Interacting Partner	Detection_method	PPI_type	Lit_support	PPI_score	Source_databases
ALK	Affinity Capture-Western	physical	14968112	NA	BioGRID
AP3S1	Reconstituted Complex	physical	9792713	NA	BioGRID
APP	Reconstituted Complex	physical	21832049	NA	BioGRID
BCAR3	Affinity Capture-Luminescence, Two-hybrid, luminescence based mammalian interactome mapping, two hybrid array, validated two hybrid	physical, physical association	25814554	0.57	BioGRID, IntAct
BCL2	Affinity Capture-Western	physical	10679027	NA	BioGRID
BCL2L1	Affinity Capture-Western	physical	10679027	NA	BioGRID
CBL	Affinity Capture-Western	physical	10854852	NA	BioGRID
CBLB	Affinity Capture-Western	physical	16734387	NA	BioGRID
CHUK	Affinity Capture-Western	physical	12351658	NA	BioGRID
CUL7	Affinity Capture-Western	physical	18498745	NA	BioGRID
DVL2	Affinity Capture-Western	physical	24616100	NA	BioGRID
EGFR	Protein-peptide, protein array	direct interaction, physical	16273093	0.44	BioGRID, IntAct, MINT
ERBB2	Protein-peptide, protein array	direct interaction, physical	16273093	0.44	BioGRID, IntAct, MINT
ESR1	Affinity Capture-Western	physical	12821935	NA	BioGRID
FBXO25	Biochemical Activity	physical	23940030	NA	BioGRID
FBXW8	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	18498745, 23045529	NA	BioGRID
GRB10	Affinity Capture-Western, Reconstituted Complex	physical	12783867, 8621530	NA	BioGRID
GRB2	Affinity Capture-MS, Affinity Capture-Western, Protein-peptide, Reconstituted Complex, anti tag coimmunoprecipitation	association, physical	12173038, 21706016, 22974441, 8491186, 8536716	0.35	BioGRID, IntAct
HDAC2	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	15522123	NA	BioGRID
IGF1R	Affinity Capture-Western, Two-hybrid, two hybrid	physical, physical association	10082579, 7541045, 7559507, 8776723	0.37	BioGRID, IntAct
IKBKB	Affinity Capture-Western	physical	12351658	NA	BioGRID
INSR	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, two hybrid	association, direct interaction, physical, physical association	11606564, 11781100, 16582879, 17167487, 25667086, 7499194, 7935368, 8626379, 8662806	0.35, 0.70	BioGRID, IntAct, MINT
IRS2	Co-fractionation	physical	12554758	NA	BioGRID
JAK1	Affinity Capture-Western, Biochemical Activity	physical	7499365, 9492017	NA	BioGRID
JAK2	Affinity Capture-Western, Biochemical Activity	physical	11208867, 9492017	NA	BioGRID
JAK3	Affinity Capture-Western	physical	7499365	NA	BioGRID
KHDRBS1	Affinity Capture-Western	physical	11604231, 8175658	NA	BioGRID
MAPK3	Biochemical Activity	physical	17640984	NA	BioGRID
MAPK8	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	10722755, 11606564	NA	BioGRID
MTOR	Affinity Capture-Western, Biochemical Activity	physical	11287630, 16354680	NA	BioGRID
NCK2	Reconstituted Complex	physical	9843575	NA	BioGRID
NEDD4	Reconstituted Complex	physical	19953087	NA	BioGRID
NISCH	Affinity Capture-Western	physical	11912194	NA	BioGRID
NUMB	Two-hybrid	physical	25814554	NA	BioGRID
PELI1	Two-hybrid, two hybrid array	physical, physical association	25814554	0.37	BioGRID, IntAct
PIK3CA	Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down	association, direct interaction, physical, physical association	12933652, 14511371, 16150444, 16354680, 23604317, 23643389	0.75	BioGRID, IntAct, MINT
PIK3CB	Affinity Capture-Western	physical	23604317	NA	BioGRID
PIK3R1	Affinity Capture-Luminescence, Affinity Capture-Western, Far Western, Protein-peptide, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, cross-linking study, enzymatic study, luminescence based mammalian interactome mapping, nuclear magnetic resonance, pull down, surface plasmon resonance, two hybrid, two hybrid array, validated two hybrid	association, physical, physical association	11403293, 11416002, 12107746, 12173038, 12730242, 1381348, 14511371, 14632132, 15514089, 16150444, 16230374, 16354680, 17640984, 19561084, 22974441, 23439647, 23643389, 25814554, 7680095, 7680644, 8175658, 8382612, 8628286, 9564850	0.57, 0.92	BioGRID, IntAct, MINT
PIK3R2	Affinity Capture-Western	physical	23604317	NA	BioGRID
PIK3R3	Affinity Capture-Luminescence, Affinity Capture-Western, Two-hybrid, luminescence based mammalian interactome mapping, two hybrid array, validated two hybrid	physical, physical association	10417350, 25814554, 9415396	0.57	BioGRID, IntAct
PLCG2	Protein-peptide	physical	22974441	NA	BioGRID
PRKCD	Affinity Capture-Western, Biochemical Activity	physical	12031982, 15516986	NA	BioGRID
PTK2	Affinity Capture-Western, Two-hybrid	physical	9822703	NA	BioGRID
PTPN1	Affinity Capture-Western, Reconstituted Complex, phosphatase assay	dephosphorylation reaction, physical	10660596, 11579209	0.44	BioGRID, IntAct, MINT
PTPN11	Affinity Capture-Western, Biochemical Activity, Protein-peptide, Reconstituted Complex, surface plasmon resonance	association, physical	11781100, 22974441, 7513703, 8505282, 9756938	0.35	BioGRID, IntAct, MINT
PTPRU	Biochemical Activity	physical	11781100	NA	BioGRID
RPS6KB1	Biochemical Activity, Reconstituted Complex	physical	18498745, 23045529	NA	BioGRID
RPTOR	Affinity Capture-Western, Reconstituted Complex	physical	16354680, 19561084	NA	BioGRID
SFN	Affinity Capture-MS, tandem affinity purification	physical, physical association	15778465	0.40	BioGRID, IntAct, MINT
SH2B1	Protein-peptide	physical	22974441	NA	BioGRID
SIRT1	Affinity Capture-Western, anti bait coimmunoprecipitation	physical, physical association	17901049, 21241768	0.40	BioGRID, IntAct
SMAD3	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074	0.40	BioGRID, IntAct
SOCS1	Affinity Capture-Western	physical	12228220, 17276034	NA	BioGRID
SOCS3	Affinity Capture-Western	physical	15514089	NA	BioGRID
UBC	Reconstituted Complex	physical	23045529	NA	BioGRID
UBTF	Affinity Capture-Western	physical	12554758, 17332342	NA	BioGRID
YWHAB	Reconstituted Complex	physical	9422753	NA	BioGRID
YWHAE	Reconstituted Complex, Two-hybrid, competition binding, pull down, two hybrid	association, direct interaction, physical, physical association	9111084, 9312143	0.68	BioGRID, IntAct, MINT
YWHAH	Affinity Capture-Western	physical	11969417	NA	BioGRID