Interacting Partner Detection_method PPI_type Lit_support PPI_score Source_databases AP1B1 tandem affinity purification association 23178491 0.35 IntAct APP Reconstituted Complex physical 21832049 NA BioGRID ARHGAP1 Two-hybrid, two hybrid array physical, physical association 21988832 0.37 BioGRID, IntAct ATAD5 Synthetic Lethality genetic 27453043 NA BioGRID ATM Biochemical Activity, Reconstituted Complex physical 10713094, 10744722, 10973490, 15064416, 15790808 NA BioGRID ATR Biochemical Activity, Synthetic Lethality genetic, physical 10973490, 17035231, 27453043 NA BioGRID BAALC Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT BEX1 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT BLM Synthetic Lethality genetic 27453043 NA BioGRID BRCA1 Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation association, physical 10724175, 12438214, 17380128, 17525332, 18804494, 26121674 0.35 BioGRID, IntAct BRCA2 Affinity Capture-Western, Protein-peptide physical 14623252, 17525332 NA BioGRID BRD4 Synthetic Lethality genetic 27453043 NA BioGRID BUB3 tandem affinity purification association 23178491 0.35 IntAct CCAR2 Affinity Capture-Western physical 25361978 NA BioGRID CCL5 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT CDC14A Synthetic Lethality genetic 27453043 NA BioGRID CDC25A Biochemical Activity, Reconstituted Complex, coimmunoprecipitation phosphorylation reaction, physical 10724175, 11298456, 12676583, 12759351, 18480045 0.62 BioGRID, IntAct, MINT CDC25C Biochemical Activity physical 10744722, 11053450, 11438675, 12024051, 12402044, 12909615, 16311512, 16705183, 25361978 NA BioGRID CDC6 Synthetic Lethality genetic 27453043 NA BioGRID CDC73 Synthetic Lethality genetic 27453043 NA BioGRID CDH13 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT CDK11A anti tag coimmunoprecipitation, protein kinase assay, tandem affinity purification association, physical association 23178491 0.35, 0.52 IntAct CDK4 Negative Genetic genetic 28319113 NA BioGRID CHEK1 Synthetic Lethality genetic 27453043 NA BioGRID CHEK2 Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Reconstituted Complex, cross-linking study, protein kinase assay, x-ray crystallography direct interaction, phosphorylation reaction, physical 11438675, 11901158, 12024051, 12676583, 12909615, 16794575, 18239682, 25361978 0.72 BioGRID, IntAct, MINT CSNK2A1 tandem affinity purification association 23178491 0.35 IntAct CSNK2A2 tandem affinity purification association 23178491 0.35 IntAct CUL1 Affinity Capture-Western physical 23109433 NA BioGRID CUL4A Affinity Capture-Western physical 23109433 NA BioGRID CYP17A1 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT DAAM1 Synthetic Lethality genetic 27453043 NA BioGRID DAPK3 Biochemical Activity physical 15001356 NA BioGRID DHX9 tandem affinity purification association 23178491 0.35 IntAct DIRAS3 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT EBI-4399559 pull down physical association 22266820 0.40 IntAct EEF1D tandem affinity purification association 23178491 0.35 IntAct EEF1G tandem affinity purification association 23178491 0.35 IntAct EFTUD2 tandem affinity purification association 23178491 0.35 IntAct EIF3A tandem affinity purification association 23178491 0.35 IntAct ELAVL1 Affinity Capture-RNA, Affinity Capture-Western, Biochemical Activity, Two-hybrid physical 17317627, 19322201 NA BioGRID ENO1 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT ERBB2 Negative Genetic genetic 28319113 NA BioGRID FAM84B Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, fluorescence microscopy, two hybrid array colocalization, physical, physical association 25640309 0.54 BioGRID, IntAct, MINT FARSA tandem affinity purification association 23178491 0.35 IntAct FBXO22 tandem affinity purification association 23178491 0.35 IntAct FKBP4 tandem affinity purification association 23178491 0.35 IntAct FOS Affinity Capture-MS, tandem affinity purification association, physical 25609649 0.35 BioGRID, IntAct, MINT FOXK1 Affinity Capture-MS physical 25609649 NA BioGRID FOXK1 tandem affinity purification association 25609649 0.35 IntAct, MINT FOXK2 Affinity Capture-MS, tandem affinity purification association, physical 25609649 0.35 BioGRID, IntAct, MINT FOXM1 Biochemical Activity physical 17101782 NA BioGRID FZR1 Synthetic Lethality genetic 27453043 NA BioGRID GINS2 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical, physical association 17525332 0.50 BioGRID, IntAct GNAS Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT GTF2I tandem affinity purification association 23178491 0.35 IntAct HMGN1 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT HNRNPAB tandem affinity purification association 23178491 0.35 IntAct HNRNPK tandem affinity purification association 23178491 0.35 IntAct HNRNPU tandem affinity purification association 23178491 0.35 IntAct HOXC6 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT IL24 Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, two hybrid array physical, physical association 25640309 0.51 BioGRID, IntAct, MINT ILKAP Co-fractionation physical 26344197 NA BioGRID ITIH5 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT KAT2B Affinity Capture-Western physical 19176998 NA BioGRID KLK7 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT KLK9 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT KMT2D Negative Genetic genetic 28319113 NA BioGRID KPNA2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, tandem affinity purification, two hybrid array, two hybrid pooling approach association, physical, physical association 12909615, 23178491 0.73 BioGRID, IntAct, MINT KPNB1 tandem affinity purification association 23178491 0.35 IntAct LATS2 Biochemical Activity physical 21118956 NA BioGRID LLGL1 Synthetic Lethality genetic 27453043 NA BioGRID LMNB1 tandem affinity purification association 23178491 0.35 IntAct LRRC8A tandem affinity purification association 23178491 0.35 IntAct LYPD3 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT MAPK1 Co-fractionation physical 26344197 NA BioGRID MAPK3 Co-fractionation physical 26344197 NA BioGRID MCM3 tandem affinity purification association 23178491 0.35 IntAct MCM5 tandem affinity purification association 23178491 0.35 IntAct MCM7 tandem affinity purification association 23178491 0.35 IntAct MDC1 Affinity Capture-Western, Reconstituted Complex physical 12607004 NA BioGRID MDM2 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, experimental interaction detection, pull down direct interaction, phosphorylation reaction, physical, physical association 15862297, 16943424, 19176998 0.66 BioGRID, IntAct, MINT MDM4 Biochemical Activity physical 16163388 NA BioGRID MSH2 Affinity Capture-Western, Reconstituted Complex physical 12447371, 15647386 NA BioGRID MUS81 Affinity Capture-Western, Reconstituted Complex physical 11741546 NA BioGRID MYBBP1A tandem affinity purification association 23178491 0.35 IntAct NBN experimental interaction detection, imaging technique colocalization, phosphorylation reaction 11438675 0.40 IntAct, MINT NONO tandem affinity purification association 23178491 0.35 IntAct NR4A1 Two-hybrid, two hybrid physical, physical association 21988832 0.37 BioGRID, IntAct NSD3 Two-hybrid physical 25640309 NA BioGRID NSD3 two hybrid array physical association 25640309 0.37 IntAct, MINT PAICS tandem affinity purification association 23178491 0.35 IntAct PCBP1 tandem affinity purification association 23178491 0.35 IntAct PCBP2 tandem affinity purification association 23178491 0.35 IntAct PER3 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical, physical association 21070773 0.50 BioGRID, IntAct, MINT PKM protein kinase assay, tandem affinity purification association, phosphorylation reaction 23178491, 24606918 0.35, 0.44 IntAct PLK1 Affinity Capture-Western, Biochemical Activity, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy, protein kinase assay colocalization, phosphorylation reaction, physical, physical association 12493754, 20126263 0.72 BioGRID, IntAct PLK3 Affinity Capture-Western, Biochemical Activity physical 12242661 NA BioGRID PML Affinity Capture-Western, Biochemical Activity physical 12402044 NA BioGRID POLR2L Two-hybrid, two hybrid array physical, physical association 21988832 0.37 BioGRID, IntAct PPM1D Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 16311512 NA BioGRID PPM1G tandem affinity purification association 23178491 0.35 IntAct PPP2CA Affinity Capture-Western, Biochemical Activity, tandem affinity purification association, physical 15380617, 16596250, 23178491 0.35 BioGRID, IntAct PPP2R1A Affinity Capture-Western, tandem affinity purification association, physical 15380617, 23178491 0.35 BioGRID, IntAct PPP2R2B Two-hybrid physical 15380617 NA BioGRID PPP2R5A Reconstituted Complex, Two-hybrid, pull down, two hybrid physical, physical association 15380617 0.51 BioGRID, IntAct PPP2R5B Reconstituted Complex, pull down, two hybrid physical, physical association 15380617 0.51 BioGRID, IntAct PPP2R5C Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, protein kinase assay, pull down, tandem affinity purification, two hybrid association, phosphorylation reaction, physical, physical association 15380617, 23178491 0.35, 0.51, 0.60, 0.63 BioGRID, IntAct PPP2R5D Reconstituted Complex, Two-hybrid, two hybrid physical, physical association 15380617 0.37 BioGRID, IntAct PPP2R5E Reconstituted Complex, Two-hybrid, pull down, two hybrid physical, physical association 15380617 0.51 BioGRID, IntAct PRDM14 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT PRKDC Biochemical Activity physical 10713094 NA BioGRID PRMT2 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT PRPF40A tandem affinity purification association 23178491 0.35 IntAct PSMC3IP Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT PSME3 Affinity Capture-Western, Biochemical Activity physical 19556897, 25361978 NA BioGRID PUF60 tandem affinity purification association 23178491 0.35 IntAct RAD17 Synthetic Lethality genetic 27453043 NA BioGRID RAD50 Affinity Capture-Western, anti bait coimmunoprecipitation association, physical 17525332 0.35 BioGRID, IntAct RB1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay phosphorylation reaction, physical, physical association 17380128 0.60 BioGRID, IntAct, MINT RBM25 tandem affinity purification association 23178491 0.35 IntAct RCHY1 Affinity Capture-Western, Biochemical Activity physical 23449389 NA BioGRID REV3L Biochemical Activity physical 18622427 NA BioGRID RFC1 Synthetic Lethality genetic 27453043 NA BioGRID RHOBTB2 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT RNF20 Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, two hybrid array physical, physical association 25640309 0.51 BioGRID, IntAct, MINT RNF8 Affinity Capture-Western, Biochemical Activity physical 22266820 NA BioGRID RNF8 pull down physical association 22266820 0.40 IntAct RPS10 Synthetic Lethality genetic 27453043 NA BioGRID RUVBL1 tandem affinity purification association 23178491 0.35 IntAct SF3B1 tandem affinity purification association 23178491 0.35 IntAct SF3B2 tandem affinity purification association 23178491 0.35 IntAct SF3B3 tandem affinity purification association 23178491 0.35 IntAct SFPQ tandem affinity purification association 23178491 0.35 IntAct SIAH2 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 26751770 NA BioGRID SIRT1 Affinity Capture-Western physical 25361978 NA BioGRID SLC25A6 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT SMC1A tandem affinity purification association 23178491 0.35 IntAct SMC2 tandem affinity purification association 23178491 0.35 IntAct SMC3 tandem affinity purification association 23178491 0.35 IntAct SMC4 tandem affinity purification association 23178491 0.35 IntAct SRPK1 Biochemical Activity physical 23602568 NA BioGRID SRPK1 protein kinase assay phosphorylation reaction 23602568 0.44 IntAct SRPK2 Biochemical Activity physical 26167880 NA BioGRID ST14 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT STMN1 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT STRAP Biochemical Activity, protein kinase assay phosphorylation reaction, physical 18833288 0.44 BioGRID, IntAct, MINT SYNCRIP tandem affinity purification association 23178491 0.35 IntAct TARDBP tandem affinity purification association 23178491 0.35 IntAct TEX264 Affinity Capture-MS physical 26186194, 28514442 NA BioGRID TLR3 Two-hybrid, two hybrid array physical, physical association 25640309 0.37 BioGRID, IntAct, MINT TP53 Affinity Capture-Western, Biochemical Activity, experimental interaction detection, protein kinase assay phosphorylation reaction, physical 10673501, 10710310, 10724175, 12810724, 15862297, 18833288 0.65 BioGRID, IntAct, MINT TP53BP1 Affinity Capture-Western physical 17525332 NA BioGRID TP53BP1 anti bait coimmunoprecipitation association 17525332 0.35 IntAct TP63 Affinity Capture-MS physical 28514442 NA BioGRID TPR tandem affinity purification association 23178491 0.35 IntAct TRIM28 Affinity Capture-Western physical 22496453 NA BioGRID TTN Synthetic Lethality genetic 27453043 NA BioGRID TUBA1A Synthetic Lethality genetic 27453043 NA BioGRID UBE2O tandem affinity purification association 23178491 0.35 IntAct UBR4 tandem affinity purification association 23178491 0.35 IntAct UBR5 Affinity Capture-MS, Affinity Capture-Western physical 17074762 NA BioGRID USP7 tandem affinity purification association 23178491 0.35 IntAct VCP Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 17525332 0.52 BioGRID, IntAct VHL Affinity Capture-Western, Biochemical Activity physical 22071692 NA BioGRID WEE1 Synthetic Lethality genetic 27453043 NA BioGRID WRN Synthetic Lethality genetic 27453043 NA BioGRID XRCC1 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay, pull down direct interaction, phosphorylation reaction, physical association 18971944 0.65 IntAct, MINT XRCC5 tandem affinity purification association 23178491 0.35 IntAct