Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
PPP6C	9323	COSM1686099,	skin	carcinoma	p.L305F	Substitution - Missense	9:125149678-125149678,	PATHOGENIC	0.99496	28481359
PPP6C	9323	COSM1686099,	skin	malignant_melanoma	p.L305F	Substitution - Missense	9:125149678-125149678,	PATHOGENIC	0.99496	26343386
PPP6C	9323	COSM1167883,	NS	carcinoma	p.P186S	Substitution - Missense	9:125153646-125153646,	PATHOGENIC	0.99029	28481359
PPP6C	9323	COSM6967994,	skin	malignant_melanoma	p.P199S	Substitution - Missense	9:125153607-125153607,	PATHOGENIC	0.99029	28481359
PPP6C	9323	COSM6969063,	central_nervous_system	glioma	p.S197L	Substitution - Missense	9:125153612-125153612,	PATHOGENIC	0.99029	28481359
PPP6C	9323	COSM6937816,	urinary_tract	carcinoma	p.R293H	Substitution - Missense	9:125149713-125149713,	PATHOGENIC	0.98901	28481359
PPP6C	9323	COSM6936606,	skin	malignant_melanoma	p.G124R	Substitution - Missense	9:125158250-125158250,	PATHOGENIC	0.9878	28481359
PPP6C	9323	COSM6973241,	small_intestine	carcinoma	p.F93S	Substitution - Missense	9:125158342-125158342,	PATHOGENIC	0.98738	28481359
PPP6C	9323	COSM6975017,	central_nervous_system	glioma	p.T221I	Substitution - Missense	9:125153540-125153540,	PATHOGENIC	0.98635	28481359
PPP6C	9323	COSM3432859,	eye	malignant_melanoma	p.R177*	Substitution - Nonsense	9:125153673-125153673,	PATHOGENIC	0.98621	28481359
PPP6C	9323	COSM6972228,	NS	carcinoma	p.G213C	Substitution - Missense	9:125153565-125153565,	PATHOGENIC	0.98582	28481359
PPP6C	9323	COSM6906810,	breast	carcinoma	p.S45*	Substitution - Nonsense	9:125171122-125171122,	PATHOGENIC	0.98549	28481359
PPP6C	9323	COSM6906810,	breast	carcinoma	p.S45*	Substitution - Nonsense	9:125171122-125171122,	PATHOGENIC	0.98549	29420467
PPP6C	9323	COSM221754,	skin	malignant_melanoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	28481359
PPP6C	9323	COSM221754,	skin	malignant_melanoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	28356599
PPP6C	9323	COSM221754,	skin	malignant_melanoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	28356599
PPP6C	9323	COSM221754,	skin	malignant_melanoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	28481359
PPP6C	9323	COSM221754,	skin	malignant_melanoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	26343386
PPP6C	9323	COSM221754,	skin	carcinoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	28481359
PPP6C	9323	COSM221754,	skin	malignant_melanoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	28481359
PPP6C	9323	COSM221754,	skin	malignant_melanoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	28356599
PPP6C	9323	COSM221754,	NS	malignant_melanoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	28481359
PPP6C	9323	COSM221754,	NS	malignant_melanoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	24336958
PPP6C	9323	COSM6952255,	large_intestine	carcinoma	p.E281*	Substitution - Nonsense	9:125149750-125149750,	PATHOGENIC	0.98407	28481359
PPP6C	9323	COSM6958337,	soft_tissue	desmoplastic_small_round_cell_tumour	p.W256*	Substitution - Nonsense	9:125149823-125149823,	PATHOGENIC	0.98351	28481359
PPP6C	9323	COSM228125,	skin	malignant_melanoma	p.S270L	Substitution - Missense	9:125149782-125149782,	PATHOGENIC	0.98267	28481359
PPP6C	9323	COSM228125,	salivary_gland	carcinoma	p.S270L	Substitution - Missense	9:125149782-125149782,	PATHOGENIC	0.98267	28481359
PPP6C	9323	COSM1105142,	skin	malignant_melanoma	p.D53N	Substitution - Missense	9:125171099-125171099,	PATHOGENIC	0.98258	28481359
PPP6C	9323	COSM177866,	endometrium	carcinoma	p.E180K	Substitution - Missense	9:125153664-125153664,	PATHOGENIC	0.98154	28481359
PPP6C	9323	COSM6965507,	urinary_tract	carcinoma	p.D203N	Substitution - Missense	9:125153595-125153595,	PATHOGENIC	0.98154	28481359
PPP6C	9323	COSM177866,	endometrium	carcinoma	p.E180K	Substitution - Missense	9:125153664-125153664,	PATHOGENIC	0.98154	25233892
PPP6C	9323	COSM5609973,	skin	malignant_melanoma	p.G211E	Substitution - Missense	9:125153570-125153570,	PATHOGENIC	0.98154	26343386
PPP6C	9323	COSM6961909,	pancreas	carcinoid-endocrine_tumour	p.G211R	Substitution - Missense	9:125153571-125153571,	PATHOGENIC	0.98154	28481359
PPP6C	9323	COSM6928662,	cervix	carcinoma	p.D174N	Substitution - Missense	9:125153682-125153682,	PATHOGENIC	0.98154	28481359
PPP6C	9323	COSM6503474,	skin	malignant_melanoma	p.D193Y	Substitution - Missense	9:125153625-125153625,	PATHOGENIC	0.98028	28356599
PPP6C	9323	COSM6956644,	breast	carcinoma	p.D105H	Substitution - Missense	9:125158307-125158307,	PATHOGENIC	0.9765	28481359
PPP6C	9323	COSM6948846,	urinary_tract	carcinoma	p.E200K	Substitution - Missense	9:125153604-125153604,	PATHOGENIC	0.97559	28481359
PPP6C	9323	COSM5413506,	NS	malignant_melanoma	p.R181Q	Substitution - Missense	9:125153660-125153660,	PATHOGENIC	0.97559	28481359
PPP6C	9323	COSM5413506,	NS	malignant_melanoma	p.R181Q	Substitution - Missense	9:125153660-125153660,	PATHOGENIC	0.97559	28481359
PPP6C	9323	COSM5415295,	endometrium	carcinoma	p.G86C	Substitution - Missense	9:125158364-125158364,	PATHOGENIC	0.97479	25233892
PPP6C	9323	COSM5731126,	breast	other	p.R264L	Substitution - Missense	9:125149800-125149800,	PATHOGENIC	0.97046	26832993
PPP6C	9323	COSM6957468,	penis	carcinoma	p.V122A	Substitution - Missense	9:125158255-125158255,	PATHOGENIC	0.97023	28481359
PPP6C	9323	COSM6983905,	large_intestine	carcinoma	p.?	Unknown	9:125171182-125171182,	PATHOGENIC	0.96793	28481359
PPP6C	9323	COSM3654316,	skin	malignant_melanoma	p.F304F	Substitution - coding silent	9:125149679-125149679,	PATHOGENIC	0.96474	26343386
PPP6C	9323	COSM3654316,	skin	malignant_melanoma	p.F304F	Substitution - coding silent	9:125149679-125149679,	PATHOGENIC	0.96474	26343386
PPP6C	9323	COSM6942564,	urinary_tract	carcinoma	p.M79V	Substitution - Missense	9:125160843-125160843,	PATHOGENIC	0.94256	28481359
PPP6C	9323	COSM6754539,	NS	carcinoma	p.R286W	Substitution - Missense	9:125149735-125149735,	PATHOGENIC	0.94247	28481359
PPP6C	9323	COSM6943627,	NS	carcinoma	p.Y141*	Substitution - Nonsense	9:125153942-125153942,	PATHOGENIC	0.93453	28481359
PPP6C	9323	COSM6955464,	prostate	carcinoma	p.R111G	Substitution - Missense	9:125158289-125158289,	PATHOGENIC	0.92778	28481359
PPP6C	9323	COSM5799451,	endometrium	carcinoma	p.R111*	Substitution - Nonsense	9:125158289-125158289,	PATHOGENIC	0.9136	28481359
PPP6C	9323	COSM6980298,	lung	carcinoma	p.V10M	Substitution - Missense	9:125189691-125189691,	PATHOGENIC	0.90999	28481359
PPP6C	9323	COSM5413519, COSM5521405,	NS	malignant_melanoma	p.P259S, p.R264C	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	23890154
PPP6C	9323	COSM5413518, COSM5413519, COSM5413520, COSM5413521, COSM5413522, COSM5413523, COSM5413524, COSM5413525, COSM5413526, COSM5413527, COSM5413528, COSM5413529, COSM5413530, COSM5413531, COSM5413532, COSM5413533, COSM5413534, COSM5413535, COSM5413536, COSM5413537, COSM5413538, COSM5413539, COSM5413540, COSM5413541, COSM5413542, COSM5413543, COSM5413544, COSM5413545, COSM5413546, COSM5413547, COSM5413548, COSM5413549, COSM5413550, COSM5414955, COSM5414957,	NS	malignant_melanoma	p.?, p.A136V, p.A138T, p.A138V, p.A212T, p.A218V, p.C51Y, p.G112R, p.G189R, p.G211R, p.G213D, p.G266R, p.L215P, p.M272T, p.P186S, p.P199L, p.P199S, p.R177L, p.R210*, p.R264C, p.S197L, p.T204I, p.T204N, p.T279I, p.T299L, p.T300I, p.T46I, p.V195I, p.V277I, p.V50M, p.W196*, p.W205*, p.W214*, p.W214R, p.W256*	Substitution - Missense, Substitution - Nonsense	Info_not_available	Info_not_available	Info_not_available	24336958
PPP6C	9323	COSM5413519,	skin	malignant_melanoma	p.R264C	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	25070294
PPP6C	9323	COSM6927244, COSM6942351, COSM6956606, COSM6979863, COSM6984202,	NS, biliary_tract, breast, large_intestine, prostate	carcinoma	p.F274fs*4, p.R140fs*12, p.R286W, p.R85fs*10, p.V162fs*7	Deletion - Frameshift, Substitution - Missense	9:125149735-125149736, 9:125149769-125149769, 9:125153717-125153718, 9:125153947-125153947, 9:125158353-125158368,	Info_not_available	Info_not_available	28481359