Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
MDM2	6973	COSM6848009,	pleura	mesothelioma	p.N453I	Substitution - Missense	12:68839713-68839713,	PATHOGENIC	0.99107	26928227
MDM2	6973	COSM6910825,	central_nervous_system	glioma	p.G462E	Substitution - Missense	12:68839740-68839740,	PATHOGENIC	0.99095	28481359
MDM2	6973	COSM6929420,	urinary_tract	carcinoma	p.L493R	Substitution - Missense	12:68839833-68839833,	PATHOGENIC	0.99037	28481359
MDM2	6973	COSM6930601,	soft_tissue	liposarcoma	p.W309C	Substitution - Missense	12:68839282-68839282,	PATHOGENIC	0.98829	28481359
MDM2	6973	COSM6912767,	testis	germ_cell_tumour	p.W329S	Substitution - Missense	12:68839341-68839341,	PATHOGENIC	0.97619	28481359
MDM2	6973	COSM6931938,	central_nervous_system	glioma	p.E263K	Substitution - Missense	12:68835931-68835931,	PATHOGENIC	0.97091	28481359
MDM2	6973	COSM6917598,	breast	carcinoma	p.D243H	Substitution - Missense	12:68835871-68835871,	PATHOGENIC	0.97022	28481359
MDM2	6973	COSM6965688,	breast	carcinoma	p.E419G	Substitution - Missense	12:68839611-68839611,	PATHOGENIC	0.96959	28481359
MDM2	6973	COSM6914570,	prostate	carcinoma	p.C481R	Substitution - Missense	12:68839796-68839796,	PATHOGENIC	0.96647	28481359
MDM2	6973	COSM6964837,	large_intestine	carcinoma	p.Y282C	Substitution - Missense	12:68836676-68836676,	PATHOGENIC	0.96647	28481359
MDM2	6973	COSM6985976,	lung	carcinoma	p.R332P	Substitution - Missense	12:68839350-68839350,	PATHOGENIC	0.96622	28481359
MDM2	6973	COSM48557,	lung	carcinoma	p.W335G	Substitution - Missense	12:68839358-68839358,	PATHOGENIC	0.9635	18948947
MDM2	6973	COSM6945992,	kidney	carcinoma	p.L336R	Substitution - Missense	12:68839362-68839362,	PATHOGENIC	0.9635	28481359
MDM2	6973	COSM6984530,	endometrium	carcinoma	p.K370T	Substitution - Missense	12:68839464-68839464,	PATHOGENIC	0.96303	28481359
MDM2	6973	COSM5749131,	testis	germ_cell_tumour	p.R332H	Substitution - Missense	12:68839350-68839350,	PATHOGENIC	0.96053	26956871
MDM2	6973	COSM6913420,	urinary_tract	carcinoma	p.D399H	Substitution - Missense	12:68839550-68839550,	PATHOGENIC	0.95763	28481359
MDM2	6973	COSM6972157,	lung	carcinoma	p.C328Y	Substitution - Missense	12:68839338-68839338,	PATHOGENIC	0.95759	28481359
MDM2	6973	COSM6965686,	breast	carcinoma	p.S413G	Substitution - Missense	12:68839592-68839592,	PATHOGENIC	0.95709	28481359
MDM2	6973	COSM6933862,	lung	carcinoma	p.D74N	Substitution - Missense	12:68816857-68816857,	PATHOGENIC	0.9568	28481359
MDM2	6973	COSM5749116,	testis	germ_cell_tumour	p.S413R	Substitution - Missense	12:68839592-68839592,	PATHOGENIC	0.95649	26956871
MDM2	6973	COSM6980344,	breast	carcinoma	p.E419K	Substitution - Missense	12:68839610-68839610,	PATHOGENIC	0.95446	28481359
MDM2	6973	COSM48558,	lung	carcinoma	p.M465I	Substitution - Missense	12:68839750-68839750,	PATHOGENIC	0.95175	18948947
MDM2	6973	COSM6913418,	urinary_tract	carcinoma	p.D293N	Substitution - Missense	12:68836708-68836708,	PATHOGENIC	0.94849	28481359
MDM2	6973	COSM6926847,	skin	carcinoma	p.Q426*	Substitution - Nonsense	12:68839631-68839631,	PATHOGENIC	0.94699	28481359
MDM2	6973	COSM6968212,	breast	carcinoma	p.S226W	Substitution - Missense	12:68828924-68828924,	PATHOGENIC	0.94308	28481359
MDM2	6973	COSM6956588,	lung	carcinoma	p.P320A	Substitution - Missense	12:68839313-68839313,	PATHOGENIC	0.94238	28481359
MDM2	6973	COSM6930193,	skin	malignant_melanoma	p.V284D	Substitution - Missense	12:68836682-68836682,	PATHOGENIC	0.94212	28481359
MDM2	6973	COSM4605490,	upper_aerodigestive_tract	carcinoma	p.S165*	Substitution - Nonsense	12:68824622-68824622,	PATHOGENIC	0.94192	25056374
MDM2	6973	COSM4701330,	central_nervous_system	glioma	p.S235N	Substitution - Missense	12:68835848-68835848,	PATHOGENIC	0.94159	28481359
MDM2	6973	COSM6921608,	pancreas	carcinoma	p.S226*	Substitution - Nonsense	12:68828924-68828924,	PATHOGENIC	0.94116	28481359
MDM2	6973	COSM6932188,	biliary_tract	carcinoma	p.E361Q	Substitution - Missense	12:68839436-68839436,	PATHOGENIC	0.93509	28481359
MDM2	6973	COSM6914352,	skin	carcinoma	p.P38S	Substitution - Missense	12:68813566-68813566,	PATHOGENIC	0.93416	28481359
MDM2	6973	COSM6916631,	breast	carcinoma	p.D179Y	Substitution - Missense	12:68828782-68828782,	PATHOGENIC	0.93228	28481359
MDM2	6973	COSM6945134,	skin	malignant_melanoma	p.P320L	Substitution - Missense	12:68839314-68839314,	PATHOGENIC	0.93144	28481359
MDM2	6973	COSM6922856,	NS	malignant_melanoma	p.S98F	Substitution - Missense	12:68816930-68816930,	PATHOGENIC	0.92938	28481359
MDM2	6973	COSM5783386,	central_nervous_system	glioma	p.R332G	Substitution - Missense	12:68839349-68839349,	PATHOGENIC	0.92826	28481359
MDM2	6973	COSM6927185,	lung	carcinoma	p.S155Y	Substitution - Missense	12:68824592-68824592,	PATHOGENIC	0.92306	28481359
MDM2	6973	COSM6916629,	breast	carcinoma	p.L87I	Substitution - Missense	12:68816896-68816896,	PATHOGENIC	0.92143	28481359
MDM2	6973	COSM6931936,	central_nervous_system	glioma	p.E210K	Substitution - Missense	12:68828875-68828875,	PATHOGENIC	0.91931	28481359
MDM2	6973	COSM6918175,	lung	carcinoma	p.P162R	Substitution - Missense	12:68824613-68824613,	PATHOGENIC	0.91158	28481359
MDM2	6973	COSM4990296,	skin	carcinoma	p.E316*	Substitution - Nonsense	12:68839301-68839301,	PATHOGENIC	0.90417	25589618
MDM2	6973	COSM4896041,	soft_tissue	angiosarcoma	p.P322L	Substitution - Missense	12:68839320-68839320,	PATHOGENIC	0.90234	28481359
MDM2	6973	COSM6962598,	skin	carcinoma	p.E361K	Substitution - Missense	12:68839436-68839436,	PATHOGENIC	0.90053	28481359
MDM2	6973	COSM6920952,	breast	carcinoma	p.E316K	Substitution - Missense	12:68839301-68839301,	PATHOGENIC	0.88565	28481359
MDM2	6973	COSM6932948,	skin	carcinoma	p.L41F	Substitution - Missense	12:68813577-68813577,	PATHOGENIC	0.8767	28481359
MDM2	6973	COSM1606548,	prostate	carcinoma	p.R189H	Substitution - Missense	12:68828813-68828813,	PATHOGENIC	0.87499	28481359
MDM2	6973	COSM1606548,	large_intestine	carcinoma	p.R189H	Substitution - Missense	12:68828813-68828813,	PATHOGENIC	0.87499	28481359
MDM2	6973	COSM6942420,	lung	carcinoma	p.S166F	Substitution - Missense	12:68824625-68824625,	PATHOGENIC	0.87481	28481359
MDM2	6973	COSM6916253,	bone	chordoma	p.W241C	Substitution - Missense	12:68835867-68835867,	PATHOGENIC	0.87083	28481359
MDM2	6973	COSM6952503,	skin	malignant_melanoma	p.P162S	Substitution - Missense	12:68824612-68824612,	PATHOGENIC	0.85915	28481359
MDM2	6973	COSM6913416,	urinary_tract	carcinoma	p.R185P	Substitution - Missense	12:68828801-68828801,	PATHOGENIC	0.82934	28481359
MDM2	6973	COSM5020625,	soft_tissue	haemangioblastoma	p.L203L	Substitution - coding silent	12:68828854-68828854,	PATHOGENIC	0.78602	25589003
MDM2	6973	COSM6924769,	breast	carcinoma	p.Q141E	Substitution - Missense	12:68824425-68824425,	PATHOGENIC	0.78086	28481359
MDM2	6973	COSM6908694,	stomach	carcinoma	p.E210V	Substitution - Missense	12:68828876-68828876,	PATHOGENIC	0.77854	28481359
MDM2	6973	COSM1639226,	central_nervous_system	glioma	p.I195V	Substitution - Missense	12:68828830-68828830,	PATHOGENIC	0.77217	28481359
MDM2	6973	COSM6932796,	lung	carcinoma	p.L260V	Substitution - Missense	12:68835922-68835922,	PATHOGENIC	0.76483	28481359
MDM2	6973	COSM6986229,	soft_tissue	malignant_fibrous_histiocytoma-pleomorphic_sarcoma	p.A289T	Substitution - Missense	12:68836696-68836696,	PATHOGENIC	0.76043	28481359
MDM2	6973	COSM282733,	pancreas	carcinoma	p.E210D	Substitution - Missense	12:68828877-68828877,	PATHOGENIC	0.72207	28481359
MDM2	6973	COSM942904,	endometrium	carcinoma	p.R71Q	Substitution - Missense	12:68816849-68816849,	PATHOGENIC	0.72146	28481359
MDM2	6973	COSM6968350,	breast	carcinoma	p.D17N	Substitution - Missense	12:68809242-68809242,	NEUTRAL	0.48275	28481359
MDM2	6973	COSM5019617,	soft_tissue	haemangioblastoma	p.E360E	Substitution - coding silent	12:68839435-68839435,	NEUTRAL	0.42044	25589003
MDM2	6973	COSM5019617,	soft_tissue	haemangioblastoma	p.E360E	Substitution - coding silent	12:68839435-68839435,	NEUTRAL	0.42044	25589003
MDM2	6973	COSM6925303,	lung	carcinoma	p.M12I	Substitution - Missense	12:68809229-68809229,	NEUTRAL	0.38288	28481359
MDM2	6973	COSM4044444,	oesophagus	carcinoma	p.T224M	Substitution - Missense	12:68828918-68828918,	NEUTRAL	0.35377	28481359
MDM2	6973	COSM6462865,	breast	carcinoma	p.S182F	Substitution - Missense	12:68828792-68828792,	NEUTRAL	0.33488	28481359
MDM2	6973	COSM6957525,	penis	carcinoma	p.T371N	Substitution - Missense	12:68839467-68839467,	NEUTRAL	0.16244	28481359
MDM2	6973	COSM4990298,	skin	carcinoma	p.P320P	Substitution - coding silent	12:68839315-68839315,	NEUTRAL	0.07645	25589618
MDM2	6973	COSM249344,	kidney	carcinoma	p.T16I	Substitution - Missense	12:68809240-68809240,	NEUTRAL	0.04891	22138691
MDM2	6973	COSM1639228,	upper_aerodigestive_tract	carcinoma	p.?	Unknown	12:68835991-68835991,	Info_not_available	Info_not_available	25056374
MDM2	6973	COSM1363876, COSM240627, COSM5117070, COSM6911406, COSM6925549, COSM6935841, COSM6940116, COSM6944341, COSM6949158, COSM6959156, COSM6967670,	central_nervous_system, endometrium, large_intestine, lung, pancreas, prostate, skin	carcinoma, glioma	p.E270delE, p.E29K, p.E338D, p.G183D, p.I211_E214delICCE, p.L321fs*13, p.L321fs*52, p.P319L, p.P320F, p.S313L, p.S435R	Deletion - Frameshift, Deletion - In frame, Insertion - Frameshift, Substitution - Missense	12:68809278-68809278, 12:68828795-68828795, 12:68828875-68828886, 12:68835949-68835951, 12:68839293-68839293, 12:68839309-68839310, 12:68839310-68839310, 12:68839311-68839312, 12:68839313-68839314, 12:68839369-68839369, 12:68839660-68839660,	Info_not_available	0.51488, .6034, .61786, .62537, .68456, Info_not_available	28481359