Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
PTPN13	9646	COSM5711936,	large_intestine	carcinoma	p.M2448I	Substitution - Missense	4:86811075-86811075,	PATHOGENIC	0.99679	15155950
PTPN13	9646	COSM276948,	large_intestine	carcinoma	p.R2343*	Substitution - Nonsense	4:86807826-86807826,	PATHOGENIC	0.99553	15155950
PTPN13	9646	COSM142773,	skin	malignant_melanoma	p.Q2467L	Substitution - Missense	4:86814478-86814478,	PATHOGENIC	0.99441	19074898
PTPN13	9646	COSM2956778,	prostate	carcinoma	p.A703T	Substitution - Missense	4:86734831-86734831,	PATHOGENIC	0.99228	20579941
PTPN13	9646	COSM6022971,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R1838Q	Substitution - Missense	4:86774521-86774521,	PATHOGENIC	0.98921	27997762
PTPN13	9646	COSM6022971,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R1838Q	Substitution - Missense	4:86774521-86774521,	PATHOGENIC	0.98921	27997762
PTPN13	9646	COSM5019548,	soft_tissue	haemangioblastoma	p.H865R	Substitution - Missense	4:86745072-86745072,	PATHOGENIC	0.98912	25589003
PTPN13	9646	COSM5019548,	soft_tissue	haemangioblastoma	p.H865R	Substitution - Missense	4:86745072-86745072,	PATHOGENIC	0.98912	25589003
PTPN13	9646	COSM4343468,	large_intestine	carcinoma	p.M2312T	Substitution - Missense	4:86807734-86807734,	PATHOGENIC	0.9842	15155950
PTPN13	9646	COSM5020556,	soft_tissue	haemangioblastoma	p.T1383M	Substitution - Missense	4:86764723-86764723,	PATHOGENIC	0.9826	25589003
PTPN13	9646	COSM5711938,	large_intestine	carcinoma	p.D2159H	Substitution - Missense	4:86799159-86799159,	PATHOGENIC	0.98007	15155950
PTPN13	9646	COSM5977700,	central_nervous_system	glioma	p.A373S	Substitution - Missense	4:86701723-86701723,	PATHOGENIC	0.97762	26487540
PTPN13	9646	COSM5977641,	central_nervous_system	glioma	p.T562I	Substitution - Missense	4:86732593-86732593,	PATHOGENIC	0.97699	26487540
PTPN13	9646	COSM142769,	skin	malignant_melanoma	p.R1522*	Substitution - Nonsense	4:86769828-86769828,	PATHOGENIC	0.96974	19074898
PTPN13	9646	COSM1716814,	lung	carcinoma	p.L90V	Substitution - Missense	4:86672517-86672517,	PATHOGENIC	0.96875	22245727
PTPN13	9646	COSM249501,	kidney	carcinoma	p.Y1914F	Substitution - Missense	4:86775487-86775487,	PATHOGENIC	0.96493	22138691
PTPN13	9646	COSM6005698,	prostate	carcinoma	p.T791A	Substitution - Missense	4:86741700-86741700,	PATHOGENIC	0.96179	20579941
PTPN13	9646	COSM5711939,	large_intestine	carcinoma	p.Y2284*	Substitution - Nonsense	4:86807651-86807651,	PATHOGENIC	0.95631	15155950
PTPN13	9646	COSM5711909,	large_intestine	carcinoma	p.A529D	Substitution - Missense	4:86722412-86722412,	PATHOGENIC	0.95387	15155950
PTPN13	9646	COSM1716816,	lung	carcinoma	p.R482Q	Substitution - Missense	4:86722271-86722271,	PATHOGENIC	0.95104	22245727
PTPN13	9646	COSM2956795,	large_intestine	carcinoma	p.E952*	Substitution - Nonsense	4:86750673-86750673,	PATHOGENIC	0.93622	15155950
PTPN13	9646	COSM5711940,	large_intestine	carcinoma	p.I2463V	Substitution - Missense	4:86814465-86814465,	PATHOGENIC	0.92667	15155950
PTPN13	9646	COSM5435724,	large_intestine	carcinoma	p.E2479D	Substitution - Missense	4:86814515-86814515,	PATHOGENIC	0.92299	15155950
PTPN13	9646	COSM5019859,	soft_tissue	haemangioblastoma	p.A732T	Substitution - Missense	4:86735636-86735636,	PATHOGENIC	0.9145	25589003
PTPN13	9646	COSM142770,	skin	malignant_melanoma	p.N1525S	Substitution - Missense	4:86769838-86769838,	PATHOGENIC	0.90476	19074898
PTPN13	9646	COSM1431559,	large_intestine	carcinoma	p.R2210W	Substitution - Missense	4:86803816-86803816,	PATHOGENIC	0.88899	15155950
PTPN13	9646	COSM3736359,	soft_tissue	haemangioblastoma	p.R2210Q	Substitution - Missense	4:86803817-86803817,	PATHOGENIC	0.81314	25589003
PTPN13	9646	COSM3736359,	soft_tissue	haemangioblastoma	p.R2210Q	Substitution - Missense	4:86803817-86803817,	PATHOGENIC	0.81314	25589003
PTPN13	9646	COSM4718912,	large_intestine	carcinoma	p.R380*	Substitution - Nonsense	4:86701744-86701744,	PATHOGENIC	0.75429	15155950
PTPN13	9646	COSM5026184,	breast	carcinoma	p.S437L	Substitution - Missense	4:86717042-86717042,	PATHOGENIC	0.71313	22722193
PTPN13	9646	COSM142771,	skin	malignant_melanoma	p.I1527M	Substitution - Missense	4:86769845-86769845,	NEUTRAL	0.27022	19074898
PTPN13	9646	COSM142771,	soft_tissue	haemangioblastoma	p.I1527M	Substitution - Missense	4:86769845-86769845,	NEUTRAL	0.27022	25589003
PTPN13	9646	COSM142771,	soft_tissue	haemangioblastoma	p.I1527M	Substitution - Missense	4:86769845-86769845,	NEUTRAL	0.27022	25589003
PTPN13	9646	COSM5711941,	large_intestine	carcinoma	p.G1481C	Substitution - Missense	4:86767913-86767913,	NEUTRAL	0.09624	15155950
PTPN13	9646	COSM5047142,	oesophagus	carcinoma	p.Q2487*	Substitution - Nonsense	4:86814537-86814537,	NEUTRAL	0.0852	24686850
PTPN13	9646	COSM142772,	skin	malignant_melanoma	p.S1754L	Substitution - Missense	4:86772855-86772855,	NEUTRAL	0.06077	19074898
PTPN13	9646	COSM5711937,	large_intestine	carcinoma	p.K2136N	Substitution - Missense	4:86796921-86796921,	NEUTRAL	0.0428	15155950
PTPN13	9646	COSM1717792,	stomach	carcinoma	p.K285fs*45	Deletion - Frameshift	4:86701461-86701461,	Info_not_available	Info_not_available	18038312
PTPN13	9646	COSM26618,	kidney	renal_cell_carcinoma	p.L1443fs*21	Insertion - Frameshift	4:86766498-86766499,	Info_not_available	Info_not_available	20054297
PTPN13	9646	COSM1058489, COSM1717792, COSM2956720, COSM5711907, COSM5711908, COSM5711942,	large_intestine	carcinoma	p.H2Q, p.K285fs*45, p.P286fs*6, p.Q1696*, p.R402*, p.S443N	Deletion - Frameshift, Insertion - Frameshift, Substitution - Missense, Substitution - Nonsense	4:86635262-86635262, 4:86701461-86701461, 4:86701461-86701462, 4:86716538-86716538, 4:86717060-86717060, 4:86771438-86771438,	Info_not_available	0.57666, .62736, .65118, .65814, Info_not_available	15155950
PTPN13	9646	COSM1716815,	lung	carcinoma	p.N270H	Substitution - Missense	4:86701414-86701414,	Info_not_available	0.54166	22245727