	18:47869263-47869263,	PATHOGENIC	0.98829	23139211
SMAD2	6768	COSM6971011,	breast	carcinoma	p.M416V	Substitution - Missense	18:47845374-47845374,	PATHOGENIC	0.98814	28481359
SMAD2	6768	COSM6023525,	large_intestine	carcinoma	p.D300A	Substitution - Missense	18:47848573-47848573,	PATHOGENIC	0.98804	23139211
SMAD2	6768	COSM6023523,	large_intestine	carcinoma	p.?	Unknown	18:47869437-47869437,	PATHOGENIC	0.98795	23139211
SMAD2	6768	COSM473873,	kidney	carcinoma	p.G122V	Substitution - Missense	18:47869398-47869398,	PATHOGENIC	0.98795	28481359
SMAD2	6768	COSM417832,	urinary_tract	carcinoma	p.L446V	Substitution - Missense	18:47841895-47841895,	PATHOGENIC	0.98795	28481359
SMAD2	6768	COSM6973148,	central_nervous_system	glioma	p.E38K	Substitution - Missense	18:47896645-47896645,	PATHOGENIC	0.98791	28481359
SMAD2	6768	COSM6023536,	large_intestine	carcinoma	p.D450E	Substitution - Missense	18:47841881-47841881,	PATHOGENIC	0.98775	23139211
SMAD2	6768	COSM1645538,	large_intestine	carcinoma	p.V405F	Substitution - Missense	18:47845407-47845407,	PATHOGENIC	0.98765	23700467
SMAD2	6768	COSM6951383,	large_intestine	carcinoma	p.D304V	Substitution - Missense	18:47848561-47848561,	PATHOGENIC	0.98731	28481359
SMAD2	6768	COSM6927767,	lung	carcinoma	p.N320I	Substitution - Missense	18:47848513-47848513,	PATHOGENIC	0.98731	28481359
SMAD2	6768	COSM33160,	large_intestine	carcinoma	p.D300V	Substitution - Missense	18:47848573-47848573,	PATHOGENIC	0.98731	16959974
SMAD2	6768	COSM6984760,	lung	carcinoma	p.Y280F	Substitution - Missense	18:47848633-47848633,	PATHOGENIC	0.98731	28481359
SMAD2	6768	COSM6960315,	large_intestine	carcinoma	p.E403K	Substitution - Missense	18:47845413-47845413,	PATHOGENIC	0.98717	28481359
SMAD2	6768	COSM6023519,	large_intestine	carcinoma	p.A354T	Substitution - Missense	18:47845738-47845738,	PATHOGENIC	0.98705	23139211
SMAD2	6768	COSM6984700,	large_intestine	carcinoma	p.D300H	Substitution - Missense	18:47848574-47848574,	PATHOGENIC	0.98691	28481359
SMAD2	6768	COSM2878628,	testis	germ_cell_tumour	p.N361S	Substitution - Missense	18:47845716-47845716,	PATHOGENIC	0.98644	28481359
SMAD2	6768	COSM6057021,	liver	carcinoma	p.Q407R	Substitution - Missense	18:47845400-47845400,	PATHOGENIC	0.98642	10490821
SMAD2	6768	COSM6921880,	placenta	choriocarcinoma	p.E281K	Substitution - Missense	18:47848631-47848631,	PATHOGENIC	0.98633	28481359
SMAD2	6768	COSM188749,	endometrium	carcinoma	p.R321Q	Substitution - Missense	18:47848510-47848510,	PATHOGENIC	0.98633	27159395
SMAD2	6768	COSM188749,	endometrium	carcinoma	p.R321Q	Substitution - Missense	18:47848510-47848510,	PATHOGENIC	0.98633	27159395
SMAD2	6768	COSM304917,	large_intestine	carcinoma	p.G301S	Substitution - Missense	18:47848571-47848571,	PATHOGENIC	0.98633	21892161
SMAD2	6768	COSM6191620,	large_intestine	carcinoma	p.R329K	Substitution - Missense	18:47848486-47848486,	PATHOGENIC	0.98633	25617745
SMAD2	6768	COSM6958777,	large_intestine	carcinoma	p.G301D	Substitution - Missense	18:47848570-47848570,	PATHOGENIC	0.98633	28481359
SMAD2	6768	COSM188749,	large_intestine	carcinoma	p.R321Q	Substitution - Missense	18:47848510-47848510,	PATHOGENIC	0.98633	28978093
SMAD2	6768	COSM188749,	large_intestine	carcinoma	p.R321Q	Substitution - Missense	18:47848510-47848510,	PATHOGENIC	0.98633	16828225
SMAD2	6768	COSM188749,	large_intestine	carcinoma	p.R321Q	Substitution - Missense	18:47848510-47848510,	PATHOGENIC	0.98633	28481359
SMAD2	6768	COSM188749,	large_intestine	carcinoma	p.R321Q	Substitution - Missense	18:47848510-47848510,	PATHOGENIC	0.98633	28481359
SMAD2	6768	COSM5610579,	skin	malignant_melanoma	p.G29S	Substitution - Missense	18:47896672-47896672,	PATHOGENIC	0.98575	26343386
SMAD2	6768	COSM6912779,	large_intestine	carcinoma	p.D300G	Substitution - Missense	18:47848573-47848573,	PATHOGENIC	0.98561	28481359
SMAD2	6768	COSM6964262,	large_intestine	carcinoma	p.Q284R	Substitution - Missense	18:47848621-47848621,	PATHOGENIC	0.98561	28481359
SMAD2	6768	COSM5576103,	stomach	carcinoma	p.T303A	Substitution - Missense	18:47848565-47848565,	PATHOGENIC	0.98561	26489445
SMAD2	6768	COSM6912779,	large_intestine	carcinoma	p.D300G	Substitution - Missense	18:47848573-47848573,	PATHOGENIC	0.98561	28481359
SMAD2	6768	COSM6983333,	NS	carcinoma	p.G122R	Substitution - Missense	18:47869399-47869399,	PATHOGENIC	0.98451	28481359
SMAD2	6768	COSM6932053,	central_nervous_system	glioma	p.G30E	Substitution - Missense	18:47896668-47896668,	PATHOGENIC	0.98406	28481359
SMAD2	6768	COSM6023908,	upper_aerodigestive_tract	carcinoma	p.D158V	Substitution - Missense	18:47869290-47869290,	PATHOGENIC	0.9833	23913824
SMAD2	6768	COSM5474005,	large_intestine	carcinoma	p.R57*	Substitution - Nonsense	18:47896588-47896588,	PATHOGENIC	0.98288	28481359
SMAD2	6768	COSM3378505,	large_intestine	carcinoma	p.R133C	Substitution - Missense	18:47869366-47869366,	PATHOGENIC	0.98271	8752209
SMAD2	6768	COSM3378505,	central_nervous_system	glioma	p.R133C	Substitution - Missense	18:47869366-47869366,	PATHOGENIC	0.98271	28481359
SMAD2	6768	COSM6913022,	lung	carcinoma	p.K53E	Substitution - Missense	18:47896600-47896600,	PATHOGENIC	0.98246	28481359
SMAD2	6768	COSM318050,	lung	carcinoma	p.S359N	Substitution - Missense	18:47845722-47845722,	PATHOGENIC	0.98225	22941188
SMAD2	6768	COSM177257,	large_intestine	carcinoma	p.D300N	Substitution - Missense	18:47848574-47848574,	PATHOGENIC	0.98176	23139211
SMAD2	6768	COSM6982836,	endometrium	carcinoma	p.G27*	Substitution - Nonsense	18:47896678-47896678,	PATHOGENIC	0.98137	28481359
SMAD2	6768	COSM6922669,	large_intestine	carcinoma	p.S269P	Substitution - Missense	18:47848667-47848667,	PATHOGENIC	0.98122	28481359
SMAD2	6768	COSM6922669,	large_intestine	carcinoma	p.S269P	Substitution - Missense	18:47848667-47848667,	PATHOGENIC	0.98122	28481359
SMAD2	6768	COSM6950488,	prostate	carcinoma	p.N320K	Substitution - Missense	18:47848512-47848512,	PATHOGENIC	0.97972	28481359
SMAD2	6768	COSM6919770,	central_nervous_system	glioma	p.D59N	Substitution - Missense	18:47896582-47896582,	PATHOGENIC	0.97831	28481359
SMAD2	6768	COSM6919770,	central_nervous_system	glioma	p.D59N	Substitution - Missense	18:47896582-47896582,	PATHOGENIC	0.97831	28481359
SMAD2	6768	COSM3970568,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.T72A	Substitution - Missense	18:47896543-47896543,	PATHOGENIC	0.97806	27683039
SMAD2	6768	COSM6916273,	lung	carcinoma	p.P221S	Substitution - Missense	18:47865128-47865128,	PATHOGENIC	0.97793	28481359
SMAD2	6768	COSM6970098,	large_intestine	carcinoma	p.C436W	Substitution - Missense	18:47841923-47841923,	PATHOGENIC	0.97518	28481359
SMAD2	6768	COSM6854778,	large_intestine	other	p.I146V	Substitution - Missense	18:47869327-47869327,	PATHOGENIC	0.97116	28524162
SMAD2	6768	COSM2878646,	large_intestine	carcinoma	p.G30R	Substitution - Missense	18:47896669-47896669,	PATHOGENIC	0.96947	28481359
SMAD2	6768	COSM2878646,	large_intestine	carcinoma	p.G30R	Substitution - Missense	18:47896669-47896669,	PATHOGENIC	0.96947	28481359
SMAD2	6768	COSM988690,	endometrium	carcinoma	p.E150K	Substitution - Missense	18:47869315-47869315,	PATHOGENIC	0.9688	28481359
SMAD2	6768	COSM6981445,	large_intestine	carcinoma	p.H166Q	Substitution - Missense	18:47869265-47869265,	PATHOGENIC	0.96837	28481359
SMAD2	6768	COSM6953421,	pancreas	carcinoma	p.H198D	Substitution - Missense	18:47868386-47868386,	PATHOGENIC	0.96734	28481359
SMAD2	6768	COSM6053933,	large_intestine	carcinoma	p.Y151C	Substitution - Missense	18:47869311-47869311,	PATHOGENIC	0.96703	11172591
SMAD2	6768	COSM6937358,	lung	carcinoma	p.I277M	Substitution - Missense	18:47848641-47848641,	PATHOGENIC	0.96472	28481359
SMAD2	6768	COSM6853801,	large_intestine	carcinoma	p.T99T	Substitution - coding silent	18:47870504-47870504,	PATHOGENIC	0.95819	28978093
SMAD2	6768	COSM6920450,	breast	carcinoma	p.R120*	Substitution - Nonsense	18:47869405-47869405,	PATHOGENIC	0.95513	28481359
SMAD2	6768	COSM6920450,	large_intestine	carcinoma	p.R120*	Substitution - Nonsense	18:47869405-47869405,	PATHOGENIC	0.95513	28481359
SMAD2	6768	COSM6949300,	urinary_tract	carcinoma	p.I355M	Substitution - Missense	18:47845733-47845733,	PATHOGENIC	0.95429	28481359
SMAD2	6768	COSM5575962,	stomach	carcinoma	p.R169G	Substitution - Missense	18:47869258-47869258,	PATHOGENIC	0.95413	26489445
SMAD2	6768	COSM988687,	large_intestine	carcinoma	p.R182*	Substitution - Nonsense	18:47868434-47868434,	PATHOGENIC	0.94896	28481359
SMAD2	6768	COSM988687,	prostate	carcinoma	p.R182*	Substitution - Nonsense	18:47868434-47868434,	PATHOGENIC	0.94896	28481359
SMAD2	6768	COSM988687,	large_intestine	carcinoma	p.R182*	Substitution - Nonsense	18:47868434-47868434,	PATHOGENIC	0.94896	28481359
SMAD2	6768	COSM988687,	large_intestine	carcinoma	p.R182*	Substitution - Nonsense	18:47868434-47868434,	PATHOGENIC	0.94896	23700467
SMAD2	6768	COSM988687,	large_intestine	carcinoma	p.R182*	Substitution - Nonsense	18:47868434-47868434,	PATHOGENIC	0.94896	28481359
SMAD2	6768	COSM988687,	large_intestine	carcinoma	p.R182*	Substitution - Nonsense	18:47868434-47868434,	PATHOGENIC	0.94896	28481359
SMAD2	6768	COSM988687,	large_intestine	carcinoma	p.R182*	Substitution - Nonsense	18:47868434-47868434,	PATHOGENIC	0.94896	29420467
SMAD2	6768	COSM988687,	large_intestine	carcinoma	p.R182*	Substitution - Nonsense	18:47868434-47868434,	PATHOGENIC	0.94896	23139211
SMAD2	6768	COSM4617847,	large_intestine	carcinoma	p.T184A	Substitution - Missense	18:47868428-47868428,	PATHOGENIC	0.94245	23139211
SMAD2	6768	COSM6959587,	large_intestine	carcinoma	p.C312W	Substitution - Missense	18:47848536-47848536,	PATHOGENIC	0.94197	28481359
SMAD2	6768	COSM6023527,	large_intestine	carcinoma	p.Y128*	Substitution - Nonsense	18:47869379-47869379,	PATHOGENIC	0.94164	23139211
SMAD2	6768	COSM6906714,	large_intestine	carcinoma	p.N163K	Substitution - Missense	18:47869274-47869274,	PATHOGENIC	0.94037	29420467
SMAD2	6768	COSM6934005,	skin	malignant_melanoma	p.S433R	Substitution - Missense	18:47841932-47841932,	PATHOGENIC	0.93542	28481359
SMAD2	6768	COSM4991161,	skin	carcinoma	p.Y165Y	Substitution - coding silent	18:47869268-47869268,	PATHOGENIC	0.93298	25589618
SMAD2	6768	COSM5610581,	skin	malignant_melanoma	p.E42E	Substitution - coding silent	18:47896631-47896631,	PATHOGENIC	0.89614	26343386
SMAD2	6768	COSM6023538,	large_intestine	carcinoma	p.Q213H	Substitution - Missense	18:47868339-47868339,	PATHOGENIC	0.87365	23139211
SMAD2	6768	COSM6023534,	large_intestine	carcinoma	p.N71N	Substitution - coding silent	18:47896544-47896544,	PATHOGENIC	0.86327	23139211
SMAD2	6768	COSM6949542,	breast	carcinoma	p.R330S	Substitution - Missense	18:47848482-47848482,	PATHOGENIC	0.8216	28481359
SMAD2	6768	COSM6854461,	large_intestine	carcinoma	p.?	Unknown	18:47868461-47868461,	PATHOGENIC	0.72943	28978093
SMAD2	6768	COSM2878647,	large_intestine	carcinoma	p.P9P	Substitution - coding silent	18:47896730-47896730,	NEUTRAL	0.05927	23139211
SMAD2	6768	COSM6023921, COSM6023922,	cervix	carcinoma	p.G122fs*15, p.R428fs*4	Deletion - Frameshift, Insertion - Frameshift	18:47841947-47841947, 18:47869399-47869400,	Info_not_available	Info_not_available	12894231
SMAD2	6768	COSM32452,	large_intestine	carcinoma	p.R462fs*>4	Deletion - Frameshift	18:47841840-47841846,	Info_not_available	Info_not_available	16959974
SMAD2	6768	COSM5991624,	large_intestine	carcinoma	p.R321*	Substitution - Nonsense	Info_not_available	Info_not_available	Info_not_available	22014273
SMAD2	6768	COSM6023529,	large_intestine	carcinoma	p.S47fs*3	Deletion - Frameshift	18:47896618-47896618,	Info_not_available	Info_not_available	23139211
SMAD2	6768	COSM6845089,	ovary	carcinoma	p.L249V	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	24220311
SMAD2	6768	COSM6024161,	NS	carcinoma	p.R182*	Substitution - Nonsense	Info_not_available	Info_not_available	Info_not_available	26182302
SMAD2	6768	COSM5977588,	central_nervous_system	glioma	p.P246fs*32	Deletion - Frameshift	18:47851321-47851321,	Info_not_available	Info_not_available	26487540
SMAD2	6768	COSM2878632, COSM6920395, COSM6921987, COSM6925271, COSM6940066, COSM6940766, COSM6948623, COSM6959260, COSM6961562, COSM6965240, COSM6965242, COSM6968067, COSM6972753, COSM6974289, COSM6975986, COSM6986551, COSM6987581,	large_intestine, liver, lung, ovary, prostate, small_intestine	carcinoma	p.?, p.A272fs*10, p.D158fs*2, p.E288_T289ins*, p.F273fs*2, p.K157fs*6, p.L449fs*5, p.L87fs*20, p.P221fs*12, p.R285I, p.S467fs?, p.T197fs*8, p.T298fs*1, p.V160fs*3, p.V431fs*1, p.W437_I438insR, p.Y268fs*9	Deletion - Frameshift, Insertion - Frameshift, Insertion - In frame, Substitution - Missense, Unknown	18:47841832-47841832, 18:47841885-47841885, 18:47841918-47841919, 18:47841940-47841940, 18:47848578-47848581, 18:47848608-47848609, 18:47848617-47848618, 18:47848634-47848653, 18:47848658-47848659, 18:47848667-47848670, 18:47865128-47865128, 18:47868389-47868390, 18:47869286-47869286, 18:47869292-47869293, 18:47869293-47869293, 18:47870543-47870544,	Info_not_available	Info_not_available	28481359
SMAD2	6768	COSM6023911,	lung	carcinoma	p.T434_C436del	Deletion - In frame	18:47841923-47841931,	Info_not_available	Info_not_available	8971158