Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
MAPK3	6877	COSM6926859,	skin	carcinoma	p.Q266*	Substitution - Nonsense	16:30117265-30117265,	PATHOGENIC	0.9855	28481359
MAPK3	6877	COSM6958958,	upper_aerodigestive_tract	carcinoma	p.E339V	Substitution - Missense	16:30116895-30116895,	PATHOGENIC	0.97903	28481359
MAPK3	6877	COSM6967854,	skin	carcinoma	p.S219F	Substitution - Missense	16:30118051-30118051,	PATHOGENIC	0.96393	28481359
MAPK3	6877	COSM6946343,	large_intestine	carcinoma	p.I190T	Substitution - Missense	16:30118138-30118138,	PATHOGENIC	0.95772	28481359
MAPK3	6877	COSM6926744,	breast	carcinoma	p.R211P	Substitution - Missense	16:30118075-30118075,	PATHOGENIC	0.95563	28481359
MAPK3	6877	COSM6926744,	breast	carcinoma	p.R211P	Substitution - Missense	16:30118075-30118075,	PATHOGENIC	0.95563	28481359
MAPK3	6877	COSM6943398,	urinary_tract	carcinoma	p.E194Q	Substitution - Missense	16:30118127-30118127,	PATHOGENIC	0.95435	28481359
MAPK3	6877	COSM1588409,	penis	carcinoma	p.E77K	Substitution - Missense	16:30121948-30121948,	PATHOGENIC	0.94764	28481359
MAPK3	6877	COSM6925916,	lung	carcinoma	p.M216I	Substitution - Missense	16:30118059-30118059,	PATHOGENIC	0.94435	28481359
MAPK3	6877	COSM6982347,	upper_aerodigestive_tract	carcinoma	p.R15G	Substitution - Missense	16:30123167-30123167,	PATHOGENIC	0.94433	28481359
MAPK3	6877	COSM6973024,	large_intestine	carcinoma	p.G199D	Substitution - Missense	16:30118111-30118111,	PATHOGENIC	0.94277	28481359
MAPK3	6877	COSM6973425,	skin	malignant_melanoma	p.P328L	Substitution - Missense	16:30116928-30116928,	PATHOGENIC	0.94217	28481359
MAPK3	6877	COSM6984592,	endometrium	carcinoma	p.Q253P	Substitution - Missense	16:30117687-30117687,	PATHOGENIC	0.94071	28481359
MAPK3	6877	COSM6972323,	lung	carcinoma	p.A52P	Substitution - Missense	16:30123056-30123056,	PATHOGENIC	0.94022	28481359
MAPK3	6877	COSM6932012,	central_nervous_system	glioma	p.G153S	Substitution - Missense	16:30118435-30118435,	PATHOGENIC	0.93624	28481359
MAPK3	6877	COSM5028122,	breast	carcinoma	p.A160T	Substitution - Missense	16:30118414-30118414,	PATHOGENIC	0.93624	22722193
MAPK3	6877	COSM6943463,	biliary_tract	carcinoma	p.I257V	Substitution - Missense	16:30117676-30117676,	PATHOGENIC	0.93242	28481359
MAPK3	6877	COSM6930910,	breast	carcinoma	p.T177I	Substitution - Missense	16:30118362-30118362,	PATHOGENIC	0.92488	28481359
MAPK3	6877	COSM6933400,	large_intestine	carcinoma	p.D300E	Substitution - Missense	16:30117161-30117161,	PATHOGENIC	0.92213	28481359
MAPK3	6877	COSM6933400,	large_intestine	carcinoma	p.D300E	Substitution - Missense	16:30117161-30117161,	PATHOGENIC	0.92213	28481359
MAPK3	6877	COSM6933400,	large_intestine	carcinoma	p.D300E	Substitution - Missense	16:30117161-30117161,	PATHOGENIC	0.92213	28481359
MAPK3	6877	COSM6939496,	large_intestine	carcinoma	p.G11V	Substitution - Missense	16:30123178-30123178,	PATHOGENIC	0.92007	28481359
MAPK3	6877	COSM6954314,	urinary_tract	carcinoma	p.E13*	Substitution - Nonsense	16:30123173-30123173,	PATHOGENIC	0.91468	28481359
MAPK3	6877	COSM6948063,	lung	carcinoma	p.R108W	Substitution - Missense	16:30121855-30121855,	PATHOGENIC	0.89442	28481359
MAPK3	6877	COSM6957092,	large_intestine	carcinoma	p.D61E	Substitution - Missense	16:30121994-30121994,	PATHOGENIC	0.88434	28481359
MAPK3	6877	COSM6933163,	pancreas	carcinoid-endocrine_tumour	p.R64C	Substitution - Missense	16:30121987-30121987,	PATHOGENIC	0.85641	28481359
MAPK3	6877	COSM6937943,	urinary_tract	carcinoma	p.E98D	Substitution - Missense	16:30121883-30121883,	PATHOGENIC	0.84246	28481359
MAPK3	6877	COSM6960571,	skin	carcinoma	p.Q7H	Substitution - Missense	16:30123189-30123189,	PATHOGENIC	0.80075	28481359
MAPK3	6877	COSM6978286,	endometrium	carcinoma	p.K72N	Substitution - Missense	16:30121961-30121961,	PATHOGENIC	0.79338	28481359
MAPK3	6877	COSM3508758,	urinary_tract	carcinoma	p.R87W	Substitution - Missense	16:30121918-30121918,	PATHOGENIC	0.76832	28481359
MAPK3	6877	COSM6941914,	urinary_tract	carcinoma	p.V24F	Substitution - Missense	16:30123140-30123140,	PATHOGENIC	0.73295	28481359
MAPK3	6877	COSM3111860,	soft_tissue	malignant_fibrous_histiocytoma-pleomorphic_sarcoma	p.P25S	Substitution - Missense	16:30123137-30123137,	NEUTRAL	0.31686	28481359
MAPK3	6877	COSM1301857,	breast	carcinoma	p.E18Q	Substitution - Missense	16:30123158-30123158,	NEUTRAL	0.20519	28481359
MAPK3	6877	COSM6930185,	prostate	carcinoma	p.M30I	Substitution - Missense	16:30123120-30123120,	NEUTRAL	0.14641	28481359
MAPK3	6877	COSM6932250,	skin	carcinoma	p.L376R	Substitution - Missense	16:30116681-30116681,	NEUTRAL	0.08717	28481359
MAPK3	6877	COSM6945627, COSM6963717, COSM6964633, COSM6966702, COSM6967393, COSM6983123,	kidney, large_intestine, lung, pancreas, skin, urinary_tract	carcinoma, malignant_melanoma	p.A378G, p.A6_Q7insA, p.G374K, p.H62_S74>R, p.I260H, p.R96H	Complex - deletion inframe, Insertion - In frame, Substitution - Missense	16:30116675-30116675, 16:30116687-30116688, 16:30117282-30117283, 16:30121890-30121890, 16:30121957-30121992, 16:30123192-30123193,	Info_not_available	0.56544, .58296, Info_not_available	28481359
MAPK3	6877	COSM5019796,	soft_tissue	haemangioblastoma	p.L217L	Substitution - coding silent	16:30118056-30118056,	Info_not_available	0.5422	25589003