Interacting Partner	Detection_method	PPI_type	Lit_support	PPI_score	Source_databases
APP	Reconstituted Complex	physical	21832049	NA	BioGRID
ARHGAP1	Two-hybrid, two hybrid array	physical, physical association	21988832	0.37	BioGRID, IntAct
ATAD5	Synthetic Lethality	genetic	27453043	NA	BioGRID
ATM	Biochemical Activity, Reconstituted Complex	physical	10713094, 10744722, 10973490, 15064416, 15790808	NA	BioGRID
ATR	Biochemical Activity, Synthetic Lethality	genetic, physical	10973490, 17035231, 27453043	NA	BioGRID
BAALC	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
BEX1	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
BLM	Synthetic Lethality	genetic	27453043	NA	BioGRID
BRCA1	Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation	association, physical	10724175, 12438214, 17380128, 17525332, 18804494, 26121674	0.35	BioGRID, IntAct
BRCA2	Affinity Capture-Western, Protein-peptide	physical	14623252, 17525332	NA	BioGRID
BRD4	Synthetic Lethality	genetic	27453043	NA	BioGRID
CCAR2	Affinity Capture-Western	physical	25361978	NA	BioGRID
CCL5	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
CDC14A	Synthetic Lethality	genetic	27453043	NA	BioGRID
CDC25A	Biochemical Activity, Reconstituted Complex, coimmunoprecipitation	phosphorylation reaction, physical	10724175, 11298456, 12676583, 12759351, 18480045	0.62	BioGRID, IntAct, MINT
CDC25C	Biochemical Activity	physical	10744722, 11053450, 11438675, 12024051, 12402044, 12909615, 16311512, 16705183, 25361978	NA	BioGRID
CDC6	Synthetic Lethality	genetic	27453043	NA	BioGRID
CDC73	Synthetic Lethality	genetic	27453043	NA	BioGRID
CDH13	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
CDK4	Negative Genetic	genetic	28319113	NA	BioGRID
CHEK1	Synthetic Lethality	genetic	27453043	NA	BioGRID
CHEK2	Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Reconstituted Complex, cross-linking study, protein kinase assay, x-ray crystallography	direct interaction, phosphorylation reaction, physical	11438675, 11901158, 12024051, 12676583, 12909615, 16794575, 18239682, 25361978	0.72	BioGRID, IntAct, MINT
CUL1	Affinity Capture-Western	physical	23109433	NA	BioGRID
CUL4A	Affinity Capture-Western	physical	23109433	NA	BioGRID
CYP17A1	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
DAAM1	Synthetic Lethality	genetic	27453043	NA	BioGRID
DAPK3	Biochemical Activity	physical	15001356	NA	BioGRID
DIRAS3	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
ELAVL1	Affinity Capture-RNA, Affinity Capture-Western, Biochemical Activity, Two-hybrid	physical	17317627, 19322201	NA	BioGRID
ENO1	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
ERBB2	Negative Genetic	genetic	28319113	NA	BioGRID
FAM84B	Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, fluorescence microscopy, two hybrid array	colocalization, physical, physical association	25640309	0.54	BioGRID, IntAct, MINT
FOS	Affinity Capture-MS, tandem affinity purification	association, physical	25609649	0.35	BioGRID, IntAct, MINT
FOXK1	Affinity Capture-MS	physical	25609649	NA	BioGRID
FOXK2	Affinity Capture-MS, tandem affinity purification	association, physical	25609649	0.35	BioGRID, IntAct, MINT
FOXM1	Biochemical Activity	physical	17101782	NA	BioGRID
FZR1	Synthetic Lethality	genetic	27453043	NA	BioGRID
GINS2	Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	association, physical, physical association	17525332	0.50	BioGRID, IntAct
GNAS	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
HMGN1	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
HOXC6	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
IL24	Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, two hybrid array	physical, physical association	25640309	0.51	BioGRID, IntAct, MINT
ILKAP	Co-fractionation	physical	26344197	NA	BioGRID
ITIH5	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
KAT2B	Affinity Capture-Western	physical	19176998	NA	BioGRID
KLK7	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
KLK9	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
KMT2D	Negative Genetic	genetic	28319113	NA	BioGRID
KPNA2	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, tandem affinity purification, two hybrid array, two hybrid pooling approach	association, physical, physical association	12909615, 23178491	0.73	BioGRID, IntAct, MINT
LATS2	Biochemical Activity	physical	21118956	NA	BioGRID
LLGL1	Synthetic Lethality	genetic	27453043	NA	BioGRID
LYPD3	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
MAPK1	Co-fractionation	physical	26344197	NA	BioGRID
MAPK3	Co-fractionation	physical	26344197	NA	BioGRID
MDC1	Affinity Capture-Western, Reconstituted Complex	physical	12607004	NA	BioGRID
MDM2	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, experimental interaction detection, pull down	direct interaction, phosphorylation reaction, physical, physical association	15862297, 16943424, 19176998	0.66	BioGRID, IntAct, MINT
MDM4	Biochemical Activity	physical	16163388	NA	BioGRID
MSH2	Affinity Capture-Western, Reconstituted Complex	physical	12447371, 15647386	NA	BioGRID
MUS81	Affinity Capture-Western, Reconstituted Complex	physical	11741546	NA	BioGRID
NR4A1	Two-hybrid, two hybrid	physical, physical association	21988832	0.37	BioGRID, IntAct
NSD3	Two-hybrid	physical	25640309	NA	BioGRID
PER3	Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	association, physical, physical association	21070773	0.50	BioGRID, IntAct, MINT
PLK1	Affinity Capture-Western, Biochemical Activity, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy, protein kinase assay	colocalization, phosphorylation reaction, physical, physical association	12493754, 20126263	0.72	BioGRID, IntAct
PLK3	Affinity Capture-Western, Biochemical Activity	physical	12242661	NA	BioGRID
PML	Affinity Capture-Western, Biochemical Activity	physical	12402044	NA	BioGRID
POLR2L	Two-hybrid, two hybrid array	physical, physical association	21988832	0.37	BioGRID, IntAct
PPM1D	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	16311512	NA	BioGRID
PPP2CA	Affinity Capture-Western, Biochemical Activity, tandem affinity purification	association, physical	15380617, 16596250, 23178491	0.35	BioGRID, IntAct
PPP2R1A	Affinity Capture-Western, tandem affinity purification	association, physical	15380617, 23178491	0.35	BioGRID, IntAct
PPP2R2B	Two-hybrid	physical	15380617	NA	BioGRID
PPP2R5A	Reconstituted Complex, Two-hybrid, pull down, two hybrid	physical, physical association	15380617	0.51	BioGRID, IntAct
PPP2R5B	Reconstituted Complex, pull down, two hybrid	physical, physical association	15380617	0.51	BioGRID, IntAct
PPP2R5C	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, protein kinase assay, pull down, tandem affinity purification, two hybrid	association, phosphorylation reaction, physical, physical association	15380617, 23178491	0.35, 0.51, 0.60, 0.63	BioGRID, IntAct
PPP2R5D	Reconstituted Complex, Two-hybrid, two hybrid	physical, physical association	15380617	0.37	BioGRID, IntAct
PPP2R5E	Reconstituted Complex, Two-hybrid, pull down, two hybrid	physical, physical association	15380617	0.51	BioGRID, IntAct
PRDM14	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
PRKDC	Biochemical Activity	physical	10713094	NA	BioGRID
PRMT2	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
PSMC3IP	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
PSME3	Affinity Capture-Western, Biochemical Activity	physical	19556897, 25361978	NA	BioGRID
RAD17	Synthetic Lethality	genetic	27453043	NA	BioGRID
RAD50	Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical	17525332	0.35	BioGRID, IntAct
RB1	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay	phosphorylation reaction, physical, physical association	17380128	0.60	BioGRID, IntAct, MINT
RCHY1	Affinity Capture-Western, Biochemical Activity	physical	23449389	NA	BioGRID
REV3L	Biochemical Activity	physical	18622427	NA	BioGRID
RFC1	Synthetic Lethality	genetic	27453043	NA	BioGRID
RHOBTB2	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
RNF20	Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, two hybrid array	physical, physical association	25640309	0.51	BioGRID, IntAct, MINT
RNF8	Affinity Capture-Western, Biochemical Activity	physical	22266820	NA	BioGRID
RPS10	Synthetic Lethality	genetic	27453043	NA	BioGRID
SIAH2	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	26751770	NA	BioGRID
SIRT1	Affinity Capture-Western	physical	25361978	NA	BioGRID
SLC25A6	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
SRPK1	Biochemical Activity	physical	23602568	NA	BioGRID
SRPK2	Biochemical Activity	physical	26167880	NA	BioGRID
ST14	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
STMN1	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
STRAP	Biochemical Activity, protein kinase assay	phosphorylation reaction, physical	18833288	0.44	BioGRID, IntAct, MINT
TEX264	Affinity Capture-MS	physical	26186194, 28514442	NA	BioGRID
TLR3	Two-hybrid, two hybrid array	physical, physical association	25640309	0.37	BioGRID, IntAct, MINT
TP53	Affinity Capture-Western, Biochemical Activity, experimental interaction detection, protein kinase assay	phosphorylation reaction, physical	10673501, 10710310, 10724175, 12810724, 15862297, 18833288	0.65	BioGRID, IntAct, MINT
TP53BP1	Affinity Capture-Western	physical	17525332	NA	BioGRID
TP63	Affinity Capture-MS	physical	28514442	NA	BioGRID
TRIM28	Affinity Capture-Western	physical	22496453	NA	BioGRID
TTN	Synthetic Lethality	genetic	27453043	NA	BioGRID
TUBA1A	Synthetic Lethality	genetic	27453043	NA	BioGRID
UBR5	Affinity Capture-MS, Affinity Capture-Western	physical	17074762	NA	BioGRID
VCP	Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	physical, physical association	17525332	0.52	BioGRID, IntAct
VHL	Affinity Capture-Western, Biochemical Activity	physical	22071692	NA	BioGRID
WEE1	Synthetic Lethality	genetic	27453043	NA	BioGRID
WRN	Synthetic Lethality	genetic	27453043	NA	BioGRID