Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
PTPRO	9678	COSM142749,	skin	malignant_melanoma	p.E482K	Substitution - Missense	12:15508747-15508747,	PATHOGENIC	0.99784	19074898
PTPRO	9678	COSM142752,	skin	malignant_melanoma	p.D1075N	Substitution - Missense	12:15581769-15581769,	PATHOGENIC	0.99737	19074898
PTPRO	9678	COSM109418,	skin	malignant_melanoma	p.E854K	Substitution - Missense	12:15557456-15557456,	PATHOGENIC	0.98589	19074898
PTPRO	9678	COSM314601,	lung	carcinoma	p.K937R	Substitution - Missense	12:15569479-15569479,	PATHOGENIC	0.98459	22941188
PTPRO	9678	COSM107474,	skin	malignant_melanoma	p.S280Y	Substitution - Missense	12:15501797-15501797,	PATHOGENIC	0.9708	19074898
PTPRO	9678	COSM107474,	skin	malignant_melanoma	p.S280Y	Substitution - Missense	12:15501797-15501797,	PATHOGENIC	0.9708	21499247
PTPRO	9678	COSM142753,	skin	malignant_melanoma	p.S1169L	Substitution - Missense	12:15589550-15589550,	PATHOGENIC	0.90824	19074898
PTPRO	9678	COSM108504,	skin	malignant_melanoma	p.R1122*	Substitution - Nonsense	12:15587005-15587005,	PATHOGENIC	0.89433	19074898
PTPRO	9678	COSM107957,	skin	malignant_melanoma	p.F938L	Substitution - Missense	12:15569483-15569483,	PATHOGENIC	0.88879	19074898
PTPRO	9678	COSM142750,	skin	malignant_melanoma	p.Q768*	Substitution - Nonsense	12:15546706-15546706,	PATHOGENIC	0.87103	19074898
PTPRO	9678	COSM142751,	skin	malignant_melanoma	p.S774F	Substitution - Missense	12:15549110-15549110,	PATHOGENIC	0.8638	19074898