Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
BRCA1	1100	COSM6937357,	lung	carcinoma	p.Q780E	Substitution - Missense	17:43093193-43093193,	PATHOGENIC	0.99155	28481359
BRCA1	1100	COSM6965065,	soft_tissue	angiosarcoma	p.S1292A	Substitution - Missense	17:43091657-43091657,	PATHOGENIC	0.98619	28481359
BRCA1	1100	COSM6952377,	large_intestine	carcinoma	p.S1292Y	Substitution - Missense	17:43091656-43091656,	PATHOGENIC	0.98018	28481359
BRCA1	1100	COSM6924781,	breast	carcinoma	p.Q1395E	Substitution - Missense	17:43090946-43090946,	PATHOGENIC	0.97878	28481359
BRCA1	1100	COSM6914629,	lung	carcinoma	p.E648Q	Substitution - Missense	17:43093589-43093589,	PATHOGENIC	0.9775	28481359
BRCA1	1100	COSM6923548,	urinary_tract	carcinoma	p.S1292F	Substitution - Missense	17:43091656-43091656,	PATHOGENIC	0.97675	28481359
BRCA1	1100	COSM6931524,	breast	carcinoma	p.E648*	Substitution - Nonsense	17:43093589-43093589,	PATHOGENIC	0.97631	28481359
BRCA1	1100	COSM6927029,	large_intestine	carcinoma	p.T77M	Substitution - Missense	17:43104939-43104939,	PATHOGENIC	0.97585	28481359
BRCA1	1100	COSM6947416,	soft_tissue	malignant_peripheral_nerve_sheath_tumour	p.E1419G	Substitution - Missense	17:43082505-43082505,	PATHOGENIC	0.97494	28481359
BRCA1	1100	COSM6983533,	skin	malignant_melanoma	p.P62L	Substitution - Missense	17:43106483-43106483,	PATHOGENIC	0.97408	28481359
BRCA1	1100	COSM6971902,	endometrium	carcinoma	p.V1713A	Substitution - Missense	17:43063888-43063888,	PATHOGENIC	0.97372	28481359
BRCA1	1100	COSM6981753,	pancreas	carcinoma	p.Q1388*	Substitution - Nonsense	17:43090967-43090967,	PATHOGENIC	0.97357	28481359
BRCA1	1100	COSM35895,	breast	carcinoma	p.?	Unknown	17:43057051-43057051,	PATHOGENIC	0.97246	19593635
BRCA1	1100	COSM6910109,	soft_tissue	leiomyosarcoma	p.L1365F	Substitution - Missense	17:43091436-43091436,	PATHOGENIC	0.97227	28481359
BRCA1	1100	COSM5575478,	ovary	carcinoma	p.E384V	Substitution - Missense	17:43094380-43094380,	PATHOGENIC	0.97156	25846551
BRCA1	1100	COSM5575478,	ovary	carcinoma	p.E384V	Substitution - Missense	17:43094380-43094380,	PATHOGENIC	0.97156	25846551
BRCA1	1100	COSM6943403,	urinary_tract	carcinoma	p.E648K	Substitution - Missense	17:43093589-43093589,	PATHOGENIC	0.97155	28481359
BRCA1	1100	COSM6969903,	lung	carcinoma	p.E848*	Substitution - Nonsense	17:43092989-43092989,	PATHOGENIC	0.969	28481359
BRCA1	1100	COSM6976891,	central_nervous_system	glioma	p.E1214K	Substitution - Missense	17:43091891-43091891,	PATHOGENIC	0.96861	28481359
BRCA1	1100	COSM6922027,	prostate	carcinoma	p.?	Unknown	17:43104957-43104957,	PATHOGENIC	0.96851	28481359
BRCA1	1100	COSM6931077,	urinary_tract	carcinoma	p.E649Q	Substitution - Missense	17:43093586-43093586,	PATHOGENIC	0.96851	28481359
BRCA1	1100	COSM6922027,	endometrium	carcinoma	p.?	Unknown	17:43104957-43104957,	PATHOGENIC	0.96851	28481359
BRCA1	1100	COSM6940248,	breast	carcinoma	p.Q81E	Substitution - Missense	17:43104928-43104928,	PATHOGENIC	0.96668	28481359
BRCA1	1100	COSM6955977,	lung	carcinoma	p.A1708E	Substitution - Missense	17:43063903-43063903,	PATHOGENIC	0.96498	28481359
BRCA1	1100	COSM5414819,	lung	carcinoma	p.R71K	Substitution - Missense	17:43106456-43106456,	PATHOGENIC	0.96417	29420467
BRCA1	1100	COSM5575278,	ovary	carcinoma	p.S198N	Substitution - Missense	17:43097244-43097244,	PATHOGENIC	0.96214	25846551
BRCA1	1100	COSM5575278,	ovary	carcinoma	p.S198N	Substitution - Missense	17:43097244-43097244,	PATHOGENIC	0.96214	25846551
BRCA1	1100	COSM5575278,	ovary	carcinoma	p.S198N	Substitution - Missense	17:43097244-43097244,	PATHOGENIC	0.96214	25846551
BRCA1	1100	COSM5575278,	ovary	carcinoma	p.S198N	Substitution - Missense	17:43097244-43097244,	PATHOGENIC	0.96214	25846551
BRCA1	1100	COSM5575278,	ovary	carcinoma	p.S198N	Substitution - Missense	17:43097244-43097244,	PATHOGENIC	0.96214	25846551
BRCA1	1100	COSM5575278,	ovary	carcinoma	p.S198N	Substitution - Missense	17:43097244-43097244,	PATHOGENIC	0.96214	25846551
BRCA1	1100	COSM5575278,	ovary	carcinoma	p.S198N	Substitution - Missense	17:43097244-43097244,	PATHOGENIC	0.96214	25846551
BRCA1	1100	COSM5575278,	ovary	carcinoma	p.S198N	Substitution - Missense	17:43097244-43097244,	PATHOGENIC	0.96214	25846551
BRCA1	1100	COSM6948017,	large_intestine	carcinoma	p.V1653A	Substitution - Missense	17:43070956-43070956,	PATHOGENIC	0.95704	28481359
BRCA1	1100	COSM6916176,	ovary	carcinoma	p.A1708P	Substitution - Missense	17:43063904-43063904,	PATHOGENIC	0.95329	28481359
BRCA1	1100	COSM6918021,	upper_aerodigestive_tract	carcinoma	p.Q380E	Substitution - Missense	17:43094393-43094393,	PATHOGENIC	0.95087	28481359
BRCA1	1100	COSM5607948,	skin	malignant_melanoma	p.W1718L	Substitution - Missense	17:43063373-43063373,	PATHOGENIC	0.94897	26343386
BRCA1	1100	COSM6940664,	skin	malignant_melanoma	p.G1743V	Substitution - Missense	17:43057101-43057101,	PATHOGENIC	0.94769	28481359
BRCA1	1100	COSM5575521,	large_intestine	carcinoma	p.K1208T	Substitution - Missense	17:43091908-43091908,	PATHOGENIC	0.94583	28481359
BRCA1	1100	COSM5575521,	ovary	carcinoma	p.K1208T	Substitution - Missense	17:43091908-43091908,	PATHOGENIC	0.94583	25846551
BRCA1	1100	COSM6956683,	soft_tissue	fibrosarcoma	p.H1686Y	Substitution - Missense	17:43067626-43067626,	PATHOGENIC	0.94419	28481359
BRCA1	1100	COSM6942615,	oesophagus	carcinoma	p.A1708T	Substitution - Missense	17:43063904-43063904,	PATHOGENIC	0.9395	28481359
BRCA1	1100	COSM6976505,	large_intestine	carcinoma	p.?	Unknown	17:43067696-43067696,	PATHOGENIC	0.93816	28481359
BRCA1	1100	COSM5575301,	ovary	carcinoma	p.K50R	Substitution - Missense	17:43106519-43106519,	PATHOGENIC	0.9377	25846551
BRCA1	1100	COSM4991001,	skin	carcinoma	p.P1192L	Substitution - Missense	17:43091956-43091956,	PATHOGENIC	0.93523	25589618
BRCA1	1100	COSM7325203,	biliary_tract	carcinoma	p.?	Unknown	17:43104262-43104262,	PATHOGENIC	0.93473	29360550
BRCA1	1100	COSM6933874,	lung	carcinoma	p.R1751L	Substitution - Missense	17:43057077-43057077,	PATHOGENIC	0.9279	28481359
BRCA1	1100	COSM6940192,	lung	carcinoma	p.Q1388H	Substitution - Missense	17:43090965-43090965,	PATHOGENIC	0.92754	28481359
BRCA1	1100	COSM6922162,	lung	carcinoma	p.S267L	Substitution - Missense	17:43094731-43094731,	PATHOGENIC	0.9253	28481359
BRCA1	1100	COSM6907122,	urinary_tract	carcinoma	p.S1387F	Substitution - Missense	17:43090969-43090969,	PATHOGENIC	0.92294	29420467
BRCA1	1100	COSM6957807,	large_intestine	carcinoma	p.P115R	Substitution - Missense	17:43104219-43104219,	PATHOGENIC	0.92236	28481359
BRCA1	1100	COSM6923811,	lung	carcinoma	p.D642H	Substitution - Missense	17:43093607-43093607,	PATHOGENIC	0.92177	28481359
BRCA1	1100	COSM6928132,	urinary_tract	carcinoma	p.S426L	Substitution - Missense	17:43094254-43094254,	PATHOGENIC	0.91859	28481359
BRCA1	1100	COSM6965063,	soft_tissue	angiosarcoma	p.E1358K	Substitution - Missense	17:43091459-43091459,	PATHOGENIC	0.91757	28481359
BRCA1	1100	COSM5575488,	ovary	carcinoma	p.T775N	Substitution - Missense	17:43093207-43093207,	PATHOGENIC	0.91457	25846551
BRCA1	1100	COSM6973588,	skin	malignant_melanoma	p.Q1408*	Substitution - Nonsense	17:43082539-43082539,	PATHOGENIC	0.91261	28481359
BRCA1	1100	COSM6928112,	urinary_tract	carcinoma	p.E1836K	Substitution - Missense	17:43045764-43045764,	PATHOGENIC	0.91246	28481359
BRCA1	1100	COSM6969336,	oesophagus	carcinoma	p.P115L	Substitution - Missense	17:43104219-43104219,	PATHOGENIC	0.91236	28481359
BRCA1	1100	COSM6923800,	cervix	carcinoma	p.D120A	Substitution - Missense	17:43104204-43104204,	PATHOGENIC	0.90884	28481359
BRCA1	1100	COSM24520,	ovary	carcinoma	p.?	Unknown	17:43051118-43051118,	PATHOGENIC	0.90693	11240689
BRCA1	1100	COSM6984612,	endometrium	carcinoma	p.D1152N	Substitution - Missense	17:43092077-43092077,	PATHOGENIC	0.90603	28481359
BRCA1	1100	COSM6962657,	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	p.?	Unknown	17:43071239-43071239,	PATHOGENIC	0.90526	28481359
BRCA1	1100	COSM6944673,	soft_tissue	malignant_fibrous_histiocytoma-pleomorphic_sarcoma	p.?	Unknown	17:43099773-43099773,	PATHOGENIC	0.90469	28481359
BRCA1	1100	COSM6995429,	ovary	germ_cell_tumour	p.L52V	Substitution - Missense	17:43106514-43106514,	PATHOGENIC	0.90353	28954785
BRCA1	1100	COSM6995429,	ovary	germ_cell_tumour	p.L52V	Substitution - Missense	17:43106514-43106514,	PATHOGENIC	0.90353	28954785
BRCA1	1100	COSM5020686,	soft_tissue	haemangioblastoma	p.Y179H	Substitution - Missense	17:43099787-43099787,	PATHOGENIC	0.90279	25589003
BRCA1	1100	COSM5464046,	thyroid	carcinoma	p.R1751Q	Substitution - Missense	17:43057077-43057077,	PATHOGENIC	0.90094	28481359
BRCA1	1100	COSM3755569,	soft_tissue	haemangioblastoma	p.Q356R	Substitution - Missense	17:43094464-43094464,	PATHOGENIC	0.89866	25589003
BRCA1	1100	COSM3755569,	breast	carcinoma	p.Q356R	Substitution - Missense	17:43094464-43094464,	PATHOGENIC	0.89866	24185512
BRCA1	1100	COSM3755569,	soft_tissue	haemangioblastoma	p.Q356R	Substitution - Missense	17:43094464-43094464,	PATHOGENIC	0.89866	25589003
BRCA1	1100	COSM3755569,	breast	carcinoma	p.Q356R	Substitution - Missense	17:43094464-43094464,	PATHOGENIC	0.89866	24185512
BRCA1	1100	COSM6936779,	prostate	carcinoma	p.D40N	Substitution - Missense	17:43115742-43115742,	PATHOGENIC	0.89461	28481359
BRCA1	1100	COSM6913507,	skin	carcinoma	p.L182S	Substitution - Missense	17:43099777-43099777,	PATHOGENIC	0.8938	28481359
BRCA1	1100	COSM6948729,	skin	malignant_melanoma	p.P1562L	Substitution - Missense	17:43071229-43071229,	PATHOGENIC	0.89079	28481359
BRCA1	1100	COSM5607958,	skin	malignant_melanoma	p.P871S	Substitution - Missense	17:43092920-43092920,	PATHOGENIC	0.89052	26343386
BRCA1	1100	COSM24528,	ovary	carcinoma	p.E1725*	Substitution - Nonsense	17:43063353-43063353,	PATHOGENIC	0.8901	7795652
BRCA1	1100	COSM6918841,	thyroid	carcinoma	p.L1705V	Substitution - Missense	17:43063913-43063913,	PATHOGENIC	0.88706	28481359
BRCA1	1100	COSM6965969,	skin	malignant_melanoma	p.E1725K	Substitution - Missense	17:43063353-43063353,	PATHOGENIC	0.88203	28481359
BRCA1	1100	COSM6981150,	lung	carcinoma	p.N1742I	Substitution - Missense	17:43057104-43057104,	PATHOGENIC	0.87726	28481359
BRCA1	1100	COSM6932042,	central_nervous_system	glioma	p.V1654M	Substitution - Missense	17:43070954-43070954,	PATHOGENIC	0.87708	28481359
BRCA1	1100	COSM7325210,	biliary_tract	carcinoma	p.Q563K	Substitution - Missense	17:43093844-43093844,	PATHOGENIC	0.87232	29360550
BRCA1	1100	COSM6984164,	urinary_tract	carcinoma	p.Q544*	Substitution - Nonsense	17:43093901-43093901,	PATHOGENIC	0.87201	28481359
BRCA1	1100	COSM6986492,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Y179C	Substitution - Missense	17:43099786-43099786,	PATHOGENIC	0.86183	28481359
BRCA1	1100	COSM6924394,	urinary_tract	carcinoma	p.E1754Q	Substitution - Missense	17:43057069-43057069,	PATHOGENIC	0.85311	28481359
BRCA1	1100	COSM6954055,	skin	malignant_melanoma	p.E1754K	Substitution - Missense	17:43057069-43057069,	PATHOGENIC	0.85201	28481359
BRCA1	1100	COSM6940458,	urinary_tract	carcinoma	p.E1060D	Substitution - Missense	17:43092351-43092351,	PATHOGENIC	0.85033	28481359
BRCA1	1100	COSM6950033,	NS	carcinoma	p.G1567*	Substitution - Nonsense	17:43071215-43071215,	PATHOGENIC	0.84888	28481359
BRCA1	1100	COSM5575372,	ovary	carcinoma	p.D1343E	Substitution - Missense	17:43091502-43091502,	PATHOGENIC	0.84373	25846551
BRCA1	1100	COSM6930929,	ovary	carcinoma	p.E1167*	Substitution - Nonsense	17:43092032-43092032,	PATHOGENIC	0.83007	28481359
BRCA1	1100	COSM6936547,	urinary_tract	carcinoma	p.E1817K	Substitution - Missense	17:43047661-43047661,	PATHOGENIC	0.82962	28481359
BRCA1	1100	COSM6934977,	upper_aerodigestive_tract	carcinoma	p.C24F	Substitution - Missense	17:43124026-43124026,	PATHOGENIC	0.82648	28481359
BRCA1	1100	COSM3734724,	ovary	carcinoma	p.?	Unknown	17:43124016-43124016,	PATHOGENIC	0.82613	9796975
BRCA1	1100	COSM93980,	lung	carcinoma	p.M297V	Substitution - Missense	17:43094642-43094642,	PATHOGENIC	0.82368	20668451
BRCA1	1100	COSM6918178,	lung	carcinoma	p.E1053K	Substitution - Missense	17:43092374-43092374,	PATHOGENIC	0.81523	28481359
BRCA1	1100	COSM6934372,	lung	carcinoma	p.L512F	Substitution - Missense	17:43093997-43093997,	PATHOGENIC	0.81139	28481359
BRCA1	1100	COSM6934372,	oesophagus	carcinoma	p.L512F	Substitution - Missense	17:43093997-43093997,	PATHOGENIC	0.81139	28481359
BRCA1	1100	COSM4991003,	skin	carcinoma	p.P1192S	Substitution - Missense	17:43091957-43091957,	PATHOGENIC	0.81102	25589618
BRCA1	1100	COSM4985686,	soft_tissue	haemangioblastoma	p.M1652I	Substitution - Missense	17:43070958-43070958,	PATHOGENIC	0.80959	25589003
BRCA1	1100	COSM6929869,	lung	carcinoma	p.L283V	Substitution - Missense	17:43094684-43094684,	PATHOGENIC	0.80633	28481359
BRCA1	1100	COSM5575464,	ovary	carcinoma	p.H41Q	Substitution - Missense	17:43115737-43115737,	PATHOGENIC	0.8053	25846551
BRCA1	1100	COSM5020112,	soft_tissue	haemangioblastoma	p.C197C	Substitution - coding silent	17:43097246-43097246,	PATHOGENIC	0.80468	25589003
BRCA1	1100	COSM6935538,	endometrium	carcinoma	p.S265Y	Substitution - Missense	17:43094737-43094737,	PATHOGENIC	0.80409	28481359
BRCA1	1100	COSM1577248,	ovary	carcinoma	p.E1794*	Substitution - Nonsense	17:43049147-43049147,	PATHOGENIC	0.80016	23633455
BRCA1	1100	COSM6927705,	breast	carcinoma	p.I373L	Substitution - Missense	17:43094414-43094414,	PATHOGENIC	0.79956	28481359
BRCA1	1100	COSM5025050,	breast	carcinoma	p.L30F	Substitution - Missense	17:43115770-43115770,	PATHOGENIC	0.79226	25850943
BRCA1	1100	COSM6908861,	stomach	carcinoma	p.K1793N	Substitution - Missense	17:43049148-43049148,	PATHOGENIC	0.79166	28481359
BRCA1	1100	COSM6962603,	skin	carcinoma	p.Q317*	Substitution - Nonsense	17:43094582-43094582,	PATHOGENIC	0.78613	28481359
BRCA1	1100	COSM23958,	breast	carcinoma	p.W372*	Substitution - Nonsense	17:43094415-43094415,	PATHOGENIC	0.78292	15712267
BRCA1	1100	COSM23933,	ovary	carcinoma	p.S1009*	Substitution - Nonsense	17:43092505-43092505,	PATHOGENIC	0.78281	10467410
BRCA1	1100	COSM13841,	breast	carcinoma	p.L30F	Substitution - Missense	17:43115770-43115770,	PATHOGENIC	0.77986	16959974
BRCA1	1100	COSM5575468,	ovary	carcinoma	p.L147M	Substitution - Missense	17:43104124-43104124,	PATHOGENIC	0.77925	25846551
BRCA1	1100	COSM5575267,	ovary	carcinoma	p.A1823S	Substitution - Missense	17:43047643-43047643,	PATHOGENIC	0.76815	25846551
BRCA1	1100	COSM6974518,	breast	carcinoma	p.K1724*	Substitution - Nonsense	17:43063356-43063356,	PATHOGENIC	0.76598	28481359
BRCA1	1100	COSM6506421,	breast	carcinoma	p.E1419*	Substitution - Nonsense	17:43082506-43082506,	PATHOGENIC	0.75857	26011570
BRCA1	1100	COSM6956872,	stomach	carcinoma	p.E1683D	Substitution - Missense	17:43067633-43067633,	PATHOGENIC	0.75746	28481359
BRCA1	1100	COSM6956872,	oesophagus	carcinoma	p.E1683D	Substitution - Missense	17:43067633-43067633,	PATHOGENIC	0.75746	28481359
BRCA1	1100	COSM6923475,	lung	carcinoma	p.Q1356E	Substitution - Missense	17:43091465-43091465,	PATHOGENIC	0.75042	28481359
BRCA1	1100	COSM6995494,	ovary	germ_cell_tumour	p.L1844L	Substitution - coding silent	17:43045738-43045738,	PATHOGENIC	0.74374	28954785
BRCA1	1100	COSM6937197,	skin	carcinoma	p.A224S	Substitution - Missense	17:43095846-43095846,	PATHOGENIC	0.74188	28481359
BRCA1	1100	COSM6933613,	urinary_tract	carcinoma	p.R1726T	Substitution - Missense	17:43063349-43063349,	PATHOGENIC	0.73959	28481359
BRCA1	1100	COSM6980843,	endometrium	carcinoma	p.Q1848R	Substitution - Missense	17:43045727-43045727,	PATHOGENIC	0.73275	28481359
BRCA1	1100	COSM6978590,	breast	carcinoma	p.Y101N	Substitution - Missense	17:43104868-43104868,	PATHOGENIC	0.7194	28481359
BRCA1	1100	COSM48262,	lung	carcinoma	p.G1077W	Substitution - Missense	17:43092302-43092302,	PATHOGENIC	0.70213	18948947
BRCA1	1100	COSM6949403,	breast	carcinoma	p.E1066K	Substitution - Missense	17:43092335-43092335,	PATHOGENIC	0.70157	28481359
BRCA1	1100	COSM5575370,	ovary	carcinoma	p.?	Unknown	17:43074525-43074525,	NEUTRAL	0.48555	25846551
BRCA1	1100	COSM6936279,	lung	carcinoma	p.S889C	Substitution - Missense	17:43092865-43092865,	NEUTRAL	0.48468	28481359
BRCA1	1100	COSM6923992,	central_nervous_system	glioma	p.D430N	Substitution - Missense	17:43094243-43094243,	NEUTRAL	0.47513	28481359
BRCA1	1100	COSM6958307,	skin	malignant_melanoma	p.E1373K	Substitution - Missense	17:43091012-43091012,	NEUTRAL	0.46226	28481359
BRCA1	1100	COSM6921165,	skin	malignant_melanoma	p.D1757E	Substitution - Missense	17:43057058-43057058,	NEUTRAL	0.41153	28481359
BRCA1	1100	COSM6960734,	skin	malignant_melanoma	p.E638D	Substitution - Missense	17:43093617-43093617,	NEUTRAL	0.4038	28481359
BRCA1	1100	COSM3190097,	oesophagus	carcinoma	p.K604E	Substitution - Missense	17:43093721-43093721,	NEUTRAL	0.39925	24686850
BRCA1	1100	COSM6906937,	urinary_tract	carcinoma	p.S1551C	Substitution - Missense	17:43074354-43074354,	NEUTRAL	0.38037	29420467
BRCA1	1100	COSM6906937,	lung	carcinoma	p.S1551C	Substitution - Missense	17:43074354-43074354,	NEUTRAL	0.38037	28481359
BRCA1	1100	COSM6906937,	urinary_tract	carcinoma	p.S1551C	Substitution - Missense	17:43074354-43074354,	NEUTRAL	0.38037	28481359
BRCA1	1100	COSM6950330,	NS	carcinoma	p.D1813N	Substitution - Missense	17:43047673-43047673,	NEUTRAL	0.37931	28481359
BRCA1	1100	COSM5009696,	large_intestine	carcinoma	p.E1092V	Substitution - Missense	17:43092256-43092256,	NEUTRAL	0.33442	24951259
BRCA1	1100	COSM95782,	breast	carcinoma	p.L1335L	Substitution - coding silent	17:43091526-43091526,	NEUTRAL	0.33111	20668451
BRCA1	1100	COSM6911599,	large_intestine	carcinoma	p.T710I	Substitution - Missense	17:43093402-43093402,	NEUTRAL	0.32395	28481359
BRCA1	1100	COSM6911599,	large_intestine	carcinoma	p.T710I	Substitution - Missense	17:43093402-43093402,	NEUTRAL	0.32395	28481359
BRCA1	1100	COSM6919337,	large_intestine	carcinoma	p.K520N	Substitution - Missense	17:43093971-43093971,	NEUTRAL	0.32139	28481359
BRCA1	1100	COSM6951927,	salivary_gland	carcinoma	p.T1720I	Substitution - Missense	17:43063367-43063367,	NEUTRAL	0.32096	28481359
BRCA1	1100	COSM6950246,	central_nervous_system	glioma	p.E111K	Substitution - Missense	17:43104232-43104232,	NEUTRAL	0.30968	28481359
BRCA1	1100	COSM5575376,	ovary	carcinoma	p.N916I	Substitution - Missense	17:43092784-43092784,	NEUTRAL	0.30792	25846551
BRCA1	1100	COSM6937983,	urinary_tract	carcinoma	p.N113K	Substitution - Missense	17:43104224-43104224,	NEUTRAL	0.30662	28481359
BRCA1	1100	COSM5031244,	urinary_tract	carcinoma	p.E597K	Substitution - Missense	17:43093742-43093742,	NEUTRAL	0.30546	28481359
BRCA1	1100	COSM5031244,	urinary_tract	carcinoma	p.E597K	Substitution - Missense	17:43093742-43093742,	NEUTRAL	0.30546	28481359
BRCA1	1100	COSM93978,	lung	carcinoma	p.Q687P	Substitution - Missense	17:43093471-43093471,	NEUTRAL	0.30155	20668451
BRCA1	1100	COSM5731630,	NS	malignant_melanoma	p.N630H	Substitution - Missense	17:43093643-43093643,	NEUTRAL	0.29674	25886620
BRCA1	1100	COSM133663,	breast	carcinoma	p.S988*	Substitution - Nonsense	17:43092568-43092568,	NEUTRAL	0.29302	22116506
BRCA1	1100	COSM6964074,	lung	carcinoma	p.P1659L	Substitution - Missense	17:43070938-43070938,	NEUTRAL	0.29206	28481359
BRCA1	1100	COSM6933055,	urinary_tract	carcinoma	p.S1320C	Substitution - Missense	17:43091572-43091572,	NEUTRAL	0.2791	28481359
BRCA1	1100	COSM5575338,	ovary	carcinoma	p.N113S	Substitution - Missense	17:43104225-43104225,	NEUTRAL	0.27554	25846551
BRCA1	1100	COSM5575434,	salivary_gland	carcinoma	p.E842*	Substitution - Nonsense	17:43093007-43093007,	NEUTRAL	0.2739	27334835
BRCA1	1100	COSM5575434,	ovary	carcinoma	p.E842*	Substitution - Nonsense	17:43093007-43093007,	NEUTRAL	0.2739	25846551
BRCA1	1100	COSM5020169,	soft_tissue	haemangioblastoma	p.K1109N	Substitution - Missense	17:43092204-43092204,	NEUTRAL	0.2694	25589003
BRCA1	1100	COSM6943401,	urinary_tract	carcinoma	p.E649D	Substitution - Missense	17:43093584-43093584,	NEUTRAL	0.26023	28481359
BRCA1	1100	COSM6959703,	lung	carcinoma	p.T1310S	Substitution - Missense	17:43091603-43091603,	NEUTRAL	0.26023	28481359
BRCA1	1100	COSM6969846,	lung	carcinoma	p.E362G	Substitution - Missense	17:43094446-43094446,	NEUTRAL	0.2586	28481359
BRCA1	1100	COSM979730,	salivary_gland	carcinoma	p.R1443*	Substitution - Nonsense	17:43082434-43082434,	NEUTRAL	0.24687	27334835
BRCA1	1100	COSM6941397,	large_intestine	carcinoma	p.A1615V	Substitution - Missense	17:43071070-43071070,	NEUTRAL	0.24276	28481359
BRCA1	1100	COSM6947316,	lung	carcinoma	p.E904*	Substitution - Nonsense	17:43092821-43092821,	NEUTRAL	0.23506	28481359
BRCA1	1100	COSM7325182,	biliary_tract	carcinoma	p.E1107*	Substitution - Nonsense	17:43092212-43092212,	NEUTRAL	0.22756	29360550
BRCA1	1100	COSM6948420,	lung	carcinoma	p.S741F	Substitution - Missense	17:43093309-43093309,	NEUTRAL	0.22111	28481359
BRCA1	1100	COSM6942636,	large_intestine	carcinoma	p.K1264N	Substitution - Missense	17:43091739-43091739,	NEUTRAL	0.21609	28481359
BRCA1	1100	COSM6944157,	breast	carcinoma	p.P364R	Substitution - Missense	17:43094440-43094440,	NEUTRAL	0.2118	28481359
BRCA1	1100	COSM6907423,	urinary_tract	carcinoma	p.S1286T	Substitution - Missense	17:43091674-43091674,	NEUTRAL	0.20144	25225064
BRCA1	1100	COSM5575523,	ovary	carcinoma	p.N913Y	Substitution - Missense	17:43092794-43092794,	NEUTRAL	0.19983	25846551
BRCA1	1100	COSM6919916,	ovary	carcinoma	p.E1446*	Substitution - Nonsense	17:43082425-43082425,	NEUTRAL	0.19901	28481359
BRCA1	1100	COSM6956228,	large_intestine	carcinoma	p.L1564P	Substitution - Missense	17:43071223-43071223,	NEUTRAL	0.1972	28481359
BRCA1	1100	COSM6995466,	ovary	germ_cell_tumour	p.E349K	Substitution - Missense	17:43094486-43094486,	NEUTRAL	0.19181	28954785
BRCA1	1100	COSM6953777,	skin	carcinoma	p.P1190L	Substitution - Missense	17:43091962-43091962,	NEUTRAL	0.18969	28481359
BRCA1	1100	COSM6907422,	urinary_tract	carcinoma	p.P364A	Substitution - Missense	17:43094441-43094441,	NEUTRAL	0.18829	25225064
BRCA1	1100	COSM133664,	breast	carcinoma	p.K38N	Substitution - Missense	17:43115746-43115746,	NEUTRAL	0.1866	22116506
BRCA1	1100	COSM5730331,	breast	other	p.T1249P	Substitution - Missense	17:43091786-43091786,	NEUTRAL	0.18571	26437033
BRCA1	1100	COSM6922310,	lung	carcinoma	p.N1016I	Substitution - Missense	17:43092484-43092484,	NEUTRAL	0.18416	28481359
BRCA1	1100	COSM6904368,	breast	carcinoma	p.E842K	Substitution - Missense	17:43093007-43093007,	NEUTRAL	0.1811	27925203
BRCA1	1100	COSM6955235,	large_intestine	carcinoma	p.L750I	Substitution - Missense	17:43093283-43093283,	NEUTRAL	0.17966	28481359
BRCA1	1100	COSM6951826,	central_nervous_system	glioma	p.D1123N	Substitution - Missense	17:43092164-43092164,	NEUTRAL	0.17653	28481359
BRCA1	1100	COSM6943774,	urinary_tract	carcinoma	p.P1315L	Substitution - Missense	17:43091587-43091587,	NEUTRAL	0.17155	28481359
BRCA1	1100	COSM6963363,	skin	carcinoma	p.E352D	Substitution - Missense	17:43094475-43094475,	NEUTRAL	0.17072	28481359
BRCA1	1100	COSM6968230,	skin	malignant_melanoma	p.I1237L	Substitution - Missense	17:43091822-43091822,	NEUTRAL	0.16975	28481359
BRCA1	1100	COSM6940749,	lung	carcinoma	p.L269F	Substitution - Missense	17:43094724-43094724,	NEUTRAL	0.16629	28481359
BRCA1	1100	COSM33563,	breast	carcinoma	p.G778C	Substitution - Missense	17:43093199-43093199,	NEUTRAL	0.16554	16959974
BRCA1	1100	COSM5575440,	ovary	carcinoma	p.P1562T	Substitution - Missense	17:43071230-43071230,	NEUTRAL	0.16513	25846551
BRCA1	1100	COSM6980775,	prostate	carcinoma	p.N473S	Substitution - Missense	17:43094113-43094113,	NEUTRAL	0.16198	28481359
BRCA1	1100	COSM7325180,	biliary_tract	carcinoma	p.L1558I	Substitution - Missense	17:43074334-43074334,	NEUTRAL	0.15975	29360550
BRCA1	1100	COSM7325180,	biliary_tract	carcinoma	p.L1558I	Substitution - Missense	17:43074334-43074334,	NEUTRAL	0.15975	29360550
BRCA1	1100	COSM6964076,	lung	carcinoma	p.H1244Y	Substitution - Missense	17:43091801-43091801,	NEUTRAL	0.15277	28481359
BRCA1	1100	COSM6964584,	large_intestine	carcinoma	p.G890W	Substitution - Missense	17:43092863-43092863,	NEUTRAL	0.15113	28481359
BRCA1	1100	COSM6944146,	urinary_tract	carcinoma	p.E1490Q	Substitution - Missense	17:43076504-43076504,	NEUTRAL	0.15026	28481359
BRCA1	1100	COSM6944146,	urinary_tract	carcinoma	p.E1490Q	Substitution - Missense	17:43076504-43076504,	NEUTRAL	0.15026	28481359
BRCA1	1100	COSM4066742,	skin	carcinoma	p.S1499F	Substitution - Missense	17:43074510-43074510,	NEUTRAL	0.14306	28481359
BRCA1	1100	COSM1645401,	large_intestine	carcinoma	p.N1067Y	Substitution - Missense	17:43092332-43092332,	NEUTRAL	0.142	23700467
BRCA1	1100	COSM6965200,	urinary_tract	carcinoma	p.D695N	Substitution - Missense	17:43093448-43093448,	NEUTRAL	0.14019	28481359
BRCA1	1100	COSM6946371,	large_intestine	carcinoma	p.S741Y	Substitution - Missense	17:43093309-43093309,	NEUTRAL	0.13857	28481359
BRCA1	1100	COSM6911858,	lung	carcinoma	p.A1308S	Substitution - Missense	17:43091609-43091609,	NEUTRAL	0.13746	28481359
BRCA1	1100	COSM6932046,	central_nervous_system	glioma	p.L471F	Substitution - Missense	17:43094120-43094120,	NEUTRAL	0.13685	28481359
BRCA1	1100	COSM5009557,	large_intestine	carcinoma	p.S335I	Substitution - Missense	17:43094527-43094527,	NEUTRAL	0.13564	24951259
BRCA1	1100	COSM6986490,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N550H	Substitution - Missense	17:43093883-43093883,	NEUTRAL	0.1301	28481359
BRCA1	1100	COSM5607950,	skin	malignant_melanoma	p.S1241F	Substitution - Missense	17:43091809-43091809,	NEUTRAL	0.12173	26343386
BRCA1	1100	COSM219050,	ovary	carcinoma	p.E836*	Substitution - Nonsense	17:43093025-43093025,	NEUTRAL	0.11594	20606085
BRCA1	1100	COSM6849656,	breast	carcinoma	p.E1373E	Substitution - coding silent	17:43091010-43091010,	NEUTRAL	0.11335	28270497
BRCA1	1100	COSM1577247,	ovary	carcinoma	p.L1276*	Substitution - Nonsense	17:43091704-43091704,	NEUTRAL	0.11244	23633455
BRCA1	1100	COSM6909111,	urinary_tract	carcinoma	p.H1284Y	Substitution - Missense	17:43091681-43091681,	NEUTRAL	0.11141	28481359
BRCA1	1100	COSM3190103,	large_intestine	carcinoma	p.E575K	Substitution - Missense	17:43093808-43093808,	NEUTRAL	0.10995	28481359
BRCA1	1100	COSM6910271,	breast	carcinoma	p.G1825R	Substitution - Missense	17:43045797-43045797,	NEUTRAL	0.10907	28481359
BRCA1	1100	COSM6951202,	breast	carcinoma	p.R951K	Substitution - Missense	17:43092679-43092679,	NEUTRAL	0.10898	28481359
BRCA1	1100	COSM6951007,	urinary_tract	carcinoma	p.E1413K	Substitution - Missense	17:43082524-43082524,	NEUTRAL	0.10761	28481359
BRCA1	1100	COSM6923792,	breast	carcinoma	p.S561F	Substitution - Missense	17:43093849-43093849,	NEUTRAL	0.10757	28481359
BRCA1	1100	COSM95581,	large_intestine	carcinoma	p.E1644*	Substitution - Nonsense	17:43070984-43070984,	NEUTRAL	0.10718	28481359
BRCA1	1100	COSM95581,	lung	carcinoma	p.E1644*	Substitution - Nonsense	17:43070984-43070984,	NEUTRAL	0.10718	20668451
BRCA1	1100	COSM6984614,	endometrium	carcinoma	p.E1112A	Substitution - Missense	17:43092196-43092196,	NEUTRAL	0.10672	28481359
BRCA1	1100	COSM6940989,	urinary_tract	carcinoma	p.D345H	Substitution - Missense	17:43094498-43094498,	NEUTRAL	0.10434	28481359
BRCA1	1100	COSM6920782,	lung	carcinoma	p.E1214D	Substitution - Missense	17:43091889-43091889,	NEUTRAL	0.10421	28481359
BRCA1	1100	COSM4989395,	soft_tissue	haemangioblastoma	p.D693N	Substitution - Missense	17:43093454-43093454,	NEUTRAL	0.10317	25589003
BRCA1	1100	COSM4989395,	soft_tissue	haemangioblastoma	p.D693N	Substitution - Missense	17:43093454-43093454,	NEUTRAL	0.10317	25589003
BRCA1	1100	COSM6976685,	central_nervous_system	glioma	p.P497S	Substitution - Missense	17:43094042-43094042,	NEUTRAL	0.10125	28481359
BRCA1	1100	COSM6928176,	urinary_tract	carcinoma	p.E1185Q	Substitution - Missense	17:43091978-43091978,	NEUTRAL	0.09946	28481359
BRCA1	1100	COSM5575249,	ovary	carcinoma	p.Y777*	Substitution - Nonsense	17:43093200-43093200,	NEUTRAL	0.09751	25846551
BRCA1	1100	COSM219051,	ovary	carcinoma	p.E1609*	Substitution - Nonsense	17:43071089-43071089,	NEUTRAL	0.09579	20606085
BRCA1	1100	COSM6987719,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.I946F	Substitution - Missense	17:43092695-43092695,	NEUTRAL	0.09324	28481359
BRCA1	1100	COSM5009437,	large_intestine	carcinoma	p.R1762G	Substitution - Missense	17:43051111-43051111,	NEUTRAL	0.09311	24951259
BRCA1	1100	COSM93977,	breast	carcinoma	p.I986M	Substitution - Missense	17:43092573-43092573,	NEUTRAL	0.09289	20668451
BRCA1	1100	COSM6929392,	NS	malignant_melanoma	p.S770L	Substitution - Missense	17:43093222-43093222,	NEUTRAL	0.09203	28481359
BRCA1	1100	COSM5575374,	ovary	carcinoma	p.M1008I	Substitution - Missense	17:43092507-43092507,	NEUTRAL	0.0902	25846551
BRCA1	1100	COSM5007993,	large_intestine	carcinoma	p.R979R	Substitution - coding silent	17:43092594-43092594,	NEUTRAL	0.08997	24951259
BRCA1	1100	COSM6944302,	large_intestine	carcinoma	p.K556Q	Substitution - Missense	17:43093865-43093865,	NEUTRAL	0.08484	28481359
BRCA1	1100	COSM3190057,	endometrium	carcinoma	p.E962K	Substitution - Missense	17:43092647-43092647,	NEUTRAL	0.08371	28481359
BRCA1	1100	COSM6944155,	breast	carcinoma	p.R496C	Substitution - Missense	17:43094045-43094045,	NEUTRAL	0.08315	28481359
BRCA1	1100	COSM309513,	lung	carcinoma	p.I1858I	Substitution - coding silent	17:43045696-43045696,	NEUTRAL	0.08211	22941188
BRCA1	1100	COSM6943405,	urinary_tract	carcinoma	p.E250K	Substitution - Missense	17:43094783-43094783,	NEUTRAL	0.08063	28481359
BRCA1	1100	COSM5009291,	large_intestine	carcinoma	p.S1021S	Substitution - coding silent	17:43092468-43092468,	NEUTRAL	0.0803	24951259
BRCA1	1100	COSM6913810,	breast	carcinoma	p.K608N	Substitution - Missense	17:43093707-43093707,	NEUTRAL	0.0776	28481359
BRCA1	1100	COSM5575486,	ovary	carcinoma	p.Q921H	Substitution - Missense	17:43092768-43092768,	NEUTRAL	0.07549	25846551
BRCA1	1100	COSM5575401,	ovary	carcinoma	p.?	Unknown	17:43094868-43094868,	NEUTRAL	0.07194	25846551
BRCA1	1100	COSM6950497,	autonomic_ganglia	neuroblastoma	p.E457*	Substitution - Nonsense	17:43094162-43094162,	NEUTRAL	0.07022	28481359
BRCA1	1100	COSM6971202,	urinary_tract	carcinoma	p.D1546Y	Substitution - Missense	17:43074370-43074370,	NEUTRAL	0.06978	28481359
BRCA1	1100	COSM6980253,	large_intestine	carcinoma	p.Q202R	Substitution - Missense	17:43095911-43095911,	NEUTRAL	0.0672	28481359
BRCA1	1100	COSM6924946,	lung	carcinoma	p.G1543V	Substitution - Missense	17:43074378-43074378,	NEUTRAL	0.06708	28481359
BRCA1	1100	COSM33259,	breast	carcinoma	p.L758F	Substitution - Missense	17:43093257-43093257,	NEUTRAL	0.06614	16959974
BRCA1	1100	COSM6942405,	autonomic_ganglia	neuroblastoma	p.I783L	Substitution - Missense	17:43093184-43093184,	NEUTRAL	0.06602	28481359
BRCA1	1100	COSM5575368,	ovary	carcinoma	p.S1551T	Substitution - Missense	17:43074355-43074355,	NEUTRAL	0.06316	25846551
BRCA1	1100	COSM6946369,	large_intestine	carcinoma	p.K1278Q	Substitution - Missense	17:43091699-43091699,	NEUTRAL	0.06225	28481359
BRCA1	1100	COSM4936462,	urinary_tract	carcinoma	p.A1608T	Substitution - Missense	17:43071092-43071092,	NEUTRAL	0.06047	28481359
BRCA1	1100	COSM6948299,	central_nervous_system	glioma	p.G1371E	Substitution - Missense	17:43091017-43091017,	NEUTRAL	0.05993	28481359
BRCA1	1100	COSM6918674,	skin	carcinoma	p.P1315S	Substitution - Missense	17:43091588-43091588,	NEUTRAL	0.05835	28481359
BRCA1	1100	COSM3755566,	large_intestine	carcinoma	p.L771L	Substitution - coding silent	17:43093220-43093220,	NEUTRAL	0.05772	24951259
BRCA1	1100	COSM3755566,	breast	carcinoma	p.L771L	Substitution - coding silent	17:43093220-43093220,	NEUTRAL	0.05772	28270497
BRCA1	1100	COSM6962805,	central_nervous_system	glioma	p.S242N	Substitution - Missense	17:43094806-43094806,	NEUTRAL	0.0562	28481359
BRCA1	1100	COSM6983858,	salivary_gland	carcinoma	p.S1466I	Substitution - Missense	17:43076575-43076575,	NEUTRAL	0.05608	28481359
BRCA1	1100	COSM6927490,	lung	carcinoma	p.P334S	Substitution - Missense	17:43094531-43094531,	NEUTRAL	0.05557	28481359
BRCA1	1100	COSM5575455,	ovary	carcinoma	p.T1619S	Substitution - Missense	17:43071059-43071059,	NEUTRAL	0.05258	25846551
BRCA1	1100	COSM249516,	kidney	carcinoma	p.Q895R	Substitution - Missense	17:43092847-43092847,	NEUTRAL	0.05154	22138691
BRCA1	1100	COSM35894,	breast	carcinoma	p.S1140G	Substitution - Missense	17:43092113-43092113,	NEUTRAL	0.05141	19593635
BRCA1	1100	COSM6984759,	lung	carcinoma	p.G1624W	Substitution - Missense	17:43071044-43071044,	NEUTRAL	0.05094	28481359
BRCA1	1100	COSM6972019,	biliary_tract	carcinoma	p.S708C	Substitution - Missense	17:43093408-43093408,	NEUTRAL	0.05018	28481359
BRCA1	1100	COSM5010127,	large_intestine	carcinoma	p.L735L	Substitution - coding silent	17:43093326-43093326,	NEUTRAL	0.0501	24951259
BRCA1	1100	COSM3755563,	breast	carcinoma	p.E1038G	Substitution - Missense	17:43092418-43092418,	NEUTRAL	0.05009	28270497
BRCA1	1100	COSM3755563,	thymus	thymoma	p.E1038G	Substitution - Missense	17:43092418-43092418,	NEUTRAL	0.05009	24974848
BRCA1	1100	COSM6929070,	central_nervous_system	glioma	p.S1434N	Substitution - Missense	17:43082460-43082460,	NEUTRAL	0.04749	28481359
BRCA1	1100	COSM6915241,	testis	germ_cell_tumour	p.G535R	Substitution - Missense	17:43093928-43093928,	NEUTRAL	0.04664	28481359
BRCA1	1100	COSM6965466,	salivary_gland	carcinoma	p.L413M	Substitution - Missense	17:43094294-43094294,	NEUTRAL	0.0446	28481359
BRCA1	1100	COSM6947518,	lung	carcinoma	p.P1491L	Substitution - Missense	17:43076500-43076500,	NEUTRAL	0.04459	28481359
BRCA1	1100	COSM6947518,	urinary_tract	carcinoma	p.P1491L	Substitution - Missense	17:43076500-43076500,	NEUTRAL	0.04459	28481359
BRCA1	1100	COSM4990999,	skin	carcinoma	p.L1439F	Substitution - Missense	17:43082446-43082446,	NEUTRAL	0.04416	25589618
BRCA1	1100	COSM5575519,	ovary	carcinoma	p.?	Unknown	17:43074529-43074529,	NEUTRAL	0.04394	25846551
BRCA1	1100	COSM6982900,	breast	carcinoma	p.Q1525H	Substitution - Missense	17:43074431-43074431,	NEUTRAL	0.04328	28481359
BRCA1	1100	COSM93979,	lung	carcinoma	p.V370I	Substitution - Missense	17:43094423-43094423,	NEUTRAL	0.04309	28481359
BRCA1	1100	COSM93979,	breast	carcinoma	p.V370I	Substitution - Missense	17:43094423-43094423,	NEUTRAL	0.04309	20668451
BRCA1	1100	COSM5589839,	kidney	carcinoma	p.P930S	Substitution - Missense	17:43092743-43092743,	NEUTRAL	0.04148	28481359
BRCA1	1100	COSM6956818,	lung	carcinoma	p.V1035D	Substitution - Missense	17:43092427-43092427,	NEUTRAL	0.04117	28481359
BRCA1	1100	COSM4416375,	large_intestine	carcinoma	p.S1436S	Substitution - coding silent	17:43082453-43082453,	NEUTRAL	0.04109	24951259
BRCA1	1100	COSM4883379,	ovary	carcinoma	p.D1582E	Substitution - Missense	17:43071168-43071168,	NEUTRAL	0.0392	25846551
BRCA1	1100	COSM6938515,	large_intestine	carcinoma	p.H399R	Substitution - Missense	17:43094335-43094335,	NEUTRAL	0.03899	28481359
BRCA1	1100	COSM5607952,	skin	malignant_melanoma	p.F958F	Substitution - coding silent	17:43092657-43092657,	NEUTRAL	0.03891	26343386
BRCA1	1100	COSM6923117,	central_nervous_system	glioma	p.V1378I	Substitution - Missense	17:43090997-43090997,	NEUTRAL	0.0382	28481359
BRCA1	1100	COSM5989940,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.S153R	Substitution - Missense	17:43099865-43099865,	NEUTRAL	0.03784	26648538
BRCA1	1100	COSM6915175,	lung	carcinoma	p.R1762M	Substitution - Missense	17:43051110-43051110,	NEUTRAL	0.03728	28481359
BRCA1	1100	COSM3190073,	large_intestine	carcinoma	p.T843A	Substitution - Missense	17:43093004-43093004,	NEUTRAL	0.03695	28481359
BRCA1	1100	COSM5575245,	ovary	carcinoma	p.W1508C	Substitution - Missense	17:43074482-43074482,	NEUTRAL	0.03582	25846551
BRCA1	1100	COSM6967916,	lung	carcinoma	p.N1488S	Substitution - Missense	17:43076509-43076509,	NEUTRAL	0.03457	28481359
BRCA1	1100	COSM6977429,	pancreas	carcinoma	p.P568T	Substitution - Missense	17:43093829-43093829,	NEUTRAL	0.03452	28481359
BRCA1	1100	COSM6984047,	NS	malignant_melanoma	p.G1515E	Substitution - Missense	17:43074462-43074462,	NEUTRAL	0.03418	28481359
BRCA1	1100	COSM7325173,	biliary_tract	carcinoma	p.S434N	Substitution - Missense	17:43094230-43094230,	NEUTRAL	0.03308	29360550
BRCA1	1100	COSM6911765,	central_nervous_system	glioma	p.S1360N	Substitution - Missense	17:43091452-43091452,	NEUTRAL	0.03307	28481359
BRCA1	1100	COSM1246204,	urinary_tract	carcinoma	p.R841W	Substitution - Missense	17:43093010-43093010,	NEUTRAL	0.03177	28481359
BRCA1	1100	COSM1246204,	prostate	carcinoma	p.R841W	Substitution - Missense	17:43093010-43093010,	NEUTRAL	0.03177	28481359
BRCA1	1100	COSM3755560,	thymus	thymoma	p.S1613G	Substitution - Missense	17:43071077-43071077,	NEUTRAL	0.03114	24974848
BRCA1	1100	COSM3755560,	large_intestine	carcinoma	p.S1613G	Substitution - Missense	17:43071077-43071077,	NEUTRAL	0.03114	24951259
BRCA1	1100	COSM3755560,	breast	carcinoma	p.S1613G	Substitution - Missense	17:43071077-43071077,	NEUTRAL	0.03114	28270497
BRCA1	1100	COSM6974300,	large_intestine	carcinoma	p.I1680V	Substitution - Missense	17:43067644-43067644,	NEUTRAL	0.03095	28481359
BRCA1	1100	COSM4604945,	upper_aerodigestive_tract	carcinoma	p.K912N	Substitution - Missense	17:43092795-43092795,	NEUTRAL	0.0306	25056374
BRCA1	1100	COSM6960597,	lung	carcinoma	p.G200V	Substitution - Missense	17:43095917-43095917,	NEUTRAL	0.03057	28481359
BRCA1	1100	COSM6845287,	vulva	in_situ_neoplasm	p.M1008I	Substitution - Missense	17:43092507-43092507,	NEUTRAL	0.03023	27834349
BRCA1	1100	COSM6845287,	vulva	in_situ_neoplasm	p.M1008I	Substitution - Missense	17:43092507-43092507,	NEUTRAL	0.03023	27834349
BRCA1	1100	COSM5575442,	ovary	carcinoma	p.C636F	Substitution - Missense	17:43093624-43093624,	NEUTRAL	0.028	25846551
BRCA1	1100	COSM6907057,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.F486L	Substitution - Missense	17:43094075-43094075,	NEUTRAL	0.02477	28481359
BRCA1	1100	COSM6907057,	endometrium	carcinoma	p.F486L	Substitution - Missense	17:43094075-43094075,	NEUTRAL	0.02477	29420467
BRCA1	1100	COSM6981661,	large_intestine	carcinoma	p.G1803V	Substitution - Missense	17:43047702-43047702,	NEUTRAL	0.02422	28481359
BRCA1	1100	COSM6959551,	central_nervous_system	glioma	p.G1138E	Substitution - Missense	17:43092118-43092118,	NEUTRAL	0.02402	28481359
BRCA1	1100	COSM5607954,	skin	malignant_melanoma	p.E1635E	Substitution - coding silent	17:43071009-43071009,	NEUTRAL	0.02378	26343386
BRCA1	1100	COSM5575247,	ovary	carcinoma	p.Y831F	Substitution - Missense	17:43093039-43093039,	NEUTRAL	0.02357	25846551
BRCA1	1100	COSM6977845,	prostate	carcinoma	p.T1485S	Substitution - Missense	17:43076518-43076518,	NEUTRAL	0.02179	28481359
BRCA1	1100	COSM6914389,	skin	carcinoma	p.T236I	Substitution - Missense	17:43094824-43094824,	NEUTRAL	0.01787	28481359
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	breast	carcinoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	28270497
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	large_intestine	carcinoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	24951259
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	breast	carcinoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	28270497
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	large_intestine	carcinoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	24951259
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM5575361,	ovary	carcinoma	p.V1493E	Substitution - Missense	17:43076494-43076494,	NEUTRAL	0.01519	25846551
BRCA1	1100	COSM1168835,	bone	osteosarcoma	p.T539M	Substitution - Missense	17:43093915-43093915,	NEUTRAL	0.01366	27499911
BRCA1	1100	COSM6612502,	large_intestine	carcinoma	p.L1260V	Substitution - Missense	17:43091753-43091753,	NEUTRAL	0.01236	28481359
BRCA1	1100	COSM6952888,	pancreas	carcinoma	p.Y1625C	Substitution - Missense	17:43071040-43071040,	NEUTRAL	0.0123	28481359
BRCA1	1100	COSM6976683,	central_nervous_system	glioma	p.E1540K	Substitution - Missense	17:43074388-43074388,	NEUTRAL	0.01172	28481359
BRCA1	1100	COSM6932044,	central_nervous_system	glioma	p.M751I	Substitution - Missense	17:43093278-43093278,	NEUTRAL	0.00897	28481359
BRCA1	1100	COSM6913715,	central_nervous_system	glioma	p.G200R	Substitution - Missense	17:43095918-43095918,	NEUTRAL	0.00897	28481359
BRCA1	1100	COSM6938826,	large_intestine	carcinoma	p.I171T	Substitution - Missense	17:43099810-43099810,	NEUTRAL	0.00887	28481359
BRCA1	1100	COSM1521479,	large_intestine	carcinoma	p.A622A	Substitution - coding silent	17:43093665-43093665,	NEUTRAL	0.00681	24951259
BRCA1	1100	COSM6971572,	lung	carcinoma	p.T922A	Substitution - Missense	17:43092767-43092767,	NEUTRAL	0.00579	28481359
BRCA1	1100	COSM148280,	breast	carcinoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	28270497
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	large_intestine	carcinoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	24951259
BRCA1	1100	COSM6941994,	large_intestine	carcinoma	p.S1448N	Substitution - Missense	17:43082418-43082418,	NEUTRAL	0.00445	28481359
BRCA1	1100	COSM5743853,	thyroid	adenoma-nodule-goitre	p.R496H	Substitution - Missense	17:43094044-43094044,	NEUTRAL	0.00389	28481359
BRCA1	1100	COSM5008016,	large_intestine	carcinoma	p.R332Q	Substitution - Missense	17:43094536-43094536,	NEUTRAL	0.00324	24951259
BRCA1	1100	COSM5010125,	large_intestine	carcinoma	p.S1587P	Substitution - Missense	17:43071155-43071155,	NEUTRAL	0.00177	24951259
BRCA1	1100	COSM5575550,	ovary	carcinoma	p.D1506N	Substitution - Missense	17:43074490-43074490,	NEUTRAL	0.00168	25846551
BRCA1	1100	COSM6943772,	urinary_tract	carcinoma	p.E1478Q	Substitution - Missense	17:43076540-43076540,	NEUTRAL	0.00082	28481359
BRCA1	1100	COSM23931,	endometrium	carcinoma	p.K1183fs*4	Deletion - Frameshift	17:43091982-43091983,	Info_not_available	Info_not_available	10451700
BRCA1	1100	COSM23934,	breast	carcinoma	p.I925fs*13	Insertion - Frameshift	17:43092757-43092758,	Info_not_available	Info_not_available	10467410
BRCA1	1100	COSM24626,	ovary	carcinoma	p.F869fs*35	Insertion - Frameshift	17:43092926-43092927,	Info_not_available	Info_not_available	10686936
BRCA1	1100	COSM23932,	ovary	carcinoma	p.C1146fs*8	Deletion - Frameshift	17:43092092-43092095,	Info_not_available	Info_not_available	11240689
BRCA1	1100	COSM23959,	breast	carcinoma	p.E1288fs*19	Deletion - Frameshift	17:43091669-43091669,	Info_not_available	Info_not_available	15712267
BRCA1	1100	COSM35891, COSM35892, COSM35893,	breast	carcinoma	p.E23fs*17, p.P724fs*12, p.Q1756fs*74	Deletion - Frameshift, Insertion - Frameshift	17:43057065-43057066, 17:43093362-43093362, 17:43124030-43124031,	Info_not_available	Info_not_available	19593635
BRCA1	1100	COSM219048, COSM219049, COSM219052, COSM219053, COSM219054, COSM219055,	ovary	carcinoma	p.?, p.E29*, p.G1738R, p.H816fs*3, p.K654fs*47, p.N287fs*6	Deletion - Frameshift, Substitution - Missense, Substitution - Nonsense, Unknown	17:43093075-43093085, 17:43093570-43093570, 17:43094668-43094672,	Info_not_available	Info_not_available	20606085
BRCA1	1100	COSM1577246, COSM1666857,	ovary	carcinoma	p.K1254fs*11, p.V1176fs*34	Deletion - Frameshift	17:43091765-43091769, 17:43092005-43092005,	Info_not_available	Info_not_available	23633455
BRCA1	1100	COSM1666622, COSM1666623, COSM1666624, COSM1666625, COSM1666626, COSM1666627,	ovary	carcinoma	p.A17fs*14, p.E23fs*17, p.M1775fs*54, p.Q1756fs*74, p.Q1756fs*75, p.Y1522*	Frameshift, Substitution - Nonsense	Info_not_available	Info_not_available	Info_not_available	23791828
BRCA1	1100	COSM5881439,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R163G	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	24150215
BRCA1	1100	COSM4766055,	breast	carcinoma	p.S1796fs*34	Insertion - Frameshift	17:43049141-43049142,	Info_not_available	Info_not_available	24185510
BRCA1	1100	COSM1666622,	biliary_tract	carcinoma	p.Q1756fs*74	Frameshift	Info_not_available	Info_not_available	Info_not_available	24563076
BRCA1	1100	COSM4166524, COSM4172552,	skin	malignant_melanoma	p.?, p.P938S	Substitution - Missense, Unknown	Info_not_available	Info_not_available	Info_not_available	24628946
BRCA1	1100	COSM4166524,	breast	carcinoma	p.?	Unknown	Info_not_available	Info_not_available	Info_not_available	24849582
BRCA1	1100	COSM4387488,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.0	Whole gene deletion	Info_not_available	Info_not_available	Info_not_available	24997557
BRCA1	1100	COSM4603914,	upper_aerodigestive_tract	carcinoma	p.V83fs*2	Insertion - Frameshift	17:43104922-43104923,	Info_not_available	Info_not_available	25056374
BRCA1	1100	COSM5415231,	endometrium	carcinoma	p.?fs*?	Deletion - Frameshift	Info_not_available	Info_not_available	Info_not_available	25233892
BRCA1	1100	COSM1666624, COSM4603638, COSM4603639, COSM4603640,	pancreas	carcinoma	p.?, p.E1250fs*8, p.E23fs*17, p.W1508*	Frameshift, Substitution - Nonsense, Unknown	Info_not_available	Info_not_available	Info_not_available	25266736
BRCA1	1100	COSM4984808,	lung	carcinoma	p.E1011K	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	25567908
BRCA1	1100	COSM3190163,	soft_tissue	haemangioblastoma	p.E23fs*17	Deletion - Frameshift	17:43124028-43124029,	Info_not_available	Info_not_available	25589003
BRCA1	1100	COSM5032206, COSM5032207,	lung	carcinoma	p.A224S, p.K223N	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	25922291
BRCA1	1100	COSM6057040,	lung	carcinoma	p.E648Q	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	25971939
BRCA1	1100	COSM1666622, COSM6023966,	NS	carcinoma	p.C39fs*1, p.Q1756fs*74	Frameshift	Info_not_available	Info_not_available	Info_not_available	26182302
BRCA1	1100	COSM6005480,	breast	carcinoma, other	p.D1505fs*43	Deletion - Frameshift	17:43074494-43074494,	Info_not_available	Info_not_available	26806567
BRCA1	1100	COSM5702555,	ovary	germ_cell_tumour	p.L502fs*2	Deletion - Frameshift	17:43094023-43094027,	Info_not_available	Info_not_available	26822237
BRCA1	1100	COSM6022878,	lung	carcinoma	p.C903*	Substitution - Nonsense	Info_not_available	Info_not_available	Info_not_available	27528220
BRCA1	1100	COSM5985660,	lung	carcinoma	p.K1702E	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	27588476
BRCA1	1100	COSM6904461,	upper_aerodigestive_tract	carcinoma	p.D366H	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	28493366
BRCA1	1100	COSM6904546, COSM6904547,	breast	carcinoma	p.I492L, p.Q563H	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	28921573
BRCA1	1100	COSM4166524,	upper_aerodigestive_tract	carcinoma	p.?	Unknown	Info_not_available	Info_not_available	Info_not_available	28961834
BRCA1	1100	COSM6865932,	skin	malignant_melanoma	p.R841W	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	29264386
BRCA1	1100	COSM6997553,	liver	carcinoma	p.G511G	Substitution - coding silent	Info_not_available	Info_not_available	Info_not_available	29487225
BRCA1	1100	COSM23923,	ovary	carcinoma	p.A1814fs*20	Deletion - Frameshift	17:43047670-43047670,	Info_not_available	Info_not_available	7795636
BRCA1	1100	COSM24526, COSM24529,	ovary	carcinoma	p.Q12fs*5, p.S1796fs*34	Insertion - Frameshift	17:43049143-43049144, 17:43124064-43124065,	Info_not_available	Info_not_available	7795652
BRCA1	1100	COSM23942, COSM23943, COSM23945, COSM23946, COSM23947, COSM23948,	ovary	carcinoma	p.E730*, p.G817fs*29, p.Q1420*, p.R1835*, p.V757fs*8, p.Y655fs*18	Deletion - Frameshift, Insertion - Frameshift, Substitution - Nonsense	17:43093081-43093081, 17:43093262-43093262, 17:43093570-43093571,	Info_not_available	Info_not_available	9796975
BRCA1	1100	COSM3517885,	skin	carcinoma	p.P985L	Substitution - Missense	17:43092577-43092577,	Info_not_available	0.69524	25589618
BRCA1	1100	COSM6444637,	endometrium	carcinoma	p.I1568S	Substitution - Missense	17:43071211-43071211,	Info_not_available	0.67445	27159395
BRCA1	1100	COSM6906633,	urinary_tract	carcinoma	p.R1347T	Substitution - Missense	17:43091491-43091491,	Info_not_available	0.66658	29420467
BRCA1	1100	COSM6019339,	lung	carcinoma	p.E1346K	Substitution - Missense	17:43091495-43091495,	Info_not_available	0.66017	27694386
BRCA1	1100	COSM5607956,	skin	malignant_melanoma	p.V271V	Substitution - coding silent	17:43094718-43094718,	Info_not_available	0.61579	26343386
BRCA1	1100	COSM23941,	breast	carcinoma	p.?	Unknown	17:43124099-43124099,	Info_not_available	0.56487	9665150
BRCA1	1100	COSM5575269, COSM5575459, COSM5575476,	ovary	carcinoma	p.K893fs*107, p.Q921L, p.R446fs*9	Deletion - Frameshift, Substitution - Missense	17:43092769-43092769, 17:43092853-43092853, 17:43094195-43094196,	Info_not_available	0.55798, Info_not_available	25846551
BRCA1	1100	COSM133665, COSM133666, COSM133667,	breast	carcinoma	p.C64fs*1, p.G275D, p.K309Q	Deletion - Frameshift, Substitution - Missense	17:43094606-43094606, 17:43094707-43094707, 17:43106456-43106477,	Info_not_available	0.55347, .67357, Info_not_available	22116506
BRCA1	1100	COSM6024027,	ovary	carcinoma	p.Q210*	Substitution - Nonsense	17:43095888-43095888,	Info_not_available	0.53112	27533253
BRCA1	1100	COSM85905,	breast	carcinoma	p.S451*	Substitution - Nonsense	17:43094179-43094179,	Info_not_available	0.52772	21233401
BRCA1	1100	COSM5009494,	large_intestine	carcinoma	p.E143K	Substitution - Missense	17:43104136-43104136,	Info_not_available	0.52521	24951259
BRCA1	1100	COSM1383519, COSM5852615, COSM6906633, COSM6910420, COSM6910690, COSM6910855, COSM6918821, COSM6921108, COSM6921428, COSM6924678, COSM6925067, COSM6931075, COSM6931552, COSM6938537, COSM6941417, COSM6942811, COSM6943528, COSM6945217, COSM6947564, COSM6948177, COSM6949150, COSM6949163, COSM6950476, COSM6953109, COSM6955796, COSM6956392, COSM6960486, COSM6962170, COSM6963090, COSM6965785, COSM6966188, COSM6969016, COSM6970126, COSM6971372, COSM6972170, COSM6973903, COSM6974564, COSM6974566, COSM6976516, COSM6977006, COSM6978645, COSM6980798, COSM6981366, COSM6981423, COSM6981787, COSM6986934, COSM979733,	biliary_tract, breast, central_nervous_system, endometrium, eye, haematopoietic_and_lymphoid_tissue, large_intestine, lung, ovary, pancreas, prostate, skin, soft_tissue, stomach, thyroid, upper_aerodigestive_tract, urinary_tract	carcinoma, glioma, leiomyosarcoma, lymphoid_neoplasm, malignant_melanoma	p.?, p.E1013fs*4, p.E1219fs*12, p.E1258*, p.E1258D, p.E1451*, p.E23fs*18, p.E597*, p.E686fs*1, p.E729fs*10, p.E75fs*13, p.G1371fs*4, p.G1801fs*33, p.G911fs*89, p.I1723V, p.I986fs*14, p.K1079fs*2, p.K339fs*2, p.K654fs*47, p.L1317fs*1, p.L1517V, p.L1764fs*1, p.L290fs*8, p.L358fs*13, p.L666I, p.M1663V, p.M1728fs*2, p.N567fs*16, p.P1190F, p.P1192F, p.P634S, p.Q1240E, p.Q1240L, p.Q1756*, p.Q210fs*6, p.R1347T, p.R296K, p.R71fs*10, p.R7_E9>Q, p.S1497P, p.S1569G, p.S886fs*16, p.T464fs*11, p.V1654fs*4, p.V1792L, p.Y655fs*18	Complex - deletion inframe, Complex - frameshift, Deletion - Frameshift, Insertion - Frameshift, Substitution - Missense, Substitution - Nonsense, Unknown	17:43049129-43049129, 17:43049153-43049154, 17:43051106-43051106, 17:43057063-43057064, 17:43063344-43063344, 17:43063359-43063359, 17:43067695-43067695, 17:43070954-43070954, 17:43071209-43071209, 17:43074457-43074457, 17:43074517-43074517, 17:43082410-43082410, 17:43091017-43091018, 17:43091491-43091491, 17:43091581-43091581, 17:43091757-43091757, 17:43091759-43091759, 17:43091812-43091812, 17:43091813-43091813, 17:43091865-43091877, 17:43091956-43091957, 17:43091962-43091963, 17:43092294-43092294, 17:43092493-43092494, 17:43092579-43092579, 17:43092799-43092799, 17:43092873-43092874, 17:43093349-43093350, 17:43093475-43093476, 17:43093535-43093535, 17:43093569-43093570, 17:43093570-43093570, 17:43093631-43093631, 17:43093742-43093742, 17:43093825-43093832, 17:43094141-43094141, 17:43094449-43094459, 17:43094515-43094515, 17:43094644-43094644, 17:43094662-43094662, 17:43095889-43095890, 17:43095922-43095923, 17:43104946-43104946, 17:43106456-43106457, 17:43124029-43124030, 17:43124072-43124077,	Info_not_available	0.50432, .51501, .51649, .52623, .56306, .57502, .58901, .59178, .60261, .62766, .63384, .64677, .65418, .66658, .6726, .67974, Info_not_available	28481359
BRCA1	1100	COSM93976,	breast	carcinoma	p.E1011K	Substitution - Missense	17:43092500-43092500,	Info_not_available	0.50284	20668451
BRCA1	1100	COSM7325201,	biliary_tract	carcinoma	p.L1676F	Substitution - Missense	17:43067654-43067654,	Info_not_available	0.50154	29360550