Interacting Partner Detection_method PPI_type Lit_support PPI_score Source_databases ARAF Affinity Capture-MS, Biochemical Activity, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification association, physical 17979178, 24114843, 24746704, 26496610 0.69 BioGRID, IntAct ARRB2 Affinity Capture-Western physical 11226259 NA BioGRID ATAD5 Synthetic Lethality genetic 27453043 NA BioGRID AURKA two hybrid array physical association 24412244 0.37 IntAct, MINT BANP Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956, 0.49, 0.56 BioGRID, IntAct BAX two hybrid array physical association 24412244 0.37 IntAct, MINT BIRC6 anti bait coimmunoprecipitation physical association 18329369 0.40 IntAct BLM Synthetic Lethality genetic 27453043 NA BioGRID BLVRA anti bait coimmunoprecipitation association 18463290 0.35 IntAct BMPR1A two hybrid array physical association 24412244 0.37 IntAct, MINT BRAF Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Synthetic Lethality, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence technology, kinase homogeneous time resolved fluorescence, molecular sieving, protein kinase assay, pull down, surface plasmon resonance, tandem affinity purification association, direct interaction, genetic, phosphorylation reaction, physical, physical association 16810323, 16888650, 17979178, 18332145, 19371126, 20212043, 23934108, 24746704, 25155755, 25437913, 25600339, 26496610, 26627737, 27034005, 28514442 0.98 BioGRID, IntAct BRAP Affinity Capture-Western physical 18332145 NA BioGRID BRD4 Negative Genetic genetic 28319113 NA BioGRID BTRC Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy colocalization, physical, physical association 24211253 0.56 BioGRID, IntAct, MINT BUB1 two hybrid array physical association 24412244 0.37 IntAct, MINT CALR confocal microscopy colocalization 22752157 0.27 IntAct CDH1 two hybrid array physical association 24412244 0.37 IntAct, MINT CDKN2A two hybrid array physical association 24412244 0.37 IntAct, MINT CEP170P1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 0.35 BioGRID, IntAct CFLAR anti tag coimmunoprecipitation physical association 17110930 0.40 IntAct, MINT CHEK1 Negative Genetic genetic 28319113 NA BioGRID CTNNA1 two hybrid array physical association 24412244 0.37 IntAct, MINT DCP1A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 0.35 BioGRID, IntAct DGUOK Affinity Capture-MS physical 26186194 NA BioGRID ELAVL1 Affinity Capture-RNA physical 19322201 NA BioGRID ERBB2 two hybrid array physical association 24412244 0.37 IntAct, MINT FBXW7 two hybrid array physical association 24412244 0.37 IntAct, MINT FGB Affinity Capture-MS physical 28514442 NA BioGRID FH Synthetic Lethality genetic 27453043 NA BioGRID GRB10 Affinity Capture-Western, Reconstituted Complex, Two-hybrid physical 9553107 NA BioGRID HDAC2 Negative Genetic genetic 28319113 NA BioGRID HLA-B anti bait coimmunoprecipitation physical association 17353931 0.40 IntAct HNRNPD Two-hybrid physical 15231747 NA BioGRID HRAS Affinity Capture-Western physical 7969158 NA BioGRID HSCB anti bait coimmunoprecipitation association 28380382 0.35 IntAct HSPA1A Affinity Capture-MS physical 17979178 NA BioGRID HSPA8 Affinity Capture-MS, tandem affinity purification association, physical 17979178 0.35 BioGRID, IntAct ING5 Synthetic Lethality genetic 27453043 NA BioGRID IQGAP1 Affinity Capture-Western physical 24639526 NA BioGRID KAT7 Biochemical Activity physical 23319590 NA BioGRID KRAS Synthetic Growth Defect genetic 24104479 NA BioGRID KSR1 Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation, tandem affinity purification association, physical 15090600, 17979178, 18332145, 26496610, 27086506 0.64 BioGRID, IntAct KSR2 Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 12975377, 27086506 0.35 BioGRID, IntAct LAMTOR2 Affinity Capture-Western physical 11266467 NA BioGRID LAMTOR3 Affinity Capture-Western, Two-hybrid physical 11266467, 9733512 NA BioGRID LSP1 Affinity Capture-Western physical 15090600 NA BioGRID MAP2K1 Affinity Capture-MS, Biochemical Activity physical 17979178, 8226933 NA BioGRID MAP2K2 Affinity Capture-MS, Co-fractionation physical 10409742, 28514442 NA BioGRID MAP3K1 Affinity Capture-Western, anti tag coimmunoprecipitation physical, physical association 10969079, 14500727, 17110930 0.40 BioGRID, IntAct, MINT MAP3K4 Biochemical Activity physical 9841871 NA BioGRID MAP3K8 Biochemical Activity, pull down physical, physical association 12832462, 16291755, 8631303 0.40 BioGRID, IntAct MAPK1 Affinity Capture-Western, Biochemical Activity, PCA, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, protein kinase assay phosphorylation reaction, physical, physical association 10757792, 11266467, 11279118, 11352917, 11823456, 12697810, 12788955, 17255949, 19058874, 21336309, 21675959, 23241949, 24623782 0.61 BioGRID, IntAct, MINT MAPK3 Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical, physical association 10748187, 19058874, 19197339, 8226933, 8626767, 9006895, 9733512 0.50 BioGRID, IntAct, MINT MAPK8 Protein-peptide physical 16533805 NA BioGRID MAPK8IP3 Affinity Capture-Western, Reconstituted Complex physical 10523642, 11044439 NA BioGRID MLH3 two hybrid array physical association 24412244 0.37 IntAct, MINT MSH6 two hybrid array physical association 24412244 0.37 IntAct, MINT MTOR Synthetic Lethality genetic 27453043 NA BioGRID MYC Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 0.35 BioGRID, IntAct NFE2L2 Affinity Capture-Western physical 24704364 NA BioGRID NUFIP1 Affinity Capture-MS physical 26186194, 28514442 NA BioGRID ODC1 two hybrid array physical association 24412244 0.37 IntAct, MINT PDGFRL two hybrid array physical association 24412244 0.37 IntAct, MINT PDLIM5 Co-fractionation physical 26344197 NA BioGRID PEBP1 Reconstituted Complex physical 10757792 NA BioGRID PEBP4 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical 15302887, 19197339 0.46 BioGRID, IntAct, MINT PIK3CA two hybrid array physical association 24412244 0.37 IntAct, MINT PIN1 anti tag coimmunoprecipitation, two hybrid physical association 20179161 0.51 IntAct PKM protein kinase assay phosphorylation reaction 24606918 0.44 IntAct PLAU Phenotypic Suppression genetic 10402467 NA BioGRID PLIN3 Co-fractionation physical 26344197 NA BioGRID POC5 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 0.35 BioGRID, IntAct PPARG Affinity Capture-Western, Co-fractionation, Reconstituted Complex physical 17101779, 21690289 NA BioGRID PSMD10 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical 24338975 0.46 BioGRID, IntAct PTPN11 Co-fractionation physical 26344197 NA BioGRID PTPRJ two hybrid array physical association 24412244 0.37 IntAct, MINT RAF1 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, surface plasmon resonance, tandem affinity purification association, direct interaction, physical, physical association 10757792, 10958680, 15485920, 15866172, 16093354, 17724343, 17979178, 18556463, 19058874, 19197339, 20212043, 21336309, 23934108, 24746704, 25155755, 26496610, 27703006, 9311917 0.44, 0.95 BioGRID, IntAct, MINT RBM33 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 0.35 BioGRID, IntAct RNASE9 Affinity Capture-MS physical 28514442 NA BioGRID RPE Co-fractionation physical 26344197 NA BioGRID SKA3 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 0.35 BioGRID, IntAct SMAD2 two hybrid array physical association 24412244 0.37 IntAct, MINT SRC two hybrid array physical association 24412244 0.37 IntAct, MINT STK11 Synthetic Lethality, two hybrid array genetic, physical association 24412244, 27453043 0.37 BioGRID, IntAct, MINT TCTN1 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 0.35 BioGRID, IntAct TGFBR2 two hybrid array physical association 24412244 0.37 IntAct, MINT THOC2 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 0.35 BioGRID, IntAct TLR2 two hybrid array physical association 24412244 0.37 IntAct, MINT TRIB1 anti tag coimmunoprecipitation physical association 15299019 0.40 IntAct TRIB3 anti tag coimmunoprecipitation physical association 15299019 0.40 IntAct TRIM25 Affinity Capture-RNA physical 29117863 NA BioGRID TTN Synthetic Lethality genetic 27453043 NA BioGRID TUSC3 Synthetic Lethality genetic 27453043 NA BioGRID UBE2I Biochemical Activity physical 21336309 NA BioGRID VAV1 Affinity Capture-Western physical 8900182 NA BioGRID VCP Affinity Capture-MS physical 23383273 NA BioGRID VHL Negative Genetic genetic 28319113 NA BioGRID VRK2 coimmunoprecipitation, pull down association, physical association 20679487, 22752157 0.40, 0.50, 0.52 IntAct WDR83 Affinity Capture-Western physical 15118098 NA BioGRID WNK1 Two-hybrid physical 20936779 NA BioGRID WNK1 two hybrid pooling approach physical association 20936779 0.37 IntAct YAP1 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy colocalization, physical, physical association 24211253 0.56 BioGRID, IntAct, MINT YWHAB Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation, tandem affinity purification association, physical 10409742, 17979178, 24255178 0.53 BioGRID, IntAct YWHAE Affinity Capture-MS, tandem affinity purification association, physical 17979178 0.35 BioGRID, IntAct YWHAZ Affinity Capture-MS, tandem affinity purification association, physical 17979178 0.35 BioGRID, IntAct ZNF277 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 0.35 BioGRID, IntAct