Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
RAF1	9829	COSM6946112,	large_intestine	carcinoma	p.I330S	Substitution - Missense	3:12600153-12600153,	PATHOGENIC	0.99861	28481359
RAF1	9829	COSM1037805,	lung	carcinoma	p.R73Q	Substitution - Missense	3:12612052-12612052,	PATHOGENIC	0.99805	28481359
RAF1	9829	COSM6911493,	lung	carcinoma	p.S289L	Substitution - Missense	3:12600276-12600276,	PATHOGENIC	0.99753	28481359
RAF1	9829	COSM6954947,	large_intestine	carcinoma	p.Q386*	Substitution - Nonsense	3:12591745-12591745,	PATHOGENIC	0.99647	28481359
RAF1	9829	COSM1418539,	skin	malignant_melanoma	p.A389V	Substitution - Missense	3:12591735-12591735,	PATHOGENIC	0.99647	26343386
RAF1	9829	COSM6909978,	lung	carcinoma	p.S359C	Substitution - Missense	3:12599723-12599723,	PATHOGENIC	0.99614	28481359
RAF1	9829	COSM6976077,	breast	carcinoma	p.M76I	Substitution - Missense	3:12612042-12612042,	PATHOGENIC	0.99493	28481359
RAF1	9829	COSM6922356,	breast	carcinoma	p.R89T	Substitution - Missense	3:12612004-12612004,	PATHOGENIC	0.99487	28481359
RAF1	9829	COSM5417418,	lung	carcinoid-endocrine_tumour	p.R391W	Substitution - Missense	3:12591730-12591730,	PATHOGENIC	0.99471	28481359
RAF1	9829	COSM5417418,	skin	malignant_melanoma	p.R391W	Substitution - Missense	3:12591730-12591730,	PATHOGENIC	0.99471	28481359
RAF1	9829	COSM1037803,	lung	carcinoma	p.R191I	Substitution - Missense	3:12608775-12608775,	PATHOGENIC	0.99188	28481359
RAF1	9829	COSM6945471,	NS	malignant_melanoma	p.G361R	Substitution - Missense	3:12599718-12599718,	PATHOGENIC	0.99174	28481359
RAF1	9829	COSM6931642,	central_nervous_system	glioma	p.G366D	Substitution - Missense	3:12599702-12599702,	PATHOGENIC	0.99174	28481359
RAF1	9829	COSM48728,	lung	carcinoma	p.A319S	Substitution - Missense	3:12600187-12600187,	PATHOGENIC	0.99169	18948947
RAF1	9829	COSM4720028,	endometrium	carcinoma	p.G370R	Substitution - Missense	3:12599691-12599691,	PATHOGENIC	0.99131	28481359
RAF1	9829	COSM6914900,	endometrium	carcinoma	p.K365R	Substitution - Missense	3:12599705-12599705,	PATHOGENIC	0.99089	28481359
RAF1	9829	COSM6985300,	soft_tissue	malignant_fibrous_histiocytoma-pleomorphic_sarcoma	p.A319T	Substitution - Missense	3:12600187-12600187,	PATHOGENIC	0.98837	28481359
RAF1	9829	COSM6935192,	endometrium	carcinoma	p.Y534D	Substitution - Missense	3:12585190-12585190,	PATHOGENIC	0.98835	28481359
RAF1	9829	COSM5413434,	skin	malignant_melanoma	p.T491I	Substitution - Missense	3:12585745-12585745,	PATHOGENIC	0.98831	28481359
RAF1	9829	COSM6966506,	oesophagus	carcinoma	p.V531F	Substitution - Missense	3:12585199-12585199,	PATHOGENIC	0.98591	28481359
RAF1	9829	COSM6912466,	large_intestine	carcinoma	p.G205R	Substitution - Missense	3:12606268-12606268,	PATHOGENIC	0.98587	28481359
RAF1	9829	COSM6975761,	skin	carcinoma	p.A620D	Substitution - Missense	3:12584602-12584602,	PATHOGENIC	0.98478	28481359
RAF1	9829	COSM6762049,	large_intestine	carcinoma	p.R164Q	Substitution - Missense	3:12608856-12608856,	PATHOGENIC	0.98463	28481359
RAF1	9829	COSM6982145,	NS	carcinoma	p.R563Q	Substitution - Missense	3:12584962-12584962,	PATHOGENIC	0.98451	28481359
RAF1	9829	COSM6975896,	large_intestine	carcinoma	p.L86F	Substitution - Missense	3:12612014-12612014,	PATHOGENIC	0.98357	28481359
RAF1	9829	COSM174195,	pancreas	carcinoma	p.V537I	Substitution - Missense	3:12585181-12585181,	PATHOGENIC	0.98302	28481359
RAF1	9829	COSM6923697,	large_intestine	carcinoma	p.K591T	Substitution - Missense	3:12584878-12584878,	PATHOGENIC	0.98249	28481359
RAF1	9829	COSM6959837,	urinary_tract	carcinoma	p.Q501*	Substitution - Nonsense	3:12585716-12585716,	PATHOGENIC	0.98154	28481359
RAF1	9829	COSM6980374,	lung	carcinoma	p.S295C	Substitution - Missense	3:12600259-12600259,	PATHOGENIC	0.9785	28481359
RAF1	9829	COSM6980374,	lung	carcinoma	p.S295C	Substitution - Missense	3:12600259-12600259,	PATHOGENIC	0.9785	28481359
RAF1	9829	COSM6958588,	pancreas	carcinoma	p.Y458F	Substitution - Missense	3:12587635-12587635,	PATHOGENIC	0.97828	28481359
RAF1	9829	COSM6931326,	skin	malignant_melanoma	p.S199F	Substitution - Missense	3:12606285-12606285,	PATHOGENIC	0.97792	28481359
RAF1	9829	COSM6965338,	skin	malignant_melanoma	p.G485R	Substitution - Missense	3:12585764-12585764,	PATHOGENIC	0.97769	28481359
RAF1	9829	COSM6965338,	skin	malignant_melanoma	p.G485R	Substitution - Missense	3:12585764-12585764,	PATHOGENIC	0.97769	28481359
RAF1	9829	COSM6935877,	lung	carcinoma	p.?	Unknown	3:12587590-12587590,	PATHOGENIC	0.97752	28481359
RAF1	9829	COSM6977234,	skin	malignant_melanoma	p.R467K	Substitution - Missense	3:12587608-12587608,	PATHOGENIC	0.97752	28481359
RAF1	9829	COSM1223036,	urinary_tract	carcinoma	p.R282Q	Substitution - Missense	3:12600405-12600405,	PATHOGENIC	0.97528	28481359
RAF1	9829	COSM1223036,	large_intestine	carcinoma	p.R282Q	Substitution - Missense	3:12600405-12600405,	PATHOGENIC	0.97528	28481359
RAF1	9829	COSM6984350,	endometrium	carcinoma	p.A119V	Substitution - Missense	3:12609300-12609300,	PATHOGENIC	0.97523	28481359
RAF1	9829	COSM6925993,	skin	malignant_melanoma	p.H402N	Substitution - Missense	3:12590964-12590964,	PATHOGENIC	0.97299	28481359
RAF1	9829	COSM6969450,	upper_aerodigestive_tract	carcinoma	p.*649Y	Nonstop extension	3:12584514-12584514,	PATHOGENIC	0.97206	28481359
RAF1	9829	COSM6986288,	soft_tissue	desmoplastic_small_round_cell_tumour	p.I122T	Substitution - Missense	3:12609291-12609291,	PATHOGENIC	0.97148	28481359
RAF1	9829	COSM6909958,	breast	carcinoma	p.L476V	Substitution - Missense	3:12585791-12585791,	PATHOGENIC	0.97088	28481359
RAF1	9829	COSM6936562,	skin	malignant_melanoma	p.L209P	Substitution - Missense	3:12606255-12606255,	PATHOGENIC	0.96929	28481359
RAF1	9829	COSM6956639,	breast	carcinoma	p.R143W	Substitution - Missense	3:12608920-12608920,	PATHOGENIC	0.96921	28481359
RAF1	9829	COSM6952120,	large_intestine	carcinoma	p.D153Y	Substitution - Missense	3:12608890-12608890,	PATHOGENIC	0.96735	28481359
RAF1	9829	COSM99111,	stomach	carcinoma	p.R495H	Substitution - Missense	3:12585733-12585733,	PATHOGENIC	0.96684	21097718
RAF1	9829	COSM6942398,	lung	carcinoma	p.V312E	Substitution - Missense	3:12600207-12600207,	PATHOGENIC	0.96619	28481359
RAF1	9829	COSM6942398,	lung	carcinoma	p.V312E	Substitution - Missense	3:12600207-12600207,	PATHOGENIC	0.96619	28481359
RAF1	9829	COSM6958346,	stomach	carcinoma	p.S291L	Substitution - Missense	3:12600270-12600270,	PATHOGENIC	0.96565	28481359
RAF1	9829	COSM6958346,	stomach	carcinoma	p.S291L	Substitution - Missense	3:12600270-12600270,	PATHOGENIC	0.96565	28481359
RAF1	9829	COSM97875,	breast	carcinoma	p.L613V	Substitution - Missense	3:12584624-12584624,	PATHOGENIC	0.96434	28481359
RAF1	9829	COSM6921808,	NS	carcinoma	p.N198D	Substitution - Missense	3:12606289-12606289,	PATHOGENIC	0.96305	28481359
RAF1	9829	COSM6958143,	pancreas	carcinoid-endocrine_tumour	p.S204T	Substitution - Missense	3:12606270-12606270,	PATHOGENIC	0.9616	28481359
RAF1	9829	COSM6928405,	urinary_tract	carcinoma	p.E174K	Substitution - Missense	3:12608827-12608827,	PATHOGENIC	0.961	28481359
RAF1	9829	COSM6958171,	central_nervous_system	glioma	p.S188N	Substitution - Missense	3:12608784-12608784,	PATHOGENIC	0.95898	28481359
RAF1	9829	COSM6946528,	lung	carcinoma	p.H175R	Substitution - Missense	3:12608823-12608823,	PATHOGENIC	0.95677	28481359
RAF1	9829	COSM6915985,	endometrium	carcinoma	p.L603M	Substitution - Missense	3:12584654-12584654,	PATHOGENIC	0.95511	28481359
RAF1	9829	COSM246936,	skin	carcinoma	p.R215C	Substitution - Missense	3:12606238-12606238,	PATHOGENIC	0.95482	28481359
RAF1	9829	COSM6940213,	breast	carcinoma	p.F443L	Substitution - Missense	3:12590839-12590839,	PATHOGENIC	0.95155	28481359
RAF1	9829	COSM6986272,	large_intestine	carcinoma	p.L48F	Substitution - Missense	3:12618580-12618580,	PATHOGENIC	0.94957	28481359
RAF1	9829	COSM6762057,	large_intestine	carcinoma	p.R282*	Substitution - Nonsense	3:12600406-12600406,	PATHOGENIC	0.94879	28481359
RAF1	9829	COSM6923927,	central_nervous_system	glioma	p.L510F	Substitution - Missense	3:12585689-12585689,	PATHOGENIC	0.94614	28481359
RAF1	9829	COSM308576,	large_intestine	carcinoma	p.P261R	Substitution - Missense	3:12604188-12604188,	PATHOGENIC	0.94155	28481359
RAF1	9829	COSM308576,	biliary_tract	carcinoma	p.P261R	Substitution - Missense	3:12604188-12604188,	PATHOGENIC	0.94155	28481359
RAF1	9829	COSM5719965,	lung	carcinoma	p.S259C	Substitution - Missense	3:12604194-12604194,	PATHOGENIC	0.94155	28481359
RAF1	9829	COSM308576,	urinary_tract	carcinoma	p.P261R	Substitution - Missense	3:12604188-12604188,	PATHOGENIC	0.94155	28481359
RAF1	9829	COSM6973395,	lung	carcinoma	p.T260K	Substitution - Missense	3:12604191-12604191,	PATHOGENIC	0.93934	28481359
RAF1	9829	COSM4991830,	skin	carcinoma	p.P261T	Substitution - Missense	3:12604189-12604189,	PATHOGENIC	0.93934	25589618
RAF1	9829	COSM20741,	ovary	carcinoma	p.S259A	Substitution - Missense	3:12604195-12604195,	PATHOGENIC	0.93296	Info_not_available
RAF1	9829	COSM20741,	ovary	carcinoma	p.S259A	Substitution - Missense	3:12604195-12604195,	PATHOGENIC	0.93296	Info_not_available
RAF1	9829	COSM4991828,	skin	carcinoma	p.P261S	Substitution - Missense	3:12604189-12604189,	PATHOGENIC	0.93196	25589618
RAF1	9829	COSM181063,	small_intestine	carcinoma	p.S257L	Substitution - Missense	3:12604200-12604200,	PATHOGENIC	0.93196	28481359
RAF1	9829	COSM181063,	stomach	carcinoma	p.S257L	Substitution - Missense	3:12604200-12604200,	PATHOGENIC	0.93196	28481359
RAF1	9829	COSM181063,	large_intestine	carcinoma	p.S257L	Substitution - Missense	3:12604200-12604200,	PATHOGENIC	0.93196	28481359
RAF1	9829	COSM1536534,	small_intestine	carcinoma	p.S259F	Substitution - Missense	3:12604194-12604194,	PATHOGENIC	0.93196	28481359
RAF1	9829	COSM4991828,	skin	carcinoma	p.P261S	Substitution - Missense	3:12604189-12604189,	PATHOGENIC	0.93196	25589618
RAF1	9829	COSM181063,	large_intestine	carcinoma	p.S257L	Substitution - Missense	3:12604200-12604200,	PATHOGENIC	0.93196	28481359
RAF1	9829	COSM1536534,	skin	malignant_melanoma	p.S259F	Substitution - Missense	3:12604194-12604194,	PATHOGENIC	0.93196	28481359
RAF1	9829	COSM1536534,	urinary_tract	carcinoma	p.S259F	Substitution - Missense	3:12604194-12604194,	PATHOGENIC	0.93196	28481359
RAF1	9829	COSM1536534,	skin	carcinoma	p.S259F	Substitution - Missense	3:12604194-12604194,	PATHOGENIC	0.93196	28481359
RAF1	9829	COSM1536534,	NS	malignant_melanoma	p.S259F	Substitution - Missense	3:12604194-12604194,	PATHOGENIC	0.93196	28481359
RAF1	9829	COSM181063,	skin	malignant_melanoma	p.S257L	Substitution - Missense	3:12604200-12604200,	PATHOGENIC	0.93196	28481359
RAF1	9829	COSM181063,	large_intestine	carcinoma	p.S257L	Substitution - Missense	3:12604200-12604200,	PATHOGENIC	0.93196	28481359
RAF1	9829	COSM181063,	urinary_tract	carcinoma	p.S257L	Substitution - Missense	3:12604200-12604200,	PATHOGENIC	0.93196	28481359
RAF1	9829	COSM181063,	NS	malignant_melanoma	p.S257L	Substitution - Missense	3:12604200-12604200,	PATHOGENIC	0.93196	28481359
RAF1	9829	COSM181063,	large_intestine	carcinoma	p.S257L	Substitution - Missense	3:12604200-12604200,	PATHOGENIC	0.93196	28481359
RAF1	9829	COSM6933590,	lung	carcinoma	p.T260I	Substitution - Missense	3:12604191-12604191,	PATHOGENIC	0.93196	28481359
RAF1	9829	COSM181063,	lung	carcinoma	p.S257L	Substitution - Missense	3:12604200-12604200,	PATHOGENIC	0.93196	28481359
RAF1	9829	COSM181063,	vulva	carcinoma	p.S257L	Substitution - Missense	3:12604200-12604200,	PATHOGENIC	0.93196	28481359
RAF1	9829	COSM181063,	lung	carcinoma	p.S257L	Substitution - Missense	3:12604200-12604200,	PATHOGENIC	0.93196	28481359
RAF1	9829	COSM1418555,	biliary_tract	carcinoma	p.S259P	Substitution - Missense	3:12604195-12604195,	PATHOGENIC	0.93016	28481359
RAF1	9829	COSM1418555,	lung	carcinoma	p.S259P	Substitution - Missense	3:12604195-12604195,	PATHOGENIC	0.93016	28481359
RAF1	9829	COSM1418555,	stomach	carcinoma	p.S259P	Substitution - Missense	3:12604195-12604195,	PATHOGENIC	0.93016	26489445
RAF1	9829	COSM1037798,	large_intestine	carcinoma	p.R318W	Substitution - Missense	3:12600190-12600190,	PATHOGENIC	0.91455	28481359
RAF1	9829	COSM6956252,	large_intestine	carcinoma	p.L160F	Substitution - Missense	3:12608869-12608869,	PATHOGENIC	0.91282	28481359
RAF1	9829	COSM6906362,	soft_tissue	liposarcoma	p.D381N	Substitution - Missense	3:12591760-12591760,	PATHOGENIC	0.91013	28481359
RAF1	9829	COSM6952986,	large_intestine	carcinoma	p.V33L	Substitution - Missense	3:12618625-12618625,	PATHOGENIC	0.90496	28481359
RAF1	9829	COSM6955596,	breast	carcinoma	p.D273Y	Substitution - Missense	3:12604153-12604153,	PATHOGENIC	0.89909	28481359
RAF1	9829	COSM6923080,	soft_tissue	gastrointestinal_stromal_tumour	p.N140K	Substitution - Missense	3:12609236-12609236,	PATHOGENIC	0.8977	28481359
RAF1	9829	COSM6927962,	skin	malignant_melanoma	p.E104D	Substitution - Missense	3:12611958-12611958,	PATHOGENIC	0.89439	28481359
RAF1	9829	COSM6969047,	central_nervous_system	glioma	p.A208T	Substitution - Missense	3:12606259-12606259,	PATHOGENIC	0.88063	28481359
RAF1	9829	COSM6986917,	lung	carcinoma	p.T200A	Substitution - Missense	3:12606283-12606283,	PATHOGENIC	0.87522	28481359
RAF1	9829	COSM6945224,	urinary_tract	carcinoma	p.L406M	Substitution - Missense	3:12590952-12590952,	PATHOGENIC	0.85399	28481359
RAF1	9829	COSM6983188,	upper_aerodigestive_tract	carcinoma	p.I154M	Substitution - Missense	3:12608885-12608885,	PATHOGENIC	0.81392	28481359
RAF1	9829	COSM6973276,	urinary_tract	carcinoma	p.D129E	Substitution - Missense	3:12609269-12609269,	PATHOGENIC	0.78129	28481359
RAF1	9829	COSM5610447,	skin	malignant_melanoma	p.F130F	Substitution - coding silent	3:12609266-12609266,	PATHOGENIC	0.76867	26343386
RAF1	9829	COSM5577697,	skin	malignant_melanoma	p.S508S	Substitution - coding silent	3:12585693-12585693,	NEUTRAL	0.47519	26343386
RAF1	9829	COSM6922111, COSM6925242, COSM6942918, COSM6959295, COSM6968536, COSM6969309,	NS, breast, large_intestine, lung, skin, upper_aerodigestive_tract	carcinoma, malignant_melanoma	p.K365fs*21, p.L48_S55delLTDPSKTS, p.N262K, p.P51S, p.S259delS, p.S605_S612delSIELLQHS	Deletion - In frame, Insertion - Frameshift, Substitution - Missense	3:12584625-12584648, 3:12599706-12599707, 3:12604184-12604184, 3:12604194-12604196, 3:12618557-12618580, 3:12618571-12618571,	Info_not_available	0.53423, .55687, Info_not_available	28481359