Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
EPHB2	3393	COSM131750,	skin	malignant_melanoma	p.E109K	Substitution - Missense	1:22784590-22784590,	PATHOGENIC	0.98728	19718025
EPHB2	3393	COSM131754,	skin	malignant_melanoma	p.E615K	Substitution - Missense	1:22906064-22906064,	PATHOGENIC	0.98583	19718025
EPHB2	3393	COSM131754,	skin	malignant_melanoma	p.E615K	Substitution - Missense	1:22906064-22906064,	PATHOGENIC	0.98583	19718025
EPHB2	3393	COSM131753,	skin	malignant_melanoma	p.T512I	Substitution - Missense	1:22892990-22892990,	PATHOGENIC	0.98491	19718025
EPHB2	3393	COSM131755,	skin	malignant_melanoma	p.P887L	Substitution - Missense	1:22910539-22910539,	PATHOGENIC	0.98166	19718025
EPHB2	3393	COSM131751,	skin	malignant_melanoma	p.A205V	Substitution - Missense	1:22784879-22784879,	PATHOGENIC	0.97717	19718025
EPHB2	3393	COSM905420,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.T55M	Substitution - Missense	1:22784429-22784429,	PATHOGENIC	0.97325	22976956
EPHB2	3393	COSM131752,	skin	malignant_melanoma	p.D318N	Substitution - Missense	1:22863177-22863177,	PATHOGENIC	0.95625	19718025
EPHB2	3393	COSM310906,	lung	carcinoma	p.A894A	Substitution - coding silent	1:22910561-22910561,	NEUTRAL	0.02287	22941188